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Conserved domains on  [gi|25742626|ref|NP_112646|]
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apoptosis-inducing factor 1, mitochondrial precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 464-593 4.39e-81

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


:

Pssm-ID: 464279  Cd Length: 130  Bit Score: 251.03  E-value: 4.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   464 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 543
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 25742626   544 PSDPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKD 593
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-595 2.80e-65

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


:

Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 219.24  E-value: 2.80e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlphiENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 305 IGGGFLGSELACALgrksQASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKD 384
Cdd:COG1251 148 IGGGLIGLEAAAAL----RKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLAD 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:COG1251 224 GEELPADLVVVAIGVRPNTELARAAGLAVD---RGIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARV 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 464 AGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGLVDsslptvgvfakataqdnpksATEQSgtgirseseteseaseiti 542
Cdd:COG1251 301 AAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGDAE--------------------GDEEV------------------- 340

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 25742626 543 ppsdpavpqVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGE 595
Cdd:COG1251 341 ---------VVRGDPARGVYKKLVLRDGRLVGAVLVGDTSDAGALRQLIKNGR 384
AIF-MLS super family cl25936
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 8.76e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


The actual alignment was detected with superfamily member pfam14962:

Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626    51 RQMASS---GPSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLG------LSPEEKQRRAIASAAEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 25742626   122 -VPPIRVP 128
Cdd:pfam14962 108 eAPEVSVV 115
 
Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 464-593 4.39e-81

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


Pssm-ID: 464279  Cd Length: 130  Bit Score: 251.03  E-value: 4.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   464 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 543
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 25742626   544 PSDPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKD 593
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-595 2.80e-65

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 219.24  E-value: 2.80e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlphiENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 305 IGGGFLGSELACALgrksQASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKD 384
Cdd:COG1251 148 IGGGLIGLEAAAAL----RKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLAD 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:COG1251 224 GEELPADLVVVAIGVRPNTELARAAGLAVD---RGIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARV 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 464 AGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGLVDsslptvgvfakataqdnpksATEQSgtgirseseteseaseiti 542
Cdd:COG1251 301 AAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGDAE--------------------GDEEV------------------- 340

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 25742626 543 ppsdpavpqVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGE 595
Cdd:COG1251 341 ---------VVRGDPARGVYKKLVLRDGRLVGAVLVGDTSDAGALRQLIKNGR 384
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 149-461 4.81e-39

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 145.54  E-value: 4.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   149 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPnvtktlqfrqwngkeRSIYFQPPSFYVSAQDLPHIENGGVAVLT 228
Cdd:pfam07992  17 LTLAQLGGKVTLIEDEGTCPYGGCVLSKALLGAAEA---------------PEIASLWADLYKRKEEVVKKLNNGIEVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   229 GKKVVHLD-----VRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEvKSRTTLFRKIGDFRALEKISREvKSIT 303
Cdd:pfam07992  82 GTEVVSIDpgakkVVLEELVDGDGETITYDRLVIATGARPRLPPI---PGVE-LNVGFLVRTLDSAEALRLKLLP-KRVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   304 VIGGGFLGSELACALgrKSQASGIEVIQLFPEkgnMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLK 383
Cdd:pfam07992 157 VVGGGYIGVELAAAL--AKLGKEVTLIEALDR---LLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGVEVILK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25742626   384 DGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQ-ARSNIWVAGDAacfydiklGRRRVEHHDHAVVSG 461
Cdd:pfam07992 232 DGTEIDADLVVVAIGRRPNTELLEAAGLELDER-GGIVVDEYLRtSVPGIYAAGDC--------RVGGPELAQNAVAQG 301
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 148-484 2.41e-23

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 102.70  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  148 SIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTktlqfrqwngkersiYFQPPSFYVSAQdlphienggVAVL 227
Cdd:PRK09754  21 SLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQ---------------QVLPANWWQENN---------VHLH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  228 TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSrttlFRKIGDFRALEKISREVKSITVIGG 307
Cdd:PRK09754  77 SGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFT----LRHAGDAARLREVLQPERSVVIVGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  308 GFLGSELA---CALGRKsqasgIEVIQLfpEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVgVSGGKLLIKLKD 384
Cdd:PRK09754 153 GTIGLELAasaTQRRCK-----VTVIEL--AATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHV-VDGEKVELTLQS 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQ-ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:PRK09754 225 GETLQADVVIYGIGISANDQLAREANLDTA---NGIVIDEACRtCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQI 301

                        330       340
                 ....*....|....*....|.
gi 25742626  464 AGENMTGAAKPYWHQSMFWSD 484
Cdd:PRK09754 302 AAAAMLGLPLPLLPPPWFWSD 322
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 8.76e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626    51 RQMASS---GPSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLG------LSPEEKQRRAIASAAEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 25742626   122 -VPPIRVP 128
Cdd:pfam14962 108 eAPEVSVV 115
 
Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 464-593 4.39e-81

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


Pssm-ID: 464279  Cd Length: 130  Bit Score: 251.03  E-value: 4.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   464 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 543
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 25742626   544 PSDPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKD 593
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-595 2.80e-65

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 219.24  E-value: 2.80e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlphiENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 305 IGGGFLGSELACALgrksQASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKD 384
Cdd:COG1251 148 IGGGLIGLEAAAAL----RKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLAD 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:COG1251 224 GEELPADLVVVAIGVRPNTELARAAGLAVD---RGIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARV 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 464 AGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGLVDsslptvgvfakataqdnpksATEQSgtgirseseteseaseiti 542
Cdd:COG1251 301 AAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGDAE--------------------GDEEV------------------- 340

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 25742626 543 ppsdpavpqVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGE 595
Cdd:COG1251 341 ---------VVRGDPARGVYKKLVLRDGRLVGAVLVGDTSDAGALRQLIKNGR 384
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 151-485 8.41e-49

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 172.69  E-value: 8.41e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 151 ARDPGARVLIVSEDPELPYMRPPLSKELWFSDDpnvtktlqfrqwngKERSIYFQPPSFYVSAqdlphiengGVAVLTGK 230
Cdd:COG0446   1 RLGPDAEITVIEKGPHHSYQPCGLPYYVGGGIK--------------DPEDLLVRTPESFERK---------GIDVRTGT 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 231 KVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLsAIDraGAEVKSRTTLfRKIGDFRAL-EKI-SREVKSITVIGGG 308
Cdd:COG0446  58 EVTAIDPEAKTVTLRDGETLSYDKLVLATGARPRPP-PIP--GLDLPGVFTL-RTLDDADALrEALkEFKGKRAVVIGGG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 309 FLGSELACALGRKsqasGIEVIQLFPEKGNMGKILPEYlSNWTMEKVKREGVKVMPNAIVQSVgVSGGKLLIKLKDGRKV 388
Cdd:COG0446 134 PIGLELAEALRKR----GLKVTLVERAPRLLGVLDPEM-AALLEEELREHGVELRLGETVVAI-DGDDKVAVTLTDGEEI 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 389 ETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRR-RVEHHDHAVVSGRLAGE 466
Cdd:COG0446 208 PADLVVVAPGVRPNTELAKDAGLALGER-GWIKVDETLQTSdPDVYAAGDCAEVPHPVTGKTvYIPLASAANKQGRVAAE 286

                       330
                ....*....|....*....
gi 25742626 467 NMTGAAKPYWHQSMFWSDL 485
Cdd:COG0446 287 NILGGPAPFPGLGTFISKV 305
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 149-461 4.81e-39

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 145.54  E-value: 4.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   149 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPnvtktlqfrqwngkeRSIYFQPPSFYVSAQDLPHIENGGVAVLT 228
Cdd:pfam07992  17 LTLAQLGGKVTLIEDEGTCPYGGCVLSKALLGAAEA---------------PEIASLWADLYKRKEEVVKKLNNGIEVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   229 GKKVVHLD-----VRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEvKSRTTLFRKIGDFRALEKISREvKSIT 303
Cdd:pfam07992  82 GTEVVSIDpgakkVVLEELVDGDGETITYDRLVIATGARPRLPPI---PGVE-LNVGFLVRTLDSAEALRLKLLP-KRVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   304 VIGGGFLGSELACALgrKSQASGIEVIQLFPEkgnMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLK 383
Cdd:pfam07992 157 VVGGGYIGVELAAAL--AKLGKEVTLIEALDR---LLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGVEVILK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25742626   384 DGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQ-ARSNIWVAGDAacfydiklGRRRVEHHDHAVVSG 461
Cdd:pfam07992 232 DGTEIDADLVVVAIGRRPNTELLEAAGLELDER-GGIVVDEYLRtSVPGIYAAGDC--------RVGGPELAQNAVAQG 301
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 219-470 1.37e-23

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 104.01  E-value: 1.37e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 219 IENGGVAVLTGKKVVhldVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFrkigdfrALEKIsre 298
Cdd:COG1249 101 LKKNGVDVIRGRARF---VDPHTVEVTGGETLTADHIVIATGSRPRVPPIPGLDEVRVLTSDEAL-------ELEEL--- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 299 VKSITVIGGGFLGSELACALgrksQASGIEVIQLfpekGNMGKILPEY---LSNWTMEKVKREGVKVMPNAIVQSVGVSG 375
Cdd:COG1249 168 PKSLVVIGGGYIGLEFAQIF----ARLGSEVTLV----ERGDRLLPGEdpeISEALEKALEKEGIDILTGAKVTSVEKTG 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 376 GKLLIKLKDGRKVET---DHIVTAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAELQ-ARSNIWVAGDAAcfydiklGR 448
Cdd:COG1249 240 DGVTVTLEDGGGEEAveaDKVLVATGRRPNTDglgLEAA-GVELDER-GGIKVDEYLRtSVPGIYAIGDVT-------GG 310

                       250       260
                ....*....|....*....|..
gi 25742626 449 RRVEHhdHAVVSGRLAGENMTG 470
Cdd:COG1249 311 PQLAH--VASAEGRVAAENILG 330
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 148-484 2.41e-23

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 102.70  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  148 SIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTktlqfrqwngkersiYFQPPSFYVSAQdlphienggVAVL 227
Cdd:PRK09754  21 SLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQ---------------QVLPANWWQENN---------VHLH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  228 TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSrttlFRKIGDFRALEKISREVKSITVIGG 307
Cdd:PRK09754  77 SGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFT----LRHAGDAARLREVLQPERSVVIVGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  308 GFLGSELA---CALGRKsqasgIEVIQLfpEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVgVSGGKLLIKLKD 384
Cdd:PRK09754 153 GTIGLELAasaTQRRCK-----VTVIEL--AATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHV-VDGEKVELTLQS 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  385 GRKVETDHIVTAVGLEPNVELAKTGGLEIDsdfGGFRVNAELQ-ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRL 463
Cdd:PRK09754 225 GETLQADVVIYGIGISANDQLAREANLDTA---NGIVIDEACRtCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQI 301

                        330       340
                 ....*....|....*....|.
gi 25742626  464 AGENMTGAAKPYWHQSMFWSD 484
Cdd:PRK09754 302 AAAAMLGLPLPLLPPPWFWSD 322
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
217-467 4.17e-22

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 98.67  E-value: 4.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 217 PHIENGGVAVLTGKkVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRsLSAIDraGAE-----VKSR---TTLFRKIgd 288
Cdd:COG1252  64 ELLRRAGVRFIQGE-VTGIDPEARTVTLADGRTLSYDYLVIATGSVTN-FFGIP--GLAehalpLKTLedaLALRERL-- 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 289 FRALEKISREVK-SITVIGGGFLGSELACAL----GRKSQASGIEviqlfPEKGN------MGKILPEY---LSNWTMEK 354
Cdd:COG1252 138 LAAFERAERRRLlTIVVVGGGPTGVELAGELaellRKLLRYPGID-----PDKVRitlveaGPRILPGLgekLSEAAEKE 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 355 VKREGVKVMPNAIVQSVGVSGgkllIKLKDGRKVETDHIVTAVGLEPNvELAKTGGLEIDSDfGGFRVNAELQARS--NI 432
Cdd:COG1252 213 LEKRGVEVHTGTRVTEVDADG----VTLEDGEEIPADTVIWAAGVKAP-PLLADLGLPTDRR-GRVLVDPTLQVPGhpNV 286

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 25742626 433 WVAGDAACFYDI------KLGRrrvehhdHAVVSGRLAGEN 467
Cdd:COG1252 287 FAIGDCAAVPDPdgkpvpKTAQ-------AAVQQAKVLAKN 320
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 223-475 3.63e-18

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 87.40  E-value: 3.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  223 GVAVLTGKKVVHLDVRGNMVK---LNDGSQI--TFEKCLIATGGTPrSLSAIDraGAEVKSRTTLfRKIGDFRALEKISR 297
Cdd:PRK09564  70 GIDVKTEHEVVKVDAKNKTITvknLKTGSIFndTYDKLMIATGARP-IIPPIK--NINLENVYTL-KSMEDGLALKELLK 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  298 --EVKSITVIGGGFLGSELACALgrKSQASGIEVIQLfpEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVgVSG 375
Cdd:PRK09564 146 deEIKNIVIIGAGFIGLEAVEAA--KHLGKNVRIIQL--EDRILPDSFDKEITDVMEEELRENGVELHLNEFVKSL-IGE 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  376 GKLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRR-VEH 453
Cdd:PRK09564 221 DKVEGVVTDKGEYEADVVIVATGVKPNTEFLEDTGLKTLKN-GAIIVDEYGETSiENIYAAGDCATIYNIVSNKNVyVPL 299

                        250       260
                 ....*....|....*....|..
gi 25742626  454 HDHAVVSGRLAGENMTGAAKPY 475
Cdd:PRK09564 300 ATTANKLGRMVGENLAGRHVSF 321
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
289-439 4.36e-18

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 86.51  E-value: 4.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  289 FRALEKISREVKSITVIGGGFLGSELACALGRksqaSGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIV 368
Cdd:PRK04965 131 YRAAETQLRDAQRVLVVGGGLIGTELAMDLCR----AGKAVTLVDNAASLLASLMPPEVSSRLQHRLTEMGVHLLLKSQL 206

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25742626  369 QSVGVSGGKLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSdfgGFRVNAELQ-ARSNIWVAGDAA 439
Cdd:PRK04965 207 QGLEKTDSGIRATLDSGRSIEVDAVIAAAGLRPNTALARRAGLAVNR---GIVVDSYLQtSAPDIYALGDCA 275
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 220-439 3.91e-15

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 79.01  E-value: 3.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  220 ENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPrSLSAIdrAGAEVKSrTTLFRKIGDFRALEKISREV 299
Cdd:PRK14989  70 EKHGIKVLVGERAITINRQEKVIHSSAGRTVFYDKLIMATGSYP-WIPPI--KGSETQD-CFVYRTIEDLNAIEACARRS 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  300 KSITVIGGGFLGSELACALgrksQASGIE--VIQLFPEKgnMGKILPEYLSNWTMEKVKREGVKVMPN----AIVQSvGV 373
Cdd:PRK14989 146 KRGAVVGGGLLGLEAAGAL----KNLGVEthVIEFAPML--MAEQLDQMGGEQLRRKIESMGVRVHTSkntlEIVQE-GV 218

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25742626  374 SGGKLLiKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIdSDFGGFRVNAELQ-ARSNIWVAGDAA 439
Cdd:PRK14989 219 EARKTM-RFADGSELEVDFIVFSTGIRPQDKLATQCGLAV-APRGGIVINDSCQtSDPDIYAIGECA 283
PRK06116 PRK06116
glutathione reductase; Validated
 220-437 1.56e-14

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 75.96  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  220 ENGGVAVLTGKKVVhldVRGNMVKLNdGSQITFEKCLIATGGTPrslSAIDRAGAE--VKSRttlfrkigDFRALEKISr 297
Cdd:PRK06116 104 ENNGVDLIEGFARF---VDAHTVEVN-GERYTADHILIATGGRP---SIPDIPGAEygITSD--------GFFALEELP- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  298 evKSITVIGGGFLGSELACALgrksQASGIEVIQLFpeKGNmgKIL---PEYLSNWTMEKVKREGVKVMPNAIVQSVG-V 373
Cdd:PRK06116 168 --KRVAVVGAGYIAVEFAGVL----NGLGSETHLFV--RGD--APLrgfDPDIRETLVEEMEKKGIRLHTNAVPKAVEkN 237

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25742626  374 SGGKLLIKLKDGRKVETDHIVTAVGLEPNVE---LAKTgGLEIDsDFGGFRVNAELQ-ARSNIWVAGD 437
Cdd:PRK06116 238 ADGSLTLTLEDGETLTVDCLIWAIGREPNTDglgLENA-GVKLN-EKGYIIVDEYQNtNVPGIYAVGD 303
PRK06370 PRK06370
FAD-containing oxidoreductase;
246-437 3.08e-12

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 69.08  E-value: 3.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  246 DGSQITFEKCLIATGGTPR--SLSAIDRAGAevKSRTTLFrkigdfrALEKISRevkSITVIGGGFLGSELACALGRksq 323
Cdd:PRK06370 128 GGETLRAKRIFINTGARAAipPIPGLDEVGY--LTNETIF-------SLDELPE---HLVIIGGGYIGLEFAQMFRR--- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  324 aSGIEVIQLfpEKGNmgKILP---EYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLK---DGRKVETDHIVTAV 397
Cdd:PRK06370 193 -FGSEVTVI--ERGP--RLLPredEDVAAAVREILEREGIDVRLNAECIRVERDGDGIAVGLDcngGAPEITGSHILVAV 267

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 25742626  398 GLEPNVE---LAKTgGLEIDSDfGGFRVNAELQAR-SNIWVAGD 437
Cdd:PRK06370 268 GRVPNTDdlgLEAA-GVETDAR-GYIKVDDQLRTTnPGIYAAGD 309
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 246-475 3.67e-12

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 68.67  E-value: 3.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  246 DGSQITFEKCLIATGGTPRSLSAIDRA-GAEVKSRTTLFRkigdfraLEKISrevKSITVIGGGFLGSELACALGRksqa 324
Cdd:PRK06292 125 NGERIEAKNIVIATGSRVPPIPGVWLIlGDRLLTSDDAFE-------LDKLP---KSLAVIGGGVIGLELGQALSR---- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  325 SGIEVIqLFPEKGNMGKILPEYLSNWTMEKVKREgVKVMPNAIVQSVGVSGGKLLIKLKDGRKVET---DHIVTAVGLEP 401
Cdd:PRK06292 191 LGVKVT-VFERGDRILPLEDPEVSKQAQKILSKE-FKIKLGAKVTSVEKSGDEKVEELEKGGKTETieaDYVLVATGRRP 268

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25742626  402 NVE---LAKTgGLEIDSDfgGF-RVNAEL-QARSNIWVAGDAAcfydiklGRRRVEHhdHAVVSGRLAGENMTGAAKPY 475
Cdd:PRK06292 269 NTDglgLENT-GIELDER--GRpVVDEHTqTSVPGIYAAGDVN-------GKPPLLH--EAADEGRIAAENAAGDVAGG 335
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 301-385 5.03e-10

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 56.06  E-value: 5.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   301 SITVIGGGFLGSELACALGRKsqasGIEViQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLI 380
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARL----GSKV-TVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIEGNGDGVVV 75


                  ....*
gi 25742626   381 KLKDG 385
Cdd:pfam00070  76 VLTDG 80
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
242-473 1.42e-09

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 60.56  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  242 VKLNDGS--QITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLfrkigdfraLEkISREVKSITVIGGGFLGSELAC--- 316
Cdd:PRK05249 126 VECPDGEveTLTADKIVIATGSRPYRPPDVDFDHPRIYDSDSI---------LS-LDHLPRSLIIYGAGVIGCEYASifa 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  317 ALGRKsqasgIEVIqlfpekgNMGKILPEYLSNWTMEKVK---RE-GVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDH 392
Cdd:PRK05249 196 ALGVK-----VTLI-------NTRDRLLSFLDDEISDALSyhlRDsGVTIRHNEEVEKVEGGDDGVIVHLKSGKKIKADC 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  393 IVTAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAELQ-ARSNIWVAGD-------AACFYDiklgrrrvehhdhavvSG 461
Cdd:PRK05249 264 LLYANGRTGNTDglnLENA-GLEADSR-GQLKVNENYQtAVPHIYAVGDvigfpslASASMD----------------QG 325

                        250
                 ....*....|..
gi 25742626  462 RLAGENMTGAAK 473
Cdd:PRK05249 326 RIAAQHAVGEAT 337
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 223-439 8.60e-09

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 58.23  E-value: 8.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  223 GVAVLTGKKVVhldvrgnMVKLNDGSQ-ITFEKCLIATGGTPRSLSAIDRAGaevksrttlfRKIGD-FRALeKISREVK 300
Cdd:PRK06416 112 GEAKLVDPNTV-------RVMTEDGEQtYTAKNIILATGSRPRELPGIEIDG----------RVIWTsDEAL-NLDEVPK 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  301 SITVIGGGFLGSELACA---LGrkSQASGIEVI-QLFP-EKGNMGKILpeylsnwtmEKV-KREGVKVMPNAIVQSVGVS 374
Cdd:PRK06416 174 SLVVIGGGYIGVEFASAyasLG--AEVTIVEALpRILPgEDKEISKLA---------ERAlKKRGIKIKTGAKAKKVEQT 242

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25742626  375 GGKLLIKLKDGRKVET---DHIVTAVGLEPNVE---LAKTgGLEIDsdfGGF-RVNAELQAR-SNIWVAGDAA 439
Cdd:PRK06416 243 DDGVTVTLEDGGKEETleaDYVLVAVGRRPNTEnlgLEEL-GVKTD---RGFiEVDEQLRTNvPNIYAIGDIV 311
PTZ00058 PTZ00058
glutathione reductase; Provisional
 244-438 1.30e-08

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 57.70  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  244 LNDGSQITFEKCLIATGGTPRSlsaIDRAGAEVKSRTTLFRKIgdfralekisREVKSITVIGGGFLGSELACALgrksQ 323
Cdd:PTZ00058 195 LDDGQVIEGKNILIAVGNKPIF---PDVKGKEFTISSDDFFKI----------KEAKRIGIAGSGYIAVELINVV----N 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  324 ASGIEViQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSV-GVSGGKLLIKLKDGRKVET-DHIVTAVGLEP 401
Cdd:PTZ00058 258 RLGAES-YIFARGNRLLRKFDETIINELENDMKKNNINIITHANVEEIeKVKEKNLTIYLSDGRKYEHfDYVIYCVGRSP 336

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 25742626  402 NVELAKTGGLEIDSDFGGFRVNaELQARS--NIWVAGDA 438
Cdd:PTZ00058 337 NTEDLNLKALNIKTPKGYIKVD-DNQRTSvkHIYAVGDC 374
PRK07845 PRK07845
flavoprotein disulfide reductase; Reviewed
 223-437 2.00e-07

flavoprotein disulfide reductase; Reviewed


Pssm-ID: 236112 [Multi-domain]  Cd Length: 466  Bit Score: 53.71  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  223 GVAVLTGK-KVVHLDVRGNMVK--LNDGSQITFEK--CLIATGGTPRSLsaidrAGAEVKSRTTL-FRKIGDFRAL-EKi 295
Cdd:PRK07845 106 GVRVIAGRgRLIDPGLGPHRVKvtTADGGEETLDAdvVLIATGASPRIL-----PTAEPDGERILtWRQLYDLDELpEH- 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  296 srevksITVIGGGFLGSELACALgrksQASGIEVI------QLFP-EKGNMGKILpeylsnwtmEKV-KREGVKVMPNAI 367
Cdd:PRK07845 180 ------LIVVGSGVTGAEFASAY----TELGVKVTlvssrdRVLPgEDADAAEVL---------EEVfARRGMTVLKRSR 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  368 VQSVGVSGGKLLIKLKDGRKVETDHIVTAVGLEPN----------VELAKTGGLEIDsdfggfRVnaelqARSN---IWV 434
Cdd:PRK07845 241 AESVERTGDGVVVTLTDGRTVEGSHALMAVGSVPNtaglgleeagVELTPSGHITVD------RV-----SRTSvpgIYA 309


                 ...
gi 25742626  435 AGD 437
Cdd:PRK07845 310 AGD 312
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
218-439 1.55e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 50.12  E-value: 1.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 218 HIENGGVAVLTGKkVVHLDVRGN--MVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAE----------VKSRTTLFRK 285
Cdd:COG0492  66 QAERFGAEILLEE-VTSVDKDDGpfRVTTDDGTEYEAKAVIIATGAGPRKLGL---PGEEefegrgvsycATCDGFFFRG 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 286 igdfralekisrevKSITVIGGGFLGSELACAL------------GRKSQASGIEVIQLFpekgnmgkilpeylsnwtme 353
Cdd:COG0492 142 --------------KDVVVVGGGDSALEEALYLtkfaskvtlihrRDELRASKILVERLR-------------------- 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626 354 kvKREGVKVMPNAIVQSV----GVSGgkllIKLKDG-----RKVETDHIVTAVGLEPNVELAKTGGLEIDSDfGGFRVNA 424
Cdd:COG0492 188 --ANPKIEVLWNTEVTEIegdgRVEG----VTLKNVktgeeKELEVDGVFVAIGLKPNTELLKGLGLELDED-GYIVVDE 260

                       250
                ....*....|....*.
gi 25742626 425 ELQ-ARSNIWVAGDAA 439
Cdd:COG0492 261 DMEtSVPGVFAAGDVR 276
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 8.76e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 43.66  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626    51 RQMASS---GPSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLG------LSPEEKQRRAIASAAEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 25742626   122 -VPPIRVP 128
Cdd:pfam14962 108 eAPEVSVV 115
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
302-416 4.28e-04

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 42.60  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626   302 ITVIGGGFLGSELACALGRKsqasGIEVIQLFPEKGnMGKILPEY---LSNWT----MEKVKREGVKVMPNAIVQSVGVS 374
Cdd:pfam13738 158 VVVIGGYNSAVDAALELVRK----GARVTVLYRGSE-WEDRDSDPsysLSPDTlnrlEELVKNGKIKAHFNAEVKEITEV 232

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 25742626   375 GGKLLIKLKDGRKVETDHI-VTAVGLEPNVELAKTGGLEIDSD 416
Cdd:pfam13738 233 DVSYKVHTEDGRKVTSNDDpILATGYHPDLSFLKKGLFELDED 275
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 204-439 4.98e-03

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 39.77  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  204 FQPPSFYvsaqdlphiENGGVAVLTGKKVVHLDVRGNMV-----KLNDGSQITFEKCLIATGGTPRSLsaidraGAEVKS 278
Cdd:PRK13512  62 YTPEKFY---------DRKQITVKTYHEVIAINDERQTVtvlnrKTNEQFEESYDKLILSPGASANSL------GFESDI 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  279 RTTLfRKIGDFRALEK-ISR-EVKSITVIGGGFLGSELACALgrksQASGIEViQLFPEKGNMGKILPEYLSNWTMEKVK 356
Cdd:PRK13512 127 TFTL-RNLEDTDAIDQfIKAnQVDKALVVGAGYISLEVLENL----YERGLHP-TLIHRSDKINKLMDADMNQPILDELD 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25742626  357 REGVKVMPNAIVQSVGVSggklLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDsDFGGFRVNAELQAR-SNIWVA 435
Cdd:PRK13512 201 KREIPYRLNEEIDAINGN----EVTFKSGKVEHYDMIIEGVGTHPNSKFIESSNIKLD-DKGFIPVNDKFETNvPNIYAI 275


                 ....
gi 25742626  436 GDAA 439
Cdd:PRK13512 276 GDII 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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