NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|260166650|ref|NP_001159439|]
View 

transcription factor HES-7 isoform 1 [Homo sapiens]

Graphical summary

show options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HLH cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription ...
14-73 3.59e-05

Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, dimerization creates a parallel, left-handed, four helix bundle; the basic region N-terminal to the first amphipathic helix mediates high-affinity DNA-binding; there are several groups of HLH proteins: those (E12/E47) which bind specific hexanucleotide sequences such as E-box (5-CANNTG-3) or StRE 5-ATCACCCCAC-3), those lacking the basic domain (Emc, Id) function as negative regulators since they fail to bind DNA, those (hairy, E(spl), deadpan) which repress transcription although they can bind specific hexanucleotide sequences such as N-box (5-CACGc/aG-3), those which have a COE domain (Collier/Olf-1/EBF) which is involved in both in dimerization and in DNA binding, and those which bind pentanucleotides ACGTG or GCGTG and have a PAS domain which allows the dimerization between PAS proteins, the binding of small molecules (e.g., dioxin), and interactions with non-PAS proteins.


:

Pssm-ID: 238036  Cd Length: 60  Bit Score: 39.89  E-value: 3.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 260166650  14 KMLKPLVEKRRRDRINRSLEELrllllertRD---QNLRNPKLEKAEILEFAVGYLRERSRVE 73
Cdd:cd00083    5 REAHNLRERRRRERINDAFDEL--------RSllpTLPPSKKLSKAEILRKAVDYIKSLQELL 59
 
Name Accession Description Interval E-value
HLH cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription ...
14-73 3.59e-05

Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, dimerization creates a parallel, left-handed, four helix bundle; the basic region N-terminal to the first amphipathic helix mediates high-affinity DNA-binding; there are several groups of HLH proteins: those (E12/E47) which bind specific hexanucleotide sequences such as E-box (5-CANNTG-3) or StRE 5-ATCACCCCAC-3), those lacking the basic domain (Emc, Id) function as negative regulators since they fail to bind DNA, those (hairy, E(spl), deadpan) which repress transcription although they can bind specific hexanucleotide sequences such as N-box (5-CACGc/aG-3), those which have a COE domain (Collier/Olf-1/EBF) which is involved in both in dimerization and in DNA binding, and those which bind pentanucleotides ACGTG or GCGTG and have a PAS domain which allows the dimerization between PAS proteins, the binding of small molecules (e.g., dioxin), and interactions with non-PAS proteins.


Pssm-ID: 238036  Cd Length: 60  Bit Score: 39.89  E-value: 3.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 260166650  14 KMLKPLVEKRRRDRINRSLEELrllllertRD---QNLRNPKLEKAEILEFAVGYLRERSRVE 73
Cdd:cd00083    5 REAHNLRERRRRERINDAFDEL--------RSllpTLPPSKKLSKAEILRKAVDYIKSLQELL 59
HLH pfam00010
Helix-loop-helix DNA-binding domain;
14-68 5.01e-05

Helix-loop-helix DNA-binding domain;


Pssm-ID: 249505  Cd Length: 52  Bit Score: 39.36  E-value: 5.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 260166650   14 KMLKPLVEKRRRDRINRSLeelrllllertrdQNLR-------NPKLEKAEILEFAVGYLRE 68
Cdd:pfam00010   2 RKAHNERERRRRDRINDAF-------------EELRellptppNKKLSKAEILRLAIDYIKH 50
HLH smart00353
helix loop helix domain;
18-68 2.85e-03

helix loop helix domain;


Pssm-ID: 197674  Cd Length: 53  Bit Score: 34.50  E-value: 2.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 260166650    18 PLVEKRRRDRINrsleelrllllerTRDQNLR--------NPKLEKAEILEFAVGYLRE 68
Cdd:smart00353   1 NARERRRRRKIN-------------EAFDELRsllptlpkNKKLSKAEILRLAIEYIKS 46
 
Name Accession Description Interval E-value
HLH cd00083
Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription ...
14-73 3.59e-05

Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, dimerization creates a parallel, left-handed, four helix bundle; the basic region N-terminal to the first amphipathic helix mediates high-affinity DNA-binding; there are several groups of HLH proteins: those (E12/E47) which bind specific hexanucleotide sequences such as E-box (5-CANNTG-3) or StRE 5-ATCACCCCAC-3), those lacking the basic domain (Emc, Id) function as negative regulators since they fail to bind DNA, those (hairy, E(spl), deadpan) which repress transcription although they can bind specific hexanucleotide sequences such as N-box (5-CACGc/aG-3), those which have a COE domain (Collier/Olf-1/EBF) which is involved in both in dimerization and in DNA binding, and those which bind pentanucleotides ACGTG or GCGTG and have a PAS domain which allows the dimerization between PAS proteins, the binding of small molecules (e.g., dioxin), and interactions with non-PAS proteins.


Pssm-ID: 238036  Cd Length: 60  Bit Score: 39.89  E-value: 3.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 260166650  14 KMLKPLVEKRRRDRINRSLEELrllllertRD---QNLRNPKLEKAEILEFAVGYLRERSRVE 73
Cdd:cd00083    5 REAHNLRERRRRERINDAFDEL--------RSllpTLPPSKKLSKAEILRKAVDYIKSLQELL 59
HLH pfam00010
Helix-loop-helix DNA-binding domain;
14-68 5.01e-05

Helix-loop-helix DNA-binding domain;


Pssm-ID: 249505  Cd Length: 52  Bit Score: 39.36  E-value: 5.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 260166650   14 KMLKPLVEKRRRDRINRSLeelrllllertrdQNLR-------NPKLEKAEILEFAVGYLRE 68
Cdd:pfam00010   2 RKAHNERERRRRDRINDAF-------------EELRellptppNKKLSKAEILRLAIDYIKH 50
HLH smart00353
helix loop helix domain;
18-68 2.85e-03

helix loop helix domain;


Pssm-ID: 197674  Cd Length: 53  Bit Score: 34.50  E-value: 2.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 260166650    18 PLVEKRRRDRINrsleelrllllerTRDQNLR--------NPKLEKAEILEFAVGYLRE 68
Cdd:smart00353   1 NARERRRRRKIN-------------EAFDELRsllptlpkNKKLSKAEILRLAIEYIKS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.11
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH