|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
768-993 |
5.17e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.46 E-value: 5.17e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 768 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 847
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 848 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 927
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1677502311 928 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 993
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1445-1577 |
6.64e-58 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 195.97 E-value: 6.64e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1445 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1523
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1677502311 1524 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1577
Cdd:cd11559 81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
769-996 |
1.79e-53 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 186.03 E-value: 1.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 769 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 848
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 849 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 928
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1677502311 929 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 996
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1249-1361 |
4.53e-37 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 135.48 E-value: 4.53e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1249 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1328
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1677502311 1329 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1361
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1249-1361 |
4.57e-36 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 132.75 E-value: 4.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1249 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1328
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1677502311 1329 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1361
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1516-1599 |
1.28e-26 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 104.68 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1516 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1595
Cdd:smart00515 2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79
|
....
gi 1677502311 1596 LREA 1599
Cdd:smart00515 80 LQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1528-1604 |
1.02e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 96.06 E-value: 1.02e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677502311 1528 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1604
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
21-583 |
5.23e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 21 PAFPPGQTAPVVFSTPQATQMNTPS-----------QPRQGGF-RSLQHFYPSRA---QPPSSAASRVQSAAPARPGPAA 85
Cdd:PHA03247 2494 AAPDPGGGGPPDPDAPPAPSRLAPAilpdepvgepvHPRMLTWiRGLEELASDDAgdpPPPLPPAAPPAAPDRSVPPPRP 2573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 86 HVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGA-SPTEFGTYAGAYYPAQgvqqfptg 164
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPHPPPT-------- 2645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 165 vAPTPVLMNQPPqiAPKRERKTIRIRDPnqggkditeeimsgARTASTPTPPQtgGGLEPQANGETPQVAVIVRPDDRSQ 244
Cdd:PHA03247 2646 -VPPPERPRDDP--APGRVSRPRRARRL--------------GRAAQASSPPQ--RPRRRAARPTVGSLTSLADPPPPPP 2706
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 245 GAIIADRPGLPGPEHSPSESQPSspsptpspspvlepGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEP 324
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAAR--------------QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG---PPAP 2769
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 325 TPLAEPILEVEVTLSKPVPESEFSSSP-LQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAP 403
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESREsLPSPWDPADPPAAVLAPAAALP-----PAASPAGPLPPPTSAQPTAPPPPPG 2844
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 404 TAQPEELLNGAPSPPAvDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAES 483
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGG-DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 484 EKGGEELLPPESTPIP-ANLSQNLEAAAATQVAVSVPKRRrkikelnkkeavgdlLDAFKEANPAVPEVENQPPAGSNPG 562
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPW---------------LGALVPGRVAVPRFRVPQPAPSREA 2988
|
570 580
....*....|....*....|.
gi 1677502311 563 PESEGSGVPPRPEEADETWDS 583
Cdd:PHA03247 2989 PASSTPPLTGHSLSRVSSWAS 3009
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
335-520 |
1.54e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 46.45 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 335 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 409
Cdd:pfam05109 418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 410 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 472
Cdd:pfam05109 497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1677502311 473 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 520
Cdd:pfam05109 573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
|
|
| COG5373 |
COG5373 |
Uncharacterized membrane protein [Function unknown]; |
375-457 |
1.93e-04 |
|
Uncharacterized membrane protein [Function unknown];
Pssm-ID: 444140 [Multi-domain] Cd Length: 854 Bit Score: 46.15 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 375 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 454
Cdd:COG5373 31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106
|
...
gi 1677502311 455 ATS 457
Cdd:COG5373 107 FEE 109
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
768-993 |
5.17e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.46 E-value: 5.17e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 768 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 847
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 848 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 927
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1677502311 928 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 993
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1445-1577 |
6.64e-58 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 195.97 E-value: 6.64e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1445 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1523
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1677502311 1524 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1577
Cdd:cd11559 81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
769-996 |
1.79e-53 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 186.03 E-value: 1.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 769 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 848
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 849 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 928
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1677502311 929 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 996
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1249-1361 |
4.53e-37 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 135.48 E-value: 4.53e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1249 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1328
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1677502311 1329 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1361
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1249-1361 |
4.57e-36 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 132.75 E-value: 4.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1249 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1328
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1677502311 1329 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1361
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1516-1599 |
1.28e-26 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 104.68 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1516 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1595
Cdd:smart00515 2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79
|
....
gi 1677502311 1596 LREA 1599
Cdd:smart00515 80 LQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1528-1604 |
1.02e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 96.06 E-value: 1.02e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677502311 1528 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1604
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| W2 |
cd11473 |
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ... |
1446-1571 |
2.26e-23 |
|
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211395 Cd Length: 135 Bit Score: 97.16 E-value: 2.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1446 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1520
Cdd:cd11473 2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1677502311 1521 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1571
Cdd:cd11473 82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
|
|
| W2_eIF2B_epsilon |
cd11558 |
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ... |
1515-1604 |
2.83e-15 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211396 Cd Length: 169 Bit Score: 75.37 E-value: 2.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1515 AKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK 1594
Cdd:cd11558 80 GPLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIE 159
|
90
....*....|
gi 1677502311 1595 WLREAEEESD 1604
Cdd:cd11558 160 WLEEAEEESD 169
|
|
| W2_eIF5 |
cd11561 |
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ... |
1446-1604 |
2.23e-09 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211399 Cd Length: 157 Bit Score: 58.01 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1446 PSEELNR--QLEKLLKEGSSNQRVFDwIEANLSEQQIVSNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYL 1522
Cdd:cd11561 1 EEEEDERvdELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1523 CDEQKELQALYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWL 1596
Cdd:cd11561 73 TDEKAQKALLGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWL 149
|
....*...
gi 1677502311 1597 REAEEESD 1604
Cdd:cd11561 150 EEAEEEEE 157
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1442-1602 |
3.50e-08 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 55.30 E-value: 3.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1442 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1510
Cdd:cd11560 29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 1511 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1587
Cdd:cd11560 105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179
|
170
....*....|....*
gi 1677502311 1588 SVTAFFKWLREAEEE 1602
Cdd:cd11560 180 QMEPFVEWLQEAEEE 194
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
21-583 |
5.23e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 21 PAFPPGQTAPVVFSTPQATQMNTPS-----------QPRQGGF-RSLQHFYPSRA---QPPSSAASRVQSAAPARPGPAA 85
Cdd:PHA03247 2494 AAPDPGGGGPPDPDAPPAPSRLAPAilpdepvgepvHPRMLTWiRGLEELASDDAgdpPPPLPPAAPPAAPDRSVPPPRP 2573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 86 HVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGA-SPTEFGTYAGAYYPAQgvqqfptg 164
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPHPPPT-------- 2645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 165 vAPTPVLMNQPPqiAPKRERKTIRIRDPnqggkditeeimsgARTASTPTPPQtgGGLEPQANGETPQVAVIVRPDDRSQ 244
Cdd:PHA03247 2646 -VPPPERPRDDP--APGRVSRPRRARRL--------------GRAAQASSPPQ--RPRRRAARPTVGSLTSLADPPPPPP 2706
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 245 GAIIADRPGLPGPEHSPSESQPSspsptpspspvlepGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEP 324
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAAR--------------QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG---PPAP 2769
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 325 TPLAEPILEVEVTLSKPVPESEFSSSP-LQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAP 403
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESREsLPSPWDPADPPAAVLAPAAALP-----PAASPAGPLPPPTSAQPTAPPPPPG 2844
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 404 TAQPEELLNGAPSPPAvDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAES 483
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGG-DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 484 EKGGEELLPPESTPIP-ANLSQNLEAAAATQVAVSVPKRRrkikelnkkeavgdlLDAFKEANPAVPEVENQPPAGSNPG 562
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPW---------------LGALVPGRVAVPRFRVPQPAPSREA 2988
|
570 580
....*....|....*....|.
gi 1677502311 563 PESEGSGVPPRPEEADETWDS 583
Cdd:PHA03247 2989 PASSTPPLTGHSLSRVSSWAS 3009
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
123-579 |
5.55e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 5.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 123 PTQQYPVQPGAPgFYPGASPTEFGTyagayyPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDpnqggkdiTEE 202
Cdd:PHA03247 2478 PVYRRPAEARFP-FAAGAAPDPGGG------GPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRG--------LEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 203 IMSGarTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIiADRPGLPgPEHSPSESQPSSPSPTPSPspvLEPG 282
Cdd:PHA03247 2543 LASD--DAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRAPVDDRGDPRGP---APPS 2615
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 283 SEPnlavlsiPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEvEVTLSKPV---PESEFSSSPLQAPTPLA 359
Cdd:PHA03247 2616 PLP-------PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPG-RVSRPRRArrlGRAAQASSPPQRPRRRA 2687
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 360 shtveIHEPNGMVPSEDLEPEVESSPELAPPPACPSeSPVPIAPTAQ-----PEELLNGAPSPPAVDLSPVSEPEEQAKE 434
Cdd:PHA03247 2688 -----ARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAArqaspALPAAPAPPAVPAGPATPGGPARPARPP 2761
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 435 VTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI-----PANLSQNLEAA 509
Cdd:PHA03247 2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplppPTSAQPTAPPP 2841
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 510 AATQVAVSVP-----------KRRRKIKELNKKEAVGDLLDAFKEANPAV---PEVENQPPAGSNPGPESEgSGVPPRPE 575
Cdd:PHA03247 2842 PPGPPPPSLPlggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVsrsTESFALPPDQPERPPQPQ-APPPPQPQ 2920
|
....
gi 1677502311 576 EADE 579
Cdd:PHA03247 2921 PQPP 2924
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
412-580 |
1.20e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 50.26 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 412 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 491
Cdd:PRK12323 369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 492 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 567
Cdd:PRK12323 449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522
|
170
....*....|...
gi 1677502311 568 SGVPPRPEEADET 580
Cdd:PRK12323 523 AESIPDPATADPD 535
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
307-460 |
2.42e-05 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 49.27 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 307 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEFSSSPLQAPT-PLASHTVEIHEPNGMVPSEDLEPEVESS 384
Cdd:PRK10811 844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVVSAPVVEAVAEvVEEPVVVAEPQPEEVVVVETTHPEVIAA 922
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 385 PELAPPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS 457
Cdd:PRK10811 923 PVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVA 1002
|
...
gi 1677502311 458 PAQ 460
Cdd:PRK10811 1003 PAQ 1005
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
325-571 |
9.24e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 47.15 E-value: 9.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 325 TPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPT 404
Cdd:PRK07003 416 AAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPR 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 405 AQPEELLNGAPSPPAVDLSPVSEPEEqakevTASMAPPTiPSATPAtAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 484
Cdd:PRK07003 496 AAAPSAATPAAVPDARAPAAASREDA-----PAAAAPPA-PEARPP-TPAAAAPAARAGGAAAALDVLRNAGMRVSSDRG 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 485 KGgeellpPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPE 564
Cdd:PRK07003 569 AR------AAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSA 642
|
....*..
gi 1677502311 565 SEGSGVP 571
Cdd:PRK07003 643 DEGFGGP 649
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
335-520 |
1.54e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 46.45 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 335 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 409
Cdd:pfam05109 418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 410 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 472
Cdd:pfam05109 497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1677502311 473 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 520
Cdd:pfam05109 573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
191-452 |
1.67e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 46.62 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 191 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 252
Cdd:PRK10263 308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 253 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlsPEPTPLAE 329
Cdd:PRK10263 384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 330 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELAP---PPACPSESPVP 400
Cdd:PRK10263 460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAAwyqPIPEPVKEPEP 539
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1677502311 401 IAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATA 452
Cdd:PRK10263 540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANS 591
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
147-460 |
1.92e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 46.11 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 147 TYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 224
Cdd:pfam17823 116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 225 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMTTIQMSV 304
Cdd:pfam17823 195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 305 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPL-----QAPTPLASHTVEihepngmvpsedlEP 379
Cdd:pfam17823 271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAapmgaQAQGPIIQVSTD-------------QP 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 380 EVESSPELAPPPACPSESPvpiaptaqpeellNGAPSPPAVDLSPVSEPEEQAKEVTASMAP-------PTIPSATPATA 452
Cdd:pfam17823 316 VHNTAGEPTPSPSNTTLEP-------------NTPKSVASTNLAVVTTTKAQAKEPSASPVPvlhtsmiPEVEATSPTTQ 382
|
....*...
gi 1677502311 453 PSATSPAQ 460
Cdd:pfam17823 383 PSPLLPTQ 390
|
|
| COG5373 |
COG5373 |
Uncharacterized membrane protein [Function unknown]; |
375-457 |
1.93e-04 |
|
Uncharacterized membrane protein [Function unknown];
Pssm-ID: 444140 [Multi-domain] Cd Length: 854 Bit Score: 46.15 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 375 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 454
Cdd:COG5373 31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106
|
...
gi 1677502311 455 ATS 457
Cdd:COG5373 107 FEE 109
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
283-459 |
3.77e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.25 E-value: 3.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 283 SEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHT 362
Cdd:PRK12323 341 SELALAPDEYAGFTMTLLRMLAFRPGQSGGGAGPA---TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 363 VEIHEPNGMVPSEDLEPEVESSPELAP-----PPACPSESPVPIAPTAQPeellnGAPSPPAVDLSPVSEPEEQAKEVTA 437
Cdd:PRK12323 418 AVAAAPARRSPAPEALAAARQASARGPggapaPAPAPAAAPAAAARPAAA-----GPRPVAAAAAAAPARAAPAAAPAPA 492
|
170 180
....*....|....*....|....*
gi 1677502311 438 SMAPP---TIPSATPATAPSATSPA 459
Cdd:PRK12323 493 DDDPPpweELPPEFASPAPAQPDAA 517
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
351-459 |
4.37e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 44.92 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 351 PLQAPTPLASHTVEIHEPngmVPSEDLEPEVESSPELAPPPAC------------------PSESPVPIAPTAQPEEL-- 410
Cdd:PLN03209 324 PSQRVPPKESDAADGPKP---VPTKPVTPEAPSPPIEEEPPQPkavvprplspytayedlkPPTSPIPTPPSSSPASSks 400
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1677502311 411 LNGAPSPPAVDLSPVSE-----PEEQAKEVTASMA-------------PPTIPSATPATA--PSATSPA 459
Cdd:PLN03209 401 VDAVAKPAEPDVVPSPGsasnvPEVEPAQVEAKKTrplspyaryedlkPPTSPSPTAPTGvsPSVSSTS 469
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
310-620 |
4.85e-04 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 45.04 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 310 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIhEPNGMVPSEdlepevESSPELAP 389
Cdd:PHA03377 408 VSRVPWRKPRTLPWPTPKTHPVKRTLVKTSGRSDEAEQAQSTPERPGPSDQPSVPV-EPAHLTPVE------HTTVILHQ 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 390 PPacPSESPVPIAPTAQPEELLNGA-----------------------PSPPAVDLSPVSEPEEQAKEVTASMAPPTIPS 446
Cdd:PHA03377 481 PP--QSPPTVAIKPAPPPSRRRRGAcvvydddiievidvetteeeesvTQPAKPHRKVQDGFQRSGRRQKRATPPKVSPS 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 447 atpATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIK 526
Cdd:PHA03377 559 ---DRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPSVVRMFLR 635
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 527 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSgvPPRPEEADETWDSkedKIHNAENIQPGEQKYEYKSD 606
Cdd:PHA03377 636 ERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQST--PPRPSWLPSVFVL---PSVDAGRAQPSEESHLSSMS 710
|
330
....*....|....
gi 1677502311 607 QWKPLNLEEKKRYD 620
Cdd:PHA03377 711 PTQPISHEEQPRYE 724
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
315-458 |
9.45e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.93 E-value: 9.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 315 GEPYRLSPEPTPLAEPilevEVTLSKPVPESEFSSSPLQAPTPLAShtveihepngMVPSEDLEPEVESSPELAPPPACP 394
Cdd:PRK14951 369 AAEAAAPAEKKTPARP----EAAAPAAAPVAQAAAAPAPAAAPAAA----------ASAPAAPPAAAPPAPVAAPAAAAP 434
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1677502311 395 SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEeqakevTASMAPPTIPSATPATAPSATSP 458
Cdd:PRK14951 435 AAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE------PAVASAAPAPAAAPAAARLTPTE 492
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
351-519 |
2.70e-03 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 42.72 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 351 PLQAPTPL---------ASHTVEIHEP-----------NGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEL 410
Cdd:PRK10811 820 PTQSPMPLtvacaspemASGKVWIRYPvvrpqdvqveeQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPV 899
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 411 LNGAPSPPAVDlsPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEEL 490
Cdd:PRK10811 900 VVAEPQPEEVV--VVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVA 977
|
170 180
....*....|....*....|....*....
gi 1677502311 491 LPPESTPIPANLSQNLEAAAATQVAVSVP 519
Cdd:PRK10811 978 QPAAPVVAEVAAEVETVTAVEPEVAPAQV 1006
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
339-460 |
3.79e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.01 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 339 SKPVPESEfSSSPLQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAPTAQPEELlnGAPSPP 418
Cdd:PRK14951 372 AAAPAEKK-TPARPEAAAPAAAPVAQAAAAPAPAA-----APAAAASAPAAPPAAAPPAPVAAPAAAAPAAA--PAAAPA 443
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1677502311 419 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQ 460
Cdd:PRK14951 444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
339-574 |
3.80e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.06 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 339 SKPVP---ESEFSSSPLQapTPLASHTVEIHEPNGMVPSEDLEPEVESS-PELAPPPACPSESPVPIAPTAQPeellnga 414
Cdd:pfam03154 147 SIPSPqdnESDSDSSAQQ--QILQTQPPVLQAQSGAASPPSPPPPGTTQaATAGPTPSAPSVPPQGSPATSQP------- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 415 PSPPAVDLSPVSEPEEqakevTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL--- 491
Cdd:pfam03154 218 PNQTQSTAAPHTLIQQ-----TPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMqhp 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 492 -PPESTPIPANLSQNlEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA-------------------VPEV 551
Cdd:pfam03154 293 vPPQPFPLTPQSSQS-QVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAplsmphikpppttpipqlpNPQS 371
|
250 260
....*....|....*....|...
gi 1677502311 552 ENQPPAGSNPGPESEGSGVPPRP 574
Cdd:pfam03154 372 HKHPPHLSGPSPFQMNSNLPPPP 394
|
|
| Rib_recp_KP_reg |
pfam05104 |
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ... |
366-459 |
4.73e-03 |
|
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.
Pssm-ID: 461548 [Multi-domain] Cd Length: 140 Bit Score: 38.95 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 366 HEPNGMVPSEDLEPEVESSP-ELAPPPACPSESPVPiAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTI 444
Cdd:pfam05104 44 EKPNGKLPESEQADESEEEPrEFKTPDEAPSAALEP-EPVPTPVPAPVEPEPAPPSESPAPSPKEKKKKEKKSAKVEPAE 122
|
90
....*....|....*
gi 1677502311 445 PSATPATAPSATSPA 459
Cdd:pfam05104 123 TPEAVQPKPALEKEE 137
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
281-457 |
6.27e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 6.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 281 PGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPileVEVTLSKPVPESEFSSSPLQAPTPLAS 360
Cdd:PRK12323 387 PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA---RQASARGPGGAPAPAPAPAAAPAAAAR 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 361 HTVeihepngmvpsedlepevessPELAPPPACPSESPVPIAPTAQP----------EELLNGAPSPPAVDLSPVSEPEE 430
Cdd:PRK12323 464 PAA---------------------AGPRPVAAAAAAAPARAAPAAAPapadddpppwEELPPEFASPAPAQPDAAPAGWV 522
|
170 180
....*....|....*....|....*..
gi 1677502311 431 QAKEVTASMAPPTIPSATPATAPSATS 457
Cdd:PRK12323 523 AESIPDPATADPDDAFETLAPAPAAAP 549
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
330-443 |
8.66e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 40.72 E-value: 8.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677502311 330 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 409
Cdd:PRK14948 348 PRLWLEVTLLGLLPSAFISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPT 427
|
90 100 110
....*....|....*....|....*....|....
gi 1677502311 410 llngaPSPPAVDLSPVSEPEEQAKEVTASMAPPT 443
Cdd:PRK14948 428 -----PPANAANAPPSLNLEELWQQILAKLELPS 456
|
|
| |
