NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568989123|ref|XP_006519777|]
View 

F-box only protein 34 isoform X3 [Mus musculus]

Protein Classification

F-box protein( domain architecture ID 1903342)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0006511
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
559-606 9.61e-25

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22176:

Pssm-ID: 459239  Cd Length: 48  Bit Score: 97.22  E-value: 9.61e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568989123 559 MACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRWV 606
Cdd:cd22176    1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRWV 48
 
Name Accession Description Interval E-value
F-box_FBXO34 cd22176
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ...
559-606 9.61e-25

F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438947  Cd Length: 48  Bit Score: 97.22  E-value: 9.61e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568989123 559 MACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRWV 606
Cdd:cd22176    1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRWV 48
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
561-593 3.08e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.37  E-value: 3.08e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568989123  561 CLPHHIIVKIFRLLPTLSLAILKCTCRYFKSII 593
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
562-595 8.03e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.11  E-value: 8.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568989123   562 LPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEY 595
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDS 34
 
Name Accession Description Interval E-value
F-box_FBXO34 cd22176
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ...
559-606 9.61e-25

F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438947  Cd Length: 48  Bit Score: 97.22  E-value: 9.61e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568989123 559 MACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRWV 606
Cdd:cd22176    1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRWV 48
F-box_FBXO34-like cd22105
F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and ...
559-605 1.01e-20

F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and similar proteins; This family includes FBXO34 (also called FBX34) and FBXO46 (also called FBX46), both of which are substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. The SCF(FBOX46) complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438877  Cd Length: 47  Bit Score: 85.53  E-value: 1.01e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568989123 559 MACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRW 605
Cdd:cd22105    1 FLLLPDHVLSKIFSHLPTRSLAALKCTCKDFKWLIEMFDVRGSDSRW 47
F-box_FBXO46 cd22177
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ...
559-605 3.38e-17

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438948  Cd Length: 47  Bit Score: 75.72  E-value: 3.38e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568989123 559 MACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRW 605
Cdd:cd22177    1 MLLLPDHILVNIFSYLPTRSLAALKCSCHHFKDIIETYGVRATDSRW 47
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
561-593 3.08e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.37  E-value: 3.08e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568989123  561 CLPHHIIVKIFRLLPTLSLAILKCTCRYFKSII 593
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
560-594 3.98e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.89  E-value: 3.98e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568989123 560 ACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIE 594
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
559-593 5.46e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 432889 [Multi-domain]  Cd Length: 45  Bit Score: 40.93  E-value: 5.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568989123  559 MACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSII 593
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELA 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
562-595 8.03e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.11  E-value: 8.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568989123   562 LPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEY 595
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDS 34
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
558-599 5.02e-03

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 35.24  E-value: 5.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568989123 558 YMACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSII---EYYNIR 599
Cdd:cd22152    1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLsspELFRVR 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH