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Conserved domains on  [gi|6321747|ref|NP_011823|]
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siderophore transporter [Saccharomyces cerevisiae S288C]

Protein Classification

ARN family MFS transporter( domain architecture ID 13023295)

ARN family MFS transporter similar to yeast siderophore iron transporter and glutathione exchanger

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 74-586 0e+00

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 732.96  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747   74 QAILLLSAFICGYGYGLDGNIRYIYTGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVG 153
Cdd:cd17322   1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  154 TIIQSQAYDVQRYAAGAIFYNAGYVGVILILLIILSDFSSLKWRLLYQFVPTWPFIINTWIAGNITSRANPVVNWSWDVG 233
Cdd:cd17322  81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWGYG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  234 MWAFIFPLSCVPIVLCMLHMQWRARKTPEWHALKGQKSYYQEHGFIKILKQLFWMLDVVGVLLMGCSLGCILVPLTLAGG 313
Cdd:cd17322 161 MWAIILPLSSLPLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQNLVKLFWKLDIFGVILLTAGLGLILVPLTLAGG 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  314 VKTTWNDSRLIGPFVLGFVLIPILWIWEYRFARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESV 393
Cdd:cd17322 241 AKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  394 KSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLYHFRGGSQSHSGIIGALCVWGVGTTLFTYPV 473
Cdd:cd17322 321 TSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPV 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  474 TVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQTLYKQILKRMGDVALATTAYESPYTF-IETYTWGTPQRN 552
Cdd:cd17322 401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLKNLPDSLKATAAYIFPSTFvILSYPWGTPERD 480

                       490       500       510
                ....*....|....*....|....*....|....
gi 6321747  553 ALMNAYKYVQRLETIVALVFCVPLIAFSLCLRDP 586
Cdd:cd17322 481 AIIESYRYVQRILLIVALVFSAPMFALMFFLRNP 514
 
Name Accession Description Interval E-value
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 74-586 0e+00

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 732.96  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747   74 QAILLLSAFICGYGYGLDGNIRYIYTGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVG 153
Cdd:cd17322   1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  154 TIIQSQAYDVQRYAAGAIFYNAGYVGVILILLIILSDFSSLKWRLLYQFVPTWPFIINTWIAGNITSRANPVVNWSWDVG 233
Cdd:cd17322  81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWGYG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  234 MWAFIFPLSCVPIVLCMLHMQWRARKTPEWHALKGQKSYYQEHGFIKILKQLFWMLDVVGVLLMGCSLGCILVPLTLAGG 313
Cdd:cd17322 161 MWAIILPLSSLPLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQNLVKLFWKLDIFGVILLTAGLGLILVPLTLAGG 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  314 VKTTWNDSRLIGPFVLGFVLIPILWIWEYRFARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESV 393
Cdd:cd17322 241 AKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  394 KSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLYHFRGGSQSHSGIIGALCVWGVGTTLFTYPV 473
Cdd:cd17322 321 TSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPV 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  474 TVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQTLYKQILKRMGDVALATTAYESPYTF-IETYTWGTPQRN 552
Cdd:cd17322 401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLKNLPDSLKATAAYIFPSTFvILSYPWGTPERD 480

                       490       500       510
                ....*....|....*....|....*....|....
gi 6321747  553 ALMNAYKYVQRLETIVALVFCVPLIAFSLCLRDP 586
Cdd:cd17322 481 AIIESYRYVQRILLIVALVFSAPMFALMFFLRNP 514
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
291-503 5.59e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.61  E-value: 5.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  291 VVGVLLMGCSLGCILVPLtlAGGVKTTWNDSRLIgpFVLGFVLIPILWIWEYRFARDPILPYR---------LVKDRAVW 361
Cdd:COG2814 135 ALGLLGAGLGLGPALGPL--LGGLLADLFGWRWV--FLVNAVLALLALLLLLRLLPESRPAARarlrgslreLLRRPRLL 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  362 SSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGL 441
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR-RRLLLIGLLLLALGLLL 289

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  442 LyhfrGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAV 503
Cdd:COG2814 290 L----ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
291-505 2.40e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.19  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    291 VVGVLLMGCSLGCILVPLtlAGGVKTTWNDSRL--IGPFVLGFVLIPILWIWEYRFARDP-----------ILPYRLVKD 357
Cdd:pfam07690 122 ALGLVSAGFGLGAALGPL--LGGLLASLFGWRAafLILAILSLLAAVLLLLPRPPPESKRpkpaeearlslIVAWKALLR 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    358 RAVWSSMGISFLIDFIYYMAADYLYTVMIVAvNESVKSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMV 437
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321747    438 AMGLLyhFRGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGS 505
Cdd:pfam07690 279 ALGLL--LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 289-513 4.54e-06

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 49.68  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    289 LDVVGVLLMGCSLGCILvpLTLAGGVKTTWNDSRLI-GPFVLGFVLIPILWIWEYRFaRDPILPYRLVKDRAVWSSMGIS 367
Cdd:TIGR00711 188 FDFLGLLLLSVGLGSLL--YGLSEGPERGWFDSNEIlILSITGLVAIIAFVVWELTD-DNPLVDLRLFKYRNFTIGCVYM 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    368 FLIDFIYYMA----ADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLY 443
Cdd:TIGR00711 265 SLLGLGLYGSfyllPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTP 344

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    444 hfrggSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWT 513
Cdd:TIGR00711 345 -----DTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
 
Name Accession Description Interval E-value
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 74-586 0e+00

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 732.96  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747   74 QAILLLSAFICGYGYGLDGNIRYIYTGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVG 153
Cdd:cd17322   1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  154 TIIQSQAYDVQRYAAGAIFYNAGYVGVILILLIILSDFSSLKWRLLYQFVPTWPFIINTWIAGNITSRANPVVNWSWDVG 233
Cdd:cd17322  81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWGYG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  234 MWAFIFPLSCVPIVLCMLHMQWRARKTPEWHALKGQKSYYQEHGFIKILKQLFWMLDVVGVLLMGCSLGCILVPLTLAGG 313
Cdd:cd17322 161 MWAIILPLSSLPLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQNLVKLFWKLDIFGVILLTAGLGLILVPLTLAGG 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  314 VKTTWNDSRLIGPFVLGFVLIPILWIWEYRFARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESV 393
Cdd:cd17322 241 AKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  394 KSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLYHFRGGSQSHSGIIGALCVWGVGTTLFTYPV 473
Cdd:cd17322 321 TSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPV 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  474 TVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQTLYKQILKRMGDVALATTAYESPYTF-IETYTWGTPQRN 552
Cdd:cd17322 401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLKNLPDSLKATAAYIFPSTFvILSYPWGTPERD 480

                       490       500       510
                ....*....|....*....|....*....|....
gi 6321747  553 ALMNAYKYVQRLETIVALVFCVPLIAFSLCLRDP 586
Cdd:cd17322 481 AIIESYRYVQRILLIVALVFSAPMFALMFFLRNP 514
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 115-594 2.14e-37

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 145.85  E-value: 2.14e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  115 INVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVGTIIQSQAYDVQRYAAGAIFYNAGYvGVILILLIILSDFSSL 194
Cdd:cd06179  37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGA-GTQGLGAAVASELVPN 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  195 KWRLLYQFVPTWPFIINTWIAGNITSRA--NPVVNWSWDVGMWAFIFPLSCVPIVLCmlhmqwrarktpeWHAlkgqKSY 272
Cdd:cd06179 116 KYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFFF-------------YHP----PPR 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  273 YQEHGFIKilKQLFWMLDVVGVLLMGCSLGCILVPLTLAGGVkTTWNDSRLIGPFVLGFVLIPILWIWEYRFARDPILPY 352
Cdd:cd06179 179 PQLHGSST--RQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNP-YPWSSAHVIAPLVIGGVLLIAFGLYEWKGTKDGLLPP 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  353 RLVKD-RAVWSSMGISFLIDFIYY-MAADYLYTVMIVAVNESVKSATRIATLsSFVSTVASPFFALLVTRCTRLKPFIMF 430
Cdd:cd06179 256 RLLFRgRNFALILIVAFVEGMIFYsLNIFWPQQISLLFTTDPLKAGLYQLPF-GLGTLFGAILAGLLLTKIKHIKWQLVA 334

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  431 GCALWMVAMGLLYHFRGGSQSHSgiIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGA 510
Cdd:cd06179 335 GFVLFTAFLALLALITPDNKALA--IAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTS 412

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  511 IWTQTLYKQILKRMGDVALATTAYESPY-TFIETYTWGTPQR----------------NALMNAYKYVQRLETIVALVFC 573
Cdd:cd06179 413 ILSNRLSKNLPARVAPAALEAGLPASSLpALLGALASGNIAAltavpginpeiiaaatAALKQAYADSFRYVWYAAIPFG 492

                       490       500
                ....*....|....*....|...
gi 6321747  574 VPLIAFSLCLRD--PKLTDTVAV 594
Cdd:cd06179 493 VVAIIAALFLRDidSYMTDHVDA 515
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 81-516 5.52e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 104.05  E-value: 5.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747   81 AFICGYGYGLDGNIRYIY-TGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVGTIIQSQ 159
Cdd:cd06174   1 LLLGFFLTGLARGLISPLlPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  160 AYDVQRYAAGAIFYNAGYVGVILILLIILSDFSSL----KWRLLYQFVPTWPFIINTWIAGNITSRAnpVVNWSWDVGMW 235
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPErergRALGLLQAFGSVGGILGPLLGGILASSL--GFGWRAVFLIA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  236 AFIFPLSCVPIVLCMLHMQWRARKTPEwhalkgqksyyqehgfikilkqlfwmldvvgvllmgcslgcilvpltlaggvk 315
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNE----------------------------------------------------- 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  316 ttwndsrligpfvlgfvlipilwiwEYRFARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKS 395
Cdd:cd06174 186 -------------------------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  396 ATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLYHFRggsqSHSGIIGALCVWGVGTTLFTYPVTV 475
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP----SLLLLLLLLLLLGFGLGGLLPLSFA 316

                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 6321747  476 SVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQTL 516
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
291-503 5.59e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.61  E-value: 5.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  291 VVGVLLMGCSLGCILVPLtlAGGVKTTWNDSRLIgpFVLGFVLIPILWIWEYRFARDPILPYR---------LVKDRAVW 361
Cdd:COG2814 135 ALGLLGAGLGLGPALGPL--LGGLLADLFGWRWV--FLVNAVLALLALLLLLRLLPESRPAARarlrgslreLLRRPRLL 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  362 SSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGL 441
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR-RRLLLIGLLLLALGLLL 289

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  442 LyhfrGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAV 503
Cdd:COG2814 290 L----ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 291-514 8.55e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 64.11  E-value: 8.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  291 VVGVLLMGCSLGCIL-VPLTLAGGVKTTWNDSrLIGPFVLGFVLIPILWIWEYRFARDPILPY-------RLVKDRAVWS 362
Cdd:cd17324 124 AIGLVFSGLTLGLVLgRPLGGLLGQLLGWRAA-FLAIAVLALLAALLLWRLLPSLPPKKPGSLgllssllLLLRNPRLRL 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  363 SMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRctRLKPFIMFGCALWMVAMGLL 442
Cdd:cd17324 203 AYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR--GGRRALLIALLLLAAALLLL 280

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  443 YHFrggSQSHSGIIGALCVWGVGTTlFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQ 514
Cdd:cd17324 281 TLL---GPSPLLLLVGLVLWGLGFF-AAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH 348
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 348-513 5.14e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 58.36  E-value: 5.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  348 PILPYRLVKDRAVWSSMGISFLIDFIYYMAadYLYTVMIVAVNE------SVKSATRIATLSSFVSTVASPFFALLVTRc 421
Cdd:cd17504 167 PLIDLRLLRRRNVLLANITALLAGFGMFMV--FQLLPQLLQLPTptgfglGITEAGLLLLPGALVMLIAGPLAGRLIAR- 243

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  422 TRLKPFIMFGCALWMVAMGLLYHFRGgsqSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGS 501
Cdd:cd17504 244 VGPRRVLLIGLVISAVGLLLLALLHS---SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGS 320

                       170
                ....*....|..
gi 6321747  502 AVGSAVSGAIWT 513
Cdd:cd17504 321 AIGPAIAGAILT 332
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
359-515 3.89e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.65  E-value: 3.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  359 AVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRC-TRLKPFIMFGCALWMV 437
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAAL 260

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321747  438 AMGLLYHFrggsQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQT 515
Cdd:COG2271 261 ALLLLALL----PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 409-547 4.15e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 55.64  E-value: 4.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  409 VASPFFALLVTRcTRLKPFIMFGCALWMVAMGLLYHFrGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMAT 488
Cdd:cd17321 219 VAAPLAGRLADR-FGPRLVLVAGLLLTAVGLLLLALL-GADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGA 296

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6321747  489 VTALNYTLYRIGSAVGSAVSGAIWTqTLYKQILKRMGDVALATTAYESpytFIETYTWG 547
Cdd:cd17321 297 ASGILNTARQLGGALGVALLGALLT-AGLSANLGDSGVAALLSAAAAA---FAAGFHLA 351
MFS_1 pfam07690
Major Facilitator Superfamily;
291-505 2.40e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.19  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    291 VVGVLLMGCSLGCILVPLtlAGGVKTTWNDSRL--IGPFVLGFVLIPILWIWEYRFARDP-----------ILPYRLVKD 357
Cdd:pfam07690 122 ALGLVSAGFGLGAALGPL--LGGLLASLFGWRAafLILAILSLLAAVLLLLPRPPPESKRpkpaeearlslIVAWKALLR 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    358 RAVWSSMGISFLIDFIYYMAADYLYTVMIVAvNESVKSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMV 437
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321747    438 AMGLLyhFRGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGS 505
Cdd:pfam07690 279 ALGLL--LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 293-513 2.66e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.96  E-value: 2.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  293 GVLLMGCSLGCILVPLtlAGGVKTTWNDSRLigPFVLGFVLIPILWIWEYRFARDPILPY---------------RLVKD 357
Cdd:cd17325 123 GIFSSAIGLGFLIGPL--LGGLLADALGYRA--PFLVCAALALLALVLALLLLPEPRPPPnkravsaarlrsglrLLLRD 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  358 RAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMV 437
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAV 277

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321747  438 AMGLLYHfrggSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWT 513
Cdd:cd17325 278 ALLLLPL----ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
323-517 2.71e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.37  E-value: 2.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  323 LIGPFVLGFVLIPILWIWEYRFARDPILPYR-----LVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSAT 397
Cdd:COG2211 188 IFAVLGLLAFLLTFFGTKERPVPEEEKVSLKeslkaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVG 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  398 RIATLSSFVSTVASPFFALLVTRCTRLKPFImFGCALWMVAMGLLYHFRGGSQshSGIIGALCVWGVGTTLFtYPVTVSV 477
Cdd:COG2211 268 LLLALYFLAALLGAPLWPRLAKRFGKKKAFI-IGLLLAALGLLLLFFLGPGNL--WLLLVLAALAGIGLGAI-LVLPWAM 343

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6321747  478 QSAVSHE--------NMATVTALNYTLYRIGSAVGSAVSGAIWTQTLY 517
Cdd:COG2211 344 LADVVDYdewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 358-507 4.25e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 52.18  E-value: 4.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  358 RAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNES-VKSATRIATLSsFVSTVASPFFALLVTRCTRLKPFIMFGCALWM 436
Cdd:cd17502 167 RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSaTKSGVRLLPLI-IGLVIGSIISGALISKTGRYKPLIVIGTILMS 245

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  437 VAMGLLYHFRGGSqSHSGIIGALCVWGVGTTlFTYPVT-VSVQSAVSHENMATVTALNYTLYRIGSAVGSAV 507
Cdd:cd17502 246 VGAGLLTTLTLDT-SKWLLIGYLILLGLGLG-IGFQQPlVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 289-513 4.54e-06

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 49.68  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    289 LDVVGVLLMGCSLGCILvpLTLAGGVKTTWNDSRLI-GPFVLGFVLIPILWIWEYRFaRDPILPYRLVKDRAVWSSMGIS 367
Cdd:TIGR00711 188 FDFLGLLLLSVGLGSLL--YGLSEGPERGWFDSNEIlILSITGLVAIIAFVVWELTD-DNPLVDLRLFKYRNFTIGCVYM 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    368 FLIDFIYYMA----ADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLY 443
Cdd:TIGR00711 265 SLLGLGLYGSfyllPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTP 344

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    444 hfrggSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWT 513
Cdd:TIGR00711 345 -----DTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 366-517 5.21e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.96  E-value: 5.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  366 ISFLIDFIYYMAADYLYTVMIVAVNESVKSATrIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGLLyhf 445
Cdd:cd06174   4 GFFLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLF--- 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  446 rGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQTLY 517
Cdd:cd06174  79 -AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 110-357 5.97e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 49.28  E-value: 5.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    110 SLLSTINVINAVVSAasqIIYARLSDVFGRLYLFISAVILYVVGTIIQSQAYDVQRYAAGAIFYNAGyVGVILILLIILS 189
Cdd:pfam06609  81 GLFSTLWTMGQAVSI---LMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA-AGPAGASPLFIG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    190 DFSSLKWRLLYQFVPTWPFIINTWIAGNITSRANPVVNWSWDVGMWAFIFPLSCVPIVLcmlhmqWraRKTPEWHALKGQ 269
Cdd:pfam06609 157 ELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIII------W--YHPPSFAQLHGK 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    270 KSYYQEHgfikiLKQLFWmldvVGVLLMGCSLGCILVPLTLAGGVKTTWNDSRLIGPFVLGFVLIPILWIWE-YRFARDP 348
Cdd:pfam06609 229 KARKRDE-----LAKLDW----IGIFLVIAGTSLFLLGVSWGGKPNNPWNSAKIIGLISSGAGSLVIFALYEvFGKPEQP 299


                  ....*....
gi 6321747    349 ILPYRLVKD 357
Cdd:pfam06609 300 IIPPALFKD 308
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 348-514 2.21e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.19  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  348 PILPYRLVKDRAVWSSMGISFLIDFIYYMAAdYLYTVMIvavnESVK--SATRIATL---SSFVSTVASPFFALLVTRCT 422
Cdd:cd17503 168 PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAM-FLLPLYL----QNVLgySAFESGLVlapGGLASAILSPLVGRLLDKFG 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  423 rLKPFIMFGCALWMVAMGLLYHFRGGSQSHsGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSA 502
Cdd:cd17503 243 -PRLLLLAGLLLLALGTLLLAFLTPDTSLW-LIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGS 320

                       170
                ....*....|..
gi 6321747  503 VGSAVSGAIWTQ 514
Cdd:cd17503 321 IGTALLATLLTN 332
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
358-511 6.37e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 6.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  358 RAVWSSMGISFLIDFIYYMAAdYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMV 437
Cdd:COG2814  10 LALLALALGAFLSGLGIGIVL-PALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR-RRVLLLGLLLFAL 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321747  438 AMGLLyhfrGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAI 511
Cdd:COG2814  88 GSLLC----ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 325-512 1.33e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.48  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  325 GPFVLGFVLIPI-LWIW-----------EYRFARDPILPYRLVKDRAVWSSMGISFLIDFIYYMaadYLYTVMIVAVNES 392
Cdd:cd17474 153 YPFFLLAALIPVaFLAIlfllpepkekaKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA---FLTYLPFLLELLY 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  393 VKSATRI---ATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLyhfrGGSQSHSGIIGALCVWGVGTTLF 469
Cdd:cd17474 230 GISPIIIgllFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLL----GFVPSLALLLIAIVLFGLGLGLN 305

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6321747  470 TYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIW 512
Cdd:cd17474 306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
332-515 2.40e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 43.71  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  332 VLIPILWIWEYRF-------ARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYLYTvMIVAVNESVKSATRIATLSS 404
Cdd:COG2807 182 LLALLLWLPLLRRrpaaaaaAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPP-ILRDAGLSAATAGLLLSLFQ 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  405 FVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAM-GLLYHfrggsqSHSGIIGALCVWGVGT-TLFTYPVTVSVQSAVS 482
Cdd:COG2807 261 LAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLlGLLLA------PGSLPWLWAVLLGLGQgGLFPLALTLIGLRART 334

                       170       180       190
                ....*....|....*....|....*....|...
gi 6321747  483 HENMATVTALNYTLYRIGSAVGSAVSGAIWTQT 515
Cdd:COG2807 335 PAEAAALSGMAQSVGYLLAALGPLLVGALHDAT 367
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 326-511 2.57e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 43.67  E-value: 2.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  326 PFVLGFVLIPI-LWIweyRF-----------------ARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYL--YTVM 385
Cdd:cd17369 181 PFLLSAVLVAVgLYI---RLrleetpvfrrakeagqvVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFAlsYATQ 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  386 IVAVNESVksATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGLLYHFRGGSQSHSGIIGALCVWGVG 465
Cdd:cd17369 258 TLGVDRST--VLLAVLIASVVAAITIPLFGWLSDRVGR-RPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVL 334

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6321747  466 ttlftYPVTVSVQSAVSHENMAtvTALNYTLYRIGSAVGSAVSGAI 511
Cdd:cd17369 335 -----HGMMYGPQAAFLAELFP--TRVRYTGASLGYQLGAILGGGF 373
MFS_1 pfam07690
Major Facilitator Superfamily;
366-511 3.29e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    366 ISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGLLYHf 445
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-RRVLLIGLLLFALGLLLLLF- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321747    446 rggSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAI 511
Cdd:pfam07690  82 ---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
328-515 1.00e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.79  E-value: 1.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  328 VLGFVLIPILWIW-------EYRFARDPILPYR-LVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRI 399
Cdd:COG2223 167 ILLLVVAVLAWLFlrdppagAAAAAKASLRDQLeALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  400 ATLSSFVSTVASPFFALLVTRCTRLKPFiMFGCALWMVAMGLLYHFRGgsqSHSGIIGALCVWGVGTTLFTYPVTVSVQS 479
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVL-LIVFALMALGLLLLALALG---SLWLFLVLFLLLGLALGGGNGAVFALVPD 322

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6321747  480 AVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQT 515
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 327-515 1.17e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.40  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  327 FVLGFVLIPILWIWeyrfardpilpYRLVkdRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIAT---LS 403
Cdd:cd17319 161 IIEGLLGLLLAVLW-----------WFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAipfLA 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  404 SFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGLLYHFrggsQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSH 483
Cdd:cd17319 228 GAIGMILGGRLSDRLLRGAR-RLVIIIGLLLAAVGLLLAYLT----TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302

                       170       180       190
                ....*....|....*....|....*....|..
gi 6321747  484 ENMATVTALNYTLYRIGSAVGSAVSGAIWTQT 515
Cdd:cd17319 303 EAAATAGGLINSGGNLGGFVAPLLIGYLVDAT 334
Sugar_tr pfam00083
Sugar (and other) transporter;
80-271 2.16e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 40.72  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747     80 SAFICGYGYGLDGNIRYIYTGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVGTIIQSQ 159
Cdd:pfam00083  16 TGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747    160 AYD---VQRYAAGAIFYNAGYVGVILILLIILSDFSSLKWR----LLYQFVPTWPFIINTWIaGNITSRANPVVNWSWDV 232
Cdd:pfam00083  96 AKGkwsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRgalgSLYQLAITFGILLAYIF-GLGLNKTSNSDGWRIPL 174

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 6321747    233 GMwAFIFplscvPIVLCMLHMQWraRKTPEWHALKGQKS 271
Cdd:pfam00083 175 GL-QLVP-----ALLLIIGLLFL--PESPRWLVEKGRLE 205
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 77-156 2.61e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 40.24  E-value: 2.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747   77 LLLSAFIcgygYGLDGNIryIYTGYAT--SSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVGT 154
Cdd:cd17502   1 LMLALFL----AALDQTI--VATALPTivAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGS 74


                ..
gi 6321747  155 II 156
Cdd:cd17502  75 LL 76
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 301-513 4.09e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.83  E-value: 4.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  301 LGCILVPLTLAGGVKTTWNDSRLI-----GPFVLGFVLIpILWIWEYRFARDPILPYRLVK----DRAVWSSMGISFLID 371
Cdd:cd17370 135 LGAVLGPLLAALLLYLLGGNYRTIfllaaIPALLALLIL-LFVVKEYPRPPKLRKKSKKTSlkklPKAFWLYLLAVALFA 213

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  372 FIYYMAADYLYTVMIVAVNESVKSATriATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAMGLLyhfrGGSQS 451
Cdd:cd17370 214 LGNFSFAFLILRAQELGLSAALIPLL--YALFNLVYALAAYPAGRLSDRIGR-KKLLILGYLSLALAYLGF----ALGSS 286

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321747  452 HSGIIGALCVWGVGttlftYPVTVSVQSA-----VSHENMATVTALNYTLYRIGSAVGSAVSGAIWT 513
Cdd:cd17370 287 LWLLLLGFILWGLY-----MGAQESIERAavadlVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
360-511 8.12e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 8.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  360 VWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAM 439
Cdd:COG2271  11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGR-RRVLAIGLLLWGLAT 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  440 GLLyhfrGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAI 511
Cdd:COG2271  90 LLF----GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 360-511 9.97e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.75  E-value: 9.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321747  360 VWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRlKPFIMFGCALWMVAM 439
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGF 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321747  440 GLLYHFRGGSQshsgIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAI 511
Cdd:cd17329  80 ALLGFAHSPWL----FAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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