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Conserved domains on  [gi|795253494|ref|XP_011855197|]
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PREDICTED: RWD domain-containing protein 2B [Mandrillus leucophaeus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 158-286 9.14e-58

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


:

Pssm-ID: 467814  Cd Length: 122  Bit Score: 180.92  E-value: 9.14e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494 158 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDVPFDGtnd 237
Cdd:cd24163    1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 795253494 238 emerqRKFSIFEEKVFSVNGARGNHMD-FGQLYQFLNAKGCGDVFQMFFG 286
Cdd:cd24163   78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 6-137 7.56e-54

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


:

Pssm-ID: 467663  Cd Length: 129  Bit Score: 171.22  E-value: 7.56e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494   6 QAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLdvsEEAMAMFSLACILPFKYPAV 85
Cdd:cd23829    1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKI---EEPKVKVELSVTLPHEYPSV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 795253494  86 LPEITVRSVILSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYV 137
Cdd:cd23829   78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
 
Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 158-286 9.14e-58

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 180.92  E-value: 9.14e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494 158 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDVPFDGtnd 237
Cdd:cd24163    1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 795253494 238 emerqRKFSIFEEKVFSVNGARGNHMD-FGQLYQFLNAKGCGDVFQMFFG 286
Cdd:cd24163   78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 6-137 7.56e-54

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 171.22  E-value: 7.56e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494   6 QAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLdvsEEAMAMFSLACILPFKYPAV 85
Cdd:cd23829    1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKI---EEPKVKVELSVTLPHEYPSV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 795253494  86 LPEITVRSVILSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYV 137
Cdd:cd23829   78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 161-283 5.35e-22

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 88.89  E-value: 5.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494  161 LWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKP-GVVCVEGPQSACEEFWSR-LRKLNWKRI----LIRHREDVPFDG 234
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPfGLVVVEGGEKSIKKYKKLmLRRIKWTENphedFEAMKEITFEWD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795253494  235 TNDE--------------MERQRKFSIFEEKVfsvngargnHMDFGQLYQFLNAKGCGDVFQM 283
Cdd:pfam06544  81 NDEDnegednkcelvwegEVKERAFRKWKFKV---------CETEGEAREFLKKHGVEHYWDL 134
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 8-133 3.72e-14

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 67.35  E-value: 3.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494    8 EAQLAELDLLASMFPGENELIVNDQLavaelkdciekktmegRSSKVYFTINMNLDVSE-EAMAMFSLACILPFKYPAVL 86
Cdd:pfam05773   1 EEQEEELEALESIYPDEFEVISDSPY----------------ESLEIEIKLSLDSDESDsSHLPPLVLKFTLPEDYPDEP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 795253494   87 PEITVRSVI-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHA 133
Cdd:pfam05773  65 PKISLSSPWnLSDEQVLSLLEELEELAEENL-GEVMIFELIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 13-136 4.03e-14

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 67.00  E-value: 4.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494    13 ELDLLASMFPGENELIVNDqlavaelkdciekktmeGRSSKVYFTINMNLDVSEEAMAMFSLACILPFKYPAVLPEITVR 92
Cdd:smart00591   1 ELEALESIYPEDFEVIDED-----------------ARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLL 63

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 795253494    93 SV-ILSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHASGY 136
Cdd:smart00591  64 NSeGLSDEQLAELLKKLEEIAEENL-GEVMIFELVEKLQEFLSEF 107
PRK14422 PRK14422
acylphosphatase; Provisional
 181-215 2.22e-03

acylphosphatase; Provisional


Pssm-ID: 237712  Cd Length: 93  Bit Score: 36.64  E-value: 2.22e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 795253494 181 AKELSLSGFSMPGKPGVVCV--EGPQSACEEFWSRLR 215
Cdd:PRK14422  29 ALELGLTGYAANLADGRVQVvaEGPRAACEKLLQLLR 65
 
Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 158-286 9.14e-58

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 180.92  E-value: 9.14e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494 158 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDVPFDGtnd 237
Cdd:cd24163    1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 795253494 238 emerqRKFSIFEEKVFSVNGARGNHMD-FGQLYQFLNAKGCGDVFQMFFG 286
Cdd:cd24163   78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 6-137 7.56e-54

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 171.22  E-value: 7.56e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494   6 QAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLdvsEEAMAMFSLACILPFKYPAV 85
Cdd:cd23829    1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKI---EEPKVKVELSVTLPHEYPSV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 795253494  86 LPEITVRSVILSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYV 137
Cdd:cd23829   78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 158-286 4.99e-30

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 109.66  E-value: 4.99e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494 158 FTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGK-PGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDVPFDGTN 236
Cdd:cd24140    1 YHCKVFHFKHLQNKKKRFKIKENSKELSLKGLCMRIRdPGIIIVVGNEKSCKEYENLVKKRKWNEDFELHTNTGDIKEKC 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 795253494 237 demerqrkfsifEEKVFSVNGaRGNHMDFGQLYQFLNAKGCGDVFQMFFG 286
Cdd:cd24140   81 ------------HNNSISKTW-EGYLQDCKFKGWFLKVCNDQYSLLRTLG 117
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 161-283 5.35e-22

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 88.89  E-value: 5.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494  161 LWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKP-GVVCVEGPQSACEEFWSR-LRKLNWKRI----LIRHREDVPFDG 234
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPfGLVVVEGGEKSIKKYKKLmLRRIKWTENphedFEAMKEITFEWD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795253494  235 TNDE--------------MERQRKFSIFEEKVfsvngargnHMDFGQLYQFLNAKGCGDVFQM 283
Cdd:pfam06544  81 NDEDnegednkcelvwegEVKERAFRKWKFKV---------CETEGEAREFLKKHGVEHYWDL 134
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 8-133 3.72e-14

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 67.35  E-value: 3.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494    8 EAQLAELDLLASMFPGENELIVNDQLavaelkdciekktmegRSSKVYFTINMNLDVSE-EAMAMFSLACILPFKYPAVL 86
Cdd:pfam05773   1 EEQEEELEALESIYPDEFEVISDSPY----------------ESLEIEIKLSLDSDESDsSHLPPLVLKFTLPEDYPDEP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 795253494   87 PEITVRSVI-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHA 133
Cdd:pfam05773  65 PKISLSSPWnLSDEQVLSLLEELEELAEENL-GEVMIFELIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 13-136 4.03e-14

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 67.00  E-value: 4.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494    13 ELDLLASMFPGENELIVNDqlavaelkdciekktmeGRSSKVYFTINMNLDVSEEAMAMFSLACILPFKYPAVLPEITVR 92
Cdd:smart00591   1 ELEALESIYPEDFEVIDED-----------------ARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLL 63

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 795253494    93 SV-ILSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVREHASGY 136
Cdd:smart00591  64 NSeGLSDEQLAELLKKLEEIAEENL-GEVMIFELVEKLQEFLSEF 107
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 13-132 5.63e-11

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 58.49  E-value: 5.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494  13 ELDLLASMFPGENELIVNDQlavaelkdcieKKTmegrSSKVYFTINMNLDVSEEAMAmFSLACILPFKYPAVLPEITVR 92
Cdd:cd23819    2 ELSVLQAIFCGPGEFEVLSS-----------SET----SDGVSFKIQISVEGFDEDIV-LKLTFHLSPNYPSSLPDISVS 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 795253494  93 SVILSRSQQTQLNTDLTAFLQKHcHGDVCILNATEWVREH 132
Cdd:cd23819   66 SEQLTRAQCNDLQDSLLEYANSL-LGEPMVLELVLWLQEN 104
RWD_DRWD_ELF-like cd11605
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 16-129 1.63e-05

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


Pssm-ID: 467641  Cd Length: 94  Bit Score: 42.55  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494  16 LLASMFPGENELIVNDqlavaelkdciekktmegrsSKVYFTINMNLDVSEEAmAMFSLACILPFKY-PAVLPEITVRSV 94
Cdd:cd11605    1 ALESIYGDELEVLSDD--------------------SPLRFSIRLSPEEEEDD-PPLELEFTLPPGYpPEEPPLITLRSP 59

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 795253494  95 ILSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWV 129
Cdd:cd11605   60 KLSSAERLSLLKLELEEAAEENLGEPMLFDLVEAL 94
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 7-131 3.19e-05

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 42.59  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494   7 AEAQLAELDLLASMFPGENELIVNDQLAVAELKdciekktmegrsskvyFTINM--NLDVSEEAMAMFSLACILPFKYPA 84
Cdd:cd23823    1 EEEQEEELEALQSIYGDDFEDLSSKKAVWSPPE----------------FRIRLrpQEGESEENHVSVDLHVKFPPTYPD 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 795253494  85 VLPEITVRSVI-LSRSQQTQLNTDLTAFLQKHChGDVCILNATEWVRE 131
Cdd:cd23823   65 VPPEIELENVKgLSDEQLEELLKELEELAKELL-GEEMIFELAEAVQE 111
PRK14422 PRK14422
acylphosphatase; Provisional
 181-215 2.22e-03

acylphosphatase; Provisional


Pssm-ID: 237712  Cd Length: 93  Bit Score: 36.64  E-value: 2.22e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 795253494 181 AKELSLSGFSMPGKPGVVCV--EGPQSACEEFWSRLR 215
Cdd:PRK14422  29 ALELGLTGYAANLADGRVQVvaEGPRAACEKLLQLLR 65
RWD_RNF14 cd23820
RWD domain of RING finger protein 14 (RNF14) and related proteins; RNF14, also called androgen ...
 10-131 3.27e-03

RWD domain of RING finger protein 14 (RNF14) and related proteins; RNF14, also called androgen receptor (AR)-associated protein 54 (ARA54), HFB30, or Triad2 protein, is an RBR-type E3 ubiquitin-protein ligase (EC 2.3.2.31) that is highly expressed in the testis and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3). Its differential localization may play an important role in testicular development and spermatogenesis in humans. RNF14 functions as a transcriptional regulator of mitochondrial and immune function in muscles. It is a ligand-dependent AR co-activator that enhances AR-dependent transcriptional activation. It also may participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1. Moreover, RNF14 is crucial for colon cancer cell survival. It acts as a new enhancer of Wnt-dependent transcriptional outputs that act at the level of the T-cell factor/lymphoid enhancer factor (TCF/LEF)-beta-catenin complex.


Pssm-ID: 467656 [Multi-domain]  Cd Length: 125  Bit Score: 36.96  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795253494  10 QLAELDLLASMFPGENELIVNDQLAVAELKDCIEkktMEGRSSKVYFTINMNLDVSEEAMAMF---SLACILPFKYP-AV 85
Cdd:cd23820    1 QEDELEALEAIYPDDLVVDSDSSSGRGSLEIPVE---LEPPLSVVLSSDGSDEGERTLKVSHLppiTLRFSLPPGYPsTS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 795253494  86 LPEITVRSVILSRSQQTQLNTDLTAfLQKHCHGDVCILNATEWVRE 131
Cdd:cd23820   78 PPEFTLECSWLSPEQLSALCERLDE-LWEENGGDVVLFSWIDFLQD 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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