|
Name |
Accession |
Description |
Interval |
E-value |
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
10-336 |
2.05e-153 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 434.16 E-value: 2.05e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGM-DKPLSLPGFLAKFDYYmPVIAGCREAIKRIAYEFVE 88
Cdd:pfam00962 1 PKAELHLHLDGSLRPDTLLELAKRYGIILPADFPEALEPLFRKyKKERDLQDFLDKYDIG-VAVLRSPEDIRRLAFEYAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 89 MKAKEGVVYVEVRYSPHLLANSkvdpmpwnqtegDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSLEVLE 167
Cdd:pfam00962 80 DVAKDGVVYAEVRYDPQSHASR------------GLSPDTVVDAVLDAVDAAEREFGITVRLIVCAMRHeHPECSREIAE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 168 LCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:pfam00962 148 LAPRYRDQGIVAFGLAGDEKGFPPSLFRDHVEAFARARDAGLHLTVHAGEAGGPQSVWEALDDLGAERIGHGVRSAEDPR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 248 LYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNI 327
Cdd:pfam00962 228 LLDRLADRQIPLEICPTSNVQTGAVASLAEHPLKTFLRAGVPVSLNTDDPLMFGSDLLDEYQVAKRAPGFDEEELARLAK 307
|
....*....
gi 6680636 328 NAAKSSFLP 336
Cdd:pfam00962 308 NAVKGSFLP 316
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
8-336 |
1.61e-147 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 418.92 E-value: 1.61e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 8 NKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGcREAIKRIAYEFV 87
Cdd:cd01320 1 NLPKAELHLHLDGSLRPETILELAKKNGITLPASDVELLELVVAAYNFSDLQDFLAKYDFGLSVLQT-EEDFERLAYEYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 88 EMKAKEGVVYVEVRYSPHLLanskvdpmpwnqTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQP-SWSLEVL 166
Cdd:cd01320 80 EDAAADGVVYAEIRFSPQLH------------TRRGLSFDEVVEAVLRGLDEAEAEFGIKARLILCGLRHLSpESAQETL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 167 ELCKKYNQKTVVAMDLAGDETIEgssLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:cd01320 148 ELALKYRDKGVVGFDLAGDEVGF---PPEKFVRAFQRAREAGLRLTAHAGEAGGPESVRDALDLLGAERIGHGIRAIEDP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 247 ALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLN 326
Cdd:cd01320 225 ELVKRLAERNIPLEVCPTSNVQTGAVKSLAEHPLRELLDAGVKVTINTDDPTVFGTYLTDEYELLAEAFGLTEEELKKLA 304
|
330
....*....|
gi 6680636 327 INAAKSSFLP 336
Cdd:cd01320 305 RNAVEASFLS 314
|
|
| aden_deam |
TIGR01430 |
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of ... |
9-336 |
1.98e-145 |
|
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of mammals and E. coli. Other members of this family are predicted also to be adenosine deaminase, an enzyme of nucleotide degradation. This family is distantly related to AMP deaminase.
Pssm-ID: 273619 Cd Length: 324 Bit Score: 413.68 E-value: 1.98e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 9 KPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIaGCREAIKRIAYEFVE 88
Cdd:TIGR01430 1 LPKAELHLHLEGSIRPETLLELAQKNGIPLPADLQSGEELKEAYDKFRDLQDFLAKYDFGVEVL-RTEDDFKRLAYEYVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 89 MKAKEGVVYVEVRYSPHLLANSKVdpmpwnqtegdvTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSLEVLE 167
Cdd:TIGR01430 80 KAAKDGVVYAEVFFDPQLHTNRGI------------SPDTVVEAVLDGLDEAERDFGIKSRLILCGMRHkQPEAAEETLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 168 LCKKYNQKTVVAMDLAGDETIEGsslFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:TIGR01430 148 LAKPYKEQTIVGFGLAGDERGGP---PPDFVRAFAIARELGLHLTVHAGELGGPESVREALDDLGATRIGHGVRALEDPE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 248 LYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNI 327
Cdd:TIGR01430 225 LLKRLAQENITLEVCPTSNVALGVVKSLAEHPLRRFLEAGVKVTLNSDDPAYFGSYLTEEYEIAAKHAGLTEEELKQLAR 304
|
....*....
gi 6680636 328 NAAKSSFLP 336
Cdd:TIGR01430 305 NALEGSFLS 313
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
10-336 |
8.66e-107 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 315.49 E-value: 8.66e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDkplSLPGFLAKFDYYMPVIAGcREAIKRIAYEFVEM 89
Cdd:COG1816 1 PKAELHLHLEGSLRPETLLELAARNGIDLPAADVEELRAAYDFR---DLQSFLDTYDAGAAVLQT-EEDFRRLAYEYLED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 90 KAKEGVVYVEVRYSPHLLanskvdpmpwnqTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQ-PSWSLEVLEL 168
Cdd:COG1816 77 AAADGVRYAEIRFDPQLH------------TRRGLSLEEVVEAVLDGLREAEREFGISVRLILCALRHLsPEAAFETLEL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 169 CKKYNQKTVVAMDLAGDETiegssLFPG--HVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:COG1816 145 ALRYRDRGVVGFGLAGDER-----GFPPekFAEAFARAREAGLHLTAHAGEAGGPESIWEALDLLGAERIGHGVRAIEDP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 247 ALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLN 326
Cdd:COG1816 220 ALVARLADRGIPLEVCPTSNVQLGVVPSLAEHPLRRLLDAGVRVTLNTDDPLYFGTTLTDEYELAAEAFGLSDADLAQLA 299
|
330
....*....|
gi 6680636 327 INAAKSSFLP 336
Cdd:COG1816 300 RNAIEASFLP 309
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
10-336 |
3.74e-93 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 281.30 E-value: 3.74e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGcREAIKRIAYEFVEM 89
Cdd:PRK09358 11 PKAELHLHLDGSLRPETILELARRNGIALPATDVEELPWVRAAYDFRDLQSFLDKYDAGVAVLQT-EEDLRRLAFEYLED 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 90 KAKEGVVYVEVRYSPhllanskvdpmpWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRH--QPSWSLEVLE 167
Cdd:PRK09358 90 AAADGVVYAEIRFDP------------QLHTERGLPLEEVVEAVLDGLRAAEAEFGISVRLILCFMRHfgEEAAARELEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 168 LCKKYNQKTVVAMDLAGDETIEGSSLFpghVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:PRK09358 158 LAARYRDDGVVGFDLAGDELGFPPSKF---ARAFDRARDAGLRLTAHAGEAGGPESIWEALDELGAERIGHGVRAIEDPA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 248 LYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNI 327
Cdd:PRK09358 235 LMARLADRRIPLEVCPTSNVQTGAVPSLAEHPLKTLLDAGVRVTINTDDPLVFGTTLTEEYEALAEAFGLSDEDLAQLAR 314
|
....*....
gi 6680636 328 NAAKSSFLP 336
Cdd:PRK09358 315 NALEAAFLS 323
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
10-336 |
2.05e-153 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 434.16 E-value: 2.05e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGM-DKPLSLPGFLAKFDYYmPVIAGCREAIKRIAYEFVE 88
Cdd:pfam00962 1 PKAELHLHLDGSLRPDTLLELAKRYGIILPADFPEALEPLFRKyKKERDLQDFLDKYDIG-VAVLRSPEDIRRLAFEYAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 89 MKAKEGVVYVEVRYSPHLLANSkvdpmpwnqtegDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSLEVLE 167
Cdd:pfam00962 80 DVAKDGVVYAEVRYDPQSHASR------------GLSPDTVVDAVLDAVDAAEREFGITVRLIVCAMRHeHPECSREIAE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 168 LCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:pfam00962 148 LAPRYRDQGIVAFGLAGDEKGFPPSLFRDHVEAFARARDAGLHLTVHAGEAGGPQSVWEALDDLGAERIGHGVRSAEDPR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 248 LYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNI 327
Cdd:pfam00962 228 LLDRLADRQIPLEICPTSNVQTGAVASLAEHPLKTFLRAGVPVSLNTDDPLMFGSDLLDEYQVAKRAPGFDEEELARLAK 307
|
....*....
gi 6680636 328 NAAKSSFLP 336
Cdd:pfam00962 308 NAVKGSFLP 316
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
8-336 |
1.61e-147 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 418.92 E-value: 1.61e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 8 NKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGcREAIKRIAYEFV 87
Cdd:cd01320 1 NLPKAELHLHLDGSLRPETILELAKKNGITLPASDVELLELVVAAYNFSDLQDFLAKYDFGLSVLQT-EEDFERLAYEYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 88 EMKAKEGVVYVEVRYSPHLLanskvdpmpwnqTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQP-SWSLEVL 166
Cdd:cd01320 80 EDAAADGVVYAEIRFSPQLH------------TRRGLSFDEVVEAVLRGLDEAEAEFGIKARLILCGLRHLSpESAQETL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 167 ELCKKYNQKTVVAMDLAGDETIEgssLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:cd01320 148 ELALKYRDKGVVGFDLAGDEVGF---PPEKFVRAFQRAREAGLRLTAHAGEAGGPESVRDALDLLGAERIGHGIRAIEDP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 247 ALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLN 326
Cdd:cd01320 225 ELVKRLAERNIPLEVCPTSNVQTGAVKSLAEHPLRELLDAGVKVTINTDDPTVFGTYLTDEYELLAEAFGLTEEELKKLA 304
|
330
....*....|
gi 6680636 327 INAAKSSFLP 336
Cdd:cd01320 305 RNAVEASFLS 314
|
|
| aden_deam |
TIGR01430 |
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of ... |
9-336 |
1.98e-145 |
|
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of mammals and E. coli. Other members of this family are predicted also to be adenosine deaminase, an enzyme of nucleotide degradation. This family is distantly related to AMP deaminase.
Pssm-ID: 273619 Cd Length: 324 Bit Score: 413.68 E-value: 1.98e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 9 KPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIaGCREAIKRIAYEFVE 88
Cdd:TIGR01430 1 LPKAELHLHLEGSIRPETLLELAQKNGIPLPADLQSGEELKEAYDKFRDLQDFLAKYDFGVEVL-RTEDDFKRLAYEYVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 89 MKAKEGVVYVEVRYSPHLLANSKVdpmpwnqtegdvTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSLEVLE 167
Cdd:TIGR01430 80 KAAKDGVVYAEVFFDPQLHTNRGI------------SPDTVVEAVLDGLDEAERDFGIKSRLILCGMRHkQPEAAEETLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 168 LCKKYNQKTVVAMDLAGDETIEGsslFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:TIGR01430 148 LAKPYKEQTIVGFGLAGDERGGP---PPDFVRAFAIARELGLHLTVHAGELGGPESVREALDDLGATRIGHGVRALEDPE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 248 LYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNI 327
Cdd:TIGR01430 225 LLKRLAQENITLEVCPTSNVALGVVKSLAEHPLRRFLEAGVKVTLNSDDPAYFGSYLTEEYEIAAKHAGLTEEELKQLAR 304
|
....*....
gi 6680636 328 NAAKSSFLP 336
Cdd:TIGR01430 305 NALEGSFLS 313
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
10-336 |
8.66e-107 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 315.49 E-value: 8.66e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDkplSLPGFLAKFDYYMPVIAGcREAIKRIAYEFVEM 89
Cdd:COG1816 1 PKAELHLHLEGSLRPETLLELAARNGIDLPAADVEELRAAYDFR---DLQSFLDTYDAGAAVLQT-EEDFRRLAYEYLED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 90 KAKEGVVYVEVRYSPHLLanskvdpmpwnqTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQ-PSWSLEVLEL 168
Cdd:COG1816 77 AAADGVRYAEIRFDPQLH------------TRRGLSLEEVVEAVLDGLREAEREFGISVRLILCALRHLsPEAAFETLEL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 169 CKKYNQKTVVAMDLAGDETiegssLFPG--HVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:COG1816 145 ALRYRDRGVVGFGLAGDER-----GFPPekFAEAFARAREAGLHLTAHAGEAGGPESIWEALDLLGAERIGHGVRAIEDP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 247 ALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLN 326
Cdd:COG1816 220 ALVARLADRGIPLEVCPTSNVQLGVVPSLAEHPLRRLLDAGVRVTLNTDDPLYFGTTLTDEYELAAEAFGLSDADLAQLA 299
|
330
....*....|
gi 6680636 327 INAAKSSFLP 336
Cdd:COG1816 300 RNAIEASFLP 309
|
|
| ADA_AMPD |
cd00443 |
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ... |
9-336 |
1.90e-100 |
|
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Pssm-ID: 238250 Cd Length: 305 Bit Score: 298.88 E-value: 1.90e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 9 KPKVELHVHLDGAIKPETILYFGKKrgialpadtveelrniigmdkplslpGFLAKFDYYMPVIaGCREAIKRIAYEFVE 88
Cdd:cd00443 1 LPKVELHAHLSGSISPETLLELIKK--------------------------EFFEKFLLVHNLL-QKGEALARALKEVIE 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 89 MKAKEGVVYVEVRYSPHLLANSKvdpmpwnqtegDVTPDDVVDLVNQGLQEGEQAF-GIKVRSILCCMRHQPS-----WS 162
Cdd:cd00443 54 EFAEDNVQYLELRTTPRLLETEK-----------GLTKEQYWLLVIEGISEAKQWFpPIKVRLILSVDRRGPYvqnylVA 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 163 LEVLELCKKYNQkTVVAMDLAGDETIEGSsLFPGHVEAYEGAVKNG-IHRTVHAGEVGSPEVVREAVDiLKTERVGHGYH 241
Cdd:cd00443 123 SEILELAKFLSN-YVVGIDLVGDESKGEN-PLRDFYSYYEYARRLGlLGLTLHCGETGNREELLQALL-LLPDRIGHGIF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 242 TIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEE 321
Cdd:cd00443 200 LLKHPELIYLVKLRNIPIEVCPTSNVVLGTVQSYEKHPFMRFFKAGLPVSLSTDDPGIFGTSLSEEYSLAAKTFGLTFED 279
|
330
....*....|....*
gi 6680636 322 FKRLNINAAKSSFLP 336
Cdd:cd00443 280 LCELNRNSVLSSFAK 294
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
10-336 |
3.74e-93 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 281.30 E-value: 3.74e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGcREAIKRIAYEFVEM 89
Cdd:PRK09358 11 PKAELHLHLDGSLRPETILELARRNGIALPATDVEELPWVRAAYDFRDLQSFLDKYDAGVAVLQT-EEDLRRLAFEYLED 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 90 KAKEGVVYVEVRYSPhllanskvdpmpWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRH--QPSWSLEVLE 167
Cdd:PRK09358 90 AAADGVVYAEIRFDP------------QLHTERGLPLEEVVEAVLDGLRAAEAEFGISVRLILCFMRHfgEEAAARELEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 168 LCKKYNQKTVVAMDLAGDETIEGSSLFpghVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:PRK09358 158 LAARYRDDGVVGFDLAGDELGFPPSKF---ARAFDRARDAGLRLTAHAGEAGGPESIWEALDELGAERIGHGVRAIEDPA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 248 LYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNI 327
Cdd:PRK09358 235 LMARLADRRIPLEVCPTSNVQTGAVPSLAEHPLKTLLDAGVRVTINTDDPLVFGTTLTEEYEALAEAFGLSDEDLAQLAR 314
|
....*....
gi 6680636 328 NAAKSSFLP 336
Cdd:PRK09358 315 NALEAAFLS 323
|
|
| PTZ00124 |
PTZ00124 |
adenosine deaminase; Provisional |
10-335 |
5.77e-29 |
|
adenosine deaminase; Provisional
Pssm-ID: 173415 Cd Length: 362 Bit Score: 114.96 E-value: 5.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 10 PKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGcREAIKRIAYEFVEM 89
Cdd:PTZ00124 36 PKCELHCHLDLCFSVDFFLSCIRKYNLQPNLSDEEILDYYLFAKGGKSLGEFVEKAIRVADIFND-YEVIEDLAKHAVFN 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 90 KAKEGVVYVEVRYSPHLLANSKvdpmpwnqtegDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMR---HQPSWSLEVL 166
Cdd:PTZ00124 115 KYKEGVVLMEFRYSPTFVAFKH-----------NLDIDLIHQAIVKGIKEAVELLDHKIEVGLLCIGdtgHDAAPIKESA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 167 ELCKKYNQKtVVAMDLAGDETIegsslFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVRE---AVDILKTERVGHGYHTI 243
Cdd:PTZ00124 184 DFCLKHKAD-FVGFDHAGHEVD-----LKPFKDIFDYVREAGVNLTVHAGEDVTLPNLNTlysAIQVLKVKRIGHGIRVA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 244 EDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFK 323
Cdd:PTZ00124 258 ESQELIDMVKEKDILLEVCPISNVLLNNAKSMDTHPIRKLYDAGVKVSVNSDDPGMFLTNINDDYEELYTHLNFTLADFM 337
|
330
....*....|..
gi 6680636 324 RLNINAAKSSFL 335
Cdd:PTZ00124 338 KMNEWALEKSFL 349
|
|
| metallo-dependent_hydrolases |
cd01292 |
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ... |
11-331 |
3.35e-26 |
|
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
Pssm-ID: 238617 [Multi-domain] Cd Length: 275 Bit Score: 105.49 E-value: 3.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 11 KVELHVHLDGAIKPETILYFGKKRGIALpadtveelrniigmdkplslpgflakfdyympviagCREAIKRIAYEFVEMK 90
Cdd:cd01292 1 FIDTHVHLDGSALRGTRLNLELKEAEEL------------------------------------SPEDLYEDTLRALEAL 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 91 AKEGVVYVEVRYSPHLlanskvdpmpwnqtegDVTPDDVVDLVNQGLQEGEqafGIKVRSILCCMRHQPSWSLE----VL 166
Cdd:cd01292 45 LAGGVTTVVDMGSTPP----------------PTTTKAAIEAVAEAARASA---GIRVVLGLGIPGVPAAVDEDaealLL 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 167 ELCKKYNQKTVVAMDLAGDETIEGSSlFPGHVEAYEGAVKNGIHRTVHAGEVGSP-EVVREAVDILKTE---RVGHGYHT 242
Cdd:cd01292 106 ELLRRGLELGAVGLKLAGPYTATGLS-DESLRRVLEEARKLGLPVVIHAGELPDPtRALEDLVALLRLGgrvVIGHVSHL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 243 ieDEALYNRLLKENMHFEVCPWSSYLTGaWDPKTTHAVVRFKNDKANYSLNTDDPLIF-KSTLDTDYQMTKKDM--GFTE 319
Cdd:cd01292 185 --DPELLELLKEAGVSLEVCPLSNYLLG-RDGEGAEALRRLLELGIRVTLGTDGPPHPlGTDLLALLRLLLKVLrlGLSL 261
|
330
....*....|...
gi 6680636 320 EEFKRL-NINAAK 331
Cdd:cd01292 262 EEALRLaTINPAR 274
|
|
| ADGF |
cd01321 |
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors ... |
14-336 |
6.18e-11 |
|
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Pssm-ID: 238646 Cd Length: 345 Bit Score: 62.68 E-value: 6.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 14 LHVHLDGAIKPETILYFGKKRgialpadtveeLRNIIGMdkplsLPGFLAkfdyYMPVIagcREAIKRIAYEFVEmkakE 93
Cdd:cd01321 30 LHVHDTAMVSSDWLIKNATYR-----------FEQIFDI-----IDGLLT----YLPIF---RDYYRRLLEELYE----D 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 94 GVVYVEVRYSPhllanskvdPMPWNQTEGDVTPDDVVDL----VNQGLQEGEQAFGIKVrsILCCMRH-QPSWSLEVLEL 168
Cdd:cd01321 83 NVQYVELRSSF---------SPLYDLDGREYDYEETVQLleevVEKFKKTHPDFIGLKI--IYATLRNfNDSEIKESMEQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 169 CKKYNQK---TVVAMDLAGDETiEGSSLFPgHVEAYEGAVKNG--IHRTVHAGE---VGSpEVVREAVD--ILKTERVGH 238
Cdd:cd01321 152 CLNLKKKfpdFIAGFDLVGQED-AGRPLLD-FLPQLLWFPKQCaeIPFFFHAGEtngDGT-ETDENLVDalLLNTKRIGH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 239 GYHTIEDEALYNRLLKENMHFEVCPWSS-YLTGAWDPKtTHAVVRFKNDKANYSLNTDDPLIFKST-LDTD-YQMTkkdM 315
Cdd:cd01321 229 GFALPKHPLLMDLVKKKNIAIEVCPISNqVLGLVSDLR-NHPAAALLARGVPVVISSDDPGFWGAKgLSHDfYQAF---M 304
|
330 340
....*....|....*....|....*.
gi 6680636 316 GFTEEEF-----KRLNINAAKSSFLP 336
Cdd:cd01321 305 GLAPADAglrglKQLAENSIRYSALS 330
|
|
| adm_rel |
TIGR01431 |
adenosine deaminase-related growth factor; Members of this family have been described as ... |
166-336 |
7.73e-06 |
|
adenosine deaminase-related growth factor; Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, mollusks, and vertebrates.
Pssm-ID: 273620 [Multi-domain] Cd Length: 479 Bit Score: 47.48 E-value: 7.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 166 LELCKKYNQKtVVAMDLAGDETiEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGS--PEVVREAVD--ILKTERVGHGYH 241
Cdd:TIGR01431 280 MGLRIKYPDF-VAGFDLVGQED-TGHSLLDYKDALLIPSIGVKLPYFFHAGETNWqgTSVDRNLLDalLLNTTRIGHGFA 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680636 242 TIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKST-LDTDYQMT-------KK 313
Cdd:TIGR01431 358 LSKHPAVRTYSKERDIPIEVCPISNQVLKLVSDLRNHPVATLMADNYPMVISSDDPAFWGAKgLSYDFYEAfmgiagmKA 437
|
170 180
....*....|....*....|...
gi 6680636 314 DMGFteeeFKRLNINAAKSSFLP 336
Cdd:TIGR01431 438 DLRT----LKQLALNSIKYSALS 456
|
|
| |
