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Conserved domains on  [gi|731214216|ref|XP_010621559|]
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urokinase plasminogen activator surface receptor isoform X2 [Fukomys damarensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 108-192 1.70e-27

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467087  Cd Length: 85  Bit Score: 102.78  E-value: 1.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 108 GRYLECISCTSSDLSCERGREQSLQCRHPREQCLEVVTHSSLEENEMEEhHTRGCGFLPGCPGPTGFHSNHSFHYLRCCN 187
Cdd:cd23557    2 SRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSLERPKSER-RLKGCGTLPGCPGSLGFHNNDTFHLLKCCN 80


                 ....*
gi 731214216 188 STKCN 192
Cdd:cd23557   81 SSLCN 85
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 202-289 2.67e-23

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


:

Pssm-ID: 467088  Cd Length: 93  Bit Score: 92.07  E-value: 2.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 202 LPPNGVQCYSCEGNGTHGCSSSESSLVSCRGPMDRCLQATGVKGPGNMN--FTVRGCATASWCQDSHMADTFSLTHLSVS 279
Cdd:cd23558    3 LPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNqsYMVKGCATPSMCQSTALSLNQVLNSADVR 82

                         90
                 ....*....|
gi 731214216 280 CCKGTGCNNP 289
Cdd:cd23558   83 CCNGSLCNNG 92
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 21-96 3.60e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467086  Cd Length: 79  Bit Score: 83.28  E-value: 3.60e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 731214216  21 LLCFQCKSSGPCQVEE-CAPGQDLCRITVMHVWED--ELEVVERGCAHAEKTNRTMSYRVGPQIISLTETVCGSNMCNR 96
Cdd:cd23556    1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEgeELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 108-192 1.70e-27

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 102.78  E-value: 1.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 108 GRYLECISCTSSDLSCERGREQSLQCRHPREQCLEVVTHSSLEENEMEEhHTRGCGFLPGCPGPTGFHSNHSFHYLRCCN 187
Cdd:cd23557    2 SRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSLERPKSER-RLKGCGTLPGCPGSLGFHNNDTFHLLKCCN 80


                 ....*
gi 731214216 188 STKCN 192
Cdd:cd23557   81 SSLCN 85
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 202-289 2.67e-23

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 92.07  E-value: 2.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 202 LPPNGVQCYSCEGNGTHGCSSSESSLVSCRGPMDRCLQATGVKGPGNMN--FTVRGCATASWCQDSHMADTFSLTHLSVS 279
Cdd:cd23558    3 LPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNqsYMVKGCATPSMCQSTALSLNQVLNSADVR 82

                         90
                 ....*....|
gi 731214216 280 CCKGTGCNNP 289
Cdd:cd23558   83 CCNGSLCNNG 92
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 21-96 3.60e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 83.28  E-value: 3.60e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 731214216  21 LLCFQCKSSGPCQVEE-CAPGQDLCRITVMHVWED--ELEVVERGCAHAEKTNRTMSYRVGPQIISLTETVCGSNMCNR 96
Cdd:cd23556    1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEgeELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 111-195 9.00e-13

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 62.94  E-value: 9.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216   111 LECISCT-SSDLSCERGREqslqCRHPREQCLEVVTHSSLEENEmeEHHTRGCGFLPGCPGPTGFHSNHSFHYL--RCCN 187
Cdd:smart00134   1 LQCYSCTgNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSRG--SVVYKGCATSPICPGSHGYEINLTIAFLkvSCCQ 74


                   ....*...
gi 731214216   188 STKCNSGP 195
Cdd:smart00134  75 TDLCNAAG 82
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 208-292 1.23e-11

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 59.86  E-value: 1.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216   208 QCYSCEGNGTHGCssseSSLVSCRGPMDRCLQATGVKGPGN-MNFTVRGCATASWCQDSHMADTFSLTH-LSVSCCKGTG 285
Cdd:smart00134   2 QCYSCTGNPDSSC----SSEEECRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAfLKVSCCQTDL 77


                   ....*..
gi 731214216   286 CNNPASN 292
Cdd:smart00134  78 CNAAGPG 84
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-95 4.05e-10

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 55.24  E-value: 4.05e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 731214216   23 CFQCK--SSGPCQVE-ECAPGQDLCRITVMHVWED--ELEVVERGCAHaEKTNRTMSYRVGPQIISLTETVCGSNMCN 95
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGnlRGTVVSKGCAR-SSCPRLLSDFINGGIISVSESCCQSDLCN 77
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 209-287 6.76e-10

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 54.85  E-value: 6.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216  209 CYSCEGNGTHGCssseSSLVSCRGPMDRCLQATGVKGPGNMN--FTVRGCATaSWCQdSHMADTFSLTH--LSVSCCKGT 284
Cdd:pfam00021   1 CYSCLGVSNEDC----LSEVTCPLSDGQCVTTTLELPEGNLRgtVVSKGCAR-SSCP-RLLSDFINGGIisVSESCCQSD 74


                  ...
gi 731214216  285 GCN 287
Cdd:pfam00021  75 LCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-100 8.70e-10

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 54.85  E-value: 8.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216    21 LLCFQCKSSGP--CQVEE-CAPGQDLCRITVMHVWEDE-LEVVERGCAHAEKTNRTMSYRVGPQIISLTETVCGSNMCNR 96
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEeCRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCNA 80


                   ....
gi 731214216    97 PRPG 100
Cdd:smart00134  81 AGPG 84
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 108-192 1.70e-27

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 102.78  E-value: 1.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 108 GRYLECISCTSSDLSCERGREQSLQCRHPREQCLEVVTHSSLEENEMEEhHTRGCGFLPGCPGPTGFHSNHSFHYLRCCN 187
Cdd:cd23557    2 SRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSLERPKSER-RLKGCGTLPGCPGSLGFHNNDTFHLLKCCN 80


                 ....*
gi 731214216 188 STKCN 192
Cdd:cd23557   81 SSLCN 85
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 202-289 2.67e-23

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 92.07  E-value: 2.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 202 LPPNGVQCYSCEGNGTHGCSSSESSLVSCRGPMDRCLQATGVKGPGNMN--FTVRGCATASWCQDSHMADTFSLTHLSVS 279
Cdd:cd23558    3 LPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNqsYMVKGCATPSMCQSTALSLNQVLNSADVR 82

                         90
                 ....*....|
gi 731214216 280 CCKGTGCNNP 289
Cdd:cd23558   83 CCNGSLCNNG 92
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 21-96 3.60e-20

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 83.28  E-value: 3.60e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 731214216  21 LLCFQCKSSGPCQVEE-CAPGQDLCRITVMHVWED--ELEVVERGCAHAEKTNRTMSYRVGPQIISLTETVCGSNMCNR 96
Cdd:cd23556    1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEgeELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 111-195 9.00e-13

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 62.94  E-value: 9.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216   111 LECISCT-SSDLSCERGREqslqCRHPREQCLEVVTHSSLEENEmeEHHTRGCGFLPGCPGPTGFHSNHSFHYL--RCCN 187
Cdd:smart00134   1 LQCYSCTgNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSRG--SVVYKGCATSPICPGSHGYEINLTIAFLkvSCCQ 74


                   ....*...
gi 731214216   188 STKCNSGP 195
Cdd:smart00134  75 TDLCNAAG 82
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 208-292 1.23e-11

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 59.86  E-value: 1.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216   208 QCYSCEGNGTHGCssseSSLVSCRGPMDRCLQATGVKGPGN-MNFTVRGCATASWCQDSHMADTFSLTH-LSVSCCKGTG 285
Cdd:smart00134   2 QCYSCTGNPDSSC----SSEEECRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAfLKVSCCQTDL 77


                   ....*..
gi 731214216   286 CNNPASN 292
Cdd:smart00134  78 CNAAGPG 84
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-95 4.05e-10

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 55.24  E-value: 4.05e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 731214216   23 CFQCK--SSGPCQVE-ECAPGQDLCRITVMHVWED--ELEVVERGCAHaEKTNRTMSYRVGPQIISLTETVCGSNMCN 95
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGnlRGTVVSKGCAR-SSCPRLLSDFINGGIISVSESCCQSDLCN 77
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 209-287 6.76e-10

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 54.85  E-value: 6.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216  209 CYSCEGNGTHGCssseSSLVSCRGPMDRCLQATGVKGPGNMN--FTVRGCATaSWCQdSHMADTFSLTH--LSVSCCKGT 284
Cdd:pfam00021   1 CYSCLGVSNEDC----LSEVTCPLSDGQCVTTTLELPEGNLRgtVVSKGCAR-SSCP-RLLSDFINGGIisVSESCCQSD 74


                  ...
gi 731214216  285 GCN 287
Cdd:pfam00021  75 LCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-100 8.70e-10

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 54.85  E-value: 8.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216    21 LLCFQCKSSGP--CQVEE-CAPGQDLCRITVMHVWEDE-LEVVERGCAHAEKTNRTMSYRVGPQIISLTETVCGSNMCNR 96
Cdd:smart00134   1 LQCYSCTGNPDssCSSEEeCRSPDDVCLTVVAEVISDSrGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCNA 80


                   ....
gi 731214216    97 PRPG 100
Cdd:smart00134  81 AGPG 84
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 203-287 1.28e-09

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 54.25  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 203 PPNGVQCYSCEGNGtHGCSSSESSLVSCRGPMDRCLQAT--GVKGPGNMNFTVRGCATASWCQDSHMADTFSlTHLSVSC 280
Cdd:cd23557    1 RSRYLECYSCGSSD-MSCERGRLTSLQCRGPQDQCVDVTthGSLERPKSERRLKGCGTLPGCPGSLGFHNND-TFHLLKC 78


                 ....*..
gi 731214216 281 CKGTGCN 287
Cdd:cd23557   79 CNSSLCN 85
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 203-290 3.95e-07

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 47.40  E-value: 3.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 203 PPNGVQCYSCEGNGTHGCSSSESSLVSCRGPMDRCLQATGVKGPGNMNFTV----RGCATASWCQDSHMADTFSLTHLSV 278
Cdd:cd23566    5 TPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGNDNFSVpiyiKTCQAPSCTTPGSTSPWTAIISQQG 84

                         90
                 ....*....|..
gi 731214216 279 SCCKGTGCNNPA 290
Cdd:cd23566   85 SCCSGSLCNGPS 96
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 205-279 1.16e-04

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 40.10  E-value: 1.16e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731214216 205 NGVQCYSCEGNGTHGCSSSESSLvsCRGPMDRCLQATGV--KGPGNMNFTVRGCATASWCQDSHMADTFSLTHLSVS 279
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEETVN--CTGEETQCIEFSGTisGGGSSVKFAMKGCATESACDLGKGSLPFGGTSVNIT 75
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 204-287 3.96e-04

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 38.98  E-value: 3.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 204 PNGVQCYSCEGNGTHGCSSSESSLVSCRGPMDRCLQATGVKGPGNMNF--TVRGCATASWCQdSHMADTFSLThLSVSCC 281
Cdd:cd23563    1 PNGVECYSCVGNSRGACSPSNAPVVRCYGAYSGCFDGNVTLTIGNVTLslPVKGCVQDGDCT-RESKGGASVT-LKGSCC 78


                 ....*.
gi 731214216 282 KGTGCN 287
Cdd:cd23563   79 SGNLCN 84
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 208-287 7.56e-04

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 37.85  E-value: 7.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 208 QCYSCEGNGTHGCSSSESSLVSCRGPMDRCLQATGvKGPGNMNFTVRGCATASWCQDSHMADTFSL-THLSVSCCKGTGC 286
Cdd:cd00117    2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVG-KVGGGETLVIRGCATECECGCTECCSGTGTsGTTCTSCCDTDLC 80


                 .
gi 731214216 287 N 287
Cdd:cd00117   81 N 81
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 111-194 1.06e-03

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 37.76  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 111 LECISCT-SSDLSCERGREQSLQCRHPREQCLEVVTHSSLeENEMEEHHTRGCGFLPGCPGP---TGFHSNHSFHylRCC 186
Cdd:cd23558    8 IQCYSCNgNSTHGCSSEETSKVRCRGPQTQCLEATGTTAH-GGKNQSYMVKGCATPSMCQSTalsLNQVLNSADV--RCC 84


                 ....*...
gi 731214216 187 NSTKCNSG 194
Cdd:cd23558   85 NGSLCNNG 92
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 203-287 1.08e-03

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 37.39  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731214216 203 PPNGVQCYSCEGNGThgcsssESSLVSCRGPMDRCLQATGVKGPGNMnfTVRGCATAswCQDSHMADTFSLTHLSVSCCK 282
Cdd:cd23542    2 PANALQCHVCNSSSN------CTNPVNCEGSERYCKTTTVVQPSGNL--VKKGCAET--CPPSTSRQQVGSGISSVTCCQ 71


                 ....*
gi 731214216 283 GTGCN 287
Cdd:cd23542   72 GDLCN 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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