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Conserved domains on  [gi|363548513|sp|Q07085|]

RecName: Full=Esterase CM06B1

Graphical summary

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List of domain hits

 Description PssmId Multi-dom E-value
Esterase_lipase[cd00312], Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act ...
 238191 no 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


:

Cd Length: 493  Bit Score: 545.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  16 ALKASCGPVRGNIYKHddviVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQTGGFEQIaGPRTPTPEE 95
Cdd:cd00312    1 LVVTPNGKVRGVDEGG----VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGG-LWNAKLPGS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  96 AGCLTLNVFTPRNASseFKNGRPVMVYIHGGGYELCASSDFCAYSLSGTLPlkDVVVVSINYRLGVFGFLTTGDNVCPGN 175
Cdd:cd00312   76 EDCLYLNVYTPKNTK--PGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREGD--NVIVVSINYRLGVLGFLSTGDIELPGN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 176 FGLWDQTLALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRasENQAKIFRE 255
Cdd:cd00312  152 YGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQ--ENARGRAKR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 256 FAEFHGFSGRDSSALFKWYQEQSPETLSNVKGYKK--SISGFLTFIPNLDGDFFPKPLDELRKE--APKKQMMTGVTEYE 331
Cdd:cd00312  230 LARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLlfSYSPFLPFGPVVDGDFIPDDPEELIKEgkFAKVPLIIGVTKDE 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 332 GLMLASMNPAF------SPADVGLTLMPQGIYGKDvvsnpDEIQKIFYEKYVEGVDksDELAMRKKLCEALGDEFFNVG- 404
Cdd:cd00312  310 GGYFAAMLLNFdakliiETNDRWLELLPYLLFYAD-----DALADKVLEKYPGDVD--DSVESRKNLSDMLTDLLFKCPa 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 405 VIQAAKNAAKHGNEVYFYTFEYVNPDSFGMWDgmmPFKAAVHCTELRYLLGEGVYSKFEPtEEDRKVMETTTTLFSNFAK 484
Cdd:cd00312  383 RYFLAQHRKAGGSPVYAYVFDHRSSLSVGRWP---PWLGTVHGDEIFFVFGNPLLKEGLR-EEEEKLSRTMMKYWANFAK 458

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 363548513 485 YGNPNGKGaTAEIWEKYSLNrPERHYRISYPKCEMRD 521
Cdd:cd00312  459 TGNPNTEG-NLVVWPAYTSE-SEKYLDINIEGTEIKQ 493
COesterase[pfam00135], Carboxylesterase family;
215741 yes 6.10e-169

Carboxylesterase family;


:

Cd Length: 510  Bit Score: 492.24  E-value: 6.10e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513   17 LKASCGPVRGNIYKHDDVIVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQTGGFeQIAGPRTPTPEEA 96
Cdd:pfam00135   3 VETSYGKVRGLRVTVDGGPVYAFLGIPYAKPPVGELRFKKPQPPEPWTGVLDATKYGPACPQNNDL-GSEMWNKNTGMSE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513   97 GCLTLNVFTPRNASSefKNGRPVMVYIHGGGYELcASSDFCAYSLSGTLPLKDVVVVSINYRLGVFGFLTTGDNVCPGNF 176
Cdd:pfam00135  82 DCLYLNVYTPKLASE--SKKLPVMVWIHGGGFQS-GSASLDDYDGPDLAASEDVVVVTINYRLGALGFLSTGDSELPGNA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  177 GLWDQTLALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRasENQAKIFREF 256
Cdd:pfam00135 159 GLLDQVLALRWVKDNIAAFGGDPDNVTLFGESAGAASVSLLLLSPASRGLFHRAILMSGSALSPWAIT--SNPRQRAKRL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  257 AEFHGFSGRDSSA-LFKWYQEQSPETLSNVKGYKKSISGFLTFIPNLDGDFFPKPLDELRKEA--PKKQMMTGVTEYEGL 333
Cdd:pfam00135 237 AKLLGCPGEDSSAeLLECLRKKSAEELLDAQLLLLEEVGFFPFGPVVDGDFLPKDPEELLKSGwfNKVPLLIGVTSDEGL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  334 -MLASMNPAFSP-----ADVGLTLMPQGIYGKdvvSNPDEIQKIFYEKYVEGVDKSDELaMRKKLCEALGDEFFNVGVIQ 407
Cdd:pfam00135 317 lFLAYVLPDPTElsellNEDFLELLPELLPGA---PELSRIADALKEEYTDDPDDNSEE-SRDALVDLLSDYLFVCPIRL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  408 AAKNAAKHGNEVYFYTFEYVNPDSFGMWDgmMPFKAAVHCTELRYLLGEGVYSKFEPTEEDRKVMETTTTLFSNFAKYGN 487
Cdd:pfam00135 393 AAARLASAGSPVYLYRFDYRSSGSINKLW--PPWMGVSHGDDLPYVFGNPLMRKLLYSEEEEILSRRMMGYWTNFAKTGN 470

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 363548513  488 PNGKGATAEIWEKYSLNR--PERHYRISYPKCEMRDV 522
Cdd:pfam00135 471 PNGEAFGLPVWPPYTSEEylEITLLNISTNGLREEDC 507
 
Description PssmId Multi-dom E-value
Esterase_lipase[cd00312], Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act ...
 238191 no 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Cd Length: 493  Bit Score: 545.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  16 ALKASCGPVRGNIYKHddviVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQTGGFEQIaGPRTPTPEE 95
Cdd:cd00312    1 LVVTPNGKVRGVDEGG----VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGG-LWNAKLPGS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  96 AGCLTLNVFTPRNASseFKNGRPVMVYIHGGGYELCASSDFCAYSLSGTLPlkDVVVVSINYRLGVFGFLTTGDNVCPGN 175
Cdd:cd00312   76 EDCLYLNVYTPKNTK--PGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREGD--NVIVVSINYRLGVLGFLSTGDIELPGN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 176 FGLWDQTLALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRasENQAKIFRE 255
Cdd:cd00312  152 YGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQ--ENARGRAKR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 256 FAEFHGFSGRDSSALFKWYQEQSPETLSNVKGYKK--SISGFLTFIPNLDGDFFPKPLDELRKE--APKKQMMTGVTEYE 331
Cdd:cd00312  230 LARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLlfSYSPFLPFGPVVDGDFIPDDPEELIKEgkFAKVPLIIGVTKDE 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 332 GLMLASMNPAF------SPADVGLTLMPQGIYGKDvvsnpDEIQKIFYEKYVEGVDksDELAMRKKLCEALGDEFFNVG- 404
Cdd:cd00312  310 GGYFAAMLLNFdakliiETNDRWLELLPYLLFYAD-----DALADKVLEKYPGDVD--DSVESRKNLSDMLTDLLFKCPa 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 405 VIQAAKNAAKHGNEVYFYTFEYVNPDSFGMWDgmmPFKAAVHCTELRYLLGEGVYSKFEPtEEDRKVMETTTTLFSNFAK 484
Cdd:cd00312  383 RYFLAQHRKAGGSPVYAYVFDHRSSLSVGRWP---PWLGTVHGDEIFFVFGNPLLKEGLR-EEEEKLSRTMMKYWANFAK 458

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 363548513 485 YGNPNGKGaTAEIWEKYSLNrPERHYRISYPKCEMRD 521
Cdd:cd00312  459 TGNPNTEG-NLVVWPAYTSE-SEKYLDINIEGTEIKQ 493
COesterase[pfam00135], Carboxylesterase family;
215741 yes 6.10e-169

Carboxylesterase family;


Cd Length: 510  Bit Score: 492.24  E-value: 6.10e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513   17 LKASCGPVRGNIYKHDDVIVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQTGGFeQIAGPRTPTPEEA 96
Cdd:pfam00135   3 VETSYGKVRGLRVTVDGGPVYAFLGIPYAKPPVGELRFKKPQPPEPWTGVLDATKYGPACPQNNDL-GSEMWNKNTGMSE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513   97 GCLTLNVFTPRNASSefKNGRPVMVYIHGGGYELcASSDFCAYSLSGTLPLKDVVVVSINYRLGVFGFLTTGDNVCPGNF 176
Cdd:pfam00135  82 DCLYLNVYTPKLASE--SKKLPVMVWIHGGGFQS-GSASLDDYDGPDLAASEDVVVVTINYRLGALGFLSTGDSELPGNA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  177 GLWDQTLALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAIRasENQAKIFREF 256
Cdd:pfam00135 159 GLLDQVLALRWVKDNIAAFGGDPDNVTLFGESAGAASVSLLLLSPASRGLFHRAILMSGSALSPWAIT--SNPRQRAKRL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  257 AEFHGFSGRDSSA-LFKWYQEQSPETLSNVKGYKKSISGFLTFIPNLDGDFFPKPLDELRKEA--PKKQMMTGVTEYEGL 333
Cdd:pfam00135 237 AKLLGCPGEDSSAeLLECLRKKSAEELLDAQLLLLEEVGFFPFGPVVDGDFLPKDPEELLKSGwfNKVPLLIGVTSDEGL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  334 -MLASMNPAFSP-----ADVGLTLMPQGIYGKdvvSNPDEIQKIFYEKYVEGVDKSDELaMRKKLCEALGDEFFNVGVIQ 407
Cdd:pfam00135 317 lFLAYVLPDPTElsellNEDFLELLPELLPGA---PELSRIADALKEEYTDDPDDNSEE-SRDALVDLLSDYLFVCPIRL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  408 AAKNAAKHGNEVYFYTFEYVNPDSFGMWDgmMPFKAAVHCTELRYLLGEGVYSKFEPTEEDRKVMETTTTLFSNFAKYGN 487
Cdd:pfam00135 393 AAARLASAGSPVYLYRFDYRSSGSINKLW--PPWMGVSHGDDLPYVFGNPLMRKLLYSEEEEILSRRMMGYWTNFAKTGN 470

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 363548513  488 PNGKGATAEIWEKYSLNR--PERHYRISYPKCEMRDV 522
Cdd:pfam00135 471 PNGEAFGLPVWPPYTSEEylEITLLNISTNGLREEDC 507
PnbA[COG2272], Carboxylesterase type B [Lipid metabolism]
 225181 yes 1.69e-81

Carboxylesterase type B [Lipid metabolism]


Cd Length: 491  Bit Score: 265.45  E-value: 1.69e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  22 GPVRGNiykhDDVIVDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQTggFEQIAGPRTPTPEEaGCLTL 101
Cdd:COG2272   10 GKVEGI----TVNGVHSWLGIPYAAPPVGELRFRRPVPPEPWSGVRDATQFGPACPQP--FNRMGSGEDFTGSE-DCLYL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 102 NVFTPRNAssefKNGRPVMVYIHGGGYELCASSDFcAYSLSGTLPLKDVVVVSINYRLGVFGFLT----TGDNVCPGNFG 177
Cdd:COG2272   83 NIWAPEVP----AEKLPVMVYIHGGGYIMGSGSEP-LYDGSALAARGDVVVVSVNYRLGALGFLDlsslDTEDAFASNLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 178 LWDQTLALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSRDLFQRFIPISGTAHCdfaIRASENQAKIFREFA 257
Cdd:COG2272  158 LLDQILALKWVRDNIEAFGGDPQNVTLFGESAGAASILTLLAVPSAKGLFHRAIALSGAASR---VTSREEAREKAAAFA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 258 EFHGFSGRDSSALFKwyqeQSPETLsnVKGY---KKSISGFLTFIPNLDGDFFPK-PLDELRKEAP-KKQMMTGVTEYEG 332
Cdd:COG2272  235 RALGIPEATLDKLRA----LSAEDL--VKARlplIGRTFGAVPYGPVLGDSLLPRdPLEAIAQGRShGVPLMIGTNHDEG 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 333 LMLASMNPAFSPADVGLTLMpqgiygKDVVSNPDEIQKI--FYEKYVEGVDKSDELamrkklceaLGDEFFNVGVIQAAk 410
Cdd:COG2272  309 SLFINFNPDSPPGLRDKVAA------RLPGKELINAERVpaAYPGVSAAAAAFGAL---------VTDRLFKAPSIRLA- 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 411 NAAKHGNEVYFYTFEYVNPDSFGmwdgmmPFKAAVHCTELRYLLGE--GVYSKFEPTEEDRKVMETTTTLFSNFAKYGNP 488
Cdd:COG2272  373 QAQSAGAPTWLYRFDYAPDTVRV------PGFGAPHATELSLVFGNlvALGSAAQTARATAKLSRQMQDAWANFARTGSP 446

                        490
                 ....*....|....*....
gi 363548513 489 NGKGATAeiWEKYSLNRPE 507
Cdd:COG2272  447 NGLGLPD--WPAYTEERRA 463
Aes[COG0657], Esterase/lipase [Lipid metabolism]
 223730 yes 2.03e-13

Esterase/lipase [Lipid metabolism]


Cd Length: 312  Bit Score: 69.96  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513 103 VFTPRNASsefKNGRPVMVYIHGGGYELCaSSDFCAYSLSGTLPLKDVVVVSINYRLGVFG-FLTTGDNVCPgnfglwdq 181
Cdd:COG0657   68 VYRPDRKA---AATAPVVLYLHGGGWVLG-SLRTHDALVARLAAAAGAVVVSVDYRLAPEHpFPAALEDAYA-------- 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 363548513 182 tlALKWVQKHISSFGGDPNCVTVFGQSAGGASTDLLSLSPHSR 224
Cdd:COG0657  136 --AYRWLRANAAELGIDPSRIAVAGDSAGGHLALALALAARDR 176
Abhydrolase_3[pfam07859], alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 219611 yes 2.26e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Cd Length: 207  Bit Score: 56.05  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363548513  120 MVYIHGGGYELC--ASSDFCAYSLSGTLplkDVVVVSINYRLGvfgflttGDNVCPGNFglwDQTL-ALKWVQKHISSFG 196
Cdd:pfam07859   1 LVYFHGGGFVLGsaDTHDRLCRRLAAAA---GAVVVSVDYRLA-------PEHPFPAAI---EDAYaALRWLAEHAWELG 67

                          90
                  ....*....|....*
gi 363548513  197 GDPNCVTVFGQSAGG 211
Cdd:pfam07859  68 ADPSRIAVAGDSAGG 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.10
Preset Options:Database: cdsearch/cdd   Low complexity filter: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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