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Conserved domains on  [gi|328927010|ref|NP_001192230|]
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pikachurin isoform 5 precursor [Homo sapiens]

Protein Classification

FN3 and LamG domain-containing protein( domain architecture ID 10812543)

protein containing domains FN3, LamG, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 868-993 8.52e-35

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 129.08  E-value: 8.52e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   868 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRVKAVRDGQSGKITVDDYGA 946
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 328927010   947 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 993
Cdd:pfam02210   77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 391-541 5.90e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.53  E-value: 5.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  391 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 470
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 328927010  471 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVN 541
Cdd:cd00110    82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 618-765 7.34e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.76  E-value: 7.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  618 SYAATPWPlepQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 697
Cdd:cd00110     8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 328927010  698 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGVLKPFSGSIQKIILN 765
Cdd:cd00110    85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 36-133 3.91e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.23  E-value: 3.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQlhsvplSRDIPTTEEVIGDLKPGTEYRVSIA 115
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE------VTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*...
gi 328927010  116 AYSQAGKGRLSSPRHVTT 133
Cdd:cd00063    76 AVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 142-234 9.87e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 9.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  142 PAAPQQPHVIVVSDSEVALSWKPGASEGSaPIQYYSVEFiRPDFDKKWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMN 220
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEY-REKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....
gi 328927010  221 SHGPSPRSWPSDII 234
Cdd:cd00063    79 GGGESPPSESVTVT 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-820 1.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.48e-06
                          10        20
                  ....*....|....*....|....*....
gi 328927010  792 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 820
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 560-602 2.74e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 328927010  560 DVGECSSGicdeASCIHGGTCTAIKaDSYICLCPLGFKGRHCE 602
Cdd:cd00054     1 DIDECASG----NPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 868-993 8.52e-35

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 129.08  E-value: 8.52e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   868 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRVKAVRDGQSGKITVDDYGA 946
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 328927010   947 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 993
Cdd:pfam02210   77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 391-541 5.90e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.53  E-value: 5.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  391 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 470
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 328927010  471 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVN 541
Cdd:cd00110    82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 840-989 2.12e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 125.99  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  840 FIGRSYLTYDNPDILKRvsgsRSNVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS 919
Cdd:cd00110     4 FSGSSYVRLPTLPAPRT----RLSISFSFRTTSPNGLLLYAGS---QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  920 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCIS 989
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIR 146
LamG smart00282
Laminin G domain;
863-993 2.49e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 122.06  E-value: 2.49e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    863 NVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMV-NGSFNDGRWHRVKAVRDGQSGKITV 941
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGS---KGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 328927010    942 DDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 993
Cdd:smart00282   78 DGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 618-765 7.34e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.76  E-value: 7.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  618 SYAATPWPlepQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 697
Cdd:cd00110     8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 328927010  698 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGVLKPFSGSIQKIILN 765
Cdd:cd00110    85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
636-767 6.35e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.21  E-value: 6.35e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    636 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAKNGILQVDKQ 714
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 328927010    715 KIVEGMAEGGFTQIKCNTDIFIGGVPNyDDVKKNSGVLKPFSGSIQKIILNDR 767
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
415-546 2.47e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 113.57  E-value: 2.47e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   415 FRAEAEDGLLLYCGENEHGrgDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVT 494
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 328927010   495 GQSQ-GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRID 546
Cdd:pfam00054   79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
410-543 4.19e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.82  E-value: 4.19e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    410 QITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSE-TKIKLGGWHTVMLYRDGLNGLLQLN 488
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSK--GGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 328927010    489 NGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVNGR 543
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 641-767 5.70e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.51  E-value: 5.70e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   641 FRPDSGDGVLLYSYDtGSKDFLSINLAGGHVEFRFDCGSGTGVLRS-EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEG 719
Cdd:pfam02210    1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 328927010   720 MAEGGFTQIKCNTDIFIGGVPnYDDVKKNSGVLKPFSGSIQKIILNDR 767
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRVNGE 126
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 36-133 3.91e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.23  E-value: 3.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQlhsvplSRDIPTTEEVIGDLKPGTEYRVSIA 115
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE------VTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*...
gi 328927010  116 AYSQAGKGRLSSPRHVTT 133
Cdd:cd00063    76 AVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 142-234 9.87e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 9.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  142 PAAPQQPHVIVVSDSEVALSWKPGASEGSaPIQYYSVEFiRPDFDKKWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMN 220
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEY-REKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....
gi 328927010  221 SHGPSPRSWPSDII 234
Cdd:cd00063    79 GGGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 142-225 1.29e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 72.65  E-value: 1.29e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    142 PAAPQQPHVIVVSDSEVALSWKPGASEGS-APIQYYSVEfiRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMN 220
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVE--YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 328927010    221 SHGPS 225
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
144-228 4.00e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.29  E-value: 4.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   144 APQQPHVIVVSDSEVALSWKPgASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTP-PPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 328927010   224 PSPRS 228
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
36-126 2.67e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 2.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGAdkslQEQLHSVPLSRDipTTEEVIGDLKPGTEYRVSIA 115
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 328927010   116 AYSQAGKGRLS 126
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
37-261 1.58e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   37 PPLDIKLGALNCTAFSIQWkmPRHPGSPILGYTVFYSEVGADKSlqEQLHSVPlsrdipTTEEVIGDLKPGTEYRVSIAA 116
Cdd:COG3401   235 APTGLTATADTPGSVTLSW--DPVTESDATGYRVYRSNSGDGPF--TKVATVT------TTSYTDTGLTNGTTYYYRVTA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  117 YSQAG-KGRLSSPRHVTTlsqdSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGsapIQYYSVEfIRPDFDKKWTSIHER 195
Cdd:COG3401   305 VDAAGnESAPSNVVSVTT----DLTPPAAPSGLTATAVGSSSITLSWTASSDAD---VTGYNVY-RSTSGGGTYTKIAET 376

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328927010  196 IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSprSWPSDIIRTLcPEEAGSGRYGPRYITDMGAGEDD 261
Cdd:COG3401   377 VTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSAT-TASAASGESLTASVDAVPLTDVA 439
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
96-234 3.46e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 3.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQdsclPPAAPQQPHVIVVSDSEVALSWKPGASEGsapIQY 175
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTT----PPSAPTGLTATADTPGSVTLSWDPVTESD---ATG 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 328927010  176 YSVEfIRPDFDKKWTSIHErIQMDSMVIKGLDPDTNYQFAVRAMNSHGpsPRSWPSDII 234
Cdd:COG3401   264 YRVY-RSNSGDGPFTKVAT-VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAPSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 36-123 1.06e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.06e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010     36 GPPLDIKLGALNCTAFSIQWKMPRHPG--SPILGYTVFYSEVGADkslqeqlhSVPLSRDIPTTEEVIGDLKPGTEYRVS 113
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSE--------WKEVNVTPSSTSYTLTGLKPGTEYEFR 73

                            90
                    ....*....|
gi 328927010    114 IAAYSQAGKG 123
Cdd:smart00060   74 VRAVNGAGEG 83
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-820 1.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.48e-06
                          10        20
                  ....*....|....*....|....*....
gi 328927010  792 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 820
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 560-602 2.74e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 328927010  560 DVGECSSGicdeASCIHGGTCTAIKaDSYICLCPLGFKGRHCE 602
Cdd:cd00054     1 DIDECASG----NPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 788-818 1.86e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 1.86e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 328927010   788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLH 818
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-820 4.80e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.80e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 328927010    792 PCAHGGSCRPRKEGYDCDCPLGFE-GLHCQ 820
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
560-602 3.20e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.20e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 328927010    560 DVGECSSGicdeASCIHGGTCTAiKADSYICLCPLGFK-GRHCE 602
Cdd:smart00179    1 DIDECASG----NPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 569-600 4.17e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 328927010   569 CDEASCIHGGTCTAIKaDSYICLCPLGFKGRH 600
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 868-993 8.52e-35

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 129.08  E-value: 8.52e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   868 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRVKAVRDGQSGKITVDDYGA 946
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 328927010   947 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 993
Cdd:pfam02210   77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 391-541 5.90e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.53  E-value: 5.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  391 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 470
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 328927010  471 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVN 541
Cdd:cd00110    82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 840-989 2.12e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 125.99  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  840 FIGRSYLTYDNPDILKRvsgsRSNVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS 919
Cdd:cd00110     4 FSGSSYVRLPTLPAPRT----RLSISFSFRTTSPNGLLLYAGS---QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  920 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCIS 989
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIR 146
LamG smart00282
Laminin G domain;
863-993 2.49e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 122.06  E-value: 2.49e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    863 NVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMV-NGSFNDGRWHRVKAVRDGQSGKITV 941
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGS---KGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 328927010    942 DDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 993
Cdd:smart00282   78 DGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 618-765 7.34e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.76  E-value: 7.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  618 SYAATPWPlepQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 697
Cdd:cd00110     8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 328927010  698 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGVLKPFSGSIQKIILN 765
Cdd:cd00110    85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
636-767 6.35e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.21  E-value: 6.35e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    636 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAKNGILQVDKQ 714
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 328927010    715 KIVEGMAEGGFTQIKCNTDIFIGGVPNyDDVKKNSGVLKPFSGSIQKIILNDR 767
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
415-546 2.47e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 113.57  E-value: 2.47e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   415 FRAEAEDGLLLYCGENEHGrgDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVT 494
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 328927010   495 GQSQ-GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRID 546
Cdd:pfam00054   79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
410-543 4.19e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.82  E-value: 4.19e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    410 QITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSE-TKIKLGGWHTVMLYRDGLNGLLQLN 488
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSK--GGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 328927010    489 NGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVNGR 543
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 641-767 5.70e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.51  E-value: 5.70e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   641 FRPDSGDGVLLYSYDtGSKDFLSINLAGGHVEFRFDCGSGTGVLRS-EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEG 719
Cdd:pfam02210    1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 328927010   720 MAEGGFTQIKCNTDIFIGGVPnYDDVKKNSGVLKPFSGSIQKIILNDR 767
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
868-988 5.63e-27

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 107.02  E-value: 5.63e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   868 FKTTAKDGLLLWRGdspMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGAR 947
Cdd:pfam00054    1 FRTTEPSGLLLYNG---TQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 328927010   948 TGKSP-GMMRQLNINGALYVGGMKEIALHTNRQ-YMRGLVGCI 988
Cdd:pfam00054   78 TGESPlGATTDLDVDGPLYVGGLPSLGVKKRRLaISPSFDGCI 120
Laminin_G_1 pfam00054
Laminin G domain;
641-770 2.57e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 102.01  E-value: 2.57e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   641 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGM 720
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 328927010   721 AEGGFTQ-IKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIH 770
Cdd:pfam00054   81 SPLGATTdLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 415-543 1.69e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 96.72  E-value: 1.69e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   415 FRAEAEDGLLLYCGEnehGRGDFMSLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPV 493
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---GGSDFLALELVNGRLVLRYDLGSGpESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 328927010   494 TGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVNGR 543
Cdd:pfam02210   78 SSLPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 36-133 3.91e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.23  E-value: 3.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQlhsvplSRDIPTTEEVIGDLKPGTEYRVSIA 115
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE------VTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*...
gi 328927010  116 AYSQAGKGRLSSPRHVTT 133
Cdd:cd00063    76 AVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 142-234 9.87e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.08  E-value: 9.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  142 PAAPQQPHVIVVSDSEVALSWKPGASEGSaPIQYYSVEFiRPDFDKKWTSIH-ERIQMDSMVIKGLDPDTNYQFAVRAMN 220
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEY-REKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....
gi 328927010  221 SHGPSPRSWPSDII 234
Cdd:cd00063    79 GGGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 142-225 1.29e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 72.65  E-value: 1.29e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    142 PAAPQQPHVIVVSDSEVALSWKPGASEGS-APIQYYSVEfiRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMN 220
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVE--YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 328927010    221 SHGPS 225
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
144-228 4.00e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.29  E-value: 4.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   144 APQQPHVIVVSDSEVALSWKPgASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHG 223
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTP-PPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 328927010   224 PSPRS 228
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
36-126 2.67e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 2.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    36 GPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGAdkslQEQLHSVPLSRDipTTEEVIGDLKPGTEYRVSIA 115
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 328927010   116 AYSQAGKGRLS 126
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
37-261 1.58e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   37 PPLDIKLGALNCTAFSIQWkmPRHPGSPILGYTVFYSEVGADKSlqEQLHSVPlsrdipTTEEVIGDLKPGTEYRVSIAA 116
Cdd:COG3401   235 APTGLTATADTPGSVTLSW--DPVTESDATGYRVYRSNSGDGPF--TKVATVT------TTSYTDTGLTNGTTYYYRVTA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010  117 YSQAG-KGRLSSPRHVTTlsqdSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGsapIQYYSVEfIRPDFDKKWTSIHER 195
Cdd:COG3401   305 VDAAGnESAPSNVVSVTT----DLTPPAAPSGLTATAVGSSSITLSWTASSDAD---VTGYNVY-RSTSGGGTYTKIAET 376

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 328927010  196 IQMDSMVIKGLDPDTNYQFAVRAMNSHGPSprSWPSDIIRTLcPEEAGSGRYGPRYITDMGAGEDD 261
Cdd:COG3401   377 VTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSAT-TASAASGESLTASVDAVPLTDVA 439
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
96-234 3.46e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 3.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQdsclPPAAPQQPHVIVVSDSEVALSWKPGASEGsapIQY 175
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTT----PPSAPTGLTATADTPGSVTLSWDPVTESD---ATG 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 328927010  176 YSVEfIRPDFDKKWTSIHErIQMDSMVIKGLDPDTNYQFAVRAMNSHGpsPRSWPSDII 234
Cdd:COG3401   264 YRVY-RSNSGDGPFTKVAT-VTTTSYTDTGLTNGTTYYYRVTAVDAAG--NESAPSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 36-123 1.06e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 1.06e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010     36 GPPLDIKLGALNCTAFSIQWKMPRHPG--SPILGYTVFYSEVGADkslqeqlhSVPLSRDIPTTEEVIGDLKPGTEYRVS 113
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSE--------WKEVNVTPSSTSYTLTGLKPGTEYEFR 73

                            90
                    ....*....|
gi 328927010    114 IAAYSQAGKG 123
Cdd:smart00060   74 VRAVNGAGEG 83
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-820 1.48e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.48e-06
                          10        20
                  ....*....|....*....|....*....
gi 328927010  792 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 820
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 560-602 2.74e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 328927010  560 DVGECSSGicdeASCIHGGTCTAIKaDSYICLCPLGFKGRHCE 602
Cdd:cd00054     1 DIDECASG----NPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 788-818 1.86e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 1.86e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 328927010   788 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLH 818
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 145-221 4.23e-05

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 43.17  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010   145 PQQPHVIVVSDS-EVALSWKPGASEGSAPIQY-------------YSVEFirPDFDKKWTSIHeriqmdSMVIKGLDPDT 210
Cdd:pfam16656    1 PEQVHLSLTGDStSMTVSWVTPSAVTSPVVQYgtsssaltstataTSSTY--TTGDGGTGYIH------RATLTGLEPGT 72

                           90
                   ....*....|.
gi 328927010   211 NYQFAVRAMNS 221
Cdd:pfam16656   73 TYYYRVGDDNG 83
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-820 4.80e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.80e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 328927010    792 PCAHGGSCRPRKEGYDCDCPLGFE-GLHCQ 820
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 792-820 7.56e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.92  E-value: 7.56e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 328927010  792 PCAHGGSCRPRKEGYDCDCPLGFEG-LHCQ 820
Cdd:cd00053     7 PCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
560-602 3.20e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.20e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 328927010    560 DVGECSSGicdeASCIHGGTCTAiKADSYICLCPLGFK-GRHCE 602
Cdd:smart00179    1 DIDECASG----NPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 569-600 4.17e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 328927010   569 CDEASCIHGGTCTAIKaDSYICLCPLGFKGRH 600
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 49-133 7.26e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 37.00  E-value: 7.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 328927010    49 TAFSIQWKMPRHPGSPIlgytVFYSEVGADKSLQEQLHSVPLSRDIPTTEE----VIGDLKPGTEYRVSIAaysqAGKGR 124
Cdd:pfam16656   13 TSMTVSWVTPSAVTSPV----VQYGTSSSALTSTATATSSTYTTGDGGTGYihraTLTGLEPGTTYYYRVG----DDNGG 84


                   ....*....
gi 328927010   125 LSSPRHVTT 133
Cdd:pfam16656   85 WSEVYSFTT 93
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 574-602 7.56e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 7.56e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 328927010  574 CIHGGTCTAiKADSYICLCPLGFKG-RHCE 602
Cdd:cd00053     8 CSNGGTCVN-TPGSYRCVCPPGYTGdRSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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