NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1378871948|ref|XP_024609776|]
View 

testis-expressed protein 30 [Neophocaena asiaeorientalis asiaeorientalis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG3571 super family cl43903
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 1.45e-31

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


The actual alignment was detected with superfamily member COG3571:

Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 114.21  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  31 GIILTHGASGDMNLPHLMSLASHLASHGFFSLRFtckglNIVHRIK-------------AYKSVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  96 VFLGGRSMGSRAAasvmCHIEpdDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1378871948 176 qkMQAPNKVHWIEKASHSMAVK---GRSTNDVFKEINTQVLFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 1.45e-31

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 114.21  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  31 GIILTHGASGDMNLPHLMSLASHLASHGFFSLRFtckglNIVHRIK-------------AYKSVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  96 VFLGGRSMGSRAAasvmCHIEpdDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1378871948 176 qkMQAPNKVHWIEKASHSMAVK---GRSTNDVFKEINTQVLFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 8.35e-25

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 96.50  E-value: 8.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  32 IILTHGASGDMNLPHLMSLASHLASHGFFSLRFT--------CKG-------LNIVhrIKAYKSVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  97 FLGGRSMGSRAAASVMchiepddADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVASLLA-------DDSGVKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1378871948 177 KMQAPNKVHWIEKASHSMAVK---GRSTNDVFKEINTQVLFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 1.45e-31

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 114.21  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  31 GIILTHGASGDMNLPHLMSLASHLASHGFFSLRFtckglNIVHRIK-------------AYKSVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  96 VFLGGRSMGSRAAasvmCHIEpdDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1378871948 176 qkMQAPNKVHWIEKASHSMAVK---GRSTNDVFKEINTQVLFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 8.35e-25

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 96.50  E-value: 8.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  32 IILTHGASGDMNLPHLMSLASHLASHGFFSLRFT--------CKG-------LNIVhrIKAYKSVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  97 FLGGRSMGSRAAASVMchiepddADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVASLLA-------DDSGVKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1378871948 177 KMQAPNKVHWIEKASHSMAVK---GRSTNDVFKEINTQVLFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-194 1.53e-09

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 55.78  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948   1 MSHTEVKLKIPFGNKLlDAVCLVPNKSLTYGIILTHGASGDMNlpHLMSLASHLASHGFFSLRF-------TCKGLNIVH 73
Cdd:COG2267     1 MTRRLVTLPTRDGLRL-RGRRWRPAGSPRGTVVLVHGLGEHSG--RYAELAEALAAAGYAVLAFdlrghgrSDGPRGHVD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  74 RIKAY----KSVLNYLKTSGEYKlagVFLGGRSMGSRAAASVMchiepDDADDFVRGLICIS-----YPLHHPKQQHkLR 144
Cdd:COG2267    78 SFDDYvddlRAALDALRARPGLP---VVLLGHSMGGLIALLYA-----ARYPDRVAGLVLLApayraDPLLGPSARW-LR 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1378871948 145 D----EDLFRIKDPVLFVSGSADEMCEKNLLEKVAQKMQAPNKVHWIEKASHSM 194
Cdd:COG2267   149 AlrlaEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHEL 202
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
35-192 5.01e-09

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 54.01  E-value: 5.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  35 THGasGDMNLPHLMSLASHLASHGFFSLRF----TCK--GlnivhrikAY----------KSVLNYLKTSGeykLAGVFL 98
Cdd:COG2945    34 LFG--GTMDNKVVYTLARALVAAGFAVLRFnfrgVGRseG--------EFdegrgelddaAAALDWLRAQN---PLPLWL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  99 GGRSMGSRAAASVMCHIEPddaddfVRGLICISYPLHHpkqqhkLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVAQKM 178
Cdd:COG2945   101 AGFSFGAYVALQLAMRLPE------VEGLILVAPPVNR------YDFSFLAPCPAPTLVIHGEQDEVVPPAEVLDWARPL 168

                         170
                  ....*....|....
gi 1378871948 179 QAPNKVHWIEKASH 192
Cdd:COG2945   169 SPPLPVVVVPGADH 182
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-203 1.09e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 50.74  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  31 GIILTHGASGdMNlPHLMSLASHLASHGFFSL---RFTCKGLN-----------------IVHRIKAyksVLNYLKTSGE 90
Cdd:COG0412    31 GVVVLHEIFG-LN-PHIRDVARRLAAAGYVVLapdLYGRGGPGddpdearalmgaldpelLAADLRA---ALDWLKAQPE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  91 YKLAGVFLGGRSMGSRAAASVMCHIEPDDAddfvrgliCISYplhHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNL 170
Cdd:COG0412   106 VDAGRVGVVGFCFGGGLALLAAARGPDLAA--------AVSF---YGGLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQ 174

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1378871948 171 LEKVAQKMQAPNK---VHWIEKASHSMAVKGRSTND 203
Cdd:COG0412   175 VAALEAALAAAGVdveLHVYPGAGHGFTNPGRPRYD 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
32-208 1.02e-06

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 48.09  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  32 IILTHGASGDMNlPHLMSLASHLASHGFFSLRF------TCKGLNIVHRIKAYKSVLNYLKTSGEYKLAGVFLGGRSMGS 105
Cdd:COG1506    26 VVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPdyrgygESAGDWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948 106 RAAASVMCHiepddADDFVRGLICIS------------YPLHHPKQQHKLRDEDLF----------RIKDPVLFVSGSAD 163
Cdd:COG1506   105 YMALLAAAR-----HPDRFKAAVALAgvsdlrsyygttREYTERLMGGPWEDPEAYaarsplayadKLKTPLLLIHGEAD 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1378871948 164 EMCEKNLLEKVAQKMQAPNK---VHWIEKASHSMAvkGRSTNDVFKEI 208
Cdd:COG1506   180 DRVPPEQAERLYEALKKAGKpveLLVYPGEGHGFS--GAGAPDYLERI 225
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
30-221 4.31e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 46.09  E-value: 4.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  30 YGIILTHGASGDMNlpHLMSLASHLASHGFFSLRFTCKG-------LNIVHRIKAYKSV---LNYLKTSGEYklagVFLG 99
Cdd:COG1647    16 KGVLLLHGFTGSPA--EMRPLAEALAKAGYTVYAPRLPGhgtspedLLKTTWEDWLEDVeeaYEILKAGYDK----VIVI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948 100 GRSMGSrAAASVMCHIEPDdaddfVRGLICIS------------------------------------------YPLHHP 137
Cdd:COG1647    90 GLSMGG-LLALLLAARYPD-----VAGLVLLSpalkiddpsapllpllkylarslrgigsdiedpevaeyaydrTPLRAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948 138 KQQHKLRDE---DLFRIKDPVLFVSGSADEMCEKNLLEKVAQKMQAPNK-VHWIEKASHSMAVkGRSTNDVFKEINTqvl 213
Cdd:COG1647   164 AELQRLIREvrrDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKeLVWLEDSGHVITL-DKDREEVAEEILD--- 239


                  ....*...
gi 1378871948 214 fWIQEITE 221
Cdd:COG1647   240 -FLERLAA 246
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
32-215 1.43e-04

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 42.02  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  32 IILTHGASGDMNLphLMSLASHLASHGF--------------FSLRFT-----CKGLNIVHRIKAYKSVLNYLKTSGEYK 92
Cdd:COG4188    65 VVLSHGLGGSREG--YAYLAEHLASHGYvvaapdhpgsnaadLSAALDgladaLDPEELWERPLDLSFVLDQLLALNKSD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  93 --LAG------VFLGGRSMGSRAAASVMcHIEPDDAD-----DFVRGLICISYPLHHPKQQhkLRD-------------- 145
Cdd:COG4188   143 ppLAGrldldrIGVIGHSLGGYTALALA-GARLDFAAlrqycGKNPDLQCRALDLPRLAYD--LRDprikavvalapggs 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948 146 -----EDLFRIKDPVLFVSGSADEMcEKNLLE--KVAQKMQAPNK-VHWIEKASHSM---------------AVKGRSTN 202
Cdd:COG4188   220 glfgeEGLAAITIPVLLVAGSADDV-TPAPDEqiRPFDLLPGADKyLLTLEGATHFSfldpctpgaailpepDPPGPDRA 298

                         250
                  ....*....|....
gi 1378871948 203 DVFKEINTQVL-FW 215
Cdd:COG4188   299 AIHEYLNALSLaFF 312
DLH pfam01738
Dienelactone hydrolase family;
82-200 1.32e-03

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 38.49  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  82 LNYLKTSGEYKLAGVFLGGRSMGSRAAASVMCHIEPDDAddfvrgliCISYPLHHPKQQHKLRDedlfRIKDPVLFVSGS 161
Cdd:pfam01738  84 VNYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDA--------AVGFYGVGPEPPLIEAP----DIKAPILFHFGE 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1378871948 162 ADEMCEKNLLEKVAQKM---QAPNKVHWIEKASHSMAVKGRS 200
Cdd:pfam01738 152 EDHFVPADSRELIEEALkaaNVDHQIHSYPGAGHAFANDSRP 193
YpfH COG0400
Predicted esterase [General function prediction only];
32-180 4.18e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 37.19  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  32 IILTHGASGDMNlpHLMSLASHLASHG------------------FFSLRFTCKGLNIVHRIKAYKSVLNYLKT-SGEYK 92
Cdd:COG0400     8 VVLLHGYGGDEE--DLLPLAPELALPGaavlaprapvpegpggraWFDLSFLEGREDEEGLAAAAEALAAFIDElEARYG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378871948  93 LAG--VFLGGRSMGSRAAASVMCHiepddADDFVRGLICISyPLHHPKQQHKLRDEDLFRIkdPVLFVSGSADEMCEKNL 170
Cdd:COG0400    86 IDPerIVLAGFSQGAAMALSLALR-----RPELLAGVVALS-GYLPGEEALPAPEAALAGT--PVFLAHGTQDPVIPVER 157

                         170
                  ....*....|
gi 1378871948 171 LEKVAQKMQA 180
Cdd:COG0400   158 AREAAEALEA 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH