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Conserved domains on  [gi|4757708|ref|NP_004724|]
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acetyl-coenzyme A transporter 1 isoform 1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 10017492)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A0125 TIGR00901
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
86-458 1.03e-138

AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]


:

Pssm-ID: 273329 [Multi-domain]  Cd Length: 356  Bit Score: 405.62  E-value: 1.03e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708     86 GIPLGLAG-SIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDr 164
Cdd:TIGR00901   1 GLPLGLVGnTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVP- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    165 llgntddrTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKy 244
Cdd:TIGR00901  80 --------STDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPEFANT- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    245 lrfqpqprGIVTLSDFLFFWGTVFLITTTLVAL-LKKENE--VSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAK 321
Cdd:TIGR00901 151 --------GLITLWGYIFFWTALLILPGLLVTLfLAKEPQedASVPKPLTQAVLKPIREFFQRKNMIQALLLLLLIVLYK 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    322 IGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISkyTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVE 401
Cdd:TIGR00901 223 LGDSAATVLTTLFLLDMGFSKEEIALVAKINGLLGAILGGLIG--GIIMQPLNILYALLLFGIVQALTNAGFVWLASNGH 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4757708    402 HQgGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNL 458
Cdd:TIGR00901 301 HD-GITFPHLLMLFLTITLEAVTGGLGTVAFVAFLSKLSNPKFGATQMALLSSLSAL 356
 
Name Accession Description Interval E-value
2A0125 TIGR00901
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
86-458 1.03e-138

AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273329 [Multi-domain]  Cd Length: 356  Bit Score: 405.62  E-value: 1.03e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708     86 GIPLGLAG-SIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDr 164
Cdd:TIGR00901   1 GLPLGLVGnTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVP- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    165 llgntddrTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKy 244
Cdd:TIGR00901  80 --------STDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPEFANT- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    245 lrfqpqprGIVTLSDFLFFWGTVFLITTTLVAL-LKKENE--VSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAK 321
Cdd:TIGR00901 151 --------GLITLWGYIFFWTALLILPGLLVTLfLAKEPQedASVPKPLTQAVLKPIREFFQRKNMIQALLLLLLIVLYK 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    322 IGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISkyTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVE 401
Cdd:TIGR00901 223 LGDSAATVLTTLFLLDMGFSKEEIALVAKINGLLGAILGGLIG--GIIMQPLNILYALLLFGIVQALTNAGFVWLASNGH 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4757708    402 HQgGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNL 458
Cdd:TIGR00901 301 HD-GITFPHLLMLFLTITLEAVTGGLGTVAFVAFLSKLSNPKFGATQMALLSSLSAL 356
Acatn pfam13000
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ...
85-544 6.40e-128

Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.


Pssm-ID: 372424 [Multi-domain]  Cd Length: 543  Bit Score: 384.79  E-value: 6.40e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708     85 QGIPLGLA-GSIPLILQS--KNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLS-- 159
Cdd:pfam13000  11 QGIPVGLAfGTIPFLLKSmaKETSFTSLGIFSMATYPYSLKILWSPIVDSIYSKKIGRRRSWIIPVQLVSGIMLIILGyc 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    160 -------TQVDRLLG---NTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGN 229
Cdd:pfam13000  91 iskglifPGVDDAFHgrlSKGVLNVNITTLTWYFGILVFLCATQDIAVDGWALTILSKQSLSYASTAQTVGLNTGYFLSF 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    230 VLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVK--------------------- 288
Cdd:pfam13000 171 TIFLSLNSSDFANKYFRNTPLEYGLISLGGYMKFAGIIYILVTIYVIFFTKERPYASLPsvskksldekydeiskisiie 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    289 --------EETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP 360
Cdd:pfam13000 251 ynddvektKNTSSIKYVYRCFIKVLKLPSVRSLAIIHLISKFAFQCNEAATNLKLLEKGFKREDLAVTVLIDFPFEIIFG 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    361 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVW----WTP----------------KVEHQ----GGFPIYYYIVVLL 416
Cdd:pfam13000 331 YYVAKWSSDSHPLKIMNIRPMKLSRSNRIIRLLVGdagvLTPwlwgflgrllaailgsYVVKQfpkdGQITTGYFLLVII 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    417 SYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVG--ASNQNCRTP--DA 492
Cdd:pfam13000 411 QHLLGSFMSTVQFVGISAFHTRIADPVLGGTYMTLLNTLSNLGGTWPRIFIMSMIDYFTIYECVNedTSNNTILTSggNM 490
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4757708    493 VELCKKLGGSCVTALDGYYVESIICVFIG-FGWWFFLGPKFKKLQDEGSSSWK 544
Cdd:pfam13000 491 EFCTYSLGGTVSIIRDGYYVTNLICIVLGiLLYFTYLKRKAQQLQKLPISAWR 543
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
85-348 1.23e-30

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 123.11  E-value: 1.23e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708   85 QGIPLGLA-GSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQvd 163
Cdd:cd17485   9 QGLPYGFQsQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLLLALAFL-- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  164 rllgntdDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALesadfcnk 243
Cdd:cd17485  87 -------PPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWL-------- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  244 YLRFQPQPrgivtlsdfLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIG 323
Cdd:cd17485 152 YDLIGWQS---------LLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLG 222
                       250       260
                ....*....|....*....|....*
gi 4757708  324 FSAADAVTGLKLVEEGVPKEHLALL 348
Cdd:cd17485 223 EQGALAMLPPFLVDRGFSLSQIGLL 247
ampG PRK11902
muropeptide transporter; Reviewed
89-211 2.82e-08

muropeptide transporter; Reviewed


Pssm-ID: 183369 [Multi-domain]  Cd Length: 402  Bit Score: 56.01  E-value: 2.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    89 LGLAGSIPLILQS---------KNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGL---FMI 156
Cdd:PRK11902   7 LGFASGLPLALTSgtlqawmtvEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAAsiaAMA 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4757708   157 YLSTQvdrllgntddrtPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVG 211
Cdd:PRK11902  87 FCPPH------------AALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERG 129
 
Name Accession Description Interval E-value
2A0125 TIGR00901
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
86-458 1.03e-138

AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273329 [Multi-domain]  Cd Length: 356  Bit Score: 405.62  E-value: 1.03e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708     86 GIPLGLAG-SIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDr 164
Cdd:TIGR00901   1 GLPLGLVGnTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVP- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    165 llgntddrTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKy 244
Cdd:TIGR00901  80 --------STDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPEFANT- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    245 lrfqpqprGIVTLSDFLFFWGTVFLITTTLVAL-LKKENE--VSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAK 321
Cdd:TIGR00901 151 --------GLITLWGYIFFWTALLILPGLLVTLfLAKEPQedASVPKPLTQAVLKPIREFFQRKNMIQALLLLLLIVLYK 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    322 IGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISkyTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVE 401
Cdd:TIGR00901 223 LGDSAATVLTTLFLLDMGFSKEEIALVAKINGLLGAILGGLIG--GIIMQPLNILYALLLFGIVQALTNAGFVWLASNGH 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4757708    402 HQgGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNL 458
Cdd:TIGR00901 301 HD-GITFPHLLMLFLTITLEAVTGGLGTVAFVAFLSKLSNPKFGATQMALLSSLSAL 356
Acatn pfam13000
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ...
85-544 6.40e-128

Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.


Pssm-ID: 372424 [Multi-domain]  Cd Length: 543  Bit Score: 384.79  E-value: 6.40e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708     85 QGIPLGLA-GSIPLILQS--KNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLS-- 159
Cdd:pfam13000  11 QGIPVGLAfGTIPFLLKSmaKETSFTSLGIFSMATYPYSLKILWSPIVDSIYSKKIGRRRSWIIPVQLVSGIMLIILGyc 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    160 -------TQVDRLLG---NTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGN 229
Cdd:pfam13000  91 iskglifPGVDDAFHgrlSKGVLNVNITTLTWYFGILVFLCATQDIAVDGWALTILSKQSLSYASTAQTVGLNTGYFLSF 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    230 VLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVK--------------------- 288
Cdd:pfam13000 171 TIFLSLNSSDFANKYFRNTPLEYGLISLGGYMKFAGIIYILVTIYVIFFTKERPYASLPsvskksldekydeiskisiie 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    289 --------EETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP 360
Cdd:pfam13000 251 ynddvektKNTSSIKYVYRCFIKVLKLPSVRSLAIIHLISKFAFQCNEAATNLKLLEKGFKREDLAVTVLIDFPFEIIFG 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    361 LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVW----WTP----------------KVEHQ----GGFPIYYYIVVLL 416
Cdd:pfam13000 331 YYVAKWSSDSHPLKIMNIRPMKLSRSNRIIRLLVGdagvLTPwlwgflgrllaailgsYVVKQfpkdGQITTGYFLLVII 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    417 SYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVG--ASNQNCRTP--DA 492
Cdd:pfam13000 411 QHLLGSFMSTVQFVGISAFHTRIADPVLGGTYMTLLNTLSNLGGTWPRIFIMSMIDYFTIYECVNedTSNNTILTSggNM 490
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4757708    493 VELCKKLGGSCVTALDGYYVESIICVFIG-FGWWFFLGPKFKKLQDEGSSSWK 544
Cdd:pfam13000 491 EFCTYSLGGTVSIIRDGYYVTNLICIVLGiLLYFTYLKRKAQQLQKLPISAWR 543
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
85-348 1.23e-30

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 123.11  E-value: 1.23e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708   85 QGIPLGLA-GSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQvd 163
Cdd:cd17485   9 QGLPYGFQsQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLLLALAFL-- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  164 rllgntdDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALesadfcnk 243
Cdd:cd17485  87 -------PPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWL-------- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  244 YLRFQPQPrgivtlsdfLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIG 323
Cdd:cd17485 152 YDLIGWQS---------LLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLG 222
                       250       260
                ....*....|....*....|....*
gi 4757708  324 FSAADAVTGLKLVEEGVPKEHLALL 348
Cdd:cd17485 223 EQGALAMLPPFLVDRGFSLSQIGLL 247
MFS_AmpG_like cd17486
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ...
85-349 5.53e-19

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341039  Cd Length: 387  Bit Score: 88.81  E-value: 5.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708   85 QGIPLGLAGS-IPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIylstqvd 163
Cdd:cd17486   8 SGLPYLLTGTtLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTPFLGRRRGWILLTQILLMAALI------- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  164 rLLGNTDDRTPDVIALTVaFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCnsvgQTAGYFLGnvlfLALESAdfcnk 243
Cdd:cd17486  81 -ALAFLDPFTNLVLSALL-FLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGV----RVNGYRIG----MLVAGA----- 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  244 ylrfqpqprGIVTLSDFLfFWGTVFLIT---------TTLVALLKKENEVSVVKEETQgITDTYKLLFAIIKMPAVLTFC 314
Cdd:cd17486 146 ---------GALYLADSL-SWSAVYLIMaalmgpgilATLFAPEPPRTDPPANSLSET-VVAFFAPFKDFFGQPGALLIL 214
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4757708  315 LLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLA 349
Cdd:cd17486 215 AFILLYKLGDAMLGAMATPFLLDLGFTKTEIGAVY 249
ampG PRK11902
muropeptide transporter; Reviewed
89-211 2.82e-08

muropeptide transporter; Reviewed


Pssm-ID: 183369 [Multi-domain]  Cd Length: 402  Bit Score: 56.01  E-value: 2.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    89 LGLAGSIPLILQS---------KNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGL---FMI 156
Cdd:PRK11902   7 LGFASGLPLALTSgtlqawmtvEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAAsiaAMA 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4757708   157 YLSTQvdrllgntddrtPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVG 211
Cdd:PRK11902  87 FCPPH------------AALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERG 129
ampG PRK11010
muropeptide MFS transporter AmpG;
89-211 7.24e-08

muropeptide MFS transporter AmpG;


Pssm-ID: 182898  Cd Length: 491  Bit Score: 55.03  E-value: 7.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708    89 LGLAGSIPLILQS---------KNVSYTDQAFFSFVFWPFSLKLLWAPLVDAvYVKNF-GRRKSWLVPTQYILGLFMIYL 158
Cdd:PRK11010  20 LGFASGLPLALTSgtlqawmtvENIDLKTIGFFSLVGQAYVFKFLWSPLMDR-YTPPFlGRRRGWLLATQLLLLVAIAAM 98
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4757708   159 STqvdrLLGNTDDRTPDVIALTVAFFlfeflAATQDIAVDGWALTMLSRENVG 211
Cdd:PRK11010  99 GF----LEPGTQLRWLAALAVVIAFC-----SASQDIVFDAWKTDVLPAEERG 142
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
95-472 2.41e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.49  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708   95 IPLILQSKNVSYTDQ--AFFSFVFWPFSLKLLWAPLVDAvyvknFGRRKsWLVPTQYILGLFMIYLSTQvdrllgntddr 172
Cdd:cd06174  19 LPALLQSFGLSASQLglLFALFSLGYALLQPLAGLLADR-----FGRRP-VLLLGLLLFALGALLFAFA----------- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  173 tPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALesADFCNKYLRFqpqpr 252
Cdd:cd06174  82 -PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL--ASSLGFGWRA----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  253 givtlsdFLFFWGTVFLITTTLVALLKKE-NEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVT 331
Cdd:cd06174 154 -------VFLIAAALALLAAILLLLVVPDpPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLL 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757708  332 GLKLVEEG-----VPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMpyrlllGLEYALLVWWTPKvehqggf 406
Cdd:cd06174 227 PLFLLDLGglsvaVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM------ALGLALLLLAPSL------- 293
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4757708  407 piyyyIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVD 472
Cdd:cd06174 294 -----LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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