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Conserved domains on  [gi|530396073|ref|XP_005253322.1|]
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PREDICTED: autophagy-related protein 13 isoform X1 [Homo sapiens]

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATG13 super family cl12374
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-195 7.12e-07

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.


The actual alignment was detected with superfamily member pfam10033:

Pssm-ID: 287051  Cd Length: 231  Bit Score: 49.11  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAK--KAL-AGQLPAvgrsMCVEISLKTSE----- 90
Cdd:pfam10033   4 FF-TKAALLILQSRLNLPPSSSPSGTKKVNKWFNLETDETDDLREELRlwRSCdSLSLPP----LVIETYLDLSDlspnq 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   91 --------------------GDSME--LEIWCLE------MNEKCDKEIKVSYTVYNRlslllksllAI---------TR 133
Cdd:pfam10033  79 slvlkdddgkrwdvdeaskgSKKTEivLERWLIEldptspTDSSDFGSILELPTVYKK---------AIvlfrslytlLR 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073  134 VTPAYRLSR-----KQGHEYVIL-YRIYFG--------EVQLS-----GLGEGFQTVRV-GTVGTPVGTITLSCAYRINL 193
Cdd:pfam10033 150 LLPAWKLYRrlaksKNSHPALKLgCRILDGskpilskgRDGLSkplipSYSNVHLEQYKfTPVETPLGRLRISVSYRNDC 229

                  ..
gi 530396073  194 AF 195
Cdd:pfam10033 230 DF 231
 
Name Accession Description Interval E-value
ATG13 pfam10033
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-195 7.12e-07

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.


Pssm-ID: 287051  Cd Length: 231  Bit Score: 49.11  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAK--KAL-AGQLPAvgrsMCVEISLKTSE----- 90
Cdd:pfam10033   4 FF-TKAALLILQSRLNLPPSSSPSGTKKVNKWFNLETDETDDLREELRlwRSCdSLSLPP----LVIETYLDLSDlspnq 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   91 --------------------GDSME--LEIWCLE------MNEKCDKEIKVSYTVYNRlslllksllAI---------TR 133
Cdd:pfam10033  79 slvlkdddgkrwdvdeaskgSKKTEivLERWLIEldptspTDSSDFGSILELPTVYKK---------AIvlfrslytlLR 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073  134 VTPAYRLSR-----KQGHEYVIL-YRIYFG--------EVQLS-----GLGEGFQTVRV-GTVGTPVGTITLSCAYRINL 193
Cdd:pfam10033 150 LLPAWKLYRrlaksKNSHPALKLgCRILDGskpilskgRDGLSkplipSYSNVHLEQYKfTPVETPLGRLRISVSYRNDC 229

                  ..
gi 530396073  194 AF 195
Cdd:pfam10033 230 DF 231
 
Name Accession Description Interval E-value
ATG13 pfam10033
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-195 7.12e-07

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.


Pssm-ID: 287051  Cd Length: 231  Bit Score: 49.11  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAK--KAL-AGQLPAvgrsMCVEISLKTSE----- 90
Cdd:pfam10033   4 FF-TKAALLILQSRLNLPPSSSPSGTKKVNKWFNLETDETDDLREELRlwRSCdSLSLPP----LVIETYLDLSDlspnq 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   91 --------------------GDSME--LEIWCLE------MNEKCDKEIKVSYTVYNRlslllksllAI---------TR 133
Cdd:pfam10033  79 slvlkdddgkrwdvdeaskgSKKTEivLERWLIEldptspTDSSDFGSILELPTVYKK---------AIvlfrslytlLR 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073  134 VTPAYRLSR-----KQGHEYVIL-YRIYFG--------EVQLS-----GLGEGFQTVRV-GTVGTPVGTITLSCAYRINL 193
Cdd:pfam10033 150 LLPAWKLYRrlaksKNSHPALKLgCRILDGskpilskgRDGLSkplipSYSNVHLEQYKfTPVETPLGRLRISVSYRNDC 229

                  ..
gi 530396073  194 AF 195
Cdd:pfam10033 230 DF 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.15
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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