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Conserved domains on  [gi|1158866230|ref|XP_020336791|]
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kit ligand [Oncorhynchus kisutch]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCF super family cl20028
Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds ...
 1-102 2.32e-15

Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.


The actual alignment was detected with superfamily member pfam02404:

Pssm-ID: 396808  Cd Length: 275  Bit Score: 73.73  E-value: 2.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158866230   1 MKKSKIWIRICVHL-------LVCTTfgvhsSEFGDAVTDDITSISLLKQNIPKDYKIPVTYIPK--EVGGMCWVTLNVF 71
Cdd:pfam02404   1 MKKTQTWIITCIYLqlllfnpLVKTQ-----SICGNPVTDDVKDITKLVGNLPNDYMIALKYVPKmdVLPNHCWLHLMVP 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1158866230  72 HLELSLRGLADKFGNISSNKYNISILIEMLK 102
Cdd:pfam02404  76 ELSKSLTNLLDKFSEISEMLSNYSIINNLTR 106
 
Name Accession Description Interval E-value
SCF pfam02404
Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds ...
 1-102 2.32e-15

Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.


Pssm-ID: 396808  Cd Length: 275  Bit Score: 73.73  E-value: 2.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158866230   1 MKKSKIWIRICVHL-------LVCTTfgvhsSEFGDAVTDDITSISLLKQNIPKDYKIPVTYIPK--EVGGMCWVTLNVF 71
Cdd:pfam02404   1 MKKTQTWIITCIYLqlllfnpLVKTQ-----SICGNPVTDDVKDITKLVGNLPNDYMIALKYVPKmdVLPNHCWLHLMVP 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1158866230  72 HLELSLRGLADKFGNISSNKYNISILIEMLK 102
Cdd:pfam02404  76 ELSKSLTNLLDKFSEISEMLSNYSIINNLTR 106
 
Name Accession Description Interval E-value
SCF pfam02404
Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds ...
 1-102 2.32e-15

Stem cell factor; Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.


Pssm-ID: 396808  Cd Length: 275  Bit Score: 73.73  E-value: 2.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158866230   1 MKKSKIWIRICVHL-------LVCTTfgvhsSEFGDAVTDDITSISLLKQNIPKDYKIPVTYIPK--EVGGMCWVTLNVF 71
Cdd:pfam02404   1 MKKTQTWIITCIYLqlllfnpLVKTQ-----SICGNPVTDDVKDITKLVGNLPNDYMIALKYVPKmdVLPNHCWLHLMVP 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1158866230  72 HLELSLRGLADKFGNISSNKYNISILIEMLK 102
Cdd:pfam02404  76 ELSKSLTNLLDKFSEISEMLSNYSIINNLTR 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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