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Conserved domains on  [gi|4506939|ref|NP_000184|]
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sonic hedgehog protein isoform 1 preproprotein [Homo sapiens]

Protein Classification

HH_signal and Hint domain-containing protein( domain architecture ID 12014168)

HH_signal and Hint domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
39-184 6.59e-114

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


:

Pssm-ID: 426037  Cd Length: 146  Bit Score: 330.87  E-value: 6.59e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939     39 LTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP 118
Cdd:pfam01085   1 LTPLVYKQHVPNVSENTLGASGPSEGRITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQWP 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506939    119 GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCS 184
Cdd:pfam01085  81 GVKLRVTEAWDEDGHHAPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 146
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
186-448 9.05e-96

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


:

Pssm-ID: 426033 [Multi-domain]  Cd Length: 212  Bit Score: 287.23  E-value: 9.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    186 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPrERLL 265
Cdd:pfam01079   1 KAEHSVAAKSGGCFPGDATVTLEDGGTKPMSELRPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETENG-ETLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    266 LTAAHLLFVAPHNDSATGEpeassgsgppsggalgPRALFASRVRPGQRVYVvaERDGDRRLLPAAVHSVTLsEEAAGAY 345
Cdd:pfam01079  80 LTPAHLVFVAECERSSSAL----------------SRAVFASRVRPGDCVLV--PDTGGGELRPVRVVSVTT-VEATGAY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    346 APLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTdrggdsgggdrgggggrvaltapgaadapg 425
Cdd:pfam01079 141 APLTSHGTIVVNRVLASCYAVIDSHSLAHWAFAPVRLLSSLSSLFWGNAA------------------------------ 190
                         250       260
                  ....*....|....*....|...
gi 4506939    426 aGATAGIHWYSQLLYQIGTWLLD 448
Cdd:pfam01079 191 -SQTEGIHWYSNLLYGLGSLVLD 212
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
39-184 6.59e-114

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 426037  Cd Length: 146  Bit Score: 330.87  E-value: 6.59e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939     39 LTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP 118
Cdd:pfam01085   1 LTPLVYKQHVPNVSENTLGASGPSEGRITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQWP 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506939    119 GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCS 184
Cdd:pfam01085  81 GVKLRVTEAWDEDGHHAPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 146
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
186-448 9.05e-96

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 426033 [Multi-domain]  Cd Length: 212  Bit Score: 287.23  E-value: 9.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    186 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPrERLL 265
Cdd:pfam01079   1 KAEHSVAAKSGGCFPGDATVTLEDGGTKPMSELRPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETENG-ETLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    266 LTAAHLLFVAPHNDSATGEpeassgsgppsggalgPRALFASRVRPGQRVYVvaERDGDRRLLPAAVHSVTLsEEAAGAY 345
Cdd:pfam01079  80 LTPAHLVFVAECERSSSAL----------------SRAVFASRVRPGDCVLV--PDTGGGELRPVRVVSVTT-VEATGAY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    346 APLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTdrggdsgggdrgggggrvaltapgaadapg 425
Cdd:pfam01079 141 APLTSHGTIVVNRVLASCYAVIDSHSLAHWAFAPVRLLSSLSSLFWGNAA------------------------------ 190
                         250       260
                  ....*....|....*....|...
gi 4506939    426 aGATAGIHWYSQLLYQIGTWLLD 448
Cdd:pfam01079 191 -SQTEGIHWYSNLLYGLGSLVLD 212
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
198-363 1.99e-29

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 111.98  E-value: 1.99e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939  198 CFPGSATVHLEQGGTKLVKDLSP--GDRVLAADDQGRLLYSDFLTFLDRDdgAKKVFYVIETREPRErLLLTAAHLLFVA 275
Cdd:cd00081   1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTESGRE-ITLTPDHLLFVL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939  276 PHNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVVaerdgdrrlLPAAVHSVTLSEEAAGAYAPLTA-QGTI 354
Cdd:cd00081  78 EDG---------------------ELKWVFASDLKPGDYVLVP---------VLEKVKEIEEIEYTGGVYDLTVEdNHNF 127

                ....*....
gi 4506939  355 LINRVLASC 363
Cdd:cd00081 128 IANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
197-318 1.17e-23

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 94.64  E-value: 1.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939     197 GCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDqGRLLYSDFLTFLDRDDGAKKVFYVIETREPRErLLLTAAHLLFVAP 276
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALDE-GTLKYSPVKVFLVREPKGEKKFYRIKTENGRE-ITLTPDHLLLVRD 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 4506939     277 HNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVV 318
Cdd:smart00306  79 GG---------------------KLVWVFASELKPGDYVLVP 99
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
39-184 6.59e-114

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 426037  Cd Length: 146  Bit Score: 330.87  E-value: 6.59e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939     39 LTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP 118
Cdd:pfam01085   1 LTPLVYKQHVPNVSENTLGASGPSEGRITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQWP 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506939    119 GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCS 184
Cdd:pfam01085  81 GVKLRVTEAWDEDGHHAPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 146
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
186-448 9.05e-96

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 426033 [Multi-domain]  Cd Length: 212  Bit Score: 287.23  E-value: 9.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    186 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPrERLL 265
Cdd:pfam01079   1 KAEHSVAAKSGGCFPGDATVTLEDGGTKPMSELRPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETENG-ETLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    266 LTAAHLLFVAPHNDSATGEpeassgsgppsggalgPRALFASRVRPGQRVYVvaERDGDRRLLPAAVHSVTLsEEAAGAY 345
Cdd:pfam01079  80 LTPAHLVFVAECERSSSAL----------------SRAVFASRVRPGDCVLV--PDTGGGELRPVRVVSVTT-VEATGAY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939    346 APLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTdrggdsgggdrgggggrvaltapgaadapg 425
Cdd:pfam01079 141 APLTSHGTIVVNRVLASCYAVIDSHSLAHWAFAPVRLLSSLSSLFWGNAA------------------------------ 190
                         250       260
                  ....*....|....*....|...
gi 4506939    426 aGATAGIHWYSQLLYQIGTWLLD 448
Cdd:pfam01079 191 -SQTEGIHWYSNLLYGLGSLVLD 212
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
198-363 1.99e-29

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 111.98  E-value: 1.99e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939  198 CFPGSATVHLEQGGTKLVKDLSP--GDRVLAADDQGRLLYSDFLTFLDRDdgAKKVFYVIETREPRErLLLTAAHLLFVA 275
Cdd:cd00081   1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTESGRE-ITLTPDHLLFVL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939  276 PHNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVVaerdgdrrlLPAAVHSVTLSEEAAGAYAPLTA-QGTI 354
Cdd:cd00081  78 EDG---------------------ELKWVFASDLKPGDYVLVP---------VLEKVKEIEEIEYTGGVYDLTVEdNHNF 127

                ....*....
gi 4506939  355 LINRVLASC 363
Cdd:cd00081 128 IANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
197-318 1.17e-23

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 94.64  E-value: 1.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506939     197 GCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDqGRLLYSDFLTFLDRDDGAKKVFYVIETREPRErLLLTAAHLLFVAP 276
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALDE-GTLKYSPVKVFLVREPKGEKKFYRIKTENGRE-ITLTPDHLLLVRD 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 4506939     277 HNdsatgepeassgsgppsggalGPRALFASRVRPGQRVYVV 318
Cdd:smart00306  79 GG---------------------KLVWVFASELKPGDYVLVP 99
HintC smart00305
Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. ...
324-368 9.90e-05

Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197641  Cd Length: 46  Bit Score: 39.46  E-value: 9.90e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 4506939     324 DRRLLPAAVHSVTlSEEAAGAYAP-LTAQGTILINRVLASCYAVIE 368
Cdd:smart00305   1 EGDFRFVRVKSIE-ETEYTGVYDPtVTENHNFIANGILVHNCAEIE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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