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Conserved domains on  [gi|4502011|ref|NP_000467|]
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adenylate kinase isoenzyme 1 isoform 1 [Homo sapiens]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 6.91e-130

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 362.21  E-value: 6.91e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011      6 KKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVN 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     86 TSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYE 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 4502011    166 KRGIVRKVNAEGSVDSVFSQVCTHLDAL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 6.91e-130

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 362.21  E-value: 6.91e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011      6 KKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVN 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     86 TSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYE 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 4502011    166 KRGIVRKVNAEGSVDSVFSQVCTHLDAL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-182 2.23e-73

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 219.42  E-value: 2.23e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSKG 89
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   90 FLIDGYPREVQQGEEFERRI---GQPTLLLYVDAGPETMTQRLLKRGET-------------------SGRVDDNEETIK 147
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 4502011  148 KRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSV 182
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
13-167 3.91e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 213.71  E-value: 3.91e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     13 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSKGFLI 92
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     93 DGYPREVQQGEEFER---RIGQPTLLLYVDAGPETMTQRLLKRGET---------------------------SGRVDDN 142
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 4502011    143 EETIKKRLETYYKATEPVIAFYEKR 167
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-190 2.17e-64

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 197.27  E-value: 2.17e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSK 88
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   89 GFLIDGYPREVQQGEEFER---RIGQP-TLLLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:COG0563  80 GFILDGFPRTVAQAEALDEllaELGIKlDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502011  138 RVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL 190
Cdd:COG0563 160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 9-193 3.36e-62

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 191.90  E-value: 3.36e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSK 88
Cdd:PRK00279   2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    89 GFLIDGYPREVQQGEEFER---RIGQP-TLLLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:PRK00279  80 GFLLDGFPRTIPQAEALDEmlkELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502011   138 RVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDAL 193
Cdd:PRK00279 160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-193 6.91e-130

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 362.21  E-value: 6.91e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011      6 KKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVN 85
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     86 TSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYE 165
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 4502011    166 KRGIVRKVNAEGSVDSVFSQVCTHLDAL 193
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-182 2.23e-73

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 219.42  E-value: 2.23e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSKG 89
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   90 FLIDGYPREVQQGEEFERRI---GQPTLLLYVDAGPETMTQRLLKRGET-------------------SGRVDDNEETIK 147
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 4502011  148 KRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSV 182
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
13-167 3.91e-71

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 213.71  E-value: 3.91e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     13 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSKGFLI 92
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     93 DGYPREVQQGEEFER---RIGQPTLLLYVDAGPETMTQRLLKRGET---------------------------SGRVDDN 142
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 4502011    143 EETIKKRLETYYKATEPVIAFYEKR 167
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 10-186 5.59e-69

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 207.99  E-value: 5.59e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVS-SGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNtSK 88
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGS-SK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     89 GFLIDGYPREVQQGEEFERRIGQ---PTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYE 165
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDNkvnFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 4502011    166 KRGIVRKVNAEGSVDSVFSQV 186
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-190 2.17e-64

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 197.27  E-value: 2.17e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSK 88
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   89 GFLIDGYPREVQQGEEFER---RIGQP-TLLLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:COG0563  80 GFILDGFPRTVAQAEALDEllaELGIKlDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502011  138 RVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHL 190
Cdd:COG0563 160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 9-193 3.36e-62

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 191.90  E-value: 3.36e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSK 88
Cdd:PRK00279   2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    89 GFLIDGYPREVQQGEEFER---RIGQP-TLLLYVDAGPETMTQRLLKR---------------------------GETSG 137
Cdd:PRK00279  80 GFLLDGFPRTIPQAEALDEmlkELGIKlDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502011   138 RVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDAL 193
Cdd:PRK00279 160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 9-186 1.86e-55

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 174.73  E-value: 1.86e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011      9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSK 88
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     89 GFLIDGYPREVQQGEEFERRI-GQPTLLLYVDAGPETMTQRLLKRG--ETSGRV-------------------------D 140
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLeEPIDAVIELDVPDEELVERLSGRRicPSCGRVyhlkfnppkvpgcddctgellvqreD 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 4502011    141 DNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQV 186
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRI 205
PLN02200 PLN02200
adenylate kinase family protein
 10-186 5.91e-52

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.61  E-value: 5.91e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvaKVNTSKG 89
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEM--ESSDNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    90 FLIDGYPREVQQGEEFERRIG-QPTLLLYVDAGPETMTQRLLKRGEtsGRVDDNEETIKKRLETYYKATEPVIAFYEKRG 168
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
gi 4502011   169 IVRKVNAEGSVDSVFSQV 186
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 7-191 1.40e-47

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 153.81  E-value: 1.40e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     7 KTKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvaKVNT 86
Cdd:PRK14531   2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    87 SKGFLIDGYPREVQQGEEFE---RRIGQP---TLLLYVDagPETMTQRLLKRgetsGRVDDNEETIKKRLETYYKATEPV 160
Cdd:PRK14531  79 SGGWLLDGFPRTVAQAEALEpllEELKQPieaVVLLELD--DAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPL 152

                        170       180       190
                 ....*....|....*....|....*....|.
gi 4502011   161 IAFYEKRGIVRKVNAEGSVDSVFSQVCTHLD 191
Cdd:PRK14531 153 IDHYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 7-186 2.06e-46

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 151.10  E-value: 2.06e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     7 KTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAmVAKVNT 86
Cdd:PRK14527   5 KNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    87 SKgFLIDGYPREVQQGEEFER---RIGQPTL-LLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIA 162
Cdd:PRK14527  84 VR-VIFDGFPRTLAQAEALDRlleELGARLLaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVD 162

                        170       180
                 ....*....|....*....|....
gi 4502011   163 FYEKRGIVRKVNAEGSVDSVFSQV 186
Cdd:PRK14527 163 YYEARGHLKRVDGLGTPDEVYARI 186
PRK14532 PRK14532
adenylate kinase; Provisional
 10-182 2.43e-42

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 140.34  E-value: 2.43e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    10 IIFvvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSKG 89
Cdd:PRK14532   4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERL-PEAEAAGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    90 FLIDGYPREVQQGEE----FERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYE 165
Cdd:PRK14532  81 AIFDGFPRTVAQAEAldkmLASRGQKIDVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPYYA 160

                        170
                 ....*....|....*..
gi 4502011   166 KRGIVRKVNAEGSVDSV 182
Cdd:PRK14532 161 GQGKLTEVDGMGSIEAV 177
AAA_17 pfam13207
AAA domain;
14-147 1.46e-41

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 136.60  E-value: 1.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     14 VGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSarGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTSKGFLID 93
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     94 GYPREVQQGEEFER------RIGQPTLLLYVDAGPETMTQRLLKRgETSGRVDDNEETIK 147
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PRK14528 PRK14528
adenylate kinase; Provisional
 9-186 6.61e-41

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 136.68  E-value: 6.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVaKVNTSK 88
Cdd:PRK14528   3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIR-EADCKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    89 GFLIDGYPREVQQGEEFERRIGQPTL----LLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFY 164
Cdd:PRK14528  81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                        170       180
                 ....*....|....*....|..
gi 4502011   165 EKRGIVRKVNAEGSVDSVFSQV 186
Cdd:PRK14528 161 AAQKKLSQVNGVGSLEEVTSLI 182
adk PRK02496
adenylate kinase; Provisional
 8-182 2.88e-39

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 132.57  E-value: 2.88e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     8 TKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVNTS 87
Cdd:PRK02496   2 TRLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERL-QQPDAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    88 KGFLIDGYPREVQQG---EEFERRIGQP-TLLLYVDAGPETMTQRLLKRgetsGRVDDNEETIKKRLETYYKATEPVIAF 163
Cdd:PRK02496  80 NGWILDGFPRKVTQAaflDELLQEIGQSgERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                        170
                 ....*....|....*....
gi 4502011   164 YEKRGIVRKVNAEGSVDSV 182
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAV 174
PLN02842 PLN02842
nucleotide kinase
 13-191 5.67e-37

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 133.83  E-value: 5.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    13 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLI 92
Cdd:PLN02842   2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    93 DGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKR-------------------GETSGRV----DDNEETIKKR 149
Cdd:PLN02842  82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppesEEIKARLitrpDDTEEKVKAR 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 4502011   150 LETYYKATEPVIAFYEKrgIVRKVNAEGSVDSVFSQVCTHLD 191
Cdd:PLN02842 162 LQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLLS 201
PRK14530 PRK14530
adenylate kinase; Provisional
 11-192 4.92e-35

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 122.59  E-value: 4.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRS---------EVSSGSARgkklsEIMEKGQLVPLETVLDMLRDAMv 81
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVPDAVVNEIVEEAL- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    82 akvNTSKGFLIDGYPREVQQGEEFERrIGQPTLLLYVDAGPETMTQRLLKR---------------------------GE 134
Cdd:PRK14530  80 ---SDADGFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdecgGE 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 4502011   135 TSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDA 192
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PLN02674 PLN02674
adenylate kinase
 6-186 2.57e-31

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 113.83  E-value: 2.57e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     6 KKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvAKVN 85
Cdd:PLN02674  29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    86 TSKGFLIDGYPREVQQGEEFERRIGQ------PTLLLYVDAG--PETMTQRLLKrgETSGRV------------------ 139
Cdd:PLN02674 108 CQKGFILDGFPRTVVQAQKLDEMLAKqgakidKVLNFAIDDAilEERITGRWIH--PSSGRTyhtkfappkvpgvddvtg 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4502011   140 -------DDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQV 186
Cdd:PLN02674 186 epliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEV 239
PRK13808 PRK13808
adenylate kinase; Provisional
 11-193 3.97e-30

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 112.67  E-value: 3.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDaMVAKVNTSKGF 90
Cdd:PRK13808   3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    91 LIDGYPREVQQGEEFER---------------RIGQPTLLLYVdagpETMTQRLLKRGETSgRVDDNEETIKKRLETYYK 155
Cdd:PRK13808  82 ILDGFPRTVPQAEALDAllkdkqlkldavvelRVNEGALLARV----ETRVAEMRARGEEV-RADDTPEVLAKRLASYRA 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 4502011   156 ATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDAL 193
Cdd:PRK13808 157 QTEPLVHYYSEKRKLLTVDGMMTIDEVTREIGRVLAAV 194
PLN02459 PLN02459
probable adenylate kinase
 2-168 2.34e-28

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 106.47  E-value: 2.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     2 EEKLKKTKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMV 81
Cdd:PLN02459  24 LAKGRNVNWVFL-GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    82 A-KVNTSKGFLIDGYPREVQQGEEFE------------------------RRI-------------------GQPTLLLY 117
Cdd:PLN02459 103 AgEEEGESGFILDGFPRTVRQAEILEgvtdidlvvnlklreevlvekclgRRIcsecgknfnvadidlkgedGRPGIVMP 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4502011   118 VDAGPETMTQRLLKRGetsgrvDDNEETIKKRLETYYKATEPVIAFYEKRG 168
Cdd:PLN02459 183 PLLPPPECASKLITRA------DDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PRK14526 PRK14526
adenylate kinase; Provisional
 9-182 7.95e-26

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 98.77  E-value: 7.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     9 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDamvaKVNT-- 86
Cdd:PRK14526   2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVED----KINTik 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    87 -SKGFLIDGYPREVQQGEEFERRIGQPTLLLYVdAGPETMTQRLLKR---------------------------GETSGR 138
Cdd:PRK14526  77 nNDNFILDGFPRNINQAKALDKFLPNIKIINFL-IDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQR 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 4502011   139 VDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSV 182
Cdd:PRK14526 156 KDDKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 4-169 4.23e-23

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 92.17  E-value: 4.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     4 KLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAK 83
Cdd:PTZ00088   2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    84 VNT-SKGFLIDGYPREVQQGEEFErRIGQPTLLLYVDAGPETMTQRLLKR----------------------------GE 134
Cdd:PTZ00088  82 TDDcFKGFILDGFPRNLKQCKELG-KITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppAD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 4502011   135 TSG---------RVDDNEETIKKRLETYYKATEPVIAFYEKRGI 169
Cdd:PTZ00088 161 CEGckgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 11-182 1.11e-17

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 77.45  E-value: 1.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMvaKVNTSKGF 90
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    91 LIDGYPREVQQGEEFERRIGQPTLLL-YV--------DAGPETMTQRLLKR------------------------GETSG 137
Cdd:PRK14529  81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillpreVAKNRIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4502011   138 RVDD-NEETIKKRLETYYKATEPVIA---FYE---KRGIVR--KVNAEGSVDSV 182
Cdd:PRK14529 161 RADDqDEEAINKRHDIYYDTETGTLAaayFFKdlaAKGSTKyiELDGEGSIDEI 214
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 11-153 7.28e-10

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 55.01  E-value: 7.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEImekGQLVPlETVLDMLRDAMVAKVNTskgf 90
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYYTDA---TDRTY-ERLHELARIALRAGRPV---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502011     91 LIDG---YPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSG-RVDDNEETIKKRLETY 153
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARF 140
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 9-192 5.28e-09

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 53.43  E-value: 5.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011    9 KIIFVVGGPGSGKGTQCEKIVQ---KYGYTHLSTGDLlrsevsSGSARGKKLSEIMEKGQLVPLETVLDML-----RDAM 80
Cdd:cd01672   1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLlfaadRAQH 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   81 VAKV-----NTSKGFLID----------GYPR-----EVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVD 140
Cdd:cd01672  75 VEEVikpalARGKIVLSDrfvdsslayqGAGRglgeaLIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502011  141 DNEETIKKRLETYYKatepVIAFYEKRGIVrkVNAEGSVDSVFSQVCTHLDA 192
Cdd:cd01672 155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAILE 200
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-182 2.55e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 48.37  E-value: 2.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTgDLLRSEVssgsaRGKKLSEIMEKGQLVPL--ETVLDMLRDAMVAKVNTs 87
Cdd:COG0645   1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEATARtyARLLALARELLAAGRSV- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   88 kgfLIDG---YPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYykatEPVIAFY 164
Cdd:COG0645  74 ---ILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE----EPLTEDE 146

                       170
                ....*....|....*...
gi 4502011  165 EKRGIVRKVNAEGSVDSV 182
Cdd:COG0645 147 GFLLVVDTSGLEEALAAL 164
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 10-149 1.81e-06

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 45.56  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011   10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEImekgqlvpletvldmlRDAMVAK---VNT 86
Cdd:cd02020   1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASEVAAIPEV----------------RKALDERqreLAK 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502011   87 SKGFLIDGyprevqqgeefeRRIG-----QPTLLLYVDAGPETMTQR---LLKRGETSGRVDDNEETIKKR 149
Cdd:cd02020  65 KPGIVLEG------------RDIGtvvfpDADLKIFLTASPEVRAKRrakQLQAKGEGVDLEEILAEIIER 123
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
9-149 3.10e-06

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 45.71  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     9 KIIFVVGGPGSGKGtQCEKIVQKYGYTHLSTGDLLRSEVSSgsaRGKKLS-EIMEKgqlvpletVLDMLRD----AMVAK 83
Cdd:PRK01184   2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEVKK---RGLEPTdENIGK--------VAIDLRKelgmDAVAK 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502011    84 -------VNTSKGFLIDGYpREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRgetsGRVDDNE--ETIKKR 149
Cdd:PRK01184  70 rtvpkirEKGDEVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDDPKswEELEER 139
AAA_18 pfam13238
AAA domain;
11-144 2.57e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 39.33  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVntskgF 90
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN-----L 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 4502011     91 LIDGYPreVQQGEEFERRIGqptlLLYVDAGPETMTQRLLKRGETSGRVDDNEE 144
Cdd:pfam13238  76 IIDGHL--AELEPERAKDLV----GIVLRASPEELLERLEKRGYEEAKIKENEE 123
PRK04040 PRK04040
adenylate kinase; Provisional
 9-147 2.67e-04

adenylate kinase; Provisional


Pssm-ID: 235210  Cd Length: 188  Bit Score: 39.88  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     9 KIIFVVGGPGSGKGTQCEKIVQK--YGYTHLSTGDL-LRSEVSSGSARGK----KLS-EIMEKGQLVPLETVLDMLRDAM 80
Cdd:PRK04040   3 KVVVVTGVPGVGKTTVLNKALEKlkEDYKIVNFGDVmLEVAKEEGLVEHRdemrKLPpEEQKELQREAAERIAEMAGEGP 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502011    81 V-----AKVNTSKGFLIdGYPREVQqgeeferRIGQPTLLLYVDAGPETMTQRLLkRGETSGRVDDNEETIK 147
Cdd:PRK04040  83 VivdthATIKTPAGYLP-GLPEWVL-------EELNPDVIVLIEADPDEILMRRL-RDETRRRDVETEEDIE 145
PRK04182 PRK04182
cytidylate kinase; Provisional
 10-44 2.74e-04

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 39.79  E-value: 2.74e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 4502011    10 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR 44
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR 36
pseT PHA02530
polynucleotide kinase; Provisional
 7-156 1.47e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 38.46  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502011     7 KTKIIFVVGGPGSGKGTQCEKIVQK-YGYTHLSTGDLLRSEVSSGSARGKKLSEimEKGQLVpleTVldMLRDAMVAKVN 85
Cdd:PHA02530   1 MMKIILTVGVPGSGKSTWAREFAAKnPKAVNVNRDDLRQSLFGHGEWGEYKFTK--EKEDLV---TK--AQEAAALAALK 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502011    86 TSKGFLIDG---YPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDdneetIKKRLETYYKA 156
Cdd:PHA02530  74 SGKSVIISDtnlNPERRRKWKELAKELGAEFEEKVFDVPVEELVKRNRKRGERAVPED-----VLRSMFKQMKE 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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