NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767935294|ref|XP_011541446|]
View 

interleukin-31 receptor subunit alpha isoform X3 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047472)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 13-112 5.42e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 5.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294  13 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 92
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 767935294  93 CavKESKFWSDWSQEKMGMT 112
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 311-391 4.92e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294   311 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 390
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 767935294   391 G 391
Cdd:smart00060  81 G 81
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 13-112 5.42e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 5.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294  13 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 92
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 767935294  93 CavKESKFWSDWSQEKMGMT 112
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 311-391 4.92e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294   311 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 390
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 767935294   391 G 391
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 318-402 1.62e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294 318 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTN 394
Cdd:cd00063    8 RVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPP 85


                 ....*...
gi 767935294 395 GTSINFKT 402
Cdd:cd00063   86 SESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
14-105 1.71e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294   14 PPKIFRVKPVLGIKrmIQIEWIKPElAPVSSDLKYTLRFRTVNSTS-WMEVNFAKNRKdknqTYNLTGLQPFTEYVIALR 92
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPP-DGNGPITGYEVEYRPKNSGEpWNEITVPGTTT----SVTLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|...
gi 767935294   93 cAVKeSKFWSDWS 105
Cdd:pfam00041  75 -AVN-GGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
318-391 2.51e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.51e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767935294  318 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 391
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 14-93 4.25e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294    14 PPKIFRVKPVLgiKRMIQIEWIKPELAPVSSD-LKYTLRFRTVNStSWMEVNfaknRKDKNQTYNLTGLQPFTEYVIALR 92
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYiVGYRVEYREEGS-EWKEVN----VTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 767935294    93 C 93
Cdd:smart00060  76 A 76
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 13-112 5.42e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 5.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294  13 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 92
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 767935294  93 CavKESKFWSDWSQEKMGMT 112
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 311-391 4.92e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294   311 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 390
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 767935294   391 G 391
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 318-402 1.62e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294 318 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTN 394
Cdd:cd00063    8 RVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPP 85


                 ....*...
gi 767935294 395 GTSINFKT 402
Cdd:cd00063   86 SESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
14-105 1.71e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294   14 PPKIFRVKPVLGIKrmIQIEWIKPElAPVSSDLKYTLRFRTVNSTS-WMEVNFAKNRKdknqTYNLTGLQPFTEYVIALR 92
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPP-DGNGPITGYEVEYRPKNSGEpWNEITVPGTTT----SVTLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|...
gi 767935294   93 cAVKeSKFWSDWS 105
Cdd:pfam00041  75 -AVN-GGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
318-391 2.51e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.51e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767935294  318 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 391
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 14-93 4.25e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935294    14 PPKIFRVKPVLgiKRMIQIEWIKPELAPVSSD-LKYTLRFRTVNStSWMEVNfaknRKDKNQTYNLTGLQPFTEYVIALR 92
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYiVGYRVEYREEGS-EWKEVN----VTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 767935294    93 C 93
Cdd:smart00060  76 A 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH