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Conserved domains on  [gi|966751435|ref|NP_001304965|]
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beta-synuclein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Synuclein super family cl03193
Synuclein; There are three types of synucleins in humans, these are called alpha, beta and ...
 1-107 4.43e-35

Synuclein; There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.


The actual alignment was detected with superfamily member pfam01387:

Pssm-ID: 460186 [Multi-domain]  Cd Length: 134  Bit Score: 117.34  E-value: 4.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751435    1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYV--------------VAEKTKEQASHLGGAVFS-------- 58
Cdd:pfam01387   1 MDVFMKGFSKAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVgsktkegvvqsvttVAEKTKEQASHVGGAVVTsvtavaqk 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966751435   59 ---GAGNIAAATGLVKREEFPTDLKPeeVAQEAAEEPLIEPLMEPEGESYED 107
Cdd:pfam01387  81 tveGAGNIAAATGLVKKEDLVPPAPE--EEGAEASEPMDEPESPPEGEPAEA 130
 
Name Accession Description Interval E-value
Synuclein pfam01387
Synuclein; There are three types of synucleins in humans, these are called alpha, beta and ...
 1-107 4.43e-35

Synuclein; There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.


Pssm-ID: 460186 [Multi-domain]  Cd Length: 134  Bit Score: 117.34  E-value: 4.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751435    1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYV--------------VAEKTKEQASHLGGAVFS-------- 58
Cdd:pfam01387   1 MDVFMKGFSKAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVgsktkegvvqsvttVAEKTKEQASHVGGAVVTsvtavaqk 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966751435   59 ---GAGNIAAATGLVKREEFPTDLKPeeVAQEAAEEPLIEPLMEPEGESYED 107
Cdd:pfam01387  81 tveGAGNIAAATGLVKKEDLVPPAPE--EEGAEASEPMDEPESPPEGEPAEA 130
 
Name Accession Description Interval E-value
Synuclein pfam01387
Synuclein; There are three types of synucleins in humans, these are called alpha, beta and ...
 1-107 4.43e-35

Synuclein; There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.


Pssm-ID: 460186 [Multi-domain]  Cd Length: 134  Bit Score: 117.34  E-value: 4.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751435    1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYV--------------VAEKTKEQASHLGGAVFS-------- 58
Cdd:pfam01387   1 MDVFMKGFSKAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVgsktkegvvqsvttVAEKTKEQASHVGGAVVTsvtavaqk 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966751435   59 ---GAGNIAAATGLVKREEFPTDLKPeeVAQEAAEEPLIEPLMEPEGESYED 107
Cdd:pfam01387  81 tveGAGNIAAATGLVKKEDLVPPAPE--EEGAEASEPMDEPESPPEGEPAEA 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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