NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1777474491|ref|XP_031535789|]
View 

peptide chain release factor 1-like, mitochondrial isoform X2 [Vicugna pacos]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-233 2.18e-134

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 382.04  E-value: 2.18e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:COG0216   126 LFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAV 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:COG0216   206 LPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQ 285

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVEL 233
Cdd:COG0216   286 QAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAEDQAEKLAAL 355
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-233 2.18e-134

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 382.04  E-value: 2.18e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:COG0216   126 LFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAV 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:COG0216   206 LPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQ 285

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVEL 233
Cdd:COG0216   286 QAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAEDQAEKLAAL 355
prfA PRK00591
peptide chain release factor 1; Validated
 2-233 5.76e-130

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 370.95  E-value: 5.76e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:PRK00591  128 LFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:PRK00591  208 LPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKA 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVEL 233
Cdd:PRK00591  288 QAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAEDQAEKLAAL 357
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 2-235 1.80e-112

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 326.65  E-value: 1.80e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:TIGR00019 128 IFAGDLFRMYSRYAESKGWKVEILSANETELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:TIGR00019 208 MPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQ 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVELIS 235
Cdd:TIGR00019 288 QAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDEVLEGD--LDELIEALIAEDQAQQLAALSE 359
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 87-196 1.73e-61

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 188.02  E-value: 1.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  87 EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSlhLEEETTKRY 166
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE--LEEEKEEEK 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1777474491 167 NAR-KIQIGTKGRSEKIRTYNF-PQNRVTDHR 196
Cdd:pfam00472  80 KRRiKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-233 2.18e-134

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 382.04  E-value: 2.18e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:COG0216   126 LFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAV 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:COG0216   206 LPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQ 285

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVEL 233
Cdd:COG0216   286 QAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAEDQAEKLAAL 355
prfA PRK00591
peptide chain release factor 1; Validated
 2-233 5.76e-130

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 370.95  E-value: 5.76e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:PRK00591  128 LFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:PRK00591  208 LPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKA 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVEL 233
Cdd:PRK00591  288 QAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAEDQAEKLAAL 357
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 2-235 1.80e-112

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 326.65  E-value: 1.80e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   2 LFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAI 81
Cdd:TIGR00019 128 IFAGDLFRMYSRYAESKGWKVEILSANETELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEE 161
Cdd:TIGR00019 208 MPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQ 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1777474491 162 TTKRYNARKIQIGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQSLKDYANYESLVELIS 235
Cdd:TIGR00019 288 QAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDEVLEGD--LDELIEALIAEDQAQQLAALSE 359
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 5-220 3.33e-62

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 198.46  E-value: 3.33e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   5 SEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQ 84
Cdd:TIGR00020 144 SMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPE 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  85 PTE-INLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEETT 163
Cdd:TIGR00020 224 VDDdIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQA 303

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491 164 KR--YNARKIQIGTkgrSEKIRTYNF-PQNRVTDHRINKSLHDLETFMQGKylLDELVQS 220
Cdd:TIGR00020 304 EKdaKEGEKSEIGW---GSQIRSYVLhPYSMVKDLRTGYETGNVQAVLDGD--IDQFIEA 358
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 87-196 1.73e-61

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 188.02  E-value: 1.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  87 EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSlhLEEETTKRY 166
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE--LEEEKEEEK 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1777474491 167 NAR-KIQIGTKGRSEKIRTYNF-PQNRVTDHR 196
Cdd:pfam00472  80 KRRiKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 3-210 2.37e-51

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 169.60  E-value: 2.37e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   3 FTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAIL 82
Cdd:PRK05589  103 WTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASVEVL 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  83 PQPT-EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYslhleeE 161
Cdd:PRK05589  183 PELTdDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLV------E 256

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1777474491 162 TTKRYNARKIQ-----IGTKGRSEKIRTYNF-PQNRVTDHRINKSLHDLETFMQG 210
Cdd:PRK05589  257 LKERAHKEKIEdltgeLKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNVDSVMDG 311
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 10-222 3.63e-51

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 168.68  E-value: 3.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  10 MYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQPTE-I 88
Cdd:PRK08787   90 MYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDnI 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEETTKR--Y 166
Cdd:PRK08787  170 EIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKdaL 249

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1777474491 167 NARKIQIGTkgrSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGKylLDELVQ-SLK 222
Cdd:PRK08787  250 EATKSDIGW---GSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGD--LDEFVEaSLK 301
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 5-211 2.46e-50

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 166.83  E-value: 2.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491   5 SEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQ 84
Cdd:PRK06746  106 SMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPE 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  85 -PTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEEETT 163
Cdd:PRK06746  186 fNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQA 265

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1777474491 164 KRYNARKIQiGTKGRSEKIRTYNF-PQNRVTDHRINKSLHDLETFMQGK 211
Cdd:PRK06746  266 ELDEIRGEQ-KEIGWGSQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGE 313
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 10-196 5.60e-49

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 163.90  E-value: 5.60e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  10 MYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQPTE-I 88
Cdd:PRK07342  113 MYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNARRHTSFASIWVYPVIDDnI 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLE--EETTKRY 166
Cdd:PRK07342  193 EVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARLYEEELKkrEEATNAA 272

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1777474491 167 NARKIQIGTkgrSEKIRTYNF-PQNRVTDHR 196
Cdd:PRK07342  273 AASKTDIGW---GHQIRSYVLqPYQLVKDLR 300
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 1-79 2.32e-38

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 131.74  E-value: 2.32e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777474491   1 MLFTSEIFDMYQQYATFKRWHFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTV 79
Cdd:pfam03462 114 ALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 89-203 4.33e-37

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 126.78  E-value: 4.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVH------------LPTGIVSECQQERSQLKNREMAMKKLRAKLYSL 156
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1777474491 157 HLEEettKRYNARKIQIGTKGR---SEKIRtynfpqNRVTDHRINKSLHD 203
Cdd:COG1186   100 ELEP---KERRATKPTRGSKKRrlwGKQIR------SMVKDLRGNVDDGD 140
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 92-160 1.82e-21

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 88.29  E-value: 1.82e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777474491  92 INPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIVSECQQERSQLKNREMAMKKLRAKLYSLHLEE 160
Cdd:TIGR03072 103 ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQ 171
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
89-151 7.64e-12

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 60.94  E-value: 7.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777474491  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIV------HLP---------------TG---IVSECQQERSQLKNREM 144
Cdd:PRK09256    7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalaghriTKdgvIVIKAQEFRSQERNRED 86


                  ....*..
gi 1777474491 145 AMKKLRA 151
Cdd:PRK09256   87 ALERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH