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Conserved domains on  [gi|1953004335|ref|XP_038386755|]
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U3 small nucleolar RNA-associated protein 15 homolog [Canis lupus familiaris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 344-490 3.55e-64

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 205.41  E-value: 3.55e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 344 YMKQRDDILINRPSKKHLELYDRDLKNFRVSKALDRVLEPSctIKTPEITVSIIKELNRRGVLANALAGRDEKEISRVLN 423
Cdd:pfam09384   2 YKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLLK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953004335 424 FLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  80 FLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 8.44e-57

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 8.44e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQF 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKMFDART 196
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 197 NQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319   236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1953004335 275 YSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 307
Cdd:COG2319   315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 344-490 3.55e-64

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 205.41  E-value: 3.55e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 344 YMKQRDDILINRPSKKHLELYDRDLKNFRVSKALDRVLEPSctIKTPEITVSIIKELNRRGVLANALAGRDEKEISRVLN 423
Cdd:pfam09384   2 YKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLLK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953004335 424 FLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  80 FLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 8.44e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 8.44e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQF 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKMFDART 196
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 197 NQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319   236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1953004335 275 YSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 307
Cdd:COG2319   315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-315 1.33e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  72 PIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 151
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 152 PNSKEIVTFKEHSDYVRCgCASKLNPDLFVTGSYDHTVKMFDARTNQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYV 229
Cdd:cd00200    81 ETGECVRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 230 KIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGM 308
Cdd:cd00200   160 KLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGS 238


                  ....*..
gi 1953004335 309 TNGILSV 315
Cdd:cd00200   239 EDGTIRV 245
PTZ00421 PTZ00421
coronin; Provisional
 91-236 3.05e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.05  E-value: 3.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  91 DGKLLVAgSEDGGVQLFDI-------SGRAPLRQFEGHTKAVHTVDFTADKYHVVSGAD-DYTVKLWDIPNSKEIVTFKE 162
Cdd:PTZ00421   88 PQKLFTA-SEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 163 HSDYVrCGCASKLNPDLFVTGSYDHTVKMFDARTNQSVISVEHGQPVES--VLLFPSGGLLASAG-----GRYVKIWDML 235
Cdd:PTZ00421  167 HSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDTR 245


                  .
gi 1953004335 236 K 236
Cdd:PTZ00421  246 K 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-150 1.22e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1953004335  114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
114-150 2.08e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.08e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1953004335 114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 344-490 3.55e-64

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 205.41  E-value: 3.55e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 344 YMKQRDDILINRPSKKHLELYDRDLKNFRVSKALDRVLEPSctIKTPEITVSIIKELNRRGVLANALAGRDEKEISRVLN 423
Cdd:pfam09384   2 YKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLLK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1953004335 424 FLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  80 FLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 8.44e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 8.44e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQF 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKMFDART 196
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 197 NQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319   236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1953004335 275 YSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 307
Cdd:COG2319   315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 2.61e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.51  E-value: 2.61e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:COG2319   121 GAVRSVAFSPDG--KTLASGSAdgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCgCAskLNPD--LFVTGSYDHTVKMFDA 194
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS-VA--FSPDgrLLASGSADGTVRLWDL 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 195 RTNQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKV 272
Cdd:COG2319   276 ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1953004335 273 KVYSTTSYKVVHSF-DYAASILSLALAHEDETIVVG 307
Cdd:COG2319   355 RLWDLATGELLRTLtGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
39-279 3.48e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.42  E-value: 3.48e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:COG2319   163 GAVTSVAFSPDG--KLLASGSDdgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKMFDA 194
Cdd:COG2319   241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PDgkLLASGSDDGTVRLWDL 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 195 RTNQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKV 272
Cdd:COG2319   318 ATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDdGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396


                  ....*..
gi 1953004335 273 KVYSTTS 279
Cdd:COG2319   397 RLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
38-315 1.86e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.49  E-value: 1.86e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  38 FGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQ 117
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 118 FEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCgCAskLNPD--LFVTGSYDHTVKMFDAR 195
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS-VA--FSPDgkLLASGSDDGTVRLWDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 196 TNQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVK 273
Cdd:COG2319   193 TGKLLRTLTgHTGAVRSVAFSPDGKLLASGSAdGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1953004335 274 VYSTTSYKVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 315
Cdd:COG2319   272 LWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-315 1.33e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  72 PIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 151
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 152 PNSKEIVTFKEHSDYVRCgCASKLNPDLFVTGSYDHTVKMFDARTNQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYV 229
Cdd:cd00200    81 ETGECVRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 230 KIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGM 308
Cdd:cd00200   160 KLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGS 238


                  ....*..
gi 1953004335 309 TNGILSV 315
Cdd:cd00200   239 EDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-306 1.87e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.36  E-value: 1.87e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQPpyNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLR 116
Cdd:cd00200    10 GGVTCVAFSPDG--KLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 117 QFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKMFDART 196
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 197 NQSVISVE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKV 274
Cdd:cd00200   167 GKCVATLTgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1953004335 275 YSTTSYKVVHSFD-YAASILSLALaHEDETIVV 306
Cdd:cd00200   246 WDLRTGECVQTLSgHTNSVTSLAW-SPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-276 1.15e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 156.34  E-value: 1.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  39 GAVSKVDFSPQppYNYAVTASS----RIHIYGrySQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAP 114
Cdd:cd00200    52 GPVRDVAASAD--GTYLASGSSdktiRLWDLE--TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 115 LRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKMFDA 194
Cdd:cd00200   128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDL 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 195 RTNQSVIS-VEHGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKV 272
Cdd:cd00200   207 STGKCLGTlRGHENGVNSVAFSPDGYLLASGSEdGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                  ....
gi 1953004335 273 KVYS 276
Cdd:cd00200   286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
45-315 3.63e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 3.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  45 DFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQFEGHTKA 124
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 125 VHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKMFDARTNQSVIS 202
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 203 VE-HGQPVESVLLFPSGGLLASAGG-RYVKIWDmLKGGQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKVYSTTSY 280
Cdd:COG2319   158 LTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1953004335 281 KVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 315
Cdd:COG2319   237 KLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-193 2.53e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 2.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  26 WNNyKTPVQIKEF----GAVSKVDFSPQPPYnyaVTASSR---IHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAG 98
Cdd:cd00200   120 WDV-ETGKCLTTLrghtDWVNSVAFSPDGTF---VASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIVTFKEHSDYVRCGCASKLNPD 178
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                         170
                  ....*....|....*
gi 1953004335 179 LfVTGSYDHTVKMFD 193
Cdd:cd00200   276 L-ASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 91-236 3.05e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.05  E-value: 3.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  91 DGKLLVAgSEDGGVQLFDI-------SGRAPLRQFEGHTKAVHTVDFTADKYHVVSGAD-DYTVKLWDIPNSKEIVTFKE 162
Cdd:PTZ00421   88 PQKLFTA-SEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 163 HSDYVrCGCASKLNPDLFVTGSYDHTVKMFDARTNQSVISVEHGQPVES--VLLFPSGGLLASAG-----GRYVKIWDML 235
Cdd:PTZ00421  167 HSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDTR 245


                  .
gi 1953004335 236 K 236
Cdd:PTZ00421  246 K 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-150 1.22e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1953004335  114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
114-150 2.08e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.08e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1953004335 114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 85-318 3.53e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 3.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  85 CA-TFRQDGKLLVAGSEDGGVQLFDIS-----GRA---PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSK 155
Cdd:PLN00181  487 CAiGFDRDGEFFATAGVNKKIKIFECEsiikdGRDihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQ 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 156 EIVTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNQSVISVEHGQPVESVlLFPS--GGLLASAGGRY-VKIW 232
Cdd:PLN00181  567 LVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCV-QFPSesGRSLAFGSADHkVYYY 645

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 233 DMLKGGQLLVSLKNHHKTVTCLYLSSSGQrLLSGSLDRKVKVY------STTSYKVVHSFDYAASILS-LALAHEDETIV 305
Cdd:PLN00181  646 DLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWdlsmsiSGINETPLHSFMGHTNVKNfVGLSVSDGYIA 724

                         250
                  ....*....|...
gi 1953004335 306 VGMTNGILSVKHR 318
Cdd:PLN00181  725 TGSETNEVFVYHK 737
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-276 2.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1953004335  238 GQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKVYS 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-276 2.19e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1953004335 238 GQLLVSLKNHHKTVTCLYLSSSGQRLLSGSLDRKVKVYS 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 1.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1953004335  153 NSKEIVTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKMFD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
179-306 1.63e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 179 LFVTGSYDHTVKMFDARTNQSVISVEHGQPVESVLLFPSGGLL--ASAGGRYVKIWDmLKGGQLLVSLKNHHKTVTCLYl 256
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLyvADSGNGRVSVID-TATGKVVATIPVGAGPHGIAV- 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1953004335 257 SSSGQRLLSGSLDRK-----VKVYSTTSYKVVHSFDYAASILSLALAHEDETIVV 306
Cdd:COG3391   160 DPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYV 214
WD40 pfam00400
WD domain, G-beta repeat;
154-193 1.65e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1953004335 154 SKEIVTFKEHSDYVRCgCASKLNPDLFVTGSYDHTVKMFD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTS-LAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 69-108 4.51e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1953004335   69 SQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFD 108
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
55-197 6.24e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  55 AVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFDISGRAPLRQFEGHtKAVHTVDFTAD- 133
Cdd:COG3391    85 ANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDg 163

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1953004335 134 KYHVVSGADDYT----VKLWDIPNSKEIVTFKEHSDyvrcGCASKLNPD---LFVTGSY-------DHTVKMFDARTN 197
Cdd:COG3391   164 KRLYVANSGSNTvsviVSVIDTATGKVVATIPVGGG----PVGVAVSPDgrrLYVANRGsntsnggSNTVSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
38-221 8.04e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  38 FGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGKLL-VAGSEDGGVQLFDISGRAPLR 116
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 117 QFEGHTKAvHTVDFTADKYHV-VSGADDYTVKLWDIPNSKEIVTFKEHSDYVrcGCAskLNPD---LFVTGSYDHT---- 188
Cdd:COG3391   105 TIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGPH--GIA--VDPDgkrLYVANSGSNTvsvi 179

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1953004335 189 VKMFDARTNQSVISVEHGQPVESVLLFPSGGLL 221
Cdd:COG3391   180 VSVIDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
PTZ00420 PTZ00420
coronin; Provisional
 102-344 1.27e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.47  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 102 GGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVV-SGADDYTVKLWDIPNSKEIVT--------FKEHSDYVRCGCA 172
Cdd:PTZ00420   54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDW 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 173 SKLNPDLFVTGSYDHTVKMFDARTNQSVISVEHGQPVESVLLFPSGGLLA-SAGGRYVKIWDMLKgGQLLVSLKNHH--K 249
Cdd:PTZ00420  134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGNLLSgTCVGKHMHIIDPRK-QEIASSFHIHDggK 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 250 TVTCLYLSSSG---QRLLSGSLD----RKVKVYS---TTSYKVVHSFDYAASILslaLAHEDETI----VVGMTNG---- 311
Cdd:PTZ00420  213 NTKNIWIDGLGgddNYILSTGFSknnmREMKLWDlknTTSALVTMSIDNASAPL---IPHYDESTgliyLIGKGDGncry 289

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1953004335 312 -------ILSVKHRKSEAKKDSF---PKRRRPAYRTFIkGKSY 344
Cdd:PTZ00420  290 yqhslgsIRKVNEYKSCSPFRSFgflPKQICDVYKCEI-GRVY 331
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 94-320 2.42e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.06  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335  94 LLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI----PNSKEIVTFKE------- 162
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSRNTQTefprkdh 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 163 ------------HSDYVRCGCASkLNPDLFVTGSYDHTVKMFDARTNQSVISVEHgqpvesvllfPSG----GLLASAGG 226
Cdd:pfam20426 176 viaetpfhilcgHDDIITCLYVS-VELDIVISGSKDGTCIFHTLREGRYVRSIRH----------PSGcplsKLVASRHG 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953004335 227 RYVKIWDM--------LKGGQLLVSLKNHHktVTCLYLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAA-SILSLAL 297
Cdd:pfam20426 245 RIVLYADDdlslhlysINGKHIASSESNGR--LNCIELSSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGkIITSLTV 322

                         250       260
                  ....*....|....*....|....*....
gi 1953004335 298 AHEdETIVVGMTNGILSV------KHRKS 320
Cdd:pfam20426 323 TPE-ECFLAGTKDGSLLVysienpQLRKA 350
WD40 pfam00400
WD domain, G-beta repeat;
71-108 4.77e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1953004335  71 EPIKTFSRFKDTAYCATFRQDGKLLVAGSEDGGVQLFD 108
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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