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Conserved domains on  [gi|1983575813|ref|NP_001380396|]
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ankyrin repeat and MYND domain-containing protein 1 isoform 15 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-500 6.80e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 6.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 364 gEEG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEReDDN 442
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAEN-GHL 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1983575813 443 KVVKELLTQGADPNLPLTKGlGSALCVACdltyehqrnMDSKLALIDRLISHGADILK 500
Cdd:COG0666   200 EIVKLLLEAGADVNAKDNDG-KTALDLAA---------ENGNLEIVKLLLEAGADLNA 247
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
2-67 7.99e-15

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 7.99e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
zf-MYND pfam01753
MYND finger;
614-654 7.80e-09

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 51.65  E-value: 7.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1983575813 614 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 654
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.51e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575813  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
DUF2857 super family cl12747
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 247-321 6.81e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


The actual alignment was detected with superfamily member pfam11198:

Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 6.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575813 247 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 321
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-500 6.80e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 6.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 364 gEEG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEReDDN 442
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAEN-GHL 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1983575813 443 KVVKELLTQGADPNLPLTKGlGSALCVACdltyehqrnMDSKLALIDRLISHGADILK 500
Cdd:COG0666   200 EIVKLLLEAGADVNAKDNDG-KTALDLAA---------ENGNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-67 7.99e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 7.99e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-61 6.15e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 65.62  E-value: 6.15e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575813   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Cdd:PLN03185   33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
299-384 1.93e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 299 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 376
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1983575813 377 AITDVDAK 384
Cdd:pfam12796  83 KGADINVK 90
zf-MYND pfam01753
MYND finger;
614-654 7.80e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 51.65  E-value: 7.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1983575813 614 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 654
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 298-457 1.53e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.37  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 298 RTIKLLLRRGADPNLC----CVPMQVLfLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAALPGEEgVQIVEL 373
Cdd:PHA03100   87 EIVKLLLEYGANVNAPdnngITPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNS---DGENLLHLYLESNKID-LKILKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 374 LLHAITDVDAKasdeddtykpGKLDLLPSslklsnepgppqayYSTDTALPEEGGRTALHMACEREDDNkVVKELLTQGA 453
Cdd:PHA03100  162 LIDKGVDINAK----------NRVNYLLS--------------YGVPINIKDVYGFTPLHYAVYNNNPE-FVKYLLDLGA 216


                  ....
gi 1983575813 454 DPNL 457
Cdd:PHA03100  217 NPNL 220
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 428-457 1.05e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1983575813  428 GRTALHMACEReDDNKVVKELLTQGADPNL 457
Cdd:smart00248   2 GRTPLHLAAEN-GNLEVVKLLLDKGADINA 30
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 25-47 2.23e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.54  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|...
gi 1983575813  25 YHGQFYRDHCHGLGTYMWPDGSS 47
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
24-44 5.33e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.71  E-value: 5.33e-04
                           10        20
                   ....*....|....*....|.
gi 1983575813   24 SYHGQFYRDHCHGLGTYMWPD 44
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.51e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575813  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-109 2.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.62e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1983575813  77 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 109
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 247-321 6.81e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 6.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575813 247 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 321
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-500 6.80e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 6.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 364 gEEG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEReDDN 442
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAEN-GHL 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1983575813 443 KVVKELLTQGADPNLPLTKGlGSALCVACdltyehqrnMDSKLALIDRLISHGADILK 500
Cdd:COG0666   200 EIVKLLLEAGADVNAKDNDG-KTALDLAA---------ENGNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-67 7.99e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 7.99e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
287-499 3.71e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.45  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 287 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQ-VLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAalpgE 365
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNtPLHLAAANGNLEIVKLLLEAGADVNA---RDNDGETPLHLAA----E 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 366 EG-VQIVELLLHAITDVDAKASDeddtykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACEREDDNkV 444
Cdd:COG0666   196 NGhLEIVKLLLEAGADVNAKDND----------------------------------------GKTALDLAAENGNLE-I 234

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1983575813 445 VKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 499
Cdd:COG0666   235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-66 2.31e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 70.76  E-value: 2.31e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 66
Cdd:COG4642   150 YEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYA 214
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-64 5.49e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 69.60  E-value: 5.49e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 64
Cdd:COG4642   173 YEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-61 6.15e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 65.62  E-value: 6.15e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575813   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Cdd:PLN03185   33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
299-384 1.93e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 299 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 376
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1983575813 377 AITDVDAK 384
Cdd:pfam12796  83 KGADINVK 90
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-64 2.99e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.43  E-value: 2.99e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1983575813   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 64
Cdd:COG4642   126 GYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
320-457 4.04e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 320 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAAlpgEEGVQIVELLL-HAITDVDakasdeddtykpgkld 398
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAAK---NGHLEIVKLLLeHADVNLK---------------- 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1983575813 399 llpsslklsnepgppqayystdtalpeEGGRTALHMACeREDDNKVVKELLTQGADPNL 457
Cdd:pfam12796  59 ---------------------------DNGRTALHYAA-RSGHLEIVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
320-498 4.25e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 4.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 320 LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAlpgEEGVQIVELLLHAITDVDAKASDeddtykpgkldl 399
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINA---KDDGGNTLLHAAAR---NGDLEIVKLLLEAGADVNARDKD------------ 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 400 lpsslklsnepgppqayystdtalpeegGRTALHMACeREDDNKVVKELLTQGADPNLPLTKGLgSALCVACdltyehqr 479
Cdd:COG0666   120 ----------------------------GETPLHLAA-YNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAA-------- 161

                         170
                  ....*....|....*....
gi 1983575813 480 nMDSKLALIDRLISHGADI 498
Cdd:COG0666   162 -ANGNLEIVKLLLEAGADV 179
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-52 4.63e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.04  E-value: 4.63e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 52
Cdd:COG4642   219 YEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
zf-MYND pfam01753
MYND finger;
614-654 7.80e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 51.65  E-value: 7.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1983575813 614 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 654
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 298-457 1.53e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.37  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 298 RTIKLLLRRGADPNLC----CVPMQVLfLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAALPGEEgVQIVEL 373
Cdd:PHA03100   87 EIVKLLLEYGANVNAPdnngITPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNS---DGENLLHLYLESNKID-LKILKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 374 LLHAITDVDAKasdeddtykpGKLDLLPSslklsnepgppqayYSTDTALPEEGGRTALHMACEREDDNkVVKELLTQGA 453
Cdd:PHA03100  162 LIDKGVDINAK----------NRVNYLLS--------------YGVPINIKDVYGFTPLHYAVYNNNPE-FVKYLLDLGA 216


                  ....
gi 1983575813 454 DPNL 457
Cdd:PHA03100  217 NPNL 220
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 428-457 4.51e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.51  E-value: 4.51e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1983575813 428 GRTALHMACEREDDNKVVKELLTQGADPNL 457
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNA 31
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
373-498 7.68e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.49  E-value: 7.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 373 LLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACeREDDNKVVKELLTQG 452
Cdd:COG0666    32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA-RNGDLEIVKLLLEAG 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1983575813 453 ADPNLPLTKGlGSALCVACdltyehqrnMDSKLALIDRLISHGADI 498
Cdd:COG0666   111 ADVNARDKDG-ETPLHLAA---------YNGNLEIVKLLLEAGADV 146
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 2-72 9.87e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 52.14  E-value: 9.87e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK-TRLFQT 72
Cdd:PLN03185  126 YLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFYPAgSRVPAV 197
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 287-471 1.64e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 287 ALSMIERRKRWRTIKLLLRRGADPNlccVPMQV----LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAL 362
Cdd:PHA02878  171 ALHYATENKDQRLTELLLSYGANVN---IPDKTnnspLHHAVKHYNKPIVHILLENGASTDA---RDKCGNTPLHISVGY 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 363 PgeEGVQIVELLLHAITDVDAKasdeddtykpgkldllpSSLKlsnepgppqayystdtalpeegGRTALHMACEREDdn 442
Cdd:PHA02878  245 C--KDYDILKLLLEHGVDVNAK-----------------SYIL----------------------GLTALHSSIKSER-- 281

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1983575813 443 kVVKELLTQGADPNL-------PLTKGLGSALCVAC 471
Cdd:PHA02878  282 -KLKLLLEYGADINSlnsykltPLSSAVKQYLCINI 316
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 2-67 2.01e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.91  E-value: 2.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575813   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTmYMKT 67
Cdd:PLN03185   11 YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGT 75
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 288-497 2.37e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 288 LSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQlsTLTPLHIAAALpgeE 366
Cdd:PHA02875   39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPLHLATIL---K 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 367 GVQIVELLLHAITDVDAKASDEddtYKPGKLDLLPSSLKLSNEPGPPQAYystdTALPEEGGRTALHMACEREDdNKVVK 446
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTDK---FSPLHLAVMMGDIKGIELLIDHKAC----LDIEDCCGCTPLIIAMAKGD-IAICK 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1983575813 447 ELLTQGADPNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRLISHGAD 497
Cdd:PHA02875  186 MLLDSGANIDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
13-66 3.92e-05

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 46.10  E-value: 3.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1983575813  13 GYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 66
Cdd:COG4642   115 GGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYA 168
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 428-457 1.05e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1983575813  428 GRTALHMACEReDDNKVVKELLTQGADPNL 457
Cdd:smart00248   2 GRTPLHLAAEN-GNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 296-498 1.57e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 296 RWRTIKLLLRRGADPNLCCV----PMQVlFLAVKAGDVDGVRLLLEHGArtDICfPPQLSTLTPLHIAAALPGEEgVQIV 371
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKvgrtPLHV-YLSGFNINPKVIRLLLRKGA--DVN-ALDLYGMTPLAVLLKSRNAN-VELL 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575813 372 ELLLHAITDVDAKasdeDDTykpgkldllpsslklsnepgppqayystdtalpeegGRTALHMACE-REDDNKVVKELLT 450
Cdd:PHA03095  171 RLLIDAGADVYAV----DDR------------------------------------FRSLLHHHLQsFKPRARIVRELIR 210

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1983575813 451 QGADPNLPLTKGlgsalcvacdLTYEHQRNMDS--KLALIDRLISHGADI 498
Cdd:PHA03095  211 AGCDPAATDMLG----------NTPLHSMATGSscKRSLVLPLLIAGISI 250
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 25-47 2.23e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.54  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|...
gi 1983575813  25 YHGQFYRDHCHGLGTYMWPDGSS 47
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
24-44 5.33e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.71  E-value: 5.33e-04
                           10        20
                   ....*....|....*....|.
gi 1983575813   24 SYHGQFYRDHCHGLGTYMWPD 44
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.51e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575813  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_4 pfam13637
Ankyrin repeats (many copies);
317-375 1.59e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575813 317 MQVLFLAVKAGDVDGVRLLLEHGA---RTDICFppqlstLTPLHIAAAlpgEEGVQIVELLL 375
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 428-456 1.70e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*....
gi 1983575813 428 GRTALHMACeREDDNKVVKELLTQGADPN 456
Cdd:pfam13606   2 GNTPLHLAA-RNGRLEIVKLLLENGADIN 29
PHA03095 PHA03095
ankyrin-like protein; Provisional
 428-500 2.45e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 2.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575813 428 GRTALH--MACEREDDNKVVKELLTQGADPNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRLISHGADILK 500
Cdd:PHA03095   47 GKTPLHlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYN---------ATTLDVIKLLIKAGADVNA 112
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-109 2.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.62e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1983575813  77 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 109
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 6.03e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 6.03e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575813  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPL 190
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 354-384 6.62e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 6.62e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1983575813 354 TPLHIAAALPGeeGVQIVELLLHAITDVDAK 384
Cdd:pfam00023   4 TPLHLAAGRRG--NLEIVKLLLSKGADVNAR 32
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 247-321 6.81e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 6.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575813 247 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 321
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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