NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71725358|ref|NP_001025026|]
View 

proteasome activator complex subunit 2 isoform 2 [Mus musculus]

Protein Classification

PA28_alpha and PA28_beta domain-containing protein( domain architecture ID 10491457)

PA28_alpha and PA28_beta domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 86-229 1.01e-69

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


:

Pssm-ID: 460508  Cd Length: 145  Bit Score: 210.07  E-value: 1.01e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71725358    86 LPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGD 165
Cdd:pfam02252   2 VPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEVLAELTRVEESAANFLDQISKYFLSRAK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71725358   166 AVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS 229
Cdd:pfam02252  82 IVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
PA28_alpha super family cl03501
Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator ...
 9-58 7.20e-14

Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


The actual alignment was detected with superfamily member pfam02251:

Pssm-ID: 460507  Cd Length: 61  Bit Score: 64.13  E-value: 7.20e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71725358     9 VDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDI 58
Cdd:pfam02251   7 VDEFKQSLTKEAENLVSKFFPKKIIELDELLKSPSFNLSDLSSVHAPLNI 56
 
Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 86-229 1.01e-69

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460508  Cd Length: 145  Bit Score: 210.07  E-value: 1.01e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71725358    86 LPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGD 165
Cdd:pfam02252   2 VPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEVLAELTRVEESAANFLDQISKYFLSRAK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71725358   166 AVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS 229
Cdd:pfam02252  82 IVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
PA28_alpha pfam02251
Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator ...
 9-58 7.20e-14

Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460507  Cd Length: 61  Bit Score: 64.13  E-value: 7.20e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71725358     9 VDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDI 58
Cdd:pfam02251   7 VDEFKQSLTKEAENLVSKFFPKKIIELDELLKSPSFNLSDLSSVHAPLNI 56
 
Name Accession Description Interval E-value
PA28_beta pfam02252
Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of ...
 86-229 1.01e-69

Proteasome activator pa28 beta subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460508  Cd Length: 145  Bit Score: 210.07  E-value: 1.01e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71725358    86 LPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGD 165
Cdd:pfam02252   2 VPSNKKIVELLEVLKPEIRELIEDCNLVKMWIQLLIPKIEDGNNFGVSIQEEVLAELTRVEESAANFLDQISKYFLSRAK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71725358   166 AVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS 229
Cdd:pfam02252  82 IVSKVAKYPHVEDYRRALRELDEKEYISLRLVLLDLRNNYATLYDLIHKNIEKIKKPRSSNGGS 145
PA28_alpha pfam02251
Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator ...
 9-58 7.20e-14

Proteasome activator pa28 alpha subunit; PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.


Pssm-ID: 460507  Cd Length: 61  Bit Score: 64.13  E-value: 7.20e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71725358     9 VDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDI 58
Cdd:pfam02251   7 VDEFKQSLTKEAENLVSKFFPKKIIELDELLKSPSFNLSDLSSVHAPLNI 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH