|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
116-1081 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1170.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 116 IPTKPGEKKDVSGPLPPAYSPRYVEAAWYPWWVREGFFKP-EYQARLPQatGETFSMCIPPPNVTGSLHIGHALTVAIQD 194
Cdd:PTZ00419 10 SKDEKKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKPaEDAKSLNS--GKKFVIVLPPPNVTGYLHIGHALTGAIQD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 195 ALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDR 274
Cdd:PTZ00419 88 SLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 275 ECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAFPV 354
Cdd:PTZ00419 168 EVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 355 DGEPDAEVVVGTTRPETLPGDVAVAVHPDDSRYTHLHGRQLRHPLM-GQPLPLITD-YAVQPHVGTGAVKVTPAHSPADA 432
Cdd:PTZ00419 248 EDSGQEEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIpDRKIPIIADdELVDMEFGTGAVKITPAHDPNDY 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 433 EMGARHGLSPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFV 512
Cdd:PTZ00419 328 EIAKRHNLPFINIFTLDGKINENGGEF-AGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYV 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 513 RCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVV---EDHAQGEEDCWVVGRSEAEA 589
Cdd:PTZ00419 407 NCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIskgPETDPSDEEPWVVARSEEEA 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 590 REVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQ 669
Cdd:PTZ00419 487 LEKAKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDK 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 670 LPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALR 749
Cdd:PTZ00419 567 LPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALR 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 750 FTLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSP-----MDAWILSRLALAAQECE 824
Cdd:PTZ00419 647 FGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVeslpwEDKWILHRLNVAIKEVT 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 825 RGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWH---SPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLppR 901
Cdd:PTZ00419 727 EGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKqsdGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL--P 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 902 PGCPPAPSISVAPYPSacSLEHWRQPELERRFSRVQEVVQVLRALRATYQLT-KARPRVLLQSSEPGDQGLFEAFLEPLG 980
Cdd:PTZ00419 805 NYLRKSESISIAKYPQ--PNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESAENLIS 882
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 981 TLGYCGAVGLLPP---GAAAPSGWAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSL---------TARTP 1048
Cdd:PTZ00419 883 TLAKIGSVSVIPPieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYlkkisipnyEDKVP 962
|
970 980 990
....*....|....*....|....*....|...
gi 268370297 1049 SegEAGTQRQQKLSSLQLELSKLDKAASHLRQL 1081
Cdd:PTZ00419 963 E--DVRKLNDEKIDELNEEIKQLEQAIEELKSL 993
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
130-1062 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 989.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 130 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 209
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKAD-----PDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 210 VPGSDHAGIATQAVVEKQLwKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 289
Cdd:COG0525 78 QPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 290 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGEPDaEVVVGTTRP 369
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGH----------------LWHIRYPLADGSG-YIVVATTRP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 370 ETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAED 449
Cdd:COG0525 220 ETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDED 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 450 GTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGA 529
Cdd:COG0525 300 GTINENAGK-YRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 530 LElspsFHQKNWQ----HWFSHIGDWCVSRQLWWGHQIPAYLvvedHAQGEEdcwVVGRSEAearevaaelTGRPGAELT 605
Cdd:COG0525 379 IK----FVPERWEktyfHWMENIRDWCISRQLWWGHRIPAWY----CPDGEV---YVARTEP---------EACAKAGSV 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 606 -LERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDR 684
Cdd:COG0525 439 nLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDE 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 685 QGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHGVQAGDLHL 764
Cdd:COG0525 519 QGRKMSKSKGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKF 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 765 SVSEVQSCRHFCNKIWNALRFIL-NalGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHF- 842
Cdd:COG0525 562 DEERVEGYRNFANKLWNASRFVLmN--LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFv 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 843 WlHNLCDVYLEAVKPVLWH--SPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprPGCPPAPSISVAPYPSAcs 920
Cdd:COG0525 640 W-NEFCDWYLELAKPRLYGgdEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKL---PPRKEGESIMLAPWPEA-- 713
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 921 LEHWRQPELERRFSRVQEVVQVLRALRATYQLT-KARPRVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLppGAAAPS 999
Cdd:COG0525 714 DEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPpSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITIL--VDEKPE 791
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268370297 1000 GWAQApLSDTAQVYMELQGLVDpqiqlplLAARRYKLQKQLDSLtartpsEGE-AGTQRqqKLS 1062
Cdd:COG0525 792 GAASA-VVGGAEVFLPLEGLID-------VEAERARLEKELAKL------EKEiARVEK--KLS 839
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
130-1045 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 971.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 130 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlpQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 209
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD------DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 210 VPGSDHAGIATQAVVEKQLwKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 289
Cdd:PRK05729 79 LPGTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 290 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDgEPDAEVVVGTTRP 369
Cdd:PRK05729 158 VFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGK----------------LWHIRYPLA-DGSDYLVVATTRP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 370 ETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAED 449
Cdd:PRK05729 221 ETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDED 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 450 GTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGA 529
Cdd:PRK05729 301 GTINENPGE-YQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 530 LELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYlvvedhaQGEEDCWVVGRSEAEarevaaeltgrPGAELTLERD 609
Cdd:PRK05729 380 IKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAW-------YDEDGEVYVGREEPE-----------AREKALLTQD 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 610 PDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKM 689
Cdd:PRK05729 442 EDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKM 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 690 SKSLGNVLDPRDIIsgvemqvlqEKLrsgnldpaelaivaaaqkkdfphgipecGTDALRFTLCSHGVQAGDLHLSVSEV 769
Cdd:PRK05729 522 SKSKGNVIDPLDLI---------DKY----------------------------GADALRFTLAALASPGRDIRFDEERV 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 770 QSCRHFCNKIWNALRFILNALGEKFVPQPAEELSpSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCD 849
Cdd:PRK05729 565 EGYRNFANKLWNASRFVLMNLEGADVGELPDPEE-LSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCD 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 850 VYLEAVKPVLWHSPRPlGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprPGCPPAPSISVAPYPSAcslEHWRQPEL 929
Cdd:PRK05729 644 WYLELAKPVLQEAAKR-ATRATLAYVLEQILRLLHPFMPFITEELWQKL---APLGIEESIMLAPWPEA---DEAIDEAA 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 930 ERRFSRVQEVVQVLRALRATYQLTKARP-RVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLPPGAAAPSGWAQApLSD 1008
Cdd:PRK05729 717 EAEFEWLKELITAIRNIRAEMNIPPSKKlPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPEGAASA-VVG 795
|
890 900 910
....*....|....*....|....*....|....*..
gi 268370297 1009 TAQVYMELQGLVDpqiqlplLAARRYKLQKQLDSLTA 1045
Cdd:PRK05729 796 GAELFLPLEGLID-------VEAELARLEKELAKLEK 825
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
74-1078 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 950.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 74 REAKQKRLREKQATLEAEIAGESKSPAESIKAWRPK-----------ELVLYEIPTKPGEKKDVSGPLPPAYSPRYVEAA 142
Cdd:PLN02381 29 KEKELKKLKAAQKEAKAKLQAQQASDGTNVPKKSEKksrkrdvedenPEDFIDPDTPFGQKKRLSSQMAKQYSPSAVEKS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 143 WYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQA 222
Cdd:PLN02381 109 WYAWWEKSGYFGAD-----AKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 223 VVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYR 302
Cdd:PLN02381 184 VVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 303 NHQLVNWSCALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAFPVDGEPdAEVVVGTTRPETLPGDVAVAVHP 382
Cdd:PLN02381 264 DIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGL-GEIVVATTRIETMLGDTAIAIHP 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 383 DDSRYTHLHGRQLRHPLMGQPLPLITDYA-VQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGDWLQ 461
Cdd:PLN02381 343 DDERYKHLHGKFAVHPFNGRKLPIICDAIlVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 462 GLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAV---ESGALELSPSFHQ 538
Cdd:PLN02381 423 GMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAidgENKKLEFIPKQYL 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 539 KNWQHWFSHIGDWCVSRQLWWGHQIPA-YLVVEDHAQGE----EDCWVVGRSEAEAREVAAEltGRPGAELTLERDPDVL 613
Cdd:PLN02381 503 AEWKRWLENIRDWCISRQLWWGHRIPAwYVTLEDDQLKElgsyNDHWVVARNESDALLEASQ--KFPGKKFELSQDPDVL 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 614 DTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSL 693
Cdd:PLN02381 581 DTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSL 660
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 694 GNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALRFTLCSHGVQAGDLHLSVSEVQSCR 773
Cdd:PLN02381 661 GNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDALRFALVSYTAQSDKINLDILRVVGYR 740
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 774 HFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLE 853
Cdd:PLN02381 741 QWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIE 820
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 854 AVKPVL------WHSPRPlGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSAcsLEHWRQP 927
Cdd:PLN02381 821 AIKPYFagdnpeFASERA-AAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHTRKDSIMISEYPSA--VEAWTNE 897
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 928 ELERRFSRVQEVVQVLRALRATY---QLTKARPRVLLQSSEPGDQGLFEAFLEPLgTLGYCGAVGLLPPGA-AAPSGWAQ 1003
Cdd:PLN02381 898 KVEYEMDLVLSTVKCLRSLRAEVlekQKNERLPAFALCRNQEIAAIIKSHQLEIL-TLANLSSLKVLLSENdAPPAGCAF 976
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 1004 APLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPSEG-------EAGTQRQQKLSSLQLELSKLDKAAS 1076
Cdd:PLN02381 977 ENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGykekvpaNIQEEDARKLTKLLQELEFFEKESK 1056
|
..
gi 268370297 1077 HL 1078
Cdd:PLN02381 1057 RL 1058
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
130-1045 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 842.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 130 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 209
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPD-----GNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 210 VPGSDHAGIATQAVVEKQLWKErGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 289
Cdd:TIGR00422 76 LPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 290 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGEPDAEVVVGTTRP 369
Cdd:TIGR00422 155 AFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGK----------------LYYIRYPLANGSKDYLVVATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 370 ETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAED 449
Cdd:TIGR00422 219 ETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 450 GTMTSLCGDWlQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGA 529
Cdd:TIGR00422 299 GLLNENAGKY-QGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 530 LELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVEDhaqGEedcWVVGRSEAEAREVAaeltgRPGAELTLERD 609
Cdd:TIGR00422 378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKEC---GE---VYVAKEEPLPDDKT-----NTGPSVELEQD 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 610 PDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKM 689
Cdd:TIGR00422 447 TDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKM 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 690 SKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHGVQAGDLHLSVSEV 769
Cdd:TIGR00422 527 SKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKRV 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 770 QSCRHFCNKIWNALRFILNALGEKFVPQPAEElsPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCD 849
Cdd:TIGR00422 570 ESARNFLNKLWNASRFVLMNLSDDLELSGGEE--KLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCD 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 850 VYLEAVKPVLWHSPRPLGPP--QVLFSCADLGLRLLAPLMPFLAEELWQRLpprpgCPPAPSISVAPYPSAcsLEHWRQP 927
Cdd:TIGR00422 648 WYIELVKYRLYNGNEAEKKAarDTLYYVLDKALRLLHPFMPFITEEIWQHF-----KEGADSIMLQSYPVV--DAEFVDE 720
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 928 ELERRFSRVQEVVQVLRALRATYQLTKARP-RVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGLLPpgAAAPSGWAQAPL 1006
Cdd:TIGR00422 721 EAEKAFELLKEIIVSIRNLKAESNIPPNAPlKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVI--EKPEVTEAVVEL 798
|
890 900 910
....*....|....*....|....*....|....*....
gi 268370297 1007 SDTAQVYMELQGLVDpqiqlplLAARRYKLQKQLDSLTA 1045
Cdd:TIGR00422 799 VPGFEIIIPVKGLIN-------KAKELARLQKQLDKEKK 830
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
130-1040 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 734.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 130 LPPAYSPRYVEAAWYPWWVREGFFKPEYQARlpqaTGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 209
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGDEHDR----TRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 210 VPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTE 289
Cdd:PRK14900 91 LPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVRE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 290 AFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVEnrplpgHTQLRLpgcptpvsfGLLFSVAFPV-DGepDAEVVVGTTR 368
Cdd:PRK14900 171 VFVRLHEEGLIYREKKLINWCPDCRTALSDLEVE------HEEAHQ---------GELWSFAYPLaDG--SGEIVVATTR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 369 PETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYA-VQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIA 447
Cdd:PRK14900 234 PETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAIlVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 448 EDGTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVES 527
Cdd:PRK14900 314 PDGRMTAEAGP-LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQ 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 528 GALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVEDHAqgeedcwVVGRSEAEarevaaelTGRPGAELTLE 607
Cdd:PRK14900 393 GRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV-------TVARETPE--------ACSTCGKAELR 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 608 RDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGR 687
Cdd:PRK14900 458 QDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQ 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 688 KMSKSLGNVLDPRDIisgvemqvlqeklrsgnldpaelaivaaaqkkdfphgIPECGTDALRFTLCSHGVQAGDLHLSVS 767
Cdd:PRK14900 538 KMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLAKE 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 768 EVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNL 847
Cdd:PRK14900 581 RIEGYRAFANKLWNASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHEL 660
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 848 CDVYLEAVKPVLWHS-PRPLGPPQ-VLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAP-SISVAPYPSACSLEHw 924
Cdd:PRK14900 661 CDWYIELAKEALASEdPEARRSVQaVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWAdSVLAAEYPRKGEADE- 739
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 925 rqpELERRFSRVQEVVQVLRALRATYQLT-----KARPRVLLQSSEPGDQGLFE----AFLEPLGTLgycGAVGLLPPGA 995
Cdd:PRK14900 740 ---AAEAAFRPVLGIIDAVRNIRGEMGIPwkvklGAQAPVEIAVADPALRDLLQagelARVHRVAGV---EGSRLVVAAA 813
|
890 900 910 920
....*....|....*....|....*....|....*....|....*
gi 268370297 996 AAPSGWAQAPLSDTAQVYMELQGLVDpqiqlplLAARRYKLQKQL 1040
Cdd:PRK14900 814 TAPAPQSAVGVGPGFEVRVPLAGVID-------LAAETARVDKEI 851
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
144-1049 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 641.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 144 YPWWVREGFFKPEYQArlpqaTGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAV 223
Cdd:PLN02943 70 YNWWESQGYFKPNFDR-----GGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 224 VEKQLWKErGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRN 303
Cdd:PLN02943 145 VEKMLASE-GIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 304 HQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVHPD 383
Cdd:PLN02943 224 SYMVNWSPNLQTAVSDLEVEYSEEPGT----------------LYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 384 DSRYTHLHGRQLRHPLM-GQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCgdwlqG 462
Cdd:PLN02943 288 DDRYSKYIGKMAIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVA-----G 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 463 LHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQ 542
Cdd:PLN02943 363 LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYN 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 543 HWFSHIGDWCVSRQLWWGHQIPAYLVVEDHAqgEEDcWVVGRSEAEAREVAAEltgRPGAELTLERDPDVLDTWFSSALF 622
Cdd:PLN02943 443 HWLSNIKDWCISRQLWWGHRIPVWYIVGKDC--EED-YIVARSAEEALEKARE---KYGKDVEIYQDPDVLDTWFSSALW 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 623 PFSALGWPQ-ETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRD 701
Cdd:PLN02943 517 PFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLD 596
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 702 IIsgvemqvlqeklrsgnldpaelaivaaaqkKDFphgipecGTDALRFTLcSHGVQAGDLHLSVSEVQSCRHFCNKIWN 781
Cdd:PLN02943 597 TI------------------------------KEF-------GTDALRFTL-ALGTAGQDLNLSTERLTSNKAFTNKLWN 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 782 ALRFIL-------------NALGEKFvpqPAEELSPSSPM-DAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNL 847
Cdd:PLN02943 639 AGKFVLqnlpsqsdtsaweHILACKF---DKEESLLSLPLpECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDF 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 848 CDVYLEAVKPVLWHS---PRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprpgCPPAPSISVAPYPSAcSLEhw 924
Cdd:PLN02943 716 ADWYIEASKTRLYHSgdnSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL-----PYRKEALIVSPWPQT-SLP-- 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 925 RQPELERRFSRVQEVVQVLRALRATYQLTKARPrvlLQSSEPGDQGLFEAFLEPLGTLGYCGAVGL-------LPPGAAA 997
Cdd:PLN02943 788 KDLKSIKRFENLQSLTRAIRNARAEYSVEPAKR---ISASIVASAEVIEYISKEKEVLALLSRLDLqnvhftdSPPGDAN 864
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 268370297 998 PSgwAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPS 1049
Cdd:PLN02943 865 QS--VHLVASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSS 914
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
142-754 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 604.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 142 AWYPWWVREGFFKPEYQARLPQatgETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQ 221
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGK---PSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 222 AVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLY 301
Cdd:pfam00133 78 QVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 302 RNHQLVNWSCALRSAISDIEVENRPlpghtqlrlpgcptpvSFGLLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVH 381
Cdd:pfam00133 158 RGKKLVNWSPALNTALSNLEVEYKD----------------VKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVN 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 382 PD-------------------------------DSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPA 430
Cdd:pfam00133 222 PEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGEN 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 431 DAEMGARHGLSPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQW 510
Cdd:pfam00133 302 DYEVGQRHNLEVINPVDDDGTFTEEAPDF-QGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQW 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 511 FVRCQEMGARAAKAVESgaLELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYlVVED----HAQGEEDCWVVGRSE 586
Cdd:pfam00133 381 FVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAW-VSKDteevVCRGELFELVAGRFE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 587 AEAREVAAELTG----RPGAElTLERDPDVLDTWFSSALFPFSALGWP-QETPDLARFYPLSLLETGSDLLLFWVGRMVM 661
Cdd:pfam00133 458 EEGSIKWLHREAkdklGYGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPfVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 662 LGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgip 741
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID------------------------------------- 579
|
650
....*....|...
gi 268370297 742 ECGTDALRFTLCS 754
Cdd:pfam00133 580 KYGADALRLWLAN 592
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
167-764 |
2.13e-175 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 518.34 E-value: 2.13e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 167 ETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKErGVRRHELSREAFLR 246
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 247 EVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVenrp 326
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 327 lpghtqlrlpgcptpvsfgllfsvafpvdgepdaevvvgttrpetlpgdvavavhpddsrythlhgrqlrhplmgqplpl 406
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 407 itdyavqphvgtgavkvtpahspadaemgarhglsplnviaedgtmtslcgdwlqglhrfvarekimsvlsewglfrglq 486
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 487 nhpmvlpiCSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAY 566
Cdd:cd00817 156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 567 LVVEDHAqgeedcWVVGRSEAEAREVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLE 646
Cdd:cd00817 228 YCKDGGH------WVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLV 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 647 TGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISGvemqvlqeklrsgnldpaela 726
Cdd:cd00817 302 TGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG--------------------- 360
|
570 580 590
....*....|....*....|....*....|....*...
gi 268370297 727 ivaaaqkkdfphgipeCGTDALRFTLCSHGVQAGDLHL 764
Cdd:cd00817 361 ----------------YGADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
130-944 |
5.20e-134 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 425.38 E-value: 5.20e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 130 LPPAYSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLW 209
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFD-----PDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 210 VPGSDHAGIATQAVVEKqlwkERGVRRHELSREAFL---REV-WQWKEakggEICEQLRALGASLDWDRECFTMDVgSSV 285
Cdd:PRK13208 81 PQGWDDNGLPTERKVEK----YYGIRKDDISREEFIelcRELtDEDEK----KFRELWRRLGLSVDWSLEYQTISP-EYR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 286 AVT-EAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGHtqlrlpgcptpvsfglLFSVAFPVDGepDAEVVV 364
Cdd:PRK13208 152 RISqKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGK----------------LNYIKFPVED--GEEIEI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 365 GTTRPETLPGDVAVAVHPDDSRYTHLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLN 444
Cdd:PRK13208 214 ATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 445 VIAEDGTMTSLCGDwLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKA 524
Cdd:PRK13208 294 IIDEDGRMTEAAGK-LAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLER 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 525 VESgaLELSPSFHQKNWQHWFSHI-GDWCVSRQ--------LWW----GHQIPA----YLVV--EDHAQGEEDCwvvgrs 585
Cdd:PRK13208 373 GKE--INWYPEHMRVRLENWIEGLnWDWCISRQryfgtpipVWYckdcGHPILPdeedLPVDptKDEPPGYKCP------ 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 586 eaearevaaeltgRPGAElTLERDPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLETGSDLLLFW----VGRMVm 661
Cdd:PRK13208 445 -------------QCGSP-GFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAY- 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 662 lgtQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIisgvemqvlqeklrsgnldpaelaivaaaqkkdfphgIP 741
Cdd:PRK13208 510 ---LLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEEL-------------------------------------LE 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 742 ECGTDALRFTLCShGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNaLGEKFVPQPAEELspsSPMDAWILSRLALAAQ 821
Cdd:PRK13208 550 KYGADAVRYWAAS-ARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLH-FSADPEPDKAEVL---EPLDRWILAKLAKVVE 624
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 822 ECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPrplGPPQVLFSCADLG------LRLLAPLMPFLAEELW 895
Cdd:PRK13208 625 KATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGED---EEEEQKSARYTLYtvldtlLRLLAPFLPFITEEVW 701
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 268370297 896 QRLpprpgcpPAPSISVAPYPSAcsLEHWRQPELERRFSRVQEVVQVLR 944
Cdd:PRK13208 702 SWL-------YGGSVHRASWPEP--DEELIDEEDEELGELAKEILSAVR 741
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
175-948 |
3.76e-84 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 293.52 E-value: 3.76e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 175 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSD-HaG--IATQavVEKQLWKERGVRrHELSREAFLRE---- 247
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GlpIELK--VEKELGIKKKDI-EKVGIAEFREKcrey 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 248 VWQWKEakggEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPl 327
Cdd:COG0060 130 ALKYVD----EQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKD- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 328 pgHTqlrlpgCPTPVsfgllfsVAFPVDGEP------DAEVVVGTTRPETLPGDVAVAVHPD----------DSRY---- 387
Cdd:COG0060 205 --VT------SPSIY-------VKFPVKDEKalllleDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilae 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 388 -----------------------THLHGRQLRHPLMGQPlplITDYAVQ----PHV----GTGAVKVTPAHSPADAEMGA 436
Cdd:COG0060 270 alveavlkelgiedyevlatfkgAELEGLRYEHPFYYVV---GYDRAHPvilgDYVttedGTGIVHTAPGHGEDDFEVGK 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 437 RHGLSPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWG-LFRglqnHPMVL---PICSRSGD-VIeYLLKNQWF 511
Cdd:COG0060 347 KYGLPVLNPVDDDGRFTEEAPLF-AGLFVKDANPAIIEDLKERGaLLA----REKIThsyPHCWRCKTpLI-YRATPQWF 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 512 VRCQEMGARAAKAVEsgalelspsfhQKNWQ---------HWFSHIGDWCVSRQLWWGHQIPAYL--------------- 567
Cdd:COG0060 421 ISMDKLRDRALEAIE-----------KVNWIpewgegrfgNMLENRPDWCISRQRYWGVPIPIWVcedcgelhrteevig 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 568 -VVEDHAQGEEDCW--------VVGRseaearevaaELTGRPGAElTLERDPDVLDTWFSSALFPFSALGWPQETPDLAR 638
Cdd:COG0060 490 sVAELLEEEGADAWfeldlhrpFLDE----------TLKCPKCGG-TMRRVPDVLDVWFDSGSMHFAVLENREELHFPAD 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 639 FYplslLEtGSD--------LLLfwvgrmvmLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIIsgvemqv 710
Cdd:COG0060 559 FY----LE-GSDqtrgwfysSLL--------TSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI------- 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 711 lqEKLrsgnldpaelaivaaaqkkdfphgipecGTDALRFTLCSHGvQAGDLHLSVSEVQSCRHFCNKIWNALRFILNAL 790
Cdd:COG0060 619 --DKY----------------------------GADILRLWVASSD-YWGDLRFSDEILKEVRDVYRRLRNTYRFLLANL 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 791 gEKFVPQ----PAEELspsSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFwlhnlCDV-----YLEAVKPVLW- 860
Cdd:COG0060 668 -DDFDPAedavPYEDL---PELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNF-----CVEdlsnwYLDISKDRLYt 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 861 ---HSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprpGCPPAPSISVAPYPSAcsLEHWRQPELERRFSRVQ 937
Cdd:COG0060 739 eaaDSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNL----PGEAEESVHLADWPEV--DEELIDEELEAKWDLVR 812
|
890
....*....|..
gi 268370297 938 EVVQ-VLRALRA 948
Cdd:COG0060 813 EVRSaVLKALEA 824
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
168-703 |
1.44e-48 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 175.30 E-value: 1.44e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 168 TFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRrhelSREAFLRE 247
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTI----WIEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 248 VWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHqlvnwscalrsaisdievenrpl 327
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGT----------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 328 pghtqlrlpgcptpvsfgllfsvafpvdgepdaevvvgttrpetlpgdvavavHPddsrythlhgrqlrhplmgqplpli 407
Cdd:cd00668 134 -----------------------------------------------------HP------------------------- 135
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 408 tdyavqphvgtgavkvtpahspadaemgarhglsplnVIAEDgtmtslcgdwlqglHRFVArekiMSVLSEWgLFRGLQN 487
Cdd:cd00668 136 -------------------------------------VRITE--------------QWFFD----MPKFKEK-LLKALRR 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 488 HPMVlpicsrsgdvieyllKNQWFVRCQEmgaraakavesgalelspsfhqknwqhWFSHIGDWCVSRQLWWGHQIPayl 567
Cdd:cd00668 160 GKIV---------------PEHVKNRMEA---------------------------WLESLLDWAISRQRYWGTPLP--- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 568 vvedhaqgeedcwvvgrseaearevaaeltgrpgaeltlerdPDVLDTWFSSALFPFSALGWPQETPDLARFYPLSLLET 647
Cdd:cd00668 195 ------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLI 232
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 268370297 648 GSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDII 703
Cdd:cd00668 233 GKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
764-898 |
4.08e-48 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 167.35 E-value: 4.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 764 LSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEElsPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFW 843
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE--SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 268370297 844 LHNLCDVYLEAVKPVLWH--SPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRL 898
Cdd:cd07962 79 WNDFCDWYLELVKPRLYGedEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
146-939 |
7.79e-48 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 185.75 E-value: 7.79e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 146 WWVREGFFKpeyqaRL-PQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVV 224
Cdd:PLN02843 15 LWEENQVYK-----RVsDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 225 EKQLWKERgvrRHELSREAFLREVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNH 304
Cdd:PLN02843 90 LQSLDQEA---RKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 305 QLVNWSCALRSAISDIEVEnrpLP-GHTQ----LRLPGCPTPVSFGLLFSVAFPvdgepDAEVVVGTTRPETLPGDVAVA 379
Cdd:PLN02843 167 KPVHWSPSSRTALAEAELE---YPeGHVSksiyVAFPVVSPSETSPEELEEFLP-----GLSLAIWTTTPWTMPANAAVA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 380 VHP--------------DDSRYTH----------------------------------------------LHGRQLRHPL 399
Cdd:PLN02843 239 VNDklqysvvevqsfseDESTSGGnkkkrpgnvlkeqqklflivatdlvpaleakwgvklvvlktfpgsdLEGCRYIHPL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 400 MGQPLPLIT--DYaVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGDwLQGLHRFVA-REKIMSVL 476
Cdd:PLN02843 319 YNRESPVVIggDY-ITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLGEgNAAVVEAL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 477 SEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQWFVRCQEMGARAAKAVESgaLELSPSFHQKNWQHWFSHIGDWCVSRQ 556
Cdd:PLN02843 397 DEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDK--VKWIPAQGENRIRAMVSGRSDWCISRQ 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 557 LWWGHQIPAYLVVE-----------DH-----AQGEEDCWVVGRSEAEAREVAAELTGRpgaeltLERDPDVLDTWFSSA 620
Cdd:PLN02843 475 RTWGVPIPVFYHVEtkeplmneetiAHvksivAQKGSDAWWYMDVEDLLPEKYRDKASD------YEKGTDTMDVWFDSG 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 621 LfpfSALGWPQETPDLArfYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPR 700
Cdd:PLN02843 549 S---SWAGVLGSREGLS--YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 701 DIISGvemqvlqeklrsGNldpaelaivaaAQKKDfphgiPECGTDALRFTLCSHGVqAGDLHLSVSEVQSCRHFCNKIW 780
Cdd:PLN02843 624 LVIEG------------GK-----------NQKQE-----PAYGADVLRLWVASVDY-TGDVLIGPQILKQMSDIYRKLR 674
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 781 NALRFILNALGEkFVPQ---PAEELsPSspMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKP 857
Cdd:PLN02843 675 GTLRYLLGNLHD-WKPDnavPYEDL-PS--IDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKD 750
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 858 VLW----HSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSAcsLEHWRQ-PELERR 932
Cdd:PLN02843 751 RLYvggtTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESVFEAGWPTP--NEEWLSfPAEDVD 828
|
....*...
gi 268370297 933 F-SRVQEV 939
Cdd:PLN02843 829 FwSLLLEV 836
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
809-957 |
1.21e-33 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 126.36 E-value: 1.21e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 809 DAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPRPLGPPQVLFSCADLGLRLLAPLMP 888
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268370297 889 FLAEELWQRLpprpgcppapSISVAPYPSACSLEhwrQPELERRFSRVQEVVQVLRALRATYQLTKARP 957
Cdd:pfam08264 81 FITEELWQKE----------SIHLAPWPEDAELE---EAELEEAFELRQEIVQAIRKLRSELKIKKSLP 136
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
175-947 |
1.20e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 124.45 E-value: 1.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 175 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKER-------GVRRH-ELSREAFLR 246
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLGIKRrddvlkmGIDKYnEECRSIVTR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 247 EVWQWKEAkggeiceqLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVenrp 326
Cdd:PLN02882 126 YSKEWEKT--------VTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA---- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 327 lpghtQLRLPGCPTPVSFgllfsVAFPVDGEPD-AEVVVGTTRPETLPGDVAVAVHPD------------------DSRY 387
Cdd:PLN02882 194 -----GLNYKDVSDPAVM-----VSFPIVGDPDnASFVAWTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaESRL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 388 THLHGRQLRHP----------------------LMG---QPL------------PLITDYAVQPHVGTGAVKVTPAHSPA 430
Cdd:PLN02882 264 SALPTAKPKSKkgskpenaaegyevlakvpgssLVGkkyEPLfdyfsefsdtafRVVADDYVTDDSGTGVVHCAPAFGED 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 431 DAEMGARHGL-----SPLNVIAEDGTMTSLCGDWlQGLHRFVAREKIMSVLSEWGlfRGLQNHPMV--LPICSRSGDVIE 503
Cdd:PLN02882 344 DYRVCLANGIiekggNLPVPVDDDGCFTEKVTDF-SGRYVKDADKDIIAAIKAKG--RLVKSGSIThsYPFCWRSDTPLI 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 504 YLLKNQWFVRCQEMGARAakaVESGAL-ELSPSF-HQKNWQHWFSHIGDWCVSRQLWWGHQIPAYlVVEDhaqGEEdcWV 581
Cdd:PLN02882 421 YRAVPSWFVKVEEIKDRL---LENNKQtYWVPDYvKEKRFHNWLENARDWAVSRSRFWGTPLPIW-ISDD---GEE--VV 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 582 VGRSEAEAREvaaeLTGRPGAEL-------------------TLERDPDVLDTWFSSALFPFSALGWPQETPDL-ARFYP 641
Cdd:PLN02882 492 VIGSIAELEK----LSGVKVTDLhrhfidhitipssrgpefgVLRRVDDVFDCWFESGSMPYAYIHYPFENKELfEKNFP 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 642 LSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnld 721
Cdd:PLN02882 568 ADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVID----------------- 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 722 paelaivaaaqkkdfphgipECGTDALRFTLC-SHGVQAGDLHLSVSEVQSCRHFCNKIW-NALRFIL-NAL------GE 792
Cdd:PLN02882 631 --------------------KYGADALRLYLInSPVVRAEPLRFKEEGVFGVVKDVFLPWyNAYRFLVqNAKrlevegGA 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 793 KFVPQPAEEL-SPSSPMDAWILSrlalAAQECERgFLTRE-----LSLVTHALHHFwLHNLCDVYleavkpVLWHSPRPL 866
Cdd:PLN02882 691 PFVPLDLAKLqNSANVLDRWINS----ATQSLVK-FVREEmgayrLYTVVPYLVKF-IDNLTNIY------VRFNRKRLK 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 867 GPP---------QVLFSCADLGLRLLAPLMPFLAEELWQRLpPRPGCPPAPSISVAPYPSACSLEhwRQPELERRFSRVQ 937
Cdd:PLN02882 759 GRTgeedcrtalSTLYNVLLTSCKVMAPFTPFFTEVLYQNL-RKVLPGSEESIHYCSFPQVDEGE--LDERIEQSVSRMQ 835
|
890
....*....|
gi 268370297 938 EVVQVLRALR 947
Cdd:PLN02882 836 TVIELARNIR 845
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
134-898 |
6.37e-26 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 115.23 E-value: 6.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 134 YSPRYVEAAWYPWWVREGFFKPEYQARLPQATgeTFSMcIPPPnvTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGS 213
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYY--ILSM-FPYP--SGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 214 DHAGI-ATQAVVEK----QLWKERGVrrhelsreAFLREvwqwkeakggeiceQLRALGASLDWDRECFTMDVGSSVAVT 288
Cdd:TIGR00396 76 DAFGLpAENAAIKRgihpAKWTYENI--------ANMKK--------------QLQALGFSYDWDREIATCDPEYYKWTQ 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 289 EAFVRLYKAGLLYRNHQLVNWSCAL-------------RSAISDIEVENRPLP----GHT----QL-----RLPGCPTPV 342
Cdd:TIGR00396 134 WIFLELFEKGLAYVKEADVNWCPNDgtvlaneqvdsdgRSWRGDTPVEKKELKqwflKITayaeELlndleELDHWPESV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 343 ----------SFGLlfSVAFPVDGePDAEVVVGTTRPETLPGDVAVAV---HP----------------DDSRYTHLHGR 393
Cdd:TIGR00396 214 kemqrnwigkSEGV--EITFKIAD-HDEKITVFTTRPDTIFGVTYLALapeHPlvekaaennpkvaafiKKILNKTVAER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 394 QLR--------------HPLMGQPLPL-ITDYAVQpHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDGTMTSLCGD 458
Cdd:TIGR00396 291 TKAtkekkgvdtgikaiHPLTGEKIPIwVANYVLM-EYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLSLTAA 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 459 WLQ-----------GLHRFVAREKIMSVLSEWGLfrglqnhpmvlpicsrSGDVIEYLLKnqwfvrcqemgaraakaves 527
Cdd:TIGR00396 370 YTEdgvlvnsgefnGLNSSEARNAIIDMLEKEGK----------------GKRKVNYRLR-------------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 528 galelspsfhqknwqhwfshigDWCVSRQLWWGHQIPaylVVEDhaqgeEDCWVV--------------------GRSEA 587
Cdd:TIGR00396 414 ----------------------DWGFSRQRYWGEPIP---IIHC-----EDGGVVpvpeedlpvilpedvvydgdGGSPL 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 588 EAREVAAELTgRPGAELTLERDPDVLDTWFSSALFPFSALGwPQET-----PDLARFY-PLSLLETGSD-----LLL--F 654
Cdd:TIGR00396 464 SRIPEWVNVT-CPSCGKPALRETDTMDTFAGSSWYYLRYLD-PKNTdgpfdKEKAEYWlPVDLYIGGIEhailhLLYarF 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 655 WVGRMVMLGTqLTGQLPFSKVLLHPMV-----------------------RDRQGR--------KMSKSLGNVLDPRDII 703
Cdd:TIGR00396 542 FHKFLRDIGY-VNTKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIV 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 704 SgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNal 783
Cdd:TIGR00396 621 E-------------------------------------SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWN-- 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 784 rFILNALGEKFVPQPAEELspsspmdawilsrLALAAQECERGF----------LTRELSLVT------HALHHFWLHNL 847
Cdd:TIGR00396 662 -LVYEITGELDAASLTVTA-------------LEEAQKELRRDVhkflkkvtedLEKRESFNTaisammELLNKLYKAKK 727
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 268370297 848 CDVYLEAVKPVlwhsprplgppqvlfscadlgLRLLAPLMPFLAEELWQRL 898
Cdd:TIGR00396 728 EALMLEYLKGF---------------------VTVLSPFAPHLAEELWEKL 757
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
477-762 |
1.31e-24 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 106.55 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 477 SEWGLF-----RGL---QNHPMVLPICSRSGDvieyllknQWFVRCQEMGARAAKAVESgaLELSPSFHQKNWQHWFSHI 548
Cdd:cd00818 120 SVWWVFkqlheKGLlyrGYKVVPWPLIYRATP--------QWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENR 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 549 GDWCVSRQLWWGHQIPayLVVEDHAqGEEDCwvvgrseaearevaaeltgrpgaeltlERDPDVLDTWFSSALFPFSALG 628
Cdd:cd00818 190 RDWCISRQRYWGTPIP--VWYCEDC-GEVLV---------------------------RRVPDVLDVWFDSGSMPYAQLH 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 629 WPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLGNVLDPRDIisgvem 708
Cdd:cd00818 240 YPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEV------ 313
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 268370297 709 qvlqeklrsgnldpaelaivaaaqkkdfphgIPECGTDALRFTLCSHGVQAGDL 762
Cdd:cd00818 314 -------------------------------VDKYGADALRLWVASSDVYAEDL 336
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
175-898 |
7.14e-24 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 109.29 E-value: 7.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 175 PPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIAtqavVEKQLWKERGVRRHE--------LSREAFLR 246
Cdd:PTZ00427 110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLP----IEYEIEKENNINKKEdilkmgidVYNEKCRG 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 247 EVWQWKEakggEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVenrp 326
Cdd:PTZ00427 186 IVLKYSN----EWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFEL---- 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 327 lpghtQLRLPGCPTP---VSFGLL----------------------FSVAFPVDGEP----------------DAEVVVG 365
Cdd:PTZ00427 258 -----NLNYKDTPDPsiiISFVLCsdfpkveeecnieedkqllgekYSVLYNNKRENsnngnnnstnnvcyaqHSEILAW 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 366 TTRPETLPGDVAVAV---------HPDDS-----------------------------RYTHLHGRQLRH-PLMG----- 401
Cdd:PTZ00427 333 TTTPWTLPSNLALCVnehftylriHHVKSnrvvivgecrlewimkelkwnvedlkivnRFKGKELKGLRYkPLFTnfyek 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 402 -----QPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHG-LSP-----LNVIAEDGTMTSLCgDWLQGLHRFVARE 470
Cdd:PTZ00427 413 ynfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPeknifIDPLDANGYFTNEV-EEVQNLYIKEADN 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 471 KIMSVLSEWGlfRGLQNHPMV--LPICSRSGDVIEYLLKNQWFVRcqeMGARAAKAVESGALELSPSFH--QKNWQHWFS 546
Cdd:PTZ00427 492 VIKKKLKNEN--RLLSNNTIVhsYPFCWRSDTPLIYRAIPAWFIR---VSNSTNELVKNNETTYWIPAHikEKKFHNWIK 566
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 547 HIGDWCVSRQLWWGHQIPAY--------LVVEDHAQGEEDCWVVGRSEAEAREVAAELTGRPGAEL--TLERDPDVLDTW 616
Cdd:PTZ00427 567 DAKDWCISRNRYWGTPIPIWadekmetvICVESIKHLEELSGVKNINDLHRHFIDHIEIKNPKGKTypKLKRIPEVFDCW 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 617 FSSALFPFSALGWP--QETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKSLG 694
Cdd:PTZ00427 647 FESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLK 726
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 695 NVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLC-SHGVQAGDLHLS---VSEVq 770
Cdd:PTZ00427 727 NYPDPLYILD-------------------------------------KYGADSLRLYLInSVAVRAENLKFQekgVNEV- 768
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 771 sCRHFCNKIWNALRFILNAL-------GEKFVPQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFw 843
Cdd:PTZ00427 769 -VKSFILPFYHSFRFFSQEVtryeclnKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF- 846
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370297 844 LHNLCDVYLEAVKPVLWHSprpLGPPQVLFS----CADLGL--RLLAPLMPFLAEELWQRL 898
Cdd:PTZ00427 847 IENLTNWYIRLNRDRMRGS---LGEENCLQSlcttYRTLHLftVLMAPFTPFITEYIYQQL 904
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
182-941 |
9.32e-22 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 101.87 E-value: 9.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 182 LHIGHALTVAIQDALVRWHRMRGDQVLW-----VPGSDHAGIA--TQAVVEKQLW---KERGVRRHELSR--------EA 243
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIAerIARGDPETIElykSLYGIPEEELEKfkdpeyivEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 244 FLREvwqWKEAkggeiceqLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWsCAlrsaisdieVE 323
Cdd:PRK12300 81 FSEE---AKED--------MKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRY-CP---------ND 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 324 NRPLPGHTQLRLPGcPTPVSFGLLFsvaFPVDGepDAEVVVGTTRPETLPGDVAVAVHPDD--------------SRYTH 389
Cdd:PRK12300 140 NNPVGDHDLLDGEE-PEIVEYTLIK---FEESE--DLILPAATLRPETIFGVTNLWVNPDAtyvkaevdgekwivSKEAA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 390 --------------------LHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPAD--------AEMGARHGLS 441
Cdd:PRK12300 214 eklsfqdrdveiieeikgseLIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDyvalrdlkKNKELLDVIE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 442 PLNVI---------AED-----------------------------GTMTSLCGDwLQGLHRFVAREKIMSVLSEWGL-- 481
Cdd:PRK12300 294 PIPLIevegygefpAKEvveklgiksqedpeleeatkevyraefhkGVLKENTGE-YAGKPVREAREKITKDLIEKGIad 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 482 -FRGLQNHPMVlpicSRSG-DVIEYLLKNQWFVRC--QEMGARAAKAVESgaLELSPSFHQKNwqhwFSHIGDW-----C 552
Cdd:PRK12300 373 iMYEFSNRPVY----CRCGtECVVKVVKDQWFIDYsdPEWKELAHKALDN--MEIIPEEYRKE----FENTIDWlkdraC 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 553 vSRQLWWGHQIP-----------------AYLVVEDHAQGeedcwvvgrseaearevaaelTGRPGAELTlerdPDVLDT 615
Cdd:PRK12300 443 -ARRRGLGTRLPwdeewiieslsdstiymAYYTIAHKIRE---------------------YGIKPEQLT----PEFFDY 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 616 WFSSALFP---FSALGWPQETPDLAR-----FYPLSLLETGSDL----LLF-------------WVGRMVMLGtqltgql 670
Cdd:PRK12300 497 VFLGKGDPeevSKKTGIPKEILEEMReeflyWYPVDWRHSGKDLipnhLTFfifnhvaifpeekWPRGIVVNG------- 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 671 pfskvllhpMVRdRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRF 750
Cdd:PRK12300 570 ---------FVL-LEGKKMSKSKGNVIPLRKAIE-------------------------------------EYGADVVRL 602
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 751 TLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNalrFILNALGekfvpqpAEELSPSSPMDAWILSRLALA---AQECERGF 827
Cdd:PRK12300 603 YLTSSAELLQDADWREKEVESVRRQLERFYE---LAKELIE-------IGGEEELRFIDKWLLSRLNRIikeTTEAMESF 672
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 828 LTRELslVTHALhhFWLHNLCDVYLEAVKpvlwhsprplGPPQ-VLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGcpp 906
Cdd:PRK12300 673 QTRDA--VQEAF--YELLNDLRWYLRRVG----------EANNkVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGF--- 735
|
890 900 910
....*....|....*....|....*....|....*
gi 268370297 907 apsISVAPYPSACslEHWRQPELERRFSRVQEVVQ 941
Cdd:PRK12300 736 ---VSLEKWPEPD--ESKIDEEAELAEEYVKRLIE 765
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
134-918 |
1.01e-20 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 98.58 E-value: 1.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 134 YSPRYVEAAWYPWWVREGFFKPEyqarlPQATGETF---SMcIPPPnvTGSLHIGHALTVAIQDALVRWHRMRGDQVL-- 208
Cdd:COG0495 5 YNPKEIEKKWQKYWEENGTFKAD-----EDSSKPKYyvlDM-FPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 209 --WvpgsDHAGI-ATQAVVEkqlwkeRGVrrHElsreaflrEVWQWK---EAKggeicEQLRALGASLDWDREcftmdvg 282
Cdd:COG0495 77 mgW----DAFGLpAENAAIK------NGV--HP--------AEWTYEniaNMR-----RQLKRLGLSYDWSRE------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 283 ssVAVTEA---------FVRLYKAGLLYRNHQLVNW--SCA--L--------RSAISDIEVENRPLPghtQ--LR----- 334
Cdd:COG0495 125 --IATCDPeyykwtqwiFLQLYEKGLAYRKEAPVNWcpVDQtvLaneqvidgRCWRCGAPVEKKELP---QwfLKitdya 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 335 ---------LPGCPTPV----------SFGLlfSVAFPVDGePDAEVVVGTTRPETLPGD--VAVAV-HP-------DDS 385
Cdd:COG0495 200 dellddldkLDGWPEKVktmqrnwigrSEGA--EVDFPVEG-SDEKITVFTTRPDTLFGAtfMVLAPeHPlvkelatPEQ 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 386 R----------------------------YThlhGRQLRHPLMGQPLPL-ITDYaVQPHVGTGAVKVTPAHSPADAEMGA 436
Cdd:COG0495 277 NaavaafieeakkkseiertsetkektgvFT---GLYAINPLTGEKIPIwIADY-VLMDYGTGAVMAVPAHDQRDFEFAK 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 437 RHGLSPLNVIA---------------EDGTMT-SlcgDWLQGLHRFVAREKIMSVLSEWGLFRGlqnhpmvlpicsrsgd 500
Cdd:COG0495 353 KYGLPIKQVIApedgddpdileeaytGDGVLInS---GEFDGLDSEEAKEAIIEWLEEKGLGKR---------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 501 VIEYLLKnqwfvrcqemgaraakavesgalelspsfhqknwqhwfshigDWCVSRQLWWGHQIP--------AYLVVEDH 572
Cdd:COG0495 414 KVNYRLR------------------------------------------DWLISRQRYWGEPIPiihcedcgVVPVPEDQ 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 573 -------------------AQGEEdcWVvgrseaearEVAAELTGRPGaeltlERDPDVLDTWF-SSalfpfsalgW--- 629
Cdd:COG0495 452 lpvelpedvdfdptggsplARAPE--WV---------NVTCPKCGGPA-----RRETDTMDTFVdSS---------Wyyl 506
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 630 ----PQET-----PDLARFY-PLslletgsDL-----------LL---FWVgrMVM--LGtQLTGQLPFSKVLLHPMVRD 683
Cdd:COG0495 507 rytdPHNDeapfdPEAANYWlPV-------DQyiggiehailhLLyarFFT--KVLrdLG-LVSFDEPFKRLLTQGMVLE 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 684 --RQGR------KMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSh 755
Cdd:COG0495 577 vgKDGVviggieKMSKSKGNVVDPDEIIE-------------------------------------KYGADTLRLFEMF- 618
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 756 gvqAGDLHLSV--SE--VQSCRHFCNKIWNalrfilnaLGEKFVPQPAEELSPSSPMDAWILSRL----ALAAQECER-G 826
Cdd:COG0495 619 ---AGPPERDLewSDsgVEGAYRFLNRVWR--------LVVDEAEALKLDVADLSEADKELRRALhktiKKVTEDIERlR 687
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 827 FLT-----RELslvTHALHHFWLHNLCD--VYLEAVKPVlwhsprplgppqvlfscadlgLRLLAPLMPFLAEELWQRLp 899
Cdd:COG0495 688 FNTaiaalMEL---VNALYKAKDSGEADraVLREALETL---------------------VLLLAPFAPHIAEELWERL- 742
|
970
....*....|....*....
gi 268370297 900 prpgcPPAPSISVAPYPSA 918
Cdd:COG0495 743 -----GHEGSVADAPWPEA 756
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
121-480 |
3.14e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 97.20 E-value: 3.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 121 GEKKDVSGPLPPAYSPRYVEAAWYPWWVREGFFKPEYQARLPQATGETFSMcIPPPNVTGsLHIGHALTVAIQDALVRWH 200
Cdd:PLN02563 67 STTAKTTPAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDM-FPYPSGAG-LHVGHPEGYTATDILARYK 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 201 RMRGDQVLWVPGSDHAGIATQavvekQLWKERGVRrhelSREAFLREVWQWKEakggeiceQLRALGASLDWDRECFTMD 280
Cdd:PLN02563 145 RMQGYNVLHPMGWDAFGLPAE-----QYAIETGTH----PKITTLKNIARFRS--------QLKSLGFSYDWDREISTTE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 281 VGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVEN--RPLPGHTQLRLP--------------------GC 338
Cdd:PLN02563 208 PEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglSERGGHPVIRKPmrqwmlkitayadrlledldDL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 339 PTPVSFGLL----------FSVAFPVDG----EPDAEVVVGTTRPETLPGDVAVAVHPDD-------------------- 384
Cdd:PLN02563 288 DWPESIKEMqrnwigrsegAELDFSVLDgegkERDEKITVYTTRPDTLFGATYLVVAPEHpllsslttaeqkeaveeyvd 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 385 --SRYTHLHGRQL-------------RHPLMGQPLPL-ITDYaVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIA- 447
Cdd:PLN02563 368 aaSRKSDLERTELqkektgvftgsyaINPATGEAIPIwVADY-VLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKp 446
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 268370297 448 -------------EDGTM--TSLCGDWLQGLHRFVAREKIMSVLSEWG 480
Cdd:PLN02563 447 adgneddaekaytGEGVIvnSSSSGLDINGLSSKEAAKKVIEWLEETG 494
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
766-940 |
4.22e-19 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 86.07 E-value: 4.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 766 VSEVQscRHFCNKIWNALRF-ILNALGEKFVP-QPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFW 843
Cdd:cd07961 6 VREVV--RKVLLPLWNAYRFfVTYANLDGFDPgKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 844 LhNLCDVYLEAVKPVLWHSprpLGPP------QVLFSCADLGLRLLAPLMPFLAEELWQRLpPRPGCPPAPSISVAPYPS 917
Cdd:cd07961 84 D-ELTNWYIRRNRKRFWGE---EGDDdklaayATLYEVLLTLSRLMAPFTPFITEEIYQNL-RRELGDAPESVHLLDWPE 158
|
170 180
....*....|....*....|...
gi 268370297 918 AcsLEHWRQPELERRFSRVQEVV 940
Cdd:cd07961 159 V--DESLIDEELEEAMELVREIV 179
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
778-939 |
3.09e-18 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 83.73 E-value: 3.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 778 KIWNALRFILNALG---EKFVPQPAEELSPsspMDAWILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEA 854
Cdd:cd07960 15 KIRNTFRFLLGNLNdfdPAKDAVPYEELLE---LDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 855 VKPVLW----HSPRPLGPPQVLFSCADLGLRLLAPLMPFLAEELWQRLpprPGCPPAPSISVAPYPSAcsLEHWRQPELE 930
Cdd:cd07960 92 IKDRLYcdakDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHL---PGEKKEESVFLEDWPEL--PEEWKDEELE 166
|
....*....
gi 268370297 931 RRFSRVQEV 939
Cdd:cd07960 167 EKWEKLLAL 175
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
174-313 |
1.73e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 75.75 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 174 PPPNvtGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKqlwkergVRRHELSreaflrevwqWKE 253
Cdd:cd00812 9 PYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK-------IGRDPED----------WTE 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 254 AKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWsCAL 313
Cdd:cd00812 70 YNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW-CKL 128
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
173-246 |
2.14e-09 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 61.28 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 173 IPPPNvtGSLHIGHALTVaIQ-DALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVE------KQLWKERGV 234
Cdd:COG0143 9 IPYAN--GPPHIGHLYTY-IPaDILARYQRLRGHDVLFVTGTDeHgtkielaaekEGITPQELVDrihaefKELFEKLGI 85
|
90 100
....*....|....*....|...
gi 268370297 235 -----------RRHELSREAFLR 246
Cdd:COG0143 86 sfdnfirttspEHKELVQEIFQR 108
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
176-301 |
3.32e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.85 E-value: 3.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 176 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAvvekqlwKERGVRRHELSRE--AFLREVWQW 251
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGtkIEQKA-------EEEGVTPQELCDKyhEIFKDLFKW 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 268370297 252 keakggeiceqlralgASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLY 301
Cdd:cd00814 82 ----------------LNISFDYFIRTTSPRHKEIVQEFFKKLYENGYIY 115
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
176-244 |
4.21e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 60.00 E-value: 4.21e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268370297 176 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAvvekqlwKERGV-------RRHELSREAF 244
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGtpIELKA-------EKEGItpeelvdRYHEIHREDF 78
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
167-261 |
2.55e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 57.97 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 167 ETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVE------KQLW 229
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeHgqkiqrkaeeAGISPQELADrnsaafKRLW 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 268370297 230 K------ERGVRRHELSREAFLREVWQWKEAKgGEICE 261
Cdd:PRK11893 81 EalnisyDDFIRTTDPRHKEAVQEIFQRLLAN-GDIYL 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
609-898 |
1.25e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 55.66 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 609 DPD-VLDTWFSsALFPF-SALGWPQETPDLA----RFYP--LSLLetGSDLLLF----WVGRMVMLGtqltGQLPfSKVL 676
Cdd:PRK11893 217 DPKhVIYVWFD-ALTNYlTALGYPDDEELLAelfnKYWPadVHLI--GKDILRFhavyWPAFLMAAG----LPLP-KRVF 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 677 LHPMVRdRQGRKMSKSLGNVLDPRDIISgvemqvlqeklrsgnldpaelaivaaaqkkdfphgipECGTDALRFTLCSHG 756
Cdd:PRK11893 289 AHGFLT-LDGEKMSKSLGNVIDPFDLVD-------------------------------------EYGVDAVRYFLLREI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 757 VQAGDLHLSVSEVQSCR--HFCNKIWNALRFILNALGEKF---VPQPAEELSPsspmDAWILSRLALAAQECERGFLTRE 831
Cdd:PRK11893 331 PFGQDGDFSREAFINRInaDLANDLGNLAQRTLSMIAKNFdgkVPEPGALTEA----DEALLEAAAALLERVRAAMDNLA 406
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370297 832 LSLVTHALHHfwLHNLCDVYLEAVKPVLWHSPRPLGPPQVLFSCADlGLR----LLAPLMPFLAEELWQRL 898
Cdd:PRK11893 407 FDKALEAILA--LVRAANKYIDEQAPWSLAKTDPERLATVLYTLLE-VLRgiavLLQPVMPELAAKILDQL 474
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
686-898 |
2.67e-07 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 54.73 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 686 GRKMSKSLGNVLDPRDIIsgvemqvlqeklrsgnldpaelaivaaaqkKDFphgipecGTDALRFTLCSHGVQAGDLHLS 765
Cdd:COG0143 325 GEKMSKSRGNVIDPDDLL------------------------------DRY-------GPDALRYYLLREVPFGQDGDFS 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 766 VSEVQScRH---FCNKIWN----ALRFILNALGEKfVPQPAEElspsSPMDAWILSRLALAAQECERGFLTRELSlvtHA 838
Cdd:COG0143 368 WEDFVA-RVnsdLANDLGNlasrTLSMIHKYFDGK-VPEPGEL----TEADEELLAEAEAALEEVAEAMEAFEFR---KA 438
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268370297 839 LHHFW-LHNLCDVYLEAVKP-VLWHSPRP--LGppQVLFSCADLgLR----LLAPLMPFLAEELWQRL 898
Cdd:COG0143 439 LEEIMaLARAANKYIDETAPwKLAKDEDPerLA--TVLYTLLEA-LRilaiLLKPFLPETAEKILEQL 503
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
178-231 |
1.35e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.50 E-value: 1.35e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268370297 178 VTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVE------KQLWKE 231
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDeHgqkiqqaaekAGKTPQEYVDeisagfKELWKK 85
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
176-226 |
6.73e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 50.15 E-value: 6.73e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 268370297 176 PNVTGSLHIGHALTVaIQ-DALVRWHRMRGDQVLWVPGSD-H----------AGIATQAVVEK 226
Cdd:PRK00133 11 PYANGPIHLGHLVEY-IQaDIWVRYQRMRGHEVLFVCADDaHgtpimlkaekEGITPEELIAR 72
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
800-898 |
1.90e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 44.89 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 800 EELSPSSPMDAWILSRL---ALAAQECERGFLTRElslvthALHHFW--LHNLCDVYLEAVKPVLwHSprplgppQVLFS 874
Cdd:cd07959 28 GELEELTFIDRWLLSRLnrlIKETTEAYENMQFRE------ALKEGLyeLQNDLDWYRERGGAGM-NK-------DLLRR 93
|
90 100
....*....|....*....|....
gi 268370297 875 CADLGLRLLAPLMPFLAEELWQRL 898
Cdd:cd07959 94 FIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
506-703 |
4.83e-05 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 46.86 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 506 LKNQWFVR--CQEMGARAAKAVEsgALELSPSFHQKNWQHWfshIGdwcVSRQLWWGHQIPaylvvedhaqgeedcWVvg 583
Cdd:cd00812 128 LLDQWFLKysETEWKEKLLKDLE--KLDGWPEEVRAMQENW---IG---CSRQRYWGTPIP---------------WT-- 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 584 rseaearevaaeltgrpgaeltlerdpDVLDTWFSSALFPF----------SALGWPQETPDLAR-FYPLSLLETGSDL- 651
Cdd:cd00812 183 ---------------------------DTMESLSDSTWYYArytdahnleqPYEGDLEFDREEFEyWYPVDIYIGGKEHa 235
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 268370297 652 ---LLFWV-GRMVMLGTQLTGQLPFSKVLLHPMVRdRQGRKMSKSLGNVLDPRDII 703
Cdd:cd00812 236 pnhLLYSRfNHKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
139-208 |
8.31e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 46.99 E-value: 8.31e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 139 VEAAWYPWWVREGFFKPEYQARLPqATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVL 208
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAEAGDEPP-KPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
166-302 |
2.77e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 45.09 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 166 GETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAVVEKqlwkeRGVRRH-ELSRE 242
Cdd:PLN02224 68 ADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATSAAANG-----RNPPEHcDIISQ 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 243 AFlREVWQwkeakggeiceqlralGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYR 302
Cdd:PLN02224 143 SY-RTLWK----------------DLDIAYDKFIRTTDPKHEAIVKEFYARVFANGDIYR 185
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
880-898 |
4.62e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 41.05 E-value: 4.62e-04
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
606-703 |
7.24e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 43.64 E-value: 7.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 606 LERDPD-VLDTWFSsALFPF-SALGWPQETPDL-ARFYPLSLLETGSDLL----LFWVGRMVMLGtqltgqLPFSKV--- 675
Cdd:PRK12267 217 VPFDPKhVVYVWID-ALLNYiTALGYGSDDDELfKKFWPADVHLVGKDILrfhaIYWPIMLMALG------LPLPKKvfa 289
|
90 100 110
....*....|....*....|....*....|.
gi 268370297 676 ---LLhpmvrdRQGRKMSKSLGNVLDPRDII 703
Cdd:PRK12267 290 hgwWL------MKDGKMSKSKGNVVDPEELV 314
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
768-887 |
1.60e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 39.41 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 768 EVQSCRHFCNKIWNALRFILNALGEKfvpQPAEELSPSSPMDAWILSRLALAAQECERGFLTRELSLVTHALHHFwLHNL 847
Cdd:cd07375 3 RLKQARAFLNRLYRLLSFFRKALGGT---QPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKF-TNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 268370297 848 cDVYLEAVKPVLWHSPRPLGPPQVLFSCADLGLRLLAPLM 887
Cdd:cd07375 79 -NWYLDELKPALQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
174-236 |
1.84e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 39.77 E-value: 1.84e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268370297 174 PPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAG--IATQAVVEKQLWK---ERGVRR 236
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGglIGDPANKKGENAKafvERWIER 71
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
176-302 |
3.24e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 41.29 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370297 176 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVL-------WvpGSdHAGIATQAVveKQLWKeRGVrrhELSREaflrev 248
Cdd:PRK01611 120 ANPTGPLHVGHLRSAVIGDALARILEFAGYDVTreyyvndA--GT-QIGMLIASL--ELLWR-KAV---DISLD------ 184
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 268370297 249 wqwkeakggEICEQLRALGASLD-WDREcftmdvGSSV---AVTEAFVRLYKAGLLYR 302
Cdd:PRK01611 185 ---------EIKEDLDRLGVHFDvWFSE------SELYyngKVDEVVEDLKEKGLLYV 227
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
666-711 |
5.68e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.47 E-value: 5.68e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 268370297 666 LTGQlPFSKVLLHP-MVRDRqGRKMSKSLGNVLDPRDIISGVEMQVL 711
Cdd:COG0215 244 ATGK-PFARYWMHNgFLTVN-GEKMSKSLGNFFTVRDLLKKYDPEVL 288
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
176-208 |
6.12e-03 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 39.47 E-value: 6.12e-03
10 20 30
....*....|....*....|....*....|...
gi 268370297 176 PNVTGSLHIGHALTVAIQDALVRWHRMRGDQVL 208
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| |
