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Conserved domains on  [gi|545485015|ref|XP_005615357|]
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zinc finger protein 516 isoform X1 [Canis lupus familiaris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
808-1036 1.23e-11

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 68.75  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  808 SGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPGH 887
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  888 GPeqhgAPAQPPLPKPRQE---ASPRPGPtggsgfsRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGPPNKHSA 964
Cdd:PRK12323  449 AP----APAPAAAPAAAARpaaAGPRPVA-------AAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAA 517

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545485015  965 PDPLKAKFSPQPqgqphvkgdgGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPMSDG 1036
Cdd:PRK12323  518 PAGWVAESIPDP----------ATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 9.47e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 9.47e-07
                           10        20
                   ....*....|....*....|....*.
gi 545485015    48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 2.75e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.75e-04
                           10        20
                   ....*....|....*....|...
gi 545485015    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1084-1106 1.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.79e-03
                           10        20
                   ....*....|....*....|...
gi 545485015  1084 FVCVECGKRFHQPSHLRAHTQAH 1106
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 231-253 5.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.58e-03
                           10        20
                   ....*....|....*....|...
gi 545485015   231 FPCEVCGQAFSQTWFLKAHMKKH 253
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
808-1036 1.23e-11

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 68.75  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  808 SGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPGH 887
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  888 GPeqhgAPAQPPLPKPRQE---ASPRPGPtggsgfsRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGPPNKHSA 964
Cdd:PRK12323  449 AP----APAPAAAPAAAARpaaAGPRPVA-------AAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAA 517

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545485015  965 PDPLKAKFSPQPqgqphvkgdgGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPMSDG 1036
Cdd:PRK12323  518 PAGWVAESIPDP----------ATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 812-1025 6.14e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.08  E-value: 6.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   812 GPPPALGGKECQPLP--IARFTRTQVPGGAPGPKSSSSPLGVTtKAASMPKSKESHPGGPCALWVASPEGHRQAKPGHGP 889
Cdd:pfam03154  169 TQPPVLQAQSGAASPpsPPPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   890 EQHGAPAQPP--------LPKPRQEASPRPGP----TGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLG 957
Cdd:pfam03154  248 PLQPMTQPPPpsqvspqpLPQPSLHGQMPPMPhslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHT 327

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545485015   958 PPNKHSAPD---PLKAKFSPQPQGQPHVKGDggPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPAL 1025
Cdd:pfam03154  328 PPSQSQLQSqqpPREQPLPPAPLSMPHIKPP--PTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAL 396
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 9.47e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 9.47e-07
                           10        20
                   ....*....|....*....|....*.
gi 545485015    48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 838-1025 3.09e-05

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 47.98  E-value: 3.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  838 GAPGPKSSSSPLGVTTkaasmPKSKESHPGGPCALWVASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGS 917
Cdd:NF038329  120 GEPGPAGPAGPAGEQG-----PRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  918 GFSRSATPtpsviarAGSQPPAGgrpgdkyiipPAGASLGPPNKHSAPDPLKAKFSPQ-PQGQPHVKGDGGPSlPPREPP 996
Cdd:NF038329  195 GPRGETGP-------AGEQGPAG----------PAGPDGEAGPAGEDGPAGPAGDGQQgPDGDPGPTGEDGPQ-GPDGPA 256

                         170       180
                  ....*....|....*....|....*....
gi 545485015  997 SKAGQELRPPASGGAGPRGNAALPGPPAL 1025
Cdd:NF038329  257 GKDGPRGDRGEAGPDGPDGKDGERGPVGP 285
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 2.75e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.75e-04
                           10        20
                   ....*....|....*....|...
gi 545485015    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1084-1106 1.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.79e-03
                           10        20
                   ....*....|....*....|...
gi 545485015  1084 FVCVECGKRFHQPSHLRAHTQAH 1106
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 231-253 5.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.58e-03
                           10        20
                   ....*....|....*....|...
gi 545485015   231 FPCEVCGQAFSQTWFLKAHMKKH 253
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
808-1036 1.23e-11

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 68.75  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  808 SGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPGH 887
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  888 GPeqhgAPAQPPLPKPRQE---ASPRPGPtggsgfsRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGPPNKHSA 964
Cdd:PRK12323  449 AP----APAPAAAPAAAARpaaAGPRPVA-------AAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAA 517

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545485015  965 PDPLKAKFSPQPqgqphvkgdgGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPMSDG 1036
Cdd:PRK12323  518 PAGWVAESIPDP----------ATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 835-1033 2.71e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 61.54  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  835 VPGGAPGpksSSSPLGVTTKAASMPKSKESHPGGPCAlWVASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPT 914
Cdd:PRK07764  587 VVGPAPG---AAGGEGPPAPASSGPPEEAARPAAPAA-PAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  915 GGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGPPNKHSAPDPLKAKFSPQP---QGQPHVKGDGGPSLP 991
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAaqgASAPSPAADDPVPLP 742

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 545485015  992 PR-EPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPM 1033
Cdd:PRK07764  743 PEpDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 812-1015 2.06e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 58.46  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  812 GPPPALGGKECQPLPIARFTRTQV--PGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPGHGP 889
Cdd:PRK07764  589 GPAPGAAGGEGPPAPASSGPPEEAarPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  890 EQHGA-PAQPPLPKPRQEASPRPGPTGGSGFS----RSATPTPSVIARAGSQPPAGGRPGDKyiIPPAGASLGPPNKHSA 964
Cdd:PRK07764  669 WPAKAgGAAPAAPPPAPAPAAPAAPAGAAPAQpapaPAATPPAGQADDPAAQPPQAAQGASA--PSPAADDPVPLPPEPD 746

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 545485015  965 PDPLKAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRG 1015
Cdd:PRK07764  747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDED 797
PHA03247 PHA03247
large tegument protein UL36; Provisional
 814-1021 2.44e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  814 PPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPGHGP---- 889
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAalpp 2820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  890 EQHGAPAQPPLPKPRQEASPRPG-------PTGGS----------GFSRSATPTPSVIARAGSQ---PPAGGRPGDKYII 949
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPgppppslPLGGSvapggdvrrrPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFAL 2900

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545485015  950 PPAGASlGPPNKHSAPDPL---KAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQelrpPASGGAGPRGNAALPG 1021
Cdd:PHA03247 2901 PPDQPE-RPPQPQAPPPPQpqpQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE----PSGAVPQPWLGALVPG 2970
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 812-1025 6.14e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.08  E-value: 6.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   812 GPPPALGGKECQPLP--IARFTRTQVPGGAPGPKSSSSPLGVTtKAASMPKSKESHPGGPCALWVASPEGHRQAKPGHGP 889
Cdd:pfam03154  169 TQPPVLQAQSGAASPpsPPPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   890 EQHGAPAQPP--------LPKPRQEASPRPGP----TGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLG 957
Cdd:pfam03154  248 PLQPMTQPPPpsqvspqpLPQPSLHGQMPPMPhslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHT 327

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545485015   958 PPNKHSAPD---PLKAKFSPQPQGQPHVKGDggPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPAL 1025
Cdd:pfam03154  328 PPSQSQLQSqqpPREQPLPPAPLSMPHIKPP--PTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAL 396
PHA03247 PHA03247
large tegument protein UL36; Provisional
 813-1034 3.53e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  813 PPPALGGKECQPLPIARFTRTQVPGGAPGP---KSSSSPLGVTTKA----ASMPKSKESHPGGPCALWVASPEG------ 879
Cdd:PHA03247 2578 SEPAVTSRARRPDAPPQSARPRAPVDDRGDprgPAPPSPLPPDTHApdppPPSPSPAANEPDPHPPPTVPPPERprddpa 2657

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  880 ------HRQAKPGHGPEQHGAPAQPPLPK---------------PRQEASPRPGPTGGSgfsrSATPTPSVIARAGSQPP 938
Cdd:PHA03247 2658 pgrvsrPRRARRLGRAAQASSPPQRPRRRaarptvgsltsladpPPPPPTPEPAPHALV----SATPLPPGPAAARQASP 2733

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  939 AGGRPGDKYIIPPAGASLGPPNKHSAPDPLKAKFSPQPQGQPhvkgdggPSLPPREPPSKAGQELRPPASGGAGPRG--- 1015
Cdd:PHA03247 2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP-------AAGPPRRLTRPAVASLSESRESLPSPWDpad 2806

                         250       260
                  ....*....|....*....|
gi 545485015 1016 -NAALPGPPALHASKQEPMS 1034
Cdd:PHA03247 2807 pPAAVLAPAAALPPAASPAG 2826
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 806-1035 7.14e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.64  E-value: 7.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLG----VTTKAASMPKSKESHPGGPCALWVASPEGHR 881
Cdd:PHA03307   81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASpppsPAPDLSEMLRPVGSPGPPPAASPPAAGASPA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  882 QAKPGHGPEQHGAPAQ-------PPLPKPRQEASPRPGPTGGSGfsRSATPTPSVIARAGSQPPAGGR---------PGD 945
Cdd:PHA03307  161 AVASDAASSRQAALPLsspeetaRAPSSPPAEPPPSTPPAAASP--RPPRRSSPISASASSPAPAPGRsaaddagasSSD 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  946 KYIIPPAGASLGPPNKhsAPDPLKAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPAL 1025
Cdd:PHA03307  239 SSSSESSGCGWGPENE--CPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASS 316

                         250
                  ....*....|
gi 545485015 1026 HASKQEPMSD 1035
Cdd:PHA03307  317 SSSSSRESSS 326
zf-H2C2_2 pfam13465
Zinc-finger double domain;
48-73 9.47e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 9.47e-07
                           10        20
                   ....*....|....*....|....*.
gi 545485015    48 SLSQHMRKHTGEKPYKCPYCDHRASQ 73
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 805-1023 2.46e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  805 LARSGRTGPPPalggKECQPLPIARFTRTQVPGGaPGPKSSSSPLGVTTKAASMPKSKESHPGGPcalwvaSPEGHRQAK 884
Cdd:PHA03247 2695 LTSLADPPPPP----PTPEPAPHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGP------ARPARPPTT 2763

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  885 PGhgPEQHGAPAQPPLPKPRqeASPRPgPTGGSGFSRSATPTPsviaRAGSQPPAGGRPGDKYIIP---PAGASLGPPNK 961
Cdd:PHA03247 2764 AG--PPAPAPPAAPAAGPPR--RLTRP-AVASLSESRESLPSP----WDPADPPAAVLAPAAALPPaasPAGPLPPPTSA 2834

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545485015  962 HSAPDPLKAKFSPQPQGQPHVKGDGGP---SLPPREPPSKAGQELRPPASGGAGP---RGNAALPGPP 1023
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDvrrRPPSRSPAAKPAAPARPPVRRLARPavsRSTESFALPP 2902
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 912-1040 4.76e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 4.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  912 GPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDkyiiPPAGASLGPPNKHSAPDPLKAKFSPQPQGQPHVKGDGGPSLP 991
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 545485015  992 PREPPSKAGQ---ELRPPASGGAGPRGNAALPGPPALHASKQEPMSDGHEKR 1040
Cdd:PRK07764  666 GDGWPAKAGGaapAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDP 717
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 875-1038 1.18e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.60  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  875 ASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPsviARAGSQPPAGGRPGDKYIIPPAGA 954
Cdd:PRK07764  595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGV---AAPEHHPKHVAVPDASDGGDGWPA 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  955 SLGPPnkhsAPdplkAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPMS 1034
Cdd:PRK07764  672 KAGGA----AP----AAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP 743


                  ....
gi 545485015 1035 DGHE 1038
Cdd:PRK07764  744 EPDD 747
PHA03247 PHA03247
large tegument protein UL36; Provisional
 806-996 1.45e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKP 885
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALP 2901

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  886 GHGPEQHGAPAQPPLPKPRQEASPRPGPTggsgfsrSATPTPsviarAGSQPPAGGRPGDKYIIPPAGASLGPPNKHSAP 965
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQ-------PPPPPP-----PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                         170       180       190
                  ....*....|....*....|....*....|.
gi 545485015  966 DPLKAKFSPQPQGQPHVKGDGGPSLPPREPP 996
Cdd:PHA03247 2970 GRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 811-1024 2.00e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  811 TGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASmPKSKESHPGGPCALWVASPEGHRQAKPGHGPE 890
Cdd:PHA03307   69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPD-PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPP 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  891 QHGAPAQPPLPKPRQEASPRPGPTGG----SGFSRSATPTPSVIARAGSQPPAGGRPGD---KYIIPPAGASLGPPNKHS 963
Cdd:PHA03307  148 PAASPPAAGASPAAVASDAASSRQAAlplsSPEETARAPSSPPAEPPPSTPPAAASPRPprrSSPISASASSPAPAPGRS 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545485015  964 APDPLKAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPA 1024
Cdd:PHA03307  228 AADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 884-1022 2.36e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.56  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  884 KPGHG-PEQHGAPAQPPLPKPRQEASPRPGPTGGSGfsRSATPTPSVIARAGSQPPAGGRPGdKYIIPPAGASLGPPnkH 962
Cdd:PRK14951  365 KPAAAaEAAAPAEKKTPARPEAAAPAAAPVAQAAAA--PAPAAAPAAAASAPAAPPAAAPPA-PVAAPAAAAPAAAP--A 439

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545485015  963 SAPDPLkakfsPQPQGQPHVKGDGGPSLPPREPPSKAGQELRP-PASGGAGPRGNAALPGP 1022
Cdd:PRK14951  440 AAPAAV-----ALAPAPPAQAAPETVAIPVRVAPEPAVASAAPaPAAAPAAARLTPTEEGD 495
PHA03247 PHA03247
large tegument protein UL36; Provisional
 805-1040 2.98e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  805 LARSGRTGPPPALggkecQPLPIARFTRTQVPGGAPGPKSSSSPLGvttkaasmpkSKESHPGGPcalwvasPEGHRQAK 884
Cdd:PHA03247 2543 LASDDAGDPPPPL-----PPAAPPAAPDRSVPPPRPAPRPSEPAVT----------SRARRPDAP-------PQSARPRA 2600

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  885 PGHGPEQHGAPAQPPLPKPRQEA------SPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGP 958
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHApdppppSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP 2680

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  959 --PNKHSAPD---PLKAKFSPQPQGQPhvkgdggpslpPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPM 1033
Cdd:PHA03247 2681 qrPRRRAARPtvgSLTSLADPPPPPPT-----------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPA 2749


                  ....*..
gi 545485015 1034 SDGHEKR 1040
Cdd:PHA03247 2750 TPGGPAR 2756
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 838-1025 3.09e-05

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 47.98  E-value: 3.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  838 GAPGPKSSSSPLGVTTkaasmPKSKESHPGGPCALWVASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGS 917
Cdd:NF038329  120 GEPGPAGPAGPAGEQG-----PRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  918 GFSRSATPtpsviarAGSQPPAGgrpgdkyiipPAGASLGPPNKHSAPDPLKAKFSPQ-PQGQPHVKGDGGPSlPPREPP 996
Cdd:NF038329  195 GPRGETGP-------AGEQGPAG----------PAGPDGEAGPAGEDGPAGPAGDGQQgPDGDPGPTGEDGPQ-GPDGPA 256

                         170       180
                  ....*....|....*....|....*....
gi 545485015  997 SKAGQELRPPASGGAGPRGNAALPGPPAL 1025
Cdd:NF038329  257 GKDGPRGDRGEAGPDGPDGKDGERGPVGP 285
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
62-84 5.59e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.00  E-value: 5.59e-05
                           10        20
                   ....*....|....*....|...
gi 545485015    62 YKCPYCDHRASQKGNLKIHIRSH 84
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 835-1028 5.99e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 5.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  835 VPGGAPGPKSSSSPLGVTTKAASMPKSK---ESHPGGPCA----LWVASPEGHRQAKPGhGPEQHGAPAQPPLPKPRQEA 907
Cdd:PHA03247 2491 AAGAAPDPGGGGPPDPDAPPAPSRLAPAilpDEPVGEPVHprmlTWIRGLEELASDDAG-DPPPPLPPAAPPAAPDRSVP 2569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  908 SPRPGPTGGSGFSRSATPTPSVIARAGSqPPAGGRPGDKYIIPPAGASLgPPNKHsAPDPlkakfsPQPQGQPHVKGDGG 987
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQSAR-PRAPVDDRGDPRGPAPPSPL-PPDTH-APDP------PPPSPSPAANEPDP 2640

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 545485015  988 PSLPPREPPSkagQELRPPASGGAGPRGNAALPGPPALHAS 1028
Cdd:PHA03247 2641 HPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASS 2678
PHA03378 PHA03378
EBNA-3B; Provisional
 813-1032 7.69e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 7.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  813 PPPALGGKECQPL--PIARFTRTQVPGGA----PGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPG 886
Cdd:PHA03378  565 PAPGLGPLQIQPLtsPTTSQLASSAPSYAqtpwPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFN 644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  887 H--GPEQHGAPAQPPLPKPRQEASP-----RPGPTGgsgfsrSATPTPSVIARAGSQPPAGGrPGdkyiipPAGASLGPP 959
Cdd:PHA03378  645 VlvFPTPHQPPQVEITPYKPTWTQIghipyQPSPTG------ANTMLPIQWAPGTMQPPPRA-PT------PMRPPAAPP 711

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545485015  960 NKHSAPDPLKAKFSPqPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEP 1032
Cdd:PHA03378  712 GRAQRPAAATGRARP-PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAP 783
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
889-1066 1.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  889 PEQHGAPAQPplpkPRQEASPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASlgppnkhSAPDPL 968
Cdd:PRK12323  365 PGQSGGGAGP----ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS-------PAPEAL 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  969 KAKFSPQPQGqphvkGDGGPSLPPREPPSKAGQElRPPASGGAGPRGNAALPGPPALHASKQEPMSDGHEKRLDILNIFK 1048
Cdd:PRK12323  434 AAARQASARG-----PGGAPAPAPAPAAAPAAAA-RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA 507

                         170
                  ....*....|....*...
gi 545485015 1049 TYIPKDFASLYQSWGANG 1066
Cdd:PRK12323  508 SPAPAQPDAAPAGWVAES 525
PHA03378 PHA03378
EBNA-3B; Provisional
 866-1022 1.71e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  866 PGGPCALWVASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTpsviARAGSQPPAGGRPGD 945
Cdd:PHA03378  678 PTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPA----AAPGRARPPAAAPGR 753

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 545485015  946 KYiiPPAGASLGPPNKHSAPDplKAKFSPQPQGQPhvkgdgGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGP 1022
Cdd:PHA03378  754 AR--PPAAAPGRARPPAAAPG--APTPQPPPQAPP------APQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGP 820
PHA03379 PHA03379
EBNA-3A; Provisional
 806-1036 2.36e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 45.43  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKP 885
Cdd:PHA03379  401 AREALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEP 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  886 GH---GPEQHGAPAQPPLPKPRQ------EASP-----------RPGPTGGS-------GFSRSATPTPSVIARAGSQPP 938
Cdd:PHA03379  481 GDqlpGVVQDGRPACAPVPAPAGpivrpwEASLsqvpgvafapvMPQPMPVEpvpvptvALERPVCPAPPLIAMQGPGET 560

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  939 AGGRPGDKYIIPPAGAslgpPNKHSAPDPLKAKFSP---QPQGQPH-----VKGDGGPSLPPREP---PSKAGQELRP-- 1005
Cdd:PHA03379  561 SGIVRVRERWRPAPWT----PNPPRSPSQMSVRDRLarlRAEAQPYqasveVQPPQLTQVSPQQPmeyPLEPEQQMFPgs 636

                         250       260       270
                  ....*....|....*....|....*....|...
gi 545485015 1006 PASGGAGPRGNAALPG--PPALHASKQEPMSDG 1036
Cdd:PHA03379  637 PFSQVADVMRAGGVPAmqPQYFDLPLQQPISQG 669
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 886-1018 2.58e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  886 GHGPEQHGAPAQPPLPKPRQeASPRPGPTGGSgfsrSATPTPSVIARAGSQPPAGG-RPGDkyiiPPAGASLGPPNKHSA 964
Cdd:PRK07764  384 RLGVAGGAGAPAAAAPSAAA-AAPAAAPAPAA----AAPAAAAAPAPAAAPQPAPApAPAP----APPSPAGNAPAGGAP 454

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 545485015  965 PDPLKAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQ-ELRPPASGGAGPRGNAA 1018
Cdd:PRK07764  455 SPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAaAPAAPAAPAAPAGADDA 509
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 882-1030 2.63e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 2.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   882 QAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGgsgfsrSATPTPSVIARAGSQPPAGGRPG-DKYIIPPAGASLGP-- 958
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTP------SAPSVPPQGSPATSQPPNQTQSTaAPHTLIQQTPTLHPqr 241

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545485015   959 -PNKHSA-----PDPLKAKFSPQPQGQPHVKGDGGPSLPPREP-PSKAGQELRPPASGGAGPRGNAALPGPPALHASKQ 1030
Cdd:pfam03154  242 lPSPHPPlqpmtQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQ 320
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 34-56 2.75e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.75e-04
                           10        20
                   ....*....|....*....|...
gi 545485015    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 837-966 2.83e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 45.06  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  837 GGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKPghgpeqhgAPAQPPLPK-PRQEASPRPGPTG 915
Cdd:PRK14959  376 GGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATP--------APSAAPSPRvPWDDAPPAPPRSG 447

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 545485015  916 GSGFSRSATPTPSviaragsqpPAGGRPGDkyiippAGASLGPPNKHSAPD 966
Cdd:PRK14959  448 IPPRPAPRMPEAS---------PVPGAPDS------VASASDAPPTLGDPS 483
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
864-1044 2.91e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  864 SHPGGPCALWVASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEAsPRPGPTGGSGFSRSATPtpsviARAGSQPPAGGRP 943
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAA-LAPKAAAAAAATRAEAP-----PAAPAPPATADRG 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  944 GDKYIIPPAGASLGPpnKHSAPDPLKAKFSPQPQGQPHVKGDGGPSLPP---REPPSKAGQEL-------RPPASGGAGP 1013
Cdd:PRK07003  440 DDAADGDAPVPAKAN--ARASADSRCDERDAQPPADSGSASAPASDAPPdaaFEPAPRAAAPSaatpaavPDARAPAAAS 517

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 545485015 1014 RGN-AALPGPPALHASKQEPMSDGHEKR-------LDIL 1044
Cdd:PRK07003  518 REDaPAAAAPPAPEARPPTPAAAAPAARaggaaaaLDVL 556
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 810-1038 3.54e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 3.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   810 RTGPPPALGGKECQPLPI-ARFTRTQVPGG----APGPKSSSS--PLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQ 882
Cdd:pfam03154  283 QTGPSHMQHPVPPQPFPLtPQSSQSQVPPGpspaAPGQSQQRIhtPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   883 AKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSR-------SATPTPSVIARAGSQ--PPAGGRPG--DKYIIPP 951
Cdd:pfam03154  363 IPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSlsthhppSAHPPPLQLMPQSQQlpPPPAQPPVltQSQSLPP 442

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015   952 AGASlGPPNKHSAPDPLKAKFSPqpqgQPHVKGDGGPSLPPREPP---SKAGQELRPPASGG---AGPRGNAALPGPPAL 1025
Cdd:pfam03154  443 PAAS-HPPTSGLHQVPSQSPFPQ----HPFVPGGPPPITPPSGPPtstSSAMPGIQPPSSASvssSGPVPAAVSCPLPPV 517

                          250
                   ....*....|...
gi 545485015  1026 HAsKQEPMSDGHE 1038
Cdd:pfam03154  518 QI-KEEALDEAEE 529
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 806-1033 4.61e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKECQPLPiarfTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPG-GPCALWVASPEGHRQAK 884
Cdd:PHA03307  204 PRPPRRSSPISASASSPAPAP----GRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApITLPTRIWEASGWNGPS 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  885 PGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPgdkyIIPPAGASLGPPNKHSA 964
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRG----AAVSPGPSPSRSPSPSR 355

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  965 PDPLKAKFSPQPQGQPHVKGDGGPSLPPREPPSKAG-QELRPPASGGAGPRGNAALPGPPALHASKQEPM 1033
Cdd:PHA03307  356 PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARaAVAGRARRRDATGRFPAGRPRPSPLDAGAASGA 425
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
812-1035 6.25e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  812 GPPPALGGKECQPLPIArftrTQVPGGAPGPKSSSSPLGVTTKA-ASMPKSKESHPGGPCALWVASPEGHRQAKPGHGPE 890
Cdd:PRK07003  400 TAVTGAAGAALAPKAAA----AAAATRAEAPPAAPAPPATADRGdDAADGDAPVPAKANARASADSRCDERDAQPPADSG 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  891 QHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKyIIPPAGASLGPPNKH----SAPD 966
Cdd:PRK07003  476 SASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPE-ARPPTPAAAAPAARAggaaAALD 554

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545485015  967 PLKA---KFSPQPQGQPhvkgdGGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPMSD 1035
Cdd:PRK07003  555 VLRNagmRVSSDRGARA-----AAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAE 621
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
834-1017 6.98e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 6.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  834 QVPGG--APGPKssssplgvttkAASMPKSKESHPGGPCALWVASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEA-SPR 910
Cdd:PRK07003  375 RVAGAvpAPGAR-----------AAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGdDAA 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  911 PGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDkyiippAGASLGPPNKHSAPDPLKAkfSPQPQGQPHVKGDGGPSL 990
Cdd:PRK07003  444 DGDAPVPAKANARASADSRCDERDAQPPADSGSAS------APASDAPPDAAFEPAPRAA--APSAATPAAVPDARAPAA 515

                         170       180       190
                  ....*....|....*....|....*....|.
gi 545485015  991 PPR----EPPSKAGQELRPPASGGAGPRGNA 1017
Cdd:PRK07003  516 ASRedapAAAAPPAPEARPPTPAAAAPAARA 546
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 875-1018 7.62e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 43.01  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  875 ASPEGHRQAKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGA 954
Cdd:PTZ00436  209 AAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKA 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545485015  955 SLGPPNKHSAP-----DPLKAKFSPQPQGQPHVKGDGGPSlPPREPPSKAGQelrPPASGGAGPRGNAA 1018
Cdd:PTZ00436  289 AAPPAKAAAAPakaaaAPAKAAAAPAKAAAPPAKAAAPPA-KAATPPAKAAA---PPAKAAAAPVGKKA 353
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 813-1014 9.07e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  813 PPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWvaspeGHRQAKPGHGPEQH 892
Cdd:PHA03307  189 PPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGW-----GPENECPLPRPAPI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  893 GAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIaRAGSQPPAGGRPGDKYIIPPAGASLGPPNKHSAPdPLKAKF 972
Cdd:PHA03307  264 TLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPS-SPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES-SRGAAV 341

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 545485015  973 SPQPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPR 1014
Cdd:PHA03307  342 SPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAG 383
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 814-1008 9.50e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 43.38  E-value: 9.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  814 PPALGGKECQPLPIARFTRTQVPGGA-----------PGPKSSSSPLGVTTKAASMPKSKESHPGgpcalwVASPEGHRQ 882
Cdd:PLN03209  351 APSPPIEEEPPQPKAVVPRPLSPYTAyedlkpptspiPTPPSSSPASSKSVDAVAKPAEPDVVPS------PGSASNVPE 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  883 AKPGHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSA-----------TPTPSVIARAGSQPPAGGRPGDKYII-- 949
Cdd:PLN03209  425 VEPAQVEAKKTRPLSPYARYEDLKPPTSPSPTAPTGVSPSVsstssvpavpdTAPATAATDAAAPPPANMRPLSPYAVyd 504

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545485015  950 ---PPAGASLGPPNKHSAPDPLKAKFSPQPQGQPHVKGDGGPSLPPRE---PPSKAGQELRPPAS 1008
Cdd:PLN03209  505 dlkPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQPKPrplSPYTMYEDLKPPTS 569
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 62-84 9.74e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 9.74e-04
                           10        20
                   ....*....|....*....|...
gi 545485015    62 YKCPYCDHRASQKGNLKIHIRSH 84
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 806-1004 1.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKECQPLPIARFTRTQVPGGAPGPKSSSSPlgvttkAASMPKSKESHPGGPCALWVAsPEG--HRQA 883
Cdd:PHA03247 2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP------TAPPPPPGPPPPSLPLGGSVA-PGGdvRRRP 2866

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  884 KPGHGPEQHGAPAQPP---LPKPRQEASPRPGPTGGSGFSRSatPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGP-- 958
Cdd:PHA03247 2867 PSRSPAAKPAAPARPPvrrLARPAVSRSTESFALPPDQPERP--PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPla 2944

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 545485015  959 PNKHSAPDPLKAKFSPQPQGQPHVKGDGG-------PSLPPREPPSKAGQELR 1004
Cdd:PHA03247 2945 PTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfrvpQPAPSREAPASSTPPLT 2997
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 876-1024 1.19e-03

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 41.65  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  876 SPEGHrQAKPGHGPEQHGAPAQPPLPKPRQEASP----RPGPTGGSGFSRSATPTPSVIARAGSQPPaggRPGDKyiipP 951
Cdd:PHA03418   36 LPAPH-HPNPQEDPDKNPSPPPDPPLTPRPPAQPnghnKPPVTKQPGGEGTEEDHQAPLAADADDDP---RPGKR----S 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545485015  952 AGASLGPPNKHSAPDPLKAKFSPQPqgqPHvkgdGGPSLPP------REPPSKAGQELRPPASGGAGPRGNAALPGPPA 1024
Cdd:PHA03418  108 KADEHGPAPGRAALAPFKLDLDQDP---LH----GDPDPPPgatggqGEEPPEGGEESQPPLGEGEGAVEGHPPPLPPA 179
dnaA PRK14086
chromosomal replication initiator protein DnaA;
869-1036 1.31e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.89  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  869 PCALWVASPEGHRQAKPGhgPEQHGAPAQPPLPKPRQEASPRpgPTGGSGFSRSATPTPSVIARA-GSQPPAGGRPGDKY 947
Cdd:PRK14086   90 PSAGEPAPPPPHARRTSE--PELPRPGRRPYEGYGGPRADDR--PPGLPRQDQLPTARPAYPAYQqRPEPGAWPRAADDY 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  948 iiPPAGASLGPPNkhSAPDPLKAKFSPQPQGQPHVKGDGGPSLPPR-----------EPPSKAGQEL-RPPASGGAGPRG 1015
Cdd:PRK14086  166 --GWQQQRLGFPP--RAPYASPASYAPEQERDREPYDAGRPEYDQRrrdydhprpdwDRPRRDRTDRpEPPPGAGHVHRG 241

                         170       180
                  ....*....|....*....|.
gi 545485015 1016 NaalPGPPALHASKQEPMSDG 1036
Cdd:PRK14086  242 G---PGPPERDDAPVVPIRPS 259
PHA03378 PHA03378
EBNA-3B; Provisional
 809-1029 1.57e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  809 GRTGPPPALGGKecQPLPIARFTRTQVPGGAPGPkssSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGhrQAKPGHG 888
Cdd:PHA03378  692 GTMQPPPRAPTP--MRPPAAPPGRAQRPAAATGR---ARPPAAAPGRARPPAAAPGRARPPAAAPGRARPP--AAAPGRA 764

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  889 PEQHGAPAQP-PLPKPRQEASPRPGPTGGsgfsrsatPTPSviaragsQPPAGgrpgdkyiiPPAGASLGPPNKHSAPDP 967
Cdd:PHA03378  765 RPPAAAPGAPtPQPPPQAPPAPQQRPRGA--------PTPQ-------PPPQA---------GPTSMQLMPRAAPGQQGP 820

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545485015  968 LKAKFSPQPQGQPHvkgDGGPSLppREPpsKAGQELRP------PASGGAGPRGNAALPGPPALHASK 1029
Cdd:PHA03378  821 TKQILRQLLTGGVK---RGRPSL--KKP--AALERQAAagptpsPGSGTSDKIVQAPVFYPPVLQPIQ 881
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1084-1106 1.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.79e-03
                           10        20
                   ....*....|....*....|...
gi 545485015  1084 FVCVECGKRFHQPSHLRAHTQAH 1106
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 806-1003 3.39e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKECQPLPIARFTRTQvPGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAKP 885
Cdd:PRK07764  625 AAPAPAGAAAAPAEASAAPAPGVAAPEHH-PKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP 703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  886 GHGPEQHGAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPsviaragSQPPAGGRPGDKYIIPPAGASLGPPNKHSAP 965
Cdd:PRK07764  704 APAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP-------DDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 545485015  966 dplkakfSPQPQGQPHVKGD-GGPSLPPREPPSKAGQEL 1003
Cdd:PRK07764  777 -------SPPSEEEEMAEDDaPSMDDEDRRDAEEVAMEL 808
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 836-945 3.57e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  836 PGGAPGPKSSSSPLGVTTKAASMPKSKESHPGGPCALWVASPEGHRQAkPGHGPEQHGAPAQPPLPKPRQEASPrpgptg 915
Cdd:PRK07764  412 PAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA-AAPSAQPAPAPAAAPEPTAAPAPAP------ 484

                          90       100       110
                  ....*....|....*....|....*....|
gi 545485015  916 gsgfsrSATPTPSVIARAGSQPPAGGRPGD 945
Cdd:PRK07764  485 ------PAAPAPAAAPAAPAAPAAPAGADD 508
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 874-1035 3.57e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  874 VASPEGHRQAKP---GHGPEQHGAPAQPPLPKPRQEASPRpgptggsgfSRSATPTPSVIARAGSQPPAGGRPGdkyiiP 950
Cdd:PHA03307   43 LVSDSAELAAVTvvaGAAACDRFEPPTGPPPGPGTEAPAN---------ESRSTPTWSLSTLAPASPAREGSPT-----P 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  951 PAGASLGPPnkHSAPDPLKAKFSPQPQGQPHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRGNA-ALPGPPALHASK 1029
Cdd:PHA03307  109 PGPSSPDPP--PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAlPLSSPEETARAP 186


                  ....*.
gi 545485015 1030 QEPMSD 1035
Cdd:PHA03307  187 SSPPAE 192
dnaA PRK14086
chromosomal replication initiator protein DnaA;
810-967 3.66e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.35  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  810 RTGPPPALGGKECQPLPIARFTRTQvPGGAPGPKSSSS----PLGVTTKAASMPKSKESHPGGPcalWVASPEGHRQAKP 885
Cdd:PRK14086  130 PPGLPRQDQLPTARPAYPAYQQRPE-PGAWPRAADDYGwqqqRLGFPPRAPYASPASYAPEQER---DREPYDAGRPEYD 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  886 GHGPEQHGApaQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGdkyiiPPAGAS---LGPPNKH 962
Cdd:PRK14086  206 QRRRDYDHP--RPDWDRPRRDRTDRPEPPPGAGHVHRGGPGPPERDDAPVVPIRPSAPG-----PLAAQPapaPGPGEPT 278


                  ....*
gi 545485015  963 SAPDP 967
Cdd:PRK14086  279 ARLNP 283
PHA03378 PHA03378
EBNA-3B; Provisional
 806-1013 3.70e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  806 ARSGRTGPPPALGGKEC-QPLPIARFTRTQVPGGAPGPkssssplgvttkaasMPKSKeshpGGPCALWVaspeghrqak 884
Cdd:PHA03378  759 AAPGRARPPAAAPGAPTpQPPPQAPPAPQQRPRGAPTP---------------QPPPQ----AGPTSMQL---------- 809

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  885 pghgpeqhgAPAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIAR---AGSQPPAGGRPGDKYI-----IPPAGASL 956
Cdd:PHA03378  810 ---------MPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERqaaAGPTPSPGSGTSDKIVqapvfYPPVLQPI 880

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545485015  957 GPPNKHSAPDPLKAKFSPQ-PQGQPHVKGDGGPSLPPREPPSKAGQE----LRPPASGGAGP 1013
Cdd:PHA03378  881 QVMRQLGSVRAAAASTVTQaPTEYTGERRGVGPMHPTDIPPSKRAKTdayvESQPPHGGQSH 942
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 903-1032 4.19e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  903 PRQEASPRPGPTGGSGfsrsATPTPSVIARAGSqPPAGGRPGDkyiiPPAGASLGPPNKHSAPDPLKAkfsPQPQGQPHV 982
Cdd:PRK07764  376 ARLERLERRLGVAGGA----GAPAAAAPSAAAA-APAAAPAPA----AAAPAAAAAPAPAAAPQPAPA---PAPAPAPPS 443

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 545485015  983 KGDGGPSLPPREPPSKAGQELRP-PASGGAGPRGNAALPGPPALHASKQEP 1032
Cdd:PRK07764  444 PAGNAPAGGAPSPPPAAAPSAQPaPAPAAAPEPTAAPAPAPPAAPAPAAAP 494
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 894-1037 5.09e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  894 APAQPPLPKPRQEASPRPGPTGGSGFSRSATPTPSVIARAGSQPPAGGRPGDKYIIPPAGASLGP---PNKHSAPDPLKA 970
Cdd:PHA03307  771 ALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGParpPGAAARPPPARS 850

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  971 KFSPQPQGQ---PHVKGDGGPSLPPREPPSKAGQELRPPASGGAGPRGNAALPGPPALHASKQEPMSDGH 1037
Cdd:PHA03307  851 SESSKSKPAaagGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGG 920
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 231-253 5.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.58e-03
                           10        20
                   ....*....|....*....|...
gi 545485015   231 FPCEVCGQAFSQTWFLKAHMKKH 253
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 34-56 6.15e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 6.15e-03
                           10        20
                   ....*....|....*....|...
gi 545485015    34 HSCCICGKSFPFQSSLSQHMRKH 56
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 835-1035 7.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  835 VPGGAP--GPKSSSSPLGVTTKAASMPKSKESHPGGPCA----LWVASPEGHRQAKPghgpeqhgAPAQPPLPKPRQEAS 908
Cdd:PHA03247  254 APAPPPvvGEGADRAPETARGATGPPPPPEAAAPNGAAAppdgVWGAALAGAPLALP--------APPDPPPPAPAGDAE 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  909 PRPGPTGGSgfsRSATPTPSVIARAGSQPPAGGRPGdkyIIPPAGA---SLGPPNKHSAPDPLKAKFSPQPQGQPHVKGD 985
Cdd:PHA03247  326 EEDDEDGAM---EVVSPLPRPRQHYPLGFPKRRRPT---WTPPSSLedlSAGRHHPKRASLPTRKRRSARHAATPFARGP 399

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 545485015  986 GGPSLPPREPPSKAGqelrPPASGgaGPRGNAALPGPPALHASKQEPMSD 1035
Cdd:PHA03247  400 GGDDQTRPAAPVPAS----VPTPA--PTPVPASAPPPPATPLPSAEPGSD 443
PHA03247 PHA03247
large tegument protein UL36; Provisional
 812-1024 7.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  812 GPPPALGGKECQPLPIARFTRTQVP---GGAPGPKSSSSP--LGVTTKAA--SMPKSKESHPGGPC-----------ALW 873
Cdd:PHA03247  256 APPPVVGEGADRAPETARGATGPPPppeAAAPNGAAAPPDgvWGAALAGAplALPAPPDPPPPAPAgdaeeeddedgAME 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  874 VASPEGHRQA----------KPGHGP----------EQHGAPAQPPLPK---PRQEASPRPGPTGGSGFSRSATPTPSVI 930
Cdd:PHA03247  336 VVSPLPRPRQhyplgfpkrrRPTWTPpssledlsagRHHPKRASLPTRKrrsARHAATPFARGPGGDDQTRPAAPVPASV 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545485015  931 ARAGSQPPAGGRPgdkyiIPPAGaslgppnkhsapdplkakfsPQPQGQPhvKGDGGPSLPPREPPSKAGQELRPPASGG 1010
Cdd:PHA03247  416 PTPAPTPVPASAP-----PPPAT--------------------PLPSAEP--GSDDGPAPPPERQPPAPATEPAPDDPDD 468

                         250
                  ....*....|....*....
gi 545485015 1011 AGPRGNAAL-----PGPPA 1024
Cdd:PHA03247  469 ATRKALDALrerrpPEPPG 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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