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Conserved domains on  [gi|1039750868|ref|XP_017172418|]
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thrombopoietin isoform X1 [Mus musculus]

Protein Classification

EPO_TPO and PRK12323 domain-containing protein( domain architecture ID 10466053)

EPO_TPO and PRK12323 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EPO_TPO pfam00758
Erythropoietin/thrombopoietin;
208-347 9.73e-45

Erythropoietin/thrombopoietin;


:

Pssm-ID: 459927  Cd Length: 158  Bit Score: 155.00  E-value: 9.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750868 208 APACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEP 287
Cdd:pfam00758   1 RPICDSRVLEKYIREAKDAESRTSQCTEDCSLSTNVTLPDTKVNFGEWKAMEEQQKAQEVWQGLTLLSEAVLAGQALLAN 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039750868 288 SCLSSLLGQL--SGQVRLLLGALQGLLG--TQL--PLQG-----RTTAHKDPNALFLSLQQLLRGKVRFLL 347
Cdd:pfam00758  81 SSQSSELLQLhiDKAVSNLRSLGALLRLlgTQEisPPDAsavplRTFTVRTPSKLFQIYSNFLRGKLKLLL 151
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
413-532 3.47e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750868 413 TPGQLNQTS-RSPVQISGYLNRTHGPVNGTHGLFAGTSLQTLEASDISPGAFNKGSlafnlqGGLPPSPS--------LA 483
Cdd:pfam05109 430 TSPTLNTTGfAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGA------SPVTPSPSprdngtesKA 503
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039750868 484 PDGH-------TPFP----PSPAL--PTTHGSPPQLHPLFPDPSTT--MPNSTAPHPVTMYPHP 532
Cdd:pfam05109 504 PDMTsptsavtTPTPnatsPTPAVttPTPNATSPTLGKTSPTSAVTtpTPNATSPTPAVTTPTP 567
 
Name Accession Description Interval E-value
EPO_TPO pfam00758
Erythropoietin/thrombopoietin;
208-347 9.73e-45

Erythropoietin/thrombopoietin;


Pssm-ID: 459927  Cd Length: 158  Bit Score: 155.00  E-value: 9.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750868 208 APACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEP 287
Cdd:pfam00758   1 RPICDSRVLEKYIREAKDAESRTSQCTEDCSLSTNVTLPDTKVNFGEWKAMEEQQKAQEVWQGLTLLSEAVLAGQALLAN 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039750868 288 SCLSSLLGQL--SGQVRLLLGALQGLLG--TQL--PLQG-----RTTAHKDPNALFLSLQQLLRGKVRFLL 347
Cdd:pfam00758  81 SSQSSELLQLhiDKAVSNLRSLGALLRLlgTQEisPPDAsavplRTFTVRTPSKLFQIYSNFLRGKLKLLL 151
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
413-532 3.47e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750868 413 TPGQLNQTS-RSPVQISGYLNRTHGPVNGTHGLFAGTSLQTLEASDISPGAFNKGSlafnlqGGLPPSPS--------LA 483
Cdd:pfam05109 430 TSPTLNTTGfAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGA------SPVTPSPSprdngtesKA 503
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039750868 484 PDGH-------TPFP----PSPAL--PTTHGSPPQLHPLFPDPSTT--MPNSTAPHPVTMYPHP 532
Cdd:pfam05109 504 PDMTsptsavtTPTPnatsPTPAVttPTPNATSPTLGKTSPTSAVTtpTPNATSPTPAVTTPTP 567
 
Name Accession Description Interval E-value
EPO_TPO pfam00758
Erythropoietin/thrombopoietin;
208-347 9.73e-45

Erythropoietin/thrombopoietin;


Pssm-ID: 459927  Cd Length: 158  Bit Score: 155.00  E-value: 9.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750868 208 APACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEP 287
Cdd:pfam00758   1 RPICDSRVLEKYIREAKDAESRTSQCTEDCSLSTNVTLPDTKVNFGEWKAMEEQQKAQEVWQGLTLLSEAVLAGQALLAN 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039750868 288 SCLSSLLGQL--SGQVRLLLGALQGLLG--TQL--PLQG-----RTTAHKDPNALFLSLQQLLRGKVRFLL 347
Cdd:pfam00758  81 SSQSSELLQLhiDKAVSNLRSLGALLRLlgTQEisPPDAsavplRTFTVRTPSKLFQIYSNFLRGKLKLLL 151
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
413-532 3.47e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750868 413 TPGQLNQTS-RSPVQISGYLNRTHGPVNGTHGLFAGTSLQTLEASDISPGAFNKGSlafnlqGGLPPSPS--------LA 483
Cdd:pfam05109 430 TSPTLNTTGfAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGA------SPVTPSPSprdngtesKA 503
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039750868 484 PDGH-------TPFP----PSPAL--PTTHGSPPQLHPLFPDPSTT--MPNSTAPHPVTMYPHP 532
Cdd:pfam05109 504 PDMTsptsavtTPTPnatsPTPAVttPTPNATSPTLGKTSPTSAVTtpTPNATSPTPAVTTPTP 567
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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