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Conserved domains on  [gi|530420501|ref|XP_005261858|]
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THO complex subunit 5 homolog isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FmiP_Thoc5 super family cl24222
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
 1-113 1.74e-45

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


The actual alignment was detected with superfamily member pfam09766:

Pssm-ID: 462889  Cd Length: 347  Bit Score: 158.24  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530420501    1 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMelitpiSAGDLLSPDSVLSCLYPGDHGKKTPNPANQ 80
Cdd:pfam09766 241 LLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS------SAGDLLSDESLLSNLFPGDTGLESPNPANK 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530420501   81 YQFDKVGILTLSDYVLELGHPYLWVQKLGGLHF 113
Cdd:pfam09766 315 YQLQNLGLDEFNDNFSELGKPYKWAQRLCGLDF 347
 
Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
 1-113 1.74e-45

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


Pssm-ID: 462889  Cd Length: 347  Bit Score: 158.24  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530420501    1 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMelitpiSAGDLLSPDSVLSCLYPGDHGKKTPNPANQ 80
Cdd:pfam09766 241 LLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS------SAGDLLSDESLLSNLFPGDTGLESPNPANK 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530420501   81 YQFDKVGILTLSDYVLELGHPYLWVQKLGGLHF 113
Cdd:pfam09766 315 YQLQNLGLDEFNDNFSELGKPYKWAQRLCGLDF 347
 
Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
 1-113 1.74e-45

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


Pssm-ID: 462889  Cd Length: 347  Bit Score: 158.24  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530420501    1 MLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMelitpiSAGDLLSPDSVLSCLYPGDHGKKTPNPANQ 80
Cdd:pfam09766 241 LLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS------SAGDLLSDESLLSNLFPGDTGLESPNPANK 314

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530420501   81 YQFDKVGILTLSDYVLELGHPYLWVQKLGGLHF 113
Cdd:pfam09766 315 YQLQNLGLDEFNDNFSELGKPYKWAQRLCGLDF 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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