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Conserved domains on  [gi|578826704|ref|XP_006720489|]
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protein FAM227B isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FWWh pfam14922
Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a ...
 136-257 7.39e-59

Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.


:

Pssm-ID: 464378  Cd Length: 150  Bit Score: 190.92  E-value: 7.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826704  136 ERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDRENQDCLFDRISESYVTLFMSIPLSR-KDAFFQIYPDCLAQAIYA 214
Cdd:pfam14922  28 PCYKKEWKKFFLSEASQAILLDSFWWFFLERYQPDKESQDKLFDRIAENYVKLLLTAPRPDyKDAFFKRYPDLLAQAVYT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 578826704  215 TFHEAFPESSYLFNDEFKEDLGNNIFLWCSGLKPQKGFWIHWK 257
Cdd:pfam14922 108 AFCEAFPQSWSLFNEEFKSELCNLMSLWISGIKPSPRSWKKWN 150
HOATZ-like super family cl39203
Cilia- and flagella-associated protein HOATZ-like; This entry represents cilia- and ...
 376-442 2.17e-04

Cilia- and flagella-associated protein HOATZ-like; This entry represents cilia- and flagella-associated protein, HOATZ, and related proteins, found in metazoa. In mice HOATZ is encoded by the gene designated 4833427G06Rik (C11orf88). Mouse Hoatz mRNA is specifically expressed in tissues with motile cilia and flagella. Hoatz knockout mice developed hydrocephalus and male infertility, and the ependymal cilia frequently showed disorganized axonemes.


The actual alignment was detected with superfamily member pfam17664:

Pssm-ID: 465445  Cd Length: 168  Bit Score: 42.02  E-value: 2.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578826704  376 EPLPAPTY--RDVIKEAKRQFARNQKDFRMEKLRINEEIKLL--KQQQERIDKELDRLQAKATKKPHEVKQ 442
Cdd:pfam17664  81 QPFPLENNknTDILAEALKIQESEEKEKYLQKAKKRDEILQLlrKQREERILKELISLPYKPKGKVHKAKK 151
 
Name Accession Description Interval E-value
FWWh pfam14922
Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a ...
 136-257 7.39e-59

Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.


Pssm-ID: 464378  Cd Length: 150  Bit Score: 190.92  E-value: 7.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826704  136 ERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDRENQDCLFDRISESYVTLFMSIPLSR-KDAFFQIYPDCLAQAIYA 214
Cdd:pfam14922  28 PCYKKEWKKFFLSEASQAILLDSFWWFFLERYQPDKESQDKLFDRIAENYVKLLLTAPRPDyKDAFFKRYPDLLAQAVYT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 578826704  215 TFHEAFPESSYLFNDEFKEDLGNNIFLWCSGLKPQKGFWIHWK 257
Cdd:pfam14922 108 AFCEAFPQSWSLFNEEFKSELCNLMSLWISGIKPSPRSWKKWN 150
HOATZ-like pfam17664
Cilia- and flagella-associated protein HOATZ-like; This entry represents cilia- and ...
 376-442 2.17e-04

Cilia- and flagella-associated protein HOATZ-like; This entry represents cilia- and flagella-associated protein, HOATZ, and related proteins, found in metazoa. In mice HOATZ is encoded by the gene designated 4833427G06Rik (C11orf88). Mouse Hoatz mRNA is specifically expressed in tissues with motile cilia and flagella. Hoatz knockout mice developed hydrocephalus and male infertility, and the ependymal cilia frequently showed disorganized axonemes.


Pssm-ID: 465445  Cd Length: 168  Bit Score: 42.02  E-value: 2.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578826704  376 EPLPAPTY--RDVIKEAKRQFARNQKDFRMEKLRINEEIKLL--KQQQERIDKELDRLQAKATKKPHEVKQ 442
Cdd:pfam17664  81 QPFPLENNknTDILAEALKIQESEEKEKYLQKAKKRDEILQLlrKQREERILKELISLPYKPKGKVHKAKK 151
 
Name Accession Description Interval E-value
FWWh pfam14922
Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a ...
 136-257 7.39e-59

Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.


Pssm-ID: 464378  Cd Length: 150  Bit Score: 190.92  E-value: 7.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826704  136 ERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDRENQDCLFDRISESYVTLFMSIPLSR-KDAFFQIYPDCLAQAIYA 214
Cdd:pfam14922  28 PCYKKEWKKFFLSEASQAILLDSFWWFFLERYQPDKESQDKLFDRIAENYVKLLLTAPRPDyKDAFFKRYPDLLAQAVYT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 578826704  215 TFHEAFPESSYLFNDEFKEDLGNNIFLWCSGLKPQKGFWIHWK 257
Cdd:pfam14922 108 AFCEAFPQSWSLFNEEFKSELCNLMSLWISGIKPSPRSWKKWN 150
HOATZ-like pfam17664
Cilia- and flagella-associated protein HOATZ-like; This entry represents cilia- and ...
 376-442 2.17e-04

Cilia- and flagella-associated protein HOATZ-like; This entry represents cilia- and flagella-associated protein, HOATZ, and related proteins, found in metazoa. In mice HOATZ is encoded by the gene designated 4833427G06Rik (C11orf88). Mouse Hoatz mRNA is specifically expressed in tissues with motile cilia and flagella. Hoatz knockout mice developed hydrocephalus and male infertility, and the ependymal cilia frequently showed disorganized axonemes.


Pssm-ID: 465445  Cd Length: 168  Bit Score: 42.02  E-value: 2.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578826704  376 EPLPAPTY--RDVIKEAKRQFARNQKDFRMEKLRINEEIKLL--KQQQERIDKELDRLQAKATKKPHEVKQ 442
Cdd:pfam17664  81 QPFPLENNknTDILAEALKIQESEEKEKYLQKAKKRDEILQLlrKQREERILKELISLPYKPKGKVHKAKK 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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