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Conserved domains on  [gi|1726083760|ref|XP_030319085|]
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mRNA export factor isoform X1 [Calypte anna]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 1.64e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 1.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  39 DDSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQDnGQTIpKAQQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSN 118
Cdd:COG2319   120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHP---MAAVATAERGLIV 194
Cdd:COG2319   195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPdgrLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 195 YQLENqpsefRRIESPLKHQH---RCVAIFkdkvnkPTG--FALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtntsa 269
Cdd:COG2319   273 WDLAT-----GELLRTLTGHSggvNSVAFS------PDGklLASGSDDGTVRLWDLATGKLLR---TLTGHTG------- 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1726083760 270 pqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319   332 -----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 1.64e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 1.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  39 DDSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQDnGQTIpKAQQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSN 118
Cdd:COG2319   120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHP---MAAVATAERGLIV 194
Cdd:COG2319   195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPdgrLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 195 YQLENqpsefRRIESPLKHQH---RCVAIFkdkvnkPTG--FALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtntsa 269
Cdd:COG2319   273 WDLAT-----GELLRTLTGHSggvNSVAFS------PDGklLASGSDDGTVRLWDLATGKLLR---TLTGHTG------- 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1726083760 270 pqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319   332 -----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-335 1.75e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 1.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  40 DSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQDNgqTIPKAQQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSNQ 119
Cdd:cd00200    10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 120 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHP---MAAVATAERGLIVY 195
Cdd:cd00200    85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPdgtFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 196 QLENqpseFRRIESPLKHQH--RCVAIFKDKVNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSApqdi 273
Cdd:cd00200   163 DLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHENG---- 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1726083760 274 yaVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:cd00200   222 --VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-114 1.26e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.26e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1726083760   85 HTGPVLDGCWSDDGSKVFTASCDKTAKMWD 114
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-114 1.92e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.92e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1726083760  85 HTGPVLDGCWSDDGSKVFTASCDKTAKMWD 114
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 1.64e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 1.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  39 DDSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQDnGQTIpKAQQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSN 118
Cdd:COG2319   120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHP---MAAVATAERGLIV 194
Cdd:COG2319   195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPdgrLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 195 YQLENqpsefRRIESPLKHQH---RCVAIFkdkvnkPTG--FALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtntsa 269
Cdd:COG2319   273 WDLAT-----GELLRTLTGHSggvNSVAFS------PDGklLASGSDDGTVRLWDLATGKLLR---TLTGHTG------- 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1726083760 270 pqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319   332 -----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-335 1.75e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 1.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  40 DSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQDNgqTIPKAQQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSNQ 119
Cdd:cd00200    10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 120 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHP---MAAVATAERGLIVY 195
Cdd:cd00200    85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPdgtFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 196 QLENqpseFRRIESPLKHQH--RCVAIFKDKVNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSApqdi 273
Cdd:cd00200   163 DLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHENG---- 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1726083760 274 yaVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:cd00200   222 --VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
2-335 1.09e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 1.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760   2 SLFGATSGFSTGGTSMFVSTTADNHNPMKDIEVTSPPDDSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQdnGQTIPKA 81
Cdd:COG2319    41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD---GRLLASASADGTVRLWDLA--TGLLLRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  82 QQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRS 160
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRtLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWDLAT 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 161 PTPMMTLQLPERCYCADVVHP---MAAVATAERGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDkvnkptG--FA 232
Cdd:COG2319   194 GKLLRTLTGHTGAVRSVAFSPdgkLLASGSADGTVRLWDLAT-----GKLLRTLTGHSgsvRSVAFSPD------GrlLA 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 233 LGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSE 312
Cdd:COG2319   263 SGSADGTVRLWDLATGELLR---TLTGHSG------------GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                         330       340
                  ....*....|....*....|...
gi 1726083760 313 QLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319   328 GHTGAVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
30-301 1.32e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  30 KDIEVTSPPDDSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQdnGQTIPKAQQMHTGPVLDGCWSDDGSKVFTASCDKT 109
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 110 AKMWDLNSNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHP---MAAV 185
Cdd:COG2319   270 VRLWDLATGELLRtLTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgkTLAS 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 186 ATAERGLIVYQLEnqpsefrriesplkhqhrcvaifkdkvnkpTGFALGSIEGrvaihyinppnpakdnftfkcHRSngt 265
Cdd:COG2319   348 GSDDGTVRLWDLA------------------------------TGELLRTLTG---------------------HTG--- 373

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1726083760 266 ntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWD 301
Cdd:COG2319   374 ---------AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-301 1.58e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  40 DSISCLAFSPPtlpGNFLIAGSWANDVRCWEVQDNGQTipKAQQMHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSNQ 119
Cdd:cd00200    52 GPVRDVAASAD---GTYLASGSSDKTIRLWDLETGECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 120 AIQ-IAQHDAPVKTIHWIKAPNYscVMTGSWDKTLKFWDTRSPTPMMTLQLPERCYCADVVHPMA---AVATAERGLIVY 195
Cdd:cd00200   127 CLTtLRGHTDWVNSVAFSPDGTF--VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeklLSSSSDGTIKLW 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 196 QLenqpSEFRRIESPLKHQHR--CVAIFKDKVNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtntsapqdi 273
Cdd:cd00200   205 DL----STGKCLGTLRGHENGvnSVAFSPDGYL----LASGSEDGTIRVWDLRTGECVQ---TLSGHTN----------- 262

                         250       260
                  ....*....|....*....|....*...
gi 1726083760 274 yAVNGIAFHPVHGTLATVGSDGRFSFWD 301
Cdd:cd00200   263 -SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-160 3.20e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  10 FSTGGTsMFVSTTADNH------NPMKDIEVTSPPDDSISCLAFSPPtlpGNFLIAGSWANDVRCWEVqDNGQTIpKAQQ 83
Cdd:COG2319   254 FSPDGR-LLASGSADGTvrlwdlATGELLRTLTGHSGGVNSVAFSPD---GKLLASGSDDGTVRLWDL-ATGKLL-RTLT 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1726083760  84 MHTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRS 160
Cdd:COG2319   328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRtLTGHTGAVTSVAF--SPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-337 2.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760  85 HTGPVLDGCWSDDGSKVFTASCDKTAKMWDLNSNQAI-QIAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSPTP 163
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrTLKGHTGPVRDVAAS--ADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 164 MMTLQL-PERCYCADVV--HPMAAVATAERGLIVYQLENqpseFRRIESPLKHQH--RCVAifkdkVNKPTGFALGSIEG 238
Cdd:cd00200    86 VRTLTGhTSYVSSVAFSpdGRILSSSSRDKTIKVWDVET----GKCLTTLRGHTDwvNSVA-----FSPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726083760 239 RVAIHYinppnpakDNFTFKCHRSNGTNTSapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPI 318
Cdd:cd00200   157 GTIKLW--------DLRTGKCVATLTGHTG------EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                         250
                  ....*....|....*....
gi 1726083760 319 SACCFNHNGNIFAyASSYD 337
Cdd:cd00200   223 NSVAFSPDGYLLA-SGSED 240
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-114 1.26e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.26e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1726083760   85 HTGPVLDGCWSDDGSKVFTASCDKTAKMWD 114
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-114 1.92e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.92e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1726083760  85 HTGPVLDGCWSDDGSKVFTASCDKTAKMWD 114
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-157 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1726083760  126 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:smart00320  11 HTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
126-157 2.29e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.29e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1726083760 126 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:pfam00400  10 HTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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