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Conserved domains on  [gi|1131201444|ref|XP_019790283|]
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protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X2 [Tursiops truncatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 105-136 3.94e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


:

Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 40.31  E-value: 3.94e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1131201444 105 IREEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 136
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
BET4 super family cl44255
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 49-249 1.94e-04

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5536:

Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 42.93  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444  49 KDLHLGKLALTKF--PKSPET---WIHRRWVLQQLIqetslpsfvtkgnlgiIPAERTQQLIREEMEVCGEAAGRYPSNY 123
Cdd:COG5536    45 KEYSVRALKLTQEliDKNPEFytiWNYRFSILKHVQ----------------MVSEDKEHLLDNELDFLDEALKDNPKNY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444 124 NAWSHRIWVLQHLAKldvKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSLvsqtvtdgsvleqntlrsepaivlpkde 203
Cdd:COG5536   109 QIWHHRQWMLELFPK---PSWGRELFITKKLLDSDSRNYHVWSYRRWVLRTI---------------------------- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1131201444 204 eavasaeESRVNLpHLLEEEVEFSTDLIDSYPGHETLWCHRRHVFY 249
Cdd:COG5536   158 -------EDLFNF-SDLKHELEYTTSLIETDIYNNSAWHHRYIWIE 195
 
Name Accession Description Interval E-value
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 105-136 3.94e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 40.31  E-value: 3.94e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1131201444 105 IREEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 136
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 49-249 1.94e-04

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 42.93  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444  49 KDLHLGKLALTKF--PKSPET---WIHRRWVLQQLIqetslpsfvtkgnlgiIPAERTQQLIREEMEVCGEAAGRYPSNY 123
Cdd:COG5536    45 KEYSVRALKLTQEliDKNPEFytiWNYRFSILKHVQ----------------MVSEDKEHLLDNELDFLDEALKDNPKNY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444 124 NAWSHRIWVLQHLAKldvKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSLvsqtvtdgsvleqntlrsepaivlpkde 203
Cdd:COG5536   109 QIWHHRQWMLELFPK---PSWGRELFITKKLLDSDSRNYHVWSYRRWVLRTI---------------------------- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1131201444 204 eavasaeESRVNLpHLLEEEVEFSTDLIDSYPGHETLWCHRRHVFY 249
Cdd:COG5536   158 -------EDLFNF-SDLKHELEYTTSLIETDIYNNSAWHHRYIWIE 195
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 144-175 1.57e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.69  E-value: 1.57e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1131201444 144 LLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 175
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
PLN02789 PLN02789
farnesyltranstransferase
 51-175 2.62e-03

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 39.34  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444  51 LHLGKLALTKFPKSPETWIHRRWVLQQLiqetslpsfvtkgnlgiipaertQQLIREEMEVCGEAAGRYPSNYNAWSHRI 130
Cdd:PLN02789   57 LDLTADVIRLNPGNYTVWHFRRLCLEAL-----------------------DADLEEELDFAEDVAEDNPKNYQIWHHRR 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1131201444 131 WVLQhlaKLDVKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 175
Cdd:PLN02789  114 WLAE---KLGPDAANKELEFTRKILSLDAKNYHAWSHRQWVLRTL 155
 
Name Accession Description Interval E-value
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 105-136 3.94e-05

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 40.31  E-value: 3.94e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1131201444 105 IREEMEVCGEAAGRYPSNYNAWSHRIWVLQHL 136
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
BET4 COG5536
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ...
 49-249 1.94e-04

Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227823 [Multi-domain]  Cd Length: 328  Bit Score: 42.93  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444  49 KDLHLGKLALTKF--PKSPET---WIHRRWVLQQLIqetslpsfvtkgnlgiIPAERTQQLIREEMEVCGEAAGRYPSNY 123
Cdd:COG5536    45 KEYSVRALKLTQEliDKNPEFytiWNYRFSILKHVQ----------------MVSEDKEHLLDNELDFLDEALKDNPKNY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444 124 NAWSHRIWVLQHLAKldvKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSLvsqtvtdgsvleqntlrsepaivlpkde 203
Cdd:COG5536   109 QIWHHRQWMLELFPK---PSWGRELFITKKLLDSDSRNYHVWSYRRWVLRTI---------------------------- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1131201444 204 eavasaeESRVNLpHLLEEEVEFSTDLIDSYPGHETLWCHRRHVFY 249
Cdd:COG5536   158 -------EDLFNF-SDLKHELEYTTSLIETDIYNNSAWHHRYIWIE 195
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 144-175 1.57e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.69  E-value: 1.57e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1131201444 144 LLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 175
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLLERL 32
PPTA pfam01239
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ...
 220-248 1.84e-03

Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.


Pssm-ID: 460128 [Multi-domain]  Cd Length: 32  Bit Score: 35.31  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|....*....
gi 1131201444 220 LEEEVEFSTDLIDSYPGHETLWCHRRHVF 248
Cdd:pfam01239   1 LEEELALTDKLLELNPKNYSAWNHRRWLL 29
PLN02789 PLN02789
farnesyltranstransferase
 51-175 2.62e-03

farnesyltranstransferase


Pssm-ID: 215423 [Multi-domain]  Cd Length: 320  Bit Score: 39.34  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131201444  51 LHLGKLALTKFPKSPETWIHRRWVLQQLiqetslpsfvtkgnlgiipaertQQLIREEMEVCGEAAGRYPSNYNAWSHRI 130
Cdd:PLN02789   57 LDLTADVIRLNPGNYTVWHFRRLCLEAL-----------------------DADLEEELDFAEDVAEDNPKNYQIWHHRR 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1131201444 131 WVLQhlaKLDVKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSL 175
Cdd:PLN02789  114 WLAE---KLGPDAANKELEFTRKILSLDAKNYHAWSHRQWVLRTL 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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