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Conserved domains on  [gi|768008900|ref|XP_011525220|]
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zinc finger and SCAN domain-containing protein 22 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
10-313 1.28e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  10 FVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGreSGASRNSSSAWPNLTSQEKPPSEDKFDLVDA 89
Cdd:COG5048  146 LRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV--STSIPSSSENSPLSSSYSIPSSSSDQNLENS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  90 YGTEPPYTYSGKrsskcreCRKMFQSASALEAHQKTHSRKTP--YACSECGKAFSRSTHLAQHQVVHTGA-KPHECKECG 166
Cdd:COG5048  224 SSSLPLTTNSQL-------SPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCN 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 167 KAFSRVTHLTQHQR--IHTGE--KPYKCGE--CGKTFSRSTHLTQHQRVHTGERPYECDA--CGKAFSQSTH-----LTQ 233
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNneppqSLQ 376

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 234 HQRIHTGEKPYKCD--ACGRAFSDCSALIRHLRIHSGEKPYQCK--VCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAF 309
Cdd:COG5048  377 QYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456


                 ....
gi 768008900 310 SRSS 313
Cdd:COG5048  457 RDLD 460
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
10-313 1.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  10 FVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGreSGASRNSSSAWPNLTSQEKPPSEDKFDLVDA 89
Cdd:COG5048  146 LRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV--STSIPSSSENSPLSSSYSIPSSSSDQNLENS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  90 YGTEPPYTYSGKrsskcreCRKMFQSASALEAHQKTHSRKTP--YACSECGKAFSRSTHLAQHQVVHTGA-KPHECKECG 166
Cdd:COG5048  224 SSSLPLTTNSQL-------SPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCN 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 167 KAFSRVTHLTQHQR--IHTGE--KPYKCGE--CGKTFSRSTHLTQHQRVHTGERPYECDA--CGKAFSQSTH-----LTQ 233
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNneppqSLQ 376

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 234 HQRIHTGEKPYKCD--ACGRAFSDCSALIRHLRIHSGEKPYQCK--VCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAF 309
Cdd:COG5048  377 QYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456


                 ....
gi 768008900 310 SRSS 313
Cdd:COG5048  457 RDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 7.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 768008900  174 HLTQHQRIHTGEKPYKCGECGKTFSR 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 270-322 3.27e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 3.27e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768008900 270 KPYqCKVCPKAFAQSSSLIEHQRIHTgekpYKCSDCGKAFSRSSALMVH-LRIH 322
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 103-266 6.69e-04

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.40  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 103 SSKCRECRKMFQSASAL--EAHQKTHSRKTPYAcsECGKAFsRSTHLAQHqvVHtgakpheCKECGKAFSRvTHLTQHQR 180
Cdd:PLN03086 407 TVECRNCKHYIPSRSIAlhEAYCSRHNVVCPHD--GCGIVL-RVEEAKNH--VH-------CEKCGQAFQQ-GEMEKHMK 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 181 IHtgEKPYKCGeCGKTFSRStHLTQHQRVHTGERPYECDACGKAFSQSTH----------LTQHQRIhTGEKPYKCDACG 250
Cdd:PLN03086 474 VF--HEPLQCP-CGVVLEKE-QMVQHQASTCPLRLITCRFCGDMVQAGGSamdvrdrlrgMSEHESI-CGSRTAPCDSCG 548

                        170
                 ....*....|....*.
gi 768008900 251 RafsdcSALIRHLRIH 266
Cdd:PLN03086 549 R-----SVMLKEMDIH 559
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
10-313 1.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  10 FVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGreSGASRNSSSAWPNLTSQEKPPSEDKFDLVDA 89
Cdd:COG5048  146 LRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNV--STSIPSSSENSPLSSSYSIPSSSSDQNLENS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  90 YGTEPPYTYSGKrsskcreCRKMFQSASALEAHQKTHSRKTP--YACSECGKAFSRSTHLAQHQVVHTGA-KPHECKECG 166
Cdd:COG5048  224 SSSLPLTTNSQL-------SPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCN 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 167 KAFSRVTHLTQHQR--IHTGE--KPYKCGE--CGKTFSRSTHLTQHQRVHTGERPYECDA--CGKAFSQSTH-----LTQ 233
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNneppqSLQ 376

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 234 HQRIHTGEKPYKCD--ACGRAFSDCSALIRHLRIHSGEKPYQCK--VCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAF 309
Cdd:COG5048  377 QYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456


                 ....
gi 768008900 310 SRSS 313
Cdd:COG5048  457 RDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
57-324 6.37e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 6.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900  57 RESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSgkrsSKCRECRKMFQSASALEAHQKTHSRKTPYACSE 136
Cdd:COG5048  156 SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPS----SSENSPLSSSYSIPSSSSDQNLENSSSSLPLTT 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 137 CGKAFSRSTHLAQHQVVHTGAKPHECKECGKAF--SRVTHLTQHQRIHTGE-----KPYKCGECGKTFSRSTHLTQHQR- 208
Cdd:COG5048  232 NSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRs 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 209 -VHTGE--RPYECDA--CGKAFSQSTHLTQHQRIHTGEKPYKCDACGRAFSDCSALIR----HLRIHSGEKPYQCKV--- 276
Cdd:COG5048  312 vNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSEtls 391

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768008900 277 --CPKAFAQSSSLIEHQRIHTGEKP--YKCSDCGKAFSRSSALMVHLRIHIT 324
Cdd:COG5048  392 nsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-290 1.29e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 214 RPYECDACGKAFSQSTHLTQHQRIHTGEKPYKCDACGRA--FSDCSALIRHLRIHSGEKPYQC--KVCPKAFAQSSSLIE 289
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111


                 .
gi 768008900 290 H 290
Cdd:COG5048  112 S 112
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-307 4.19e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768008900 242 KPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQS--SSLIEHQRIHTGEKPYKCSDCGK 307
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 7.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 768008900  174 HLTQHQRIHTGEKPYKCGECGKTFSR 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-283 9.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 9.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 768008900  258 ALIRHLRIHSGEKPYQCKVCPKAFAQ 283
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 768008900  286 SLIEHQRIHTGEKPYKCSDCGKAFSR 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 1.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.86e-04
                          10        20
                  ....*....|....*....|....*
gi 768008900  230 HLTQHQRIHTGEKPYKCDACGRAFS 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-227 1.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 768008900  202 HLTQHQRVHTGERPYECDACGKAFSQ 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-229 2.39e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768008900 158 KPHECKECGKAFSRVTHLTQHQRIHTGEKPYKCG--ECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQST 229
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-264 2.93e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 103 SSKCRECRKMFQSASALEAHQKT--HSRK--TPYACSE--CGKAFSRSTHLAQHQVVHTGAKPHECKEC-------GKAF 169
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 170 SRVTHLTQHQRIHTGEKPYKC--GECGKTFSRSTHLTQHQRVHTGERPYECD--ACGKAFSQSTHLTQHQRIHTGEKPYK 245
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*....
gi 768008900 246 CDACGRaFSDCSALIRHLR 264
Cdd:COG5048  449 CSILKS-FRRDLDLSNHGK 466
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 270-322 3.27e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 3.27e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768008900 270 KPYqCKVCPKAFAQSSSLIEHQRIHTgekpYKCSDCGKAFSRSSALMVH-LRIH 322
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-322 3.44e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 3.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768008900 270 KPYQCKVCPKAFAQSSSLIEHQRIHTGEKPYKCSD--CGKAFSRSSALMVHLRIH 322
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 188-210 5.01e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|...
gi 768008900  188 YKCGECGKTFSRSTHLTQHQRVH 210
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-187 5.49e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.49e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768008900 129 KTPYACSECGKAFSRSTHLAQHQVVHTGAKPHEC--KECGKAFSRVTHLTQHQRIHTGEKP 187
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 103-266 6.69e-04

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.40  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 103 SSKCRECRKMFQSASAL--EAHQKTHSRKTPYAcsECGKAFsRSTHLAQHqvVHtgakpheCKECGKAFSRvTHLTQHQR 180
Cdd:PLN03086 407 TVECRNCKHYIPSRSIAlhEAYCSRHNVVCPHD--GCGIVL-RVEEAKNH--VH-------CEKCGQAFQQ-GEMEKHMK 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008900 181 IHtgEKPYKCGeCGKTFSRStHLTQHQRVHTGERPYECDACGKAFSQSTH----------LTQHQRIhTGEKPYKCDACG 250
Cdd:PLN03086 474 VF--HEPLQCP-CGVVLEKE-QMVQHQASTCPLRLITCRFCGDMVQAGGSamdvrdrlrgMSEHESI-CGSRTAPCDSCG 548

                        170
                 ....*....|....*.
gi 768008900 251 RafsdcSALIRHLRIH 266
Cdd:PLN03086 549 R-----SVMLKEMDIH 559
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 162-210 7.74e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 7.74e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 768008900 162 CKECGKAFSRVTHLTQHQRIHTgekpYKCGECGKTFSRSTHLTQH-QRVH 210
Cdd:cd20908    4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 300-322 7.79e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 7.79e-04
                          10        20
                  ....*....|....*....|...
gi 768008900  300 YKCSDCGKAFSRSSALMVHLRIH 322
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-251 3.44e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 3.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768008900 186 KPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDA--CGKAFSQSTHLTQHQRIHTGEKPYKCDACGR 251
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
PHA00733 PHA00733
hypothetical protein
 271-319 4.36e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 4.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 768008900 271 PYQCKVCPKAFAQSSSLIEHQRIHTGEKpyKCSDCGKAFSRSSALMVHL 319
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 768008900  146 HLAQHQVVHTGAKPHECKECGKAFSR 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 160-182 4.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|...
gi 768008900  160 HECKECGKAFSRVTHLTQHQRIH 182
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 272-294 6.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.11e-03
                          10        20
                  ....*....|....*....|...
gi 768008900  272 YQCKVCPKAFAQSSSLIEHQRIH 294
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 216-238 6.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 6.81e-03
                          10        20
                  ....*....|....*....|...
gi 768008900  216 YECDACGKAFSQSTHLTQHQRIH 238
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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