NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|953953843|ref|NP_001304125|]
View 

cadherin-3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-269 5.13e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 164 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 243
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953953843 244 QATDMDGDGSTTTAVAVVEILDANDN 269
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 58-156 9.15e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 98.96  E-value: 9.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  58 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 137
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 953953843 138 ASVEDPMNISIIVTDQNDH 156
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 710-769 2.09e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 93.76  E-value: 2.09e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  710 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 769
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-381 4.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 278 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 356
Cdd:cd11304    2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 953953843 357 NEAPFVLklpTSTATIVVHVEDVNE 381
Cdd:cd11304   76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-489 3.87e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 3.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 391 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 468
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953953843 469 GSPPTTGTGTLLLTLIDVNDH 489
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-269 5.13e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 164 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 243
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953953843 244 QATDMDGDGSTTTAVAVVEILDANDN 269
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 58-156 9.15e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 98.96  E-value: 9.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  58 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 137
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 953953843 138 ASVEDPMNISIIVTDQNDH 156
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 710-769 2.09e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 93.76  E-value: 2.09e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  710 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 769
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-381 4.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 278 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 356
Cdd:cd11304    2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 953953843 357 NEAPFVLklpTSTATIVVHVEDVNE 381
Cdd:cd11304   76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
165-264 2.45e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 2.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  165 FRGSVLEGVLPGTSVMQVTATDEDDaiyTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 244
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 953953843  245 ATDMDGDGSTTTAVAVVEIL 264
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
278-377 1.75e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 1.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  278 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTITTHPesnqGILTTRKGLDFEAKNQHTLYVEVT 356
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 953953843  357 NEAPFVLklpTSTATIVVHVE 377
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-271 2.34e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 2.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   183 TATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 262
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 953953843   263 ILDANDNAP 271
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-489 3.87e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 3.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 391 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 468
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953953843 469 GSPPTTGTGTLLLTLIDVNDH 489
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
58-151 1.54e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 1.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   58 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 136
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 953953843  137 GASVEDPMNISIIVT 151
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
391-472 4.20e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 4.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  391 VVEVQEGIPTGEPVCVYTAEDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 468
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 953953843  469 GSPP 472
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 295-383 6.27e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 6.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   295 TVTDLDAPNSpaWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 374
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 953953843   375 HVEDVNEAP 383
Cdd:smart00112  72 TVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 408-491 8.14e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 8.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   408 TAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREDEQfvrnnIYEVMVLAMDNGSPPTTGTGTLLLTLID 485
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 953953843   486 VNDHGP 491
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 81-158 1.04e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.04e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843    81 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 156
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 953953843   157 KP 158
Cdd:smart00112  80 AP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-269 5.13e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 164 TFRGSVLEGVLPGTSVMQVTATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 243
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 953953843 244 QATDMDGDGSTTTAVAVVEILDANDN 269
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 58-156 9.15e-25

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 98.96  E-value: 9.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  58 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 137
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 953953843 138 ASVEDPMNISIIVTDQNDH 156
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 710-769 2.09e-23

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 93.76  E-value: 2.09e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  710 ANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 769
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-381 4.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 278 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVT 356
Cdd:cd11304    2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 953953843 357 NEAPFVLklpTSTATIVVHVEDVNE 381
Cdd:cd11304   76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
165-264 2.45e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 2.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  165 FRGSVLEGVLPGTSVMQVTATDEDDaiyTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 244
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 953953843  245 ATDMDGDGSTTTAVAVVEIL 264
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
278-377 1.75e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 1.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  278 YEAHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIMGGDDGDHFTITTHPesnqGILTTRKGLDFEAKNQHTLYVEVT 356
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 953953843  357 NEAPFVLklpTSTATIVVHVE 377
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-271 2.34e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 2.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   183 TATDEDDAIytyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 262
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 953953843   263 ILDANDNAP 271
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-489 3.87e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 3.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843 391 VVEVQEGIPTGEPVCVYTAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 468
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 953953843 469 GSPPTTGTGTLLLTLIDVNDH 489
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
58-151 1.54e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 1.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   58 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 136
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 953953843  137 GASVEDPMNISIIVT 151
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
391-472 4.20e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 4.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  391 VVEVQEGIPTGEPVCVYTAEDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTAVGTLDREdeqfvRNNIYEVMVLAMDN 468
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 953953843  469 GSPP 472
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 295-383 6.27e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 6.27e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   295 TVTDLDAPNSpaWRATYLIMGGDDGDHFTItthpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 374
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 953953843   375 HVEDVNEAP 383
Cdd:smart00112  72 TVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 408-491 8.14e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 8.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843   408 TAEDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTAVGTLDREDEQfvrnnIYEVMVLAMDNGSPPTTGTGTLLLTLID 485
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-----EYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 953953843   486 VNDHGP 491
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 81-158 1.04e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.04e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843    81 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 156
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 953953843   157 KP 158
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-156 1.18e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953953843  81 DRDT----KIFYSITGPgadsPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDH 156
Cdd:cd11304   23 DPDSgengEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH