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Conserved domains on  [gi|540344567|ref|NP_001269340|]
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protein phosphatase 1 regulatory subunit 7 isoform 4 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-229 5.66e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 108.33  E-value: 5.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  54 LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI 133
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 134 SKIENLSNLHQLQMLELGSNRiraienidtLTNLESLFLGKNKITKLQNldaltNLTVLSMQSNRLTKIEGLQNLVNLRE 213
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQR---------LPPGEKLTFDPRSLAALSN-----SLRVLNISGNNIDSLEPLAPLRNLEQ 146

                        170
                 ....*....|....*.
gi 540344567 214 LYLSHNGIEVIEGLEN 229
Cdd:cd21340  147 LDASNNQISDLEELLD 162
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-229 5.66e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 108.33  E-value: 5.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  54 LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI 133
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 134 SKIENLSNLHQLQMLELGSNRiraienidtLTNLESLFLGKNKITKLQNldaltNLTVLSMQSNRLTKIEGLQNLVNLRE 213
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQR---------LPPGEKLTFDPRSLAALSN-----SLRVLNISGNNIDSLEPLAPLRNLEQ 146

                        170
                 ....*....|....*.
gi 540344567 214 LYLSHNGIEVIEGLEN 229
Cdd:cd21340  147 LDASNNQISDLEELLD 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-229 8.13e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 8.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  52 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 130
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 131 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 206
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180
                 ....*....|....*....|...
gi 540344567 207 NLVNLRELYLSHNGIEVIEGLEN 229
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGN 248
LRR_9 pfam14580
Leucine-rich repeat;
80-201 7.97e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.23  E-value: 7.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567   80 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 157
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 540344567  158 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 201
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-222 5.85e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  75 ELQSLRELDL-YDNQIKKI-ENLEALTELEILDISFNLLRNI--EGVDKLTRLKKLFLVNNKIS-KI-ENLSNLHQLQML 148
Cdd:PLN00113 234 GLTSLNHLDLvYNNLTGPIpSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSgEIpELVIQLQNLEIL 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 149 ELGSNRI--RAIENIDTLTNLESLFLGKNKITK--LQNLDALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGIE 222
Cdd:PLN00113 314 HLFSNNFtgKIPVALTSLPRLQVLQLWSNKFSGeiPKNLGKHNNLTVLDLSTNNLTgEIpEGLCSSGNLFKLILFSNSLE 393
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-229 5.66e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 108.33  E-value: 5.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  54 LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI 133
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 134 SKIENLSNLHQLQMLELGSNRiraienidtLTNLESLFLGKNKITKLQNldaltNLTVLSMQSNRLTKIEGLQNLVNLRE 213
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQR---------LPPGEKLTFDPRSLAALSN-----SLRVLNISGNNIDSLEPLAPLRNLEQ 146

                        170
                 ....*....|....*.
gi 540344567 214 LYLSHNGIEVIEGLEN 229
Cdd:cd21340  147 LDASNNQISDLEELLD 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-229 8.13e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 8.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  52 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 130
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 131 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 206
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180
                 ....*....|....*....|...
gi 540344567 207 NLVNLRELYLSHNGIEVIEGLEN 229
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGN 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-202 5.28e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 5.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  44 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 123
Cdd:cd21340   35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 124 kklflvnnkiskIENLSNlhQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD----ALTNLTVLSMQSNRL 199
Cdd:cd21340  115 ------------LAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWPSLRELDLTGNPV 180


                 ...
gi 540344567 200 TKI 202
Cdd:cd21340  181 CKK 183
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-155 1.11e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  40 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 110
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 540344567 111 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 155
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-224 2.41e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  29 INLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISF 108
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 109 NLLRNIEGVDKLTRLKKLFLVNnkISKIENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDAL 186
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELD--LSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNL 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 540344567 187 TNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIEVI 224
Cdd:COG4886  159 TNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDL 197
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-233 1.50e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  54 LKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNK 132
Cdd:COG4886  204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 133 IS--KIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVN 210
Cdd:COG4886  284 LTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170       180
                 ....*....|....*....|...
gi 540344567 211 LRELYLSHNGIEVIEGLENNVQD 233
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLL 386
LRR_9 pfam14580
Leucine-rich repeat;
80-201 7.97e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.23  E-value: 7.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567   80 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 157
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 540344567  158 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 201
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 26-230 6.02e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 6.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  26 METINLDRDAEDVDLNHYRIGKiEGFEVLKK-------VKTLCLRQNLI------KCIENLEELQSLRELDLYDNQIKK- 91
Cdd:COG5238  173 MAKALQNNSVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDLSNNQIGDe 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  92 -----IENLEALTELEILDISFNLLRNiEGVdkltrlkklflvnnkISKIENLSNLHQLQMLELGSNRIRA------IEN 160
Cdd:COG5238  252 gvialAEALKNNTTVETLYLSGNQIGA-EGA---------------IALAKALQGNTTLTSLDLSVNRIGDegaialAEG 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 161 IDTLTNLESLFLGKNKITK------LQNLDALTNLTVLSMQSNRLTK------IEGLQNLVNLRELYLSHNGI------E 222
Cdd:COG5238  316 LQGNKTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIgkqgaeA 395


                 ....*...
gi 540344567 223 VIEGLENN 230
Cdd:COG5238  396 LIDALQTN 403
LRR_9 pfam14580
Leucine-rich repeat;
122-217 6.80e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.14  E-value: 6.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  122 RLKKLFLVNNKISKIENL-SNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL-QNLD-ALTNLTVLSMQSNR 198
Cdd:pfam14580  20 RERELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNN 99

                          90       100
                  ....*....|....*....|
gi 540344567  199 LTKIEGLQNLVNLREL-YLS 217
Cdd:pfam14580 100 LQELGDLDPLASLKKLtFLS 119
LRR_8 pfam13855
Leucine rich repeat;
165-221 4.71e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 4.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344567  165 TNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-217 1.52e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  36 EDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIK--KIENLEALTELEILDISFNLLRN 113
Cdd:COG4886  231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 114 IEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLS 193
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                        170       180
                 ....*....|....*....|....
gi 540344567 194 MQSNRLTKIEGLQNLVNLRELYLS 217
Cdd:COG4886  391 LLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
99-155 2.57e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 2.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344567   99 TELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRI 155
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
148-228 2.69e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.52  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  148 LELGSNRIRAIENID-TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI-EGL-QNLVNLRELYLSHNGIEVI 224
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQEL 103


                  ....
gi 540344567  225 EGLE 228
Cdd:pfam14580 104 GDLD 107
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 187-219 2.93e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 2.93e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 540344567  187 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 219
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-119 5.06e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 5.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344567   77 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 119
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 165-207 5.26e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 5.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344567  165 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSN-RLTKIEGLQN 207
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-222 5.85e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567  75 ELQSLRELDL-YDNQIKKI-ENLEALTELEILDISFNLLRNI--EGVDKLTRLKKLFLVNNKIS-KI-ENLSNLHQLQML 148
Cdd:PLN00113 234 GLTSLNHLDLvYNNLTGPIpSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSgEIpELVIQLQNLEIL 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567 149 ELGSNRI--RAIENIDTLTNLESLFLGKNKITK--LQNLDALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGIE 222
Cdd:PLN00113 314 HLFSNNFtgKIPVALTSLPRLQVLQLWSNKFSGeiPKNLGKHNNLTVLDLSTNNLTgEIpEGLCSSGNLFKLILFSNSLE 393
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 186-232 7.51e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 7.51e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 540344567 186 LTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNVQ 232
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTN 47
LRR_8 pfam13855
Leucine rich repeat;
121-177 8.52e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 8.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 540344567  121 TRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 177
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
38-113 1.05e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 1.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 540344567   38 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI-ENLEE-LQSLRELDLYDNQIKKIENLEALTELEILDiSFNLLRN 113
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDLDPLASLKKLT-FLSLLRN 123
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-166 1.63e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 1.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 540344567  121 TRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIraIENIDTLTN 166
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-141 3.12e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 3.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 540344567   99 TELEILDISFNLLRNIEGVDKLTRLKKLFLV-NNKISKIENLSN 141
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
78-133 5.00e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 5.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 540344567   78 SLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKI 133
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 55-96 7.68e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.37  E-value: 7.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 540344567   55 KKVKTLCLRQNLIKCIENLEELQSLRELDLYDN-QIKKIENLE 96
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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