NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1595766239|ref|XP_028346839|]
View 

apolipoprotein L domain-containing protein 1 [Physeter catodon]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ApoL super family cl20075
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 53-103 6.88e-03

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


The actual alignment was detected with superfamily member pfam05461:

Pssm-ID: 461657  Cd Length: 298  Bit Score: 36.86  E-value: 6.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1595766239  53 ANVAGSSLSAAGAVAAIVGLSLSPVTLGVSLLASAVGLGVATAGGAVTITS 103
Cdd:pfam05461  88 SNVVASSTGAVSGILTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVST 138
 
Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 53-103 6.88e-03

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


Pssm-ID: 461657  Cd Length: 298  Bit Score: 36.86  E-value: 6.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1595766239  53 ANVAGSSLSAAGAVAAIVGLSLSPVTLGVSLLASAVGLGVATAGGAVTITS 103
Cdd:pfam05461  88 SNVVASSTGAVSGILTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVST 138
 
Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 53-103 6.88e-03

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


Pssm-ID: 461657  Cd Length: 298  Bit Score: 36.86  E-value: 6.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1595766239  53 ANVAGSSLSAAGAVAAIVGLSLSPVTLGVSLLASAVGLGVATAGGAVTITS 103
Cdd:pfam05461  88 SNVVASSTGAVSGILTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVST 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH