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2-oxoglutarate dehydrogenase complex component E1 isoform X1 [Rattus norvegicus]
Protein Classification
2-oxoglutarate dehydrogenase subunit E1 ( domain architecture ID 11484076 )
2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1031
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1303.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LSLSRSS LA TMAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL H E S DLD K VF H lp T TTF 208
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRERP --- Y VP -------- E LD P A ------------- FYGL T E A DLD T VF N -- T GSL 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 I G GQE pa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K W 287
Cdd:COG0567 143 L G LET -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K Y 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 288 SSE KRF G LEG C E V LIPAL KTI I DMSSAN GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGD M KYHLG 367
Cdd:COG0567 221 VGQ KRF S LEG G E S LIPAL DEL I ERAGEL GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGD V KYHLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 m YHR ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS 446
Cdd:COG0567 301 - FSS -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG 377
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 447 Y T T H GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R NT F H KDVV V DLVCYRR N 526
Cdd:COG0567 378 Y R T G GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 527 GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F TRS K d E KILHIKH WL DSP W PG 606
Cdd:COG0567 458 GHNE G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SP 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 607 FFT L DGQ pr SMTCPS TG LEEDI L THI G NVASSV P v E N F TI H GGLSR IL KT RR ELV - TNRTV DW AL AE YM A FG SLL K EG IH 685
Cdd:COG0567 537 YRR L GED -- WDDPVD TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED RR KMA e GEKPL DW GM AE AL A YA SLL D EG YP 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 686 VRLSGQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF 765
Cdd:COG0567 614 VRLSGQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 766 N N M AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpnlqeenfdisqlydc N WI V V 845
Cdd:COG0567 693 A N G AQ VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 846 N CS TP GNF FH V LRRQ ILL PFRKPLIV F TPKSLLRH PE A RT S FD E MLP G t H FQ R VI PEDGPA aq N P D KVKR LLF C T GKVYY 925
Cdd:COG0567 753 N PT TP AQY FH L LRRQ MKR PFRKPLIV M TPKSLLRH KL A VS S LE E LAE G - S FQ E VI DDTDEL -- D P K KVKR VVL C S GKVYY 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 926 DL TR ER KA R D m AEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTIDRAKPVW YAGR D 1004
Cdd:COG0567 830 DL LE ER RE R G - RDD VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR P 908
970 980
....*....|....*....|....*..
gi 1958676725 1005 PA A A PATG NKKT H LT E LQRFLDT A FDL 1031
Cdd:COG0567 909 AS A S PATG YMSV H KA E QKALVEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1031
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1303.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LSLSRSS LA TMAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL H E S DLD K VF H lp T TTF 208
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRERP --- Y VP -------- E LD P A ------------- FYGL T E A DLD T VF N -- T GSL 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 I G GQE pa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K W 287
Cdd:COG0567 143 L G LET -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K Y 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 288 SSE KRF G LEG C E V LIPAL KTI I DMSSAN GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGD M KYHLG 367
Cdd:COG0567 221 VGQ KRF S LEG G E S LIPAL DEL I ERAGEL GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGD V KYHLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 m YHR ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS 446
Cdd:COG0567 301 - FSS -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG 377
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 447 Y T T H GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R NT F H KDVV V DLVCYRR N 526
Cdd:COG0567 378 Y R T G GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 527 GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F TRS K d E KILHIKH WL DSP W PG 606
Cdd:COG0567 458 GHNE G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SP 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 607 FFT L DGQ pr SMTCPS TG LEEDI L THI G NVASSV P v E N F TI H GGLSR IL KT RR ELV - TNRTV DW AL AE YM A FG SLL K EG IH 685
Cdd:COG0567 537 YRR L GED -- WDDPVD TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED RR KMA e GEKPL DW GM AE AL A YA SLL D EG YP 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 686 VRLSGQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF 765
Cdd:COG0567 614 VRLSGQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 766 N N M AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpnlqeenfdisqlydc N WI V V 845
Cdd:COG0567 693 A N G AQ VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 846 N CS TP GNF FH V LRRQ ILL PFRKPLIV F TPKSLLRH PE A RT S FD E MLP G t H FQ R VI PEDGPA aq N P D KVKR LLF C T GKVYY 925
Cdd:COG0567 753 N PT TP AQY FH L LRRQ MKR PFRKPLIV M TPKSLLRH KL A VS S LE E LAE G - S FQ E VI DDTDEL -- D P K KVKR VVL C S GKVYY 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 926 DL TR ER KA R D m AEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTIDRAKPVW YAGR D 1004
Cdd:COG0567 830 DL LE ER RE R G - RDD VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR P 908
970 980
....*....|....*....|....*..
gi 1958676725 1005 PA A A PATG NKKT H LT E LQRFLDT A FDL 1031
Cdd:COG0567 909 AS A S PATG YMSV H KA E QKALVEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1030
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1262.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplslsrss L A TMAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL H E S DLD KV F H lp T TTF 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LWKRP --- D VP -------- E LD P A ------------- FYGL T E A DLD RT F N -- T GSL 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 IG G Q E P A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:PRK09404 136 AL G K E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FV 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 289 SE KRF G LEG C E V LIP A L KT II DMSSAN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGD M KYHLG 367
Cdd:PRK09404 214 GQ KRF S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGD V KYHLG 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 m YHR ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L P 445
Cdd:PRK09404 294 - FSS -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L R 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 446 S Y T T H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDVV V DLVCYRR 525
Cdd:PRK09404 371 G Y R T G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 526 N GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F TRS K DEK ilh IKH WL DSP W P 605
Cdd:PRK09404 451 H GHNE G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W S 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 606 GFFTLDGQPR smtc PS TG LEEDI L THIGNVASS VP v E N F TI H GGLSR IL KT RRE LV - TNRTV DW AL AE YM AF G SLL K EG I 684
Cdd:PRK09404 528 PYLGHEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED RRE MA e GEKPI DW GM AE AL AF A SLL D EG Y 602
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 685 H VRLSGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGD 764
Cdd:PRK09404 603 P VRLSGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGD 681
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 765 F N N M AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpnlqeenfdisqlydc N WI V 844
Cdd:PRK09404 682 F A N G AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V 741
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 845 V N CS TP GNF FH V LRRQ I L L PFRKPL I V F TPKSLLRHP E A RT S FD E MLP G T h FQ R VI PE dg PAAQN P D KVKR LLF C T GKVY 924
Cdd:PRK09404 742 C N PT TP AQY FH L LRRQ A L R PFRKPL V V M TPKSLLRHP L A VS S LE E LAE G S - FQ P VI GD -- IDELD P K KVKR VVL C S GKVY 818
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 925 YDL TRE R KA R D m AEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTIDRAKPVW YAGR 1003
Cdd:PRK09404 819 YDL LEA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR 897
970 980
....*....|....*....|....*..
gi 1958676725 1004 DPA A A PA T G NKKT H LTELQRFLDT A FD 1030
Cdd:PRK09404 898 PAS A S PA V G YMSL H KKQQEALVED A LG 924
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1029
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 975.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LSLSRSS LA TM A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 AV Q s LIRAY QI RGH HV A Q LDPLG ILDA D ldss VPAD iisstdk LDL A vfkerlrmltvgg FYGL H E S DL DKV F HLPTTTF 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LKQQ D ---- KVPE ------- LDL S ------------- FYGL T E A DL QET F NIGSFVS 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 IGGQEPA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:TIGR00239 134 GKDATMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FP 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 289 SE KRF G LEG CEV L I P A LK T II DM S SAN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GD M KYH L G 367
Cdd:TIGR00239 214 GA KRF S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GD V KYH M G 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 MYHRRIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS 446
Cdd:TIGR00239 294 RFSSDFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG 372
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 447 Y TTH GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W RNTF HK DV VV DLV C YRR N 526
Cdd:TIGR00239 373 Y SVG GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y RNTF KR DV FI DLV G YRR H 452
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 527 GHNE M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FTRSKD e KILHIKHWLDSPWPG 606
Cdd:TIGR00239 453 GHNE A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTW 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 607 FFT L D g QPRSMTC P ST g L E EDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R RELVT -- NRTV DW AL AE YM AF GS L LKE GI 684
Cdd:TIGR00239 528 SPE L N - HEWDEEY P NK - V E MKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI 604
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 685 H VRLSG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGD 764
Cdd:TIGR00239 605 P VRLSG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGD 683
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 765 F N N M AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpnlqeenfdisqlydc N WI V 844
Cdd:TIGR00239 684 F A N G AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V 743
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 845 VNCS TP GNF FH V LRRQ I L LPF R K PL I V FT PKSLLRHP E A RT S FD E MLP GT h FQ R VI P -- E DGPAAQN P DK VKRL LF C T GK 922
Cdd:TIGR00239 744 CVPT TP AQV FH I LRRQ A L RGM R R PL V V MS PKSLLRHP L A VS S LE E LAE GT - FQ P VI G ei E ESGLSLD P EG VKRL VL C S GK 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 923 VYYDL t R E RKARDMAEE VAI T RIEQL S PFP FDLLLKEA Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I DRAKP V W YA 1001
Cdd:TIGR00239 823 VYYDL - H E QRRKNGQKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YA 901
970 980
....*....|....*....|....*...
gi 1958676725 1002 GR DPA A A PA T G NKKT H LTEL Q RF L DT A F 1029
Cdd:TIGR00239 902 GR PAS A S PA V G YMSL H QKQQ Q DL L ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
279-542
6.36e-178
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 518.62
E-value: 6.36e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 279 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID MSSAN GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 356
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAAEL GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 357 EGSGD M KYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 436
Cdd:cd02016 81 EGSGD V KYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 437 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDV 516
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 1958676725 517 V V DLVCYRR N GHNE M DEP M FTQPLMY 542
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
271-597
1.13e-108
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 339.69
E-value: 1.13e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 271 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DMSSAN G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 350
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAALEP G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 351 KLE aad E G S G DMKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 430
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 431 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRN 510
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 511 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF TRSK 589
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 1958676725 590 DEKIL H IK 597
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
732-879
6.84e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.55
E-value: 6.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 732 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F NNM A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 810
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 811 E - RFLQM cnddpdvlpnlqeenfdisqlyd CNWI VV NC S T P GNFFHV LR RQ I LLP f RKPL I VFTP KSL L R 879
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1031
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1303.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LSLSRSS LA TMAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL H E S DLD K VF H lp T TTF 208
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRERP --- Y VP -------- E LD P A ------------- FYGL T E A DLD T VF N -- T GSL 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 I G GQE pa LP LREII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K W 287
Cdd:COG0567 143 L G LET -- AT LREII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K Y 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 288 SSE KRF G LEG C E V LIPAL KTI I DMSSAN GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGD M KYHLG 367
Cdd:COG0567 221 VGQ KRF S LEG G E S LIPAL DEL I ERAGEL GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGD V KYHLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 m YHR ri NRV T D - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS 446
Cdd:COG0567 301 - FSS -- DVE T P g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG 377
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 447 Y T T H GT V H V V V NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R NT F H KDVV V DLVCYRR N 526
Cdd:COG0567 378 Y R T G GT I H I V I NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H 457
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 527 GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F TRS K d E KILHIKH WL DSP W PG 606
Cdd:COG0567 458 GHNE G DEP A FTQPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SP 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 607 FFT L DGQ pr SMTCPS TG LEEDI L THI G NVASSV P v E N F TI H GGLSR IL KT RR ELV - TNRTV DW AL AE YM A FG SLL K EG IH 685
Cdd:COG0567 537 YRR L GED -- WDDPVD TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED RR KMA e GEKPL DW GM AE AL A YA SLL D EG YP 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 686 VRLSGQD VE RGTFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF 765
Cdd:COG0567 614 VRLSGQD SG RGTFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 766 N N M AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpnlqeenfdisqlydc N WI V V 845
Cdd:COG0567 693 A N G AQ VV IDQFI SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 846 N CS TP GNF FH V LRRQ ILL PFRKPLIV F TPKSLLRH PE A RT S FD E MLP G t H FQ R VI PEDGPA aq N P D KVKR LLF C T GKVYY 925
Cdd:COG0567 753 N PT TP AQY FH L LRRQ MKR PFRKPLIV M TPKSLLRH KL A VS S LE E LAE G - S FQ E VI DDTDEL -- D P K KVKR VVL C S GKVYY 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 926 DL TR ER KA R D m AEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTIDRAKPVW YAGR D 1004
Cdd:COG0567 830 DL LE ER RE R G - RDD VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR P 908
970 980
....*....|....*....|....*..
gi 1958676725 1005 PA A A PATG NKKT H LT E LQRFLDT A FDL 1031
Cdd:COG0567 909 AS A S PATG YMSV H KA E QKALVEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1030
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1262.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplslsrss L A TMAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 A V QS LI R AY QI RGH HV A Q LDPLG ILDAD lds S VP adiisstd K LD L A vfkerlrmltvgg FYGL H E S DLD KV F H lp T TTF 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LWKRP --- D VP -------- E LD P A ------------- FYGL T E A DLD RT F N -- T GSL 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 IG G Q E P A l P LREII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:PRK09404 136 AL G K E T A - T LREII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FV 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 289 SE KRF G LEG C E V LIP A L KT II DMSSAN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGD M KYHLG 367
Cdd:PRK09404 214 GQ KRF S LEG G E S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGD V KYHLG 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 m YHR ri N R V TD - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L P 445
Cdd:PRK09404 294 - FSS -- D R E TD g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L R 370
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 446 S Y T T H GT V H V V V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDVV V DLVCYRR 525
Cdd:PRK09404 371 G Y R T G GT I H I V I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 526 N GHNE M DEP M FTQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F TRS K DEK ilh IKH WL DSP W P 605
Cdd:PRK09404 451 H GHNE G DEP S FTQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W S 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 606 GFFTLDGQPR smtc PS TG LEEDI L THIGNVASS VP v E N F TI H GGLSR IL KT RRE LV - TNRTV DW AL AE YM AF G SLL K EG I 684
Cdd:PRK09404 528 PYLGHEWDDP ---- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED RRE MA e GEKPI DW GM AE AL AF A SLL D EG Y 602
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 685 H VRLSGQD VE RGTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGD 764
Cdd:PRK09404 603 P VRLSGQD SG RGTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGD 681
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 765 F N N M AQ CI IDQFI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpnlqeenfdisqlydc N WI V 844
Cdd:PRK09404 682 F A N G AQ VV IDQFI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V 741
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 845 V N CS TP GNF FH V LRRQ I L L PFRKPL I V F TPKSLLRHP E A RT S FD E MLP G T h FQ R VI PE dg PAAQN P D KVKR LLF C T GKVY 924
Cdd:PRK09404 742 C N PT TP AQY FH L LRRQ A L R PFRKPL V V M TPKSLLRHP L A VS S LE E LAE G S - FQ P VI GD -- IDELD P K KVKR VVL C S GKVY 818
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 925 YDL TRE R KA R D m AEE VAI T RIEQL S PFP FDL L LK E AQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTIDRAKPVW YAGR 1003
Cdd:PRK09404 819 YDL LEA R RK R G - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR 897
970 980
....*....|....*....|....*..
gi 1958676725 1004 DPA A A PA T G NKKT H LTELQRFLDT A FD 1030
Cdd:PRK09404 898 PAS A S PA V G YMSL H KKQQEALVED A LG 924
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
117-1031
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1006.34
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 117 QPNVDKL V EDHLA V QS LI R AY QI RGH HV A QL DPL GI --- LDA DLD ssvpad IIS stdkldlavfkerlrmltvggf Y GL H 193
Cdd:PRK12270 376 PADHEDE V DKNAR V ME LI H AY RV RGH LM A DT DPL EY rqr SHP DLD ------ VLT ---------------------- H GL T 427
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 194 ES DLD KV F hl P TTT F i GG Q e PALP LR E I IRR L EMA YC QHI G V E F M F I N D L EQ CQ W IRQKF E T P g IMQF T N EE KRTL L AR L 273
Cdd:PRK12270 428 LW DLD RE F -- P VGG F - GG K - ERMK LR D I LGV L RDS YC RTV G I E Y M H I Q D P EQ RR W LQERV E R P - HEKP T R EE QKRI L SK L 502
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 274 VRSTR FE E FLQ R K WSSE KRF G LEG C E V LIP A L KTII D MSSAN G V D Y V IM GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E 353
Cdd:PRK12270 503 NAAEA FE T FLQ T K YVGQ KRF S LEG G E S LIP L L DAVL D QAAEH G L D E V VI GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D 582
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 354 - AADE GSGD M KYHLG --- MYHR rinr VTDRN I TL SL V ANPSHLEA A DPV VM G KTK A E Q FYCGD - T EG KK V MS ILLHGDAA 428
Cdd:PRK12270 583 p RSAQ GSGD V KYHLG aeg TFTQ ---- MFGDE I KV SL A ANPSHLEA V DPV LE G IVR A K Q DRLDK g E EG FT V LP ILLHGDAA 658
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 429 FAGQG I V Y ET FH LS D L PS Y T T H GT V H V VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN S DDPEAV MY V CKV A A E W 508
Cdd:PRK12270 659 FAGQG V V A ET LN LS Q L RG Y R T G GT I H I VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAV VR V ARL A F E Y 738
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 509 R NT FHKDVV V DLVCYRR N GHNE M D E P MF TQPLMY KQ I RKQKP V LQK Y A E L L VSQ G VVNQP E Y E EEISK Y DKIC E EA F TRS 588
Cdd:PRK12270 739 R QR FHKDVV I DLVCYRR R GHNE G D D P SM TQPLMY DL I DAKRS V RKL Y T E A L IGR G DITVE E A E QALRD Y QGQL E RV F NEV 818
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 589 KDEK ilhi K H wl DSPW P GFFTL D GQ P rs MTCPS T GLEEDI L TH IG NVASSV P v E N FT I H GG L SRI L KT RRE LVTNRTV DW 668
Cdd:PRK12270 819 REAE ---- K K -- PPEP P ESVES D QG P -- PAGVD T AVSAEV L ER IG DAHVNL P - E G FT V H PK L KPL L EK RRE MAREGGI DW 889
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 669 A LA E YM AFGSLL K EG IH VRLSGQD VE RGTFS H RH H VL H D QNVDKRTC i P MNH L WPN Q APYT V CN S S LSEY GVL GFE L G FA 748
Cdd:PRK12270 890 A FG E LL AFGSLL L EG TP VRLSGQD SR RGTFS Q RH A VL I D RETGEEYT - P LQN L SDD Q GKFL V YD S L LSEY AAM GFE Y G YS 968
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 749 MAS P N ALVLWEAQFGDF N N M AQ C IID Q FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdvlpnlq 828
Cdd:PRK12270 969 VER P D ALVLWEAQFGDF A N G AQ T IID E FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG -------- 1040
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 829 eenfdisqlydc N WI V VNC STP G N F FH V LRRQ I L LPF R K PL I VFTPKS L LR HPE A RTSFDEMLP G T h F QR VI PE dg P AAQ 908
Cdd:PRK12270 1041 ------------ N MT V AQP STP A N Y FH L LRRQ A L SGP R R PL V VFTPKS M LR LKA A VSDVEDFTE G K - F RP VI DD -- P TVD 1105
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 909 NPD KV K R L L F C T GK V YYDL TRE R KARD m AEEV AI T R I EQL S P F P FDL L LKEAQK YPNA - E LA W C QEE HK NQG YYDYVKPR 987
Cdd:PRK12270 1106 DGA KV R R V L L C S GK L YYDL AAR R EKDG - RDDT AI V R V EQL Y P L P RAE L REALAR YPNA t E VV W V QEE PA NQG AWPFMALN 1184
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 1958676725 988 L RTTIDRAKPVWYAG R DPA A A PATG NK K T H LT E L Q RF LD T AF DL 1031
Cdd:PRK12270 1185 L PELLPDGRRLRRVS R PAS A S PATG SA K V H AV E Q Q EL LD E AF AR 1228
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1029
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 975.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LSLSRSS LA TM A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 129 AV Q s LIRAY QI RGH HV A Q LDPLG ILDA D ldss VPAD iisstdk LDL A vfkerlrmltvgg FYGL H E S DL DKV F HLPTTTF 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LKQQ D ---- KVPE ------- LDL S ------------- FYGL T E A DL QET F NIGSFVS 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 209 IGGQEPA L PLR E IIRR L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WS 288
Cdd:TIGR00239 134 GKDATMK L SNL E LLQA L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FP 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 289 SE KRF G LEG CEV L I P A LK T II DM S SAN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GD M KYH L G 367
Cdd:TIGR00239 214 GA KRF S LEG LDA L V P M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GD V KYH M G 293
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 368 MYHRRIN r VTDRNIT L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS 446
Cdd:TIGR00239 294 RFSSDFT - TDGKLVH L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG 372
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 447 Y TTH GT V H VVV NNQIGFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W RNTF HK DV VV DLV C YRR N 526
Cdd:TIGR00239 373 Y SVG GT I H III NNQIGFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y RNTF KR DV FI DLV G YRR H 452
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 527 GHNE M DEP MF TQPLMY KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FTRSKD e KILHIKHWLDSPWPG 606
Cdd:TIGR00239 453 GHNE A DEP SA TQPLMY QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTW 527
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 607 FFT L D g QPRSMTC P ST g L E EDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R RELVT -- NRTV DW AL AE YM AF GS L LKE GI 684
Cdd:TIGR00239 528 SPE L N - HEWDEEY P NK - V E MKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI 604
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 685 H VRLSG Q D V ERGTF SH RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGD 764
Cdd:TIGR00239 605 P VRLSG E D S ERGTF FQ RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGD 683
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 765 F N N M AQ CI IDQFI CP G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpnlqeenfdisqlydc N WI V 844
Cdd:TIGR00239 684 F A N G AQ VV IDQFI SS G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V 743
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 845 VNCS TP GNF FH V LRRQ I L LPF R K PL I V FT PKSLLRHP E A RT S FD E MLP GT h FQ R VI P -- E DGPAAQN P DK VKRL LF C T GK 922
Cdd:TIGR00239 744 CVPT TP AQV FH I LRRQ A L RGM R R PL V V MS PKSLLRHP L A VS S LE E LAE GT - FQ P VI G ei E ESGLSLD P EG VKRL VL C S GK 822
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 923 VYYDL t R E RKARDMAEE VAI T RIEQL S PFP FDLLLKEA Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I DRAKP V W YA 1001
Cdd:TIGR00239 823 VYYDL - H E QRRKNGQKD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YA 901
970 980
....*....|....*....|....*...
gi 1958676725 1002 GR DPA A A PA T G NKKT H LTEL Q RF L DT A F 1029
Cdd:TIGR00239 902 GR PAS A S PA V G YMSL H QKQQ Q DL L ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
279-542
6.36e-178
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 518.62
E-value: 6.36e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 279 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID MSSAN GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 356
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAAEL GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 357 EGSGD M KYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 436
Cdd:cd02016 81 EGSGD V KYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 437 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R NT F H KDV 516
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 1958676725 517 V V DLVCYRR N GHNE M DEP M FTQPLMY 542
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
271-597
1.13e-108
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 339.69
E-value: 1.13e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 271 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DMSSAN G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 350
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAALEP G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 351 KLE aad E G S G DMKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 430
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 431 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRN 510
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 511 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF TRSK 589
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 1958676725 590 DEKIL H IK 597
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
884-1029
1.34e-79
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 255.83
E-value: 1.34e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 884 R T S FD E ML PGTHFQRVIP EDG P A a QN P D KVKR LLF C T GKVYYDL TR ER KA R DMAEE VAI T RIEQL S PFPFDLL LK E AQ KY 963
Cdd:pfam16870 1 R S S LE E FT PGTHFQRVIP DPE P L - VD P E KVKR VVL C S GKVYYDL LK ER EE R GGIKD VAI V RIEQL Y PFPFDLL KE E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958676725 964 PNA - E LA WCQEE H KNQG YYDY V K PRL R T TIDRA - KPVW YAGR D P A A A PATG N K KT HL T E LQRF LD T AF 1029
Cdd:pfam16870 80 PNA a E IV WCQEE P KNQG AWSF V Q PRL E T VLNET g HRLR YAGR P P S A S PATG S K SV HL A E QEAL LD D AF 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
664-879
4.79e-53
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 183.14
E-value: 4.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 664 RTVDWAL A EYM A FGS L L K EGIH V RLS G Q D VER GTF SHRHHV LH D qnvdkrtcipmnhlwpn Q APYT V CNSSLS E YGVL GF 743
Cdd:pfam02779 1 KKIATRK A SGE A LAE L A K RDPR V VGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 744 EL G F A MAS P N a L VLW EA Q F G DF N N M A qcii D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 822
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N R A ---- D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958676725 823 vlpnlqeenfdisqlydc NWI VV NC S TPGNFFHV LR RQ I LLPF RKP LIVFT P KS LLR 879
Cdd:pfam02779 135 ------------------ GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
732-879
6.84e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.55
E-value: 6.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 732 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F NNM A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 810
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 811 E - RFLQM cnddpdvlpnlqeenfdisqlyd CNWI VV NC S T P GNFFHV LR RQ I LLP f RKPL I VFTP KSL L R 879
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
47-87
1.27e-15
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 71.41
E-value: 1.27e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1958676725 47 EP FLSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F R N TNA G A 87
Cdd:pfam16078 1 DS FLSG ANAA Y I EE L Y EQY L KD P S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
415-587
5.93e-11
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 64.44
E-value: 5.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 415 G KKVMSILLH GD A A f AGQ G IVY E TFHLS --- D LP sytthg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 489
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676725 490 V NSD D PE AV MYVC K V A A E W - R NT f HKDVVVDL V C YR RN GH NEM D E P M ftqpl M Y K ----- QIR K QKPVLQKYAEL L VSQ G 563
Cdd:cd02000 195 V DGN D VL AV YEAA K E A V E R a R AG - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY L IEA G 268
170 180
....*....|....*....|....
gi 1958676725 564 VVNQP E YEEEISKYDKIC EEA FTR 587
Cdd:cd02000 269 ILTEE E LAAIEAEVKAEV EEA VEF 292
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
