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Conserved domains on  [gi|568974806|ref|XP_006533792|]
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contactin-associated protein 1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
123-255 2.38e-29

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.38e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    123 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVslggvlNDLSWHYVRVDRYGRDANF 201
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806    202 TLDGYAH-HFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 255
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 1-91 8.65e-29

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 112.83  E-value: 8.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    1 MKKHRIRAVATQGAFN--SWDWVTRYMLLYGDRVDSWTPFYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWN 78
Cdd:cd00057    53 GKTRRVTGIQTQGRKGggSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN 132

                          90
                  ....*....|...
gi 568974806   79 prGKIGLRLGIYG 91
Cdd:cd00057   133 --GNISLRLELYG 143
LamG smart00282
Laminin G domain;
1007-1142 3.51e-27

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.51e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   1007 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1085
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568974806   1086 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1142
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 286-437 6.42e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 6.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  286 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 364
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806  365 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 437
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 711-861 1.58e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  711 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 789
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  790 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 861
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 519-540 1.12e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.70  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|..
gi 568974806  519 SGNYTIDPDGSGPLKPFVVYCD 540
Cdd:NF040941   14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1228-1246 2.66e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.66e-05
                            10
                    ....*....|....*....
gi 568974806   1228 FYLQNHRYKGSYHTNEPKA 1246
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 508-582 1.00e-03

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 42.23  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568974806  508 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 582
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 468-497 1.83e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568974806   468 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 497
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
123-255 2.38e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.38e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    123 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVslggvlNDLSWHYVRVDRYGRDANF 201
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806    202 TLDGYAH-HFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 255
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 127-256 2.82e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 113.67  E-value: 2.82e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   127 FKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIqprpghTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGY 206
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568974806   207 AHHFVLN-GDFERLNLENEIFIGGLVGAAR-KNLAYRHNFRGCIENVIYNRI 256
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 99-254 3.83e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 3.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   99 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 177
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568974806  178 LGGVLNDLSWHYVRVDRYGRDANFTLDGYAH-HFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 254
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 1-91 8.65e-29

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 112.83  E-value: 8.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    1 MKKHRIRAVATQGAFN--SWDWVTRYMLLYGDRVDSWTPFYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWN 78
Cdd:cd00057    53 GKTRRVTGIQTQGRKGggSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN 132

                          90
                  ....*....|...
gi 568974806   79 prGKIGLRLGIYG 91
Cdd:cd00057   133 --GNISLRLELYG 143
LamG smart00282
Laminin G domain;
1007-1142 3.51e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.51e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   1007 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1085
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568974806   1086 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1142
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1012-1142 3.67e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.51  E-value: 3.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  1012 FSTNSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1091
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568974806  1092 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1142
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 286-437 6.42e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 6.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  286 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 364
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806  365 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 437
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 996-1140 9.36e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.42  E-value: 9.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  996 YRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1074
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806 1075 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1140
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
309-439 6.01e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 98.57  E-value: 6.01e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    309 VSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 388
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568974806    389 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 439
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 313-439 8.21e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   313 FRTWDLTGLLLFSHlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 392
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568974806   393 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 439
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 711-861 1.58e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  711 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 789
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  790 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 861
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 737-863 7.12e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 92.48  E-value: 7.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   737 FRTSAPSGVFLENMGGpfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 816
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568974806   817 HRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 863
Cdd:pfam02210   73 GQTVVSSLPPGESLLLNL-NGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
732-863 1.02e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.02e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    732 DVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 811
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    812 RLRVDHRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 863
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNL-DGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 1-92 3.02e-20

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 88.34  E-value: 3.02e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806      1 MKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDsWTPfYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNpr 80
Cdd:smart00231   52 GRLRTVTGVITGRRHGNGDWVTYKLEYSDDGVN-WTT-YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN-- 127

                            90
                    ....*....|..
gi 568974806     81 GKIGLRLGIYGC 92
Cdd:smart00231  128 GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 2-89 6.68e-14

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 69.78  E-value: 6.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806     2 KKHRIRAVATQGAFNSWD-WVTRYMLLYGDRVDSWTPFYqkghNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPR 80
Cdd:pfam00754   43 KPKKITGVVTQGRQDGSNgYVTSYKIEYSLDGENWTTVK----DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGG 118


                   ....*....
gi 568974806    81 GKIGLRLGI 89
Cdd:pfam00754  119 NGIALRAEL 127
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 519-540 1.12e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.70  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|..
gi 568974806  519 SGNYTIDPDGSGPLKPFVVYCD 540
Cdd:NF040941   14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1228-1246 2.66e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.66e-05
                            10
                    ....*....|....*....
gi 568974806   1228 FYLQNHRYKGSYHTNEPKA 1246
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 508-582 1.00e-03

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 42.23  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568974806  508 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 582
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 468-497 1.83e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568974806   468 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 497
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
505-549 4.89e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.20  E-value: 4.89e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568974806   505 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 549
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 466-500 7.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 7.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568974806  466 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGVTC 500
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
123-255 2.38e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.38e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    123 FAFSFKTEEKDGLLLHTEGSQG-DYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVslggvlNDLSWHYVRVDRYGRDANF 201
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806    202 TLDGYAH-HFVLNGDFERLNLENEIFIGGLV-GAARKNLAYRHNFRGCIENVIYNR 255
Cdd:smart00282   76 SVDGGNRvSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 127-256 2.82e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 113.67  E-value: 2.82e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   127 FKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIqprpghTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGY 206
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568974806   207 AHHFVLN-GDFERLNLENEIFIGGLVGAAR-KNLAYRHNFRGCIENVIYNRI 256
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 99-254 3.83e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 3.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   99 LYFDGDDAISYRFQRGASQSLwdVFAFSFKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSspiqprpGHTTVS 177
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568974806  178 LGGVLNDLSWHYVRVDRYGRDANFTLDGYAH-HFVLNGDFERLNLENEIFIGGLVGAARKN-LAYRHNFRGCIENVIYN 254
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 1-91 8.65e-29

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 112.83  E-value: 8.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    1 MKKHRIRAVATQGAFN--SWDWVTRYMLLYGDRVDSWTPFYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWN 78
Cdd:cd00057    53 GKTRRVTGIQTQGRKGggSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN 132

                          90
                  ....*....|...
gi 568974806   79 prGKIGLRLGIYG 91
Cdd:cd00057   133 --GNISLRLELYG 143
LamG smart00282
Laminin G domain;
1007-1142 3.51e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.51e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   1007 EVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1085
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568974806   1086 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1142
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1012-1142 3.67e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.51  E-value: 3.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  1012 FSTNSAPAVLLYVSSFVRDYMAVLIkEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1091
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568974806  1092 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1142
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 286-437 6.42e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 6.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  286 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLN 364
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806  365 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVD 437
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 996-1140 9.36e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.42  E-value: 9.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  996 YRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVR-DYMAVLIkEDGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1074
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALEL-EDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568974806 1075 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1140
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
309-439 6.01e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 98.57  E-value: 6.01e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    309 VSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 388
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 568974806    389 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWGcHSNQTAFHGCMELLKVDGQ 439
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 313-439 8.21e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   313 FRTWDLTGLLLFSHlGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 392
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568974806   393 RVS-YPLLIRTGTSYFFGGCPKPaSRWGCHSNQTAFHGCMELLKVDGQ 439
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 711-861 1.58e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  711 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDigNGDENLTVHS 789
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  790 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWLVYDQPLYVG--------SAELKRRPFVGCLRAMRLN 861
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 737-863 7.12e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 92.48  E-value: 7.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   737 FRTSAPSGVFLENMGGpfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 816
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568974806   817 HRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 863
Cdd:pfam02210   73 GQTVVSSLPPGESLLLNL-NGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
732-863 1.02e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.02e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    732 DVSFYFRTSAPSGVFLENMGGPfcrwRRPYVRVELNTSRdVVFAFDIGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 811
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806    812 RLRVDHRPWVLRPMPLQTYIWLVyDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 863
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNL-DGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 1-92 3.02e-20

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 88.34  E-value: 3.02e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806      1 MKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDsWTPfYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNpr 80
Cdd:smart00231   52 GRLRTVTGVITGRRHGNGDWVTYKLEYSDDGVN-WTT-YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN-- 127

                            90
                    ....*....|..
gi 568974806     81 GKIGLRLGIYGC 92
Cdd:smart00231  128 GNIILRVELLGC 139
Laminin_G_1 pfam00054
Laminin G domain;
127-255 6.25e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 78.51  E-value: 6.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   127 FKTEEKDGLLLHTEG-SQGDYVTLELQGAHLLLHMSLGSSPIqprpghtTVSLGGVLNDLSWHYVRVDRYGRDANFTLDG 205
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqTERDFLALELRDGRLEVSYDLGSGAA-------VVRSGDKLNDGKWHSVELERNGRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568974806   206 YAHHF---VLNGDFErLNLENEIFIGGL--VGAARKNLAYRHNFRGCIENVIYNR 255
Cdd:pfam00054   74 EARPTgesPLGATTD-LDVDGPLYVGGLpsLGVKKRRLAISPSFDGCIRDVIVNG 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 2-89 6.68e-14

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 69.78  E-value: 6.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806     2 KKHRIRAVATQGAFNSWD-WVTRYMLLYGDRVDSWTPFYqkghNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPR 80
Cdd:pfam00754   43 KPKKITGVVTQGRQDGSNgYVTSYKIEYSLDGENWTTVK----DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGG 118


                   ....*....
gi 568974806    81 GKIGLRLGI 89
Cdd:pfam00754  119 NGIALRAEL 127
Laminin_G_1 pfam00054
Laminin G domain;
313-442 8.55e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 8.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   313 FRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIaQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDveGAEV 392
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSY-DLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG--EARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568974806   393 RVSYPL----LIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVN 442
Cdd:pfam00054   78 TGESPLgattDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
737-866 1.06e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.79  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806   737 FRTSAPSGVFLENMGGPFcrwrRPYVRVELNTSRdVVFAFDIGNGDEnLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 816
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE----RDFLALELRDGR-LEVSYDLGSGAA-VVRSGD--KLNDGKWHSVELERNGRSGTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568974806   817 HRPWVLRPMPLQTYIWLVYDQPLYVGSA----ELKRR-----PFVGCLRAMRLNGVTLN 866
Cdd:pfam00054   73 GEARPTGESPLGATTDLDVDGPLYVGGLpslgVKKRRlaispSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1012-1142 1.62e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 1.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974806  1012 FSTNSAPAVLLYVSSFV-RDYMAVLIKeDGTLQLRYQLGTSPyVYQLTTRPVTDGQPHSVNITRVYRNLFIQVD--YFPL 1088
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELR-DGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVDgeARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568974806  1089 TEQKFSllVDSQLDSPKALYLGRvMETGVIDPEIQRyNTPGFSGCLSGVRFNNV 1142
Cdd:pfam00054   79 GESPLG--ATTDLDVDGPLYVGG-LPSLGVKKRRLA-ISPSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 519-540 1.12e-05

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 43.70  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|..
gi 568974806  519 SGNYTIDPDGSGPLKPFVVYCD 540
Cdd:NF040941   14 SGVYWIDPDGMGGLAPFQVYCD 35
4.1m smart00294
putative band 4.1 homologues' binding motif;
1228-1246 2.66e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.66e-05
                            10
                    ....*....|....*....
gi 568974806   1228 FYLQNHRYKGSYHTNEPKA 1246
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 508-582 1.00e-03

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 42.23  E-value: 1.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568974806  508 SC-EAYRLSGKYSGNYTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmdrpflgaiQYWNASWEE 582
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 468-497 1.83e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568974806   468 CSPNMCEHDGRCYQSWDDFICYCElTGYKG 497
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTG 29
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
505-549 4.89e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.20  E-value: 4.89e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568974806   505 YKESCEAYRLSGKYSGNYTIDPDGSGplKPFVVYCDIR-ENRAWTV 549
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 466-500 7.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 7.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568974806  466 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGVTC 500
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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