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Conserved domains on  [gi|71419636|ref|XP_811227|]
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peroxisome assembly protein, putative [Trypanosoma cruzi]

Protein Classification

26S protease regulatory subunit( domain architecture ID 11440662)

26S protease regulatory subunit is an AAA (ATPases Associated with various cellular Activities) family ATPase similar to 26S protease regulatory subunit 8, a component of the 19S proteasome regulatory particle (RP), which is part of the multiprotein complex 26S proteasome that is involved in the ATP-dependent degradation of ubiquitinated proteins

CATH:  1.10.8.60
Gene Ontology:  GO:0005524|GO:0016887|GO:0036402|GO:0008540

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 659-940 1.42e-94

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 301.93  E-value: 1.42e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 659 VRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKyGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDaGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPD 817
Cdd:COG1222 155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGT-SGEVQRTVNQLLAELDGF-------ESRGDVLIIAATNRPD 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 818 LLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVEsmlqr 897
Cdd:COG1222 227 LLDPALLRPGRFDRVIEVPLP-DEEAREEILKIHLRDMPLADDVDLDKLAK-LTEGFSGADLKAIVTEAGMFAIR----- 299

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 71419636 898 taaeggddtqsvgRHAEEapsffVQMRDFVRARDQLKPSVSKE 940
Cdd:COG1222 300 -------------EGRDT-----VTMEDLEKAIEKVKKKTETA 324
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 659-940 1.42e-94

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 301.93  E-value: 1.42e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 659 VRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKyGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDaGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPD 817
Cdd:COG1222 155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGT-SGEVQRTVNQLLAELDGF-------ESRGDVLIIAATNRPD 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 818 LLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVEsmlqr 897
Cdd:COG1222 227 LLDPALLRPGRFDRVIEVPLP-DEEAREEILKIHLRDMPLADDVDLDKLAK-LTEGFSGADLKAIVTEAGMFAIR----- 299

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 71419636 898 taaeggddtqsvgRHAEEapsffVQMRDFVRARDQLKPSVSKE 940
Cdd:COG1222 300 -------------EGRDT-----VTMEDLEKAIEKVKKKTETA 324
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 566-948 6.61e-89

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 299.90  E-value: 6.61e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   566 DRRIIAETLfQEAQRSFGVCKSLLLsfDSVASWTVGLSAADVVAYMQEC-LSVLRCMrLPEGVRPVLSESLCGSVLQ--- 641
Cdd:TIGR01243 347 DKRARKEIL-KVHTRNMPLAEDVDL--DKLAEVTHGFVGADLAALAKEAaMAALRRF-IREGKINFEAEEIPAEVLKelk 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   642 ----------KYQKAHGYSLVSTKLQPVRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTL 710
Cdd:TIGR01243 423 vtmkdfmealKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKmGIRPPKGVLLFGPPGTGKTL 502

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   711 LAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDAgGAMDRVVAQLLVE 790
Cdd:TIGR01243 503 LAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTE 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   791 VDGVghtrtdgSTTAQVFVIGATNRPDLLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpL 870
Cdd:TIGR01243 582 MDGI-------QELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP-DEEARKEIFKIHTRSMPLAEDVDLEELAE-M 652

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71419636   871 SMDYTGADFFALCSDAMMFAVESMLQRTAAEGGDDTQSvgrhaEEAPSFFVQMRDFVRARDQLKPSVSKEELQRYESL 948
Cdd:TIGR01243 653 TEGYTGADIEAVCREAAMAALRESIGSPAKEKLEVGEE-----EFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERL 725
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 671-835 5.00e-83

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 264.76  E-value: 5.00e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 671 KRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRA 750
Cdd:cd19527   2 KKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 751 RDNSPCIIFFDELDALAPARGAKGDAGGAMDRVVAQLLVEVDGVGHTRTDgsttaqVFVIGATNRPDLLDPSLLRPGRFD 830
Cdd:cd19527  82 RDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSGQD------VFVIGATNRPDLLDPALLRPGRFD 155


                ....*
gi 71419636 831 RLCYL 835
Cdd:cd19527 156 KLLYL 160
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 659-952 1.45e-73

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 247.44  E-value: 1.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  659 VRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:PRK03992 128 VTYEDIGGLEEQIREVREAVELPLKKPELFEEvGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIG 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPAR---GAKGDAggAMDRVVAQLLVEVDGVGhTRTDgsttaqVFVIGATN 814
Cdd:PRK03992 208 EGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsGTSGDR--EVQRTLMQLLAEMDGFD-PRGN------VKIIAATN 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  815 RPDLLDPSLLRPGRFDRLCYLGLPAT--REEqlvALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVE 892
Cdd:PRK03992 279 RIDILDPAILRPGRFDRIIEVPLPDEegRLE---ILKIHTRKMNLADDVDLEELAE-LTEGASGADLKAICTEAGMFAIR 354

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  893 SmlQRTAaeggddtqsvgrhaeeapsffVQMRDFVRARDQLKpsvSKEELQRYESLRSKF 952
Cdd:PRK03992 355 D--DRTE---------------------VTMEDFLKAIEKVM---GKEEKDSMEEPGVMF 388
cell_div_CdvC NF041006
cell division protein CdvC;
659-952 3.50e-57

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 201.50  E-value: 3.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  659 VRWKDVGGLEEAKRELRETIQLPLLHPELFSTGTKRraGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGE 738
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFPLGWPR--GILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  739 SEKNIRLLFQRAR-----DNSPCIIFFDELDALAparGAKGDAGGAMDRVVAQLLVEVDGVghtrTDGSTTAQVFVIGAT 813
Cdd:NF041006 178 AEKNVAKIFKKARekskeEGKPAIIFIDEIDALL---GVYSSEVGGEVRVRNQFLKEMDGL----QDKSENYHVYVIGAT 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  814 NRPDLLDPSLLRpgRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVES 893
Cdd:NF041006 251 NKPWRLDEPFLR--RFQKRIYIPLP-DREQRLELLKYYTSKIKLENDVDLDELAE-MTEGYTASDIRDIVQAAHMRVVKE 326

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 71419636  894 MLQRTAAEggddtqsvgrhaeeaPSfFVQMRDFVRARDQLKPSVSKEELQRYESLRSKF 952
Cdd:NF041006 327 MFEKGLGE---------------PR-PITMEDFKEVLKIRKPSVNQEMLKAYEAWHEKF 369
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 698-837 1.08e-50

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 174.32  E-value: 1.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   698 ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDag 777
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGD-- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   778 GAMDRVVAQLLVEVDGVghtrtdGSTTAQVFVIGATNRPDLLDPSLLrpGRFDRLCYLGL 837
Cdd:pfam00004  79 SESRRVVNQLLTELDGF------TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 694-838 5.63e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 78.95  E-value: 5.63e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636    694 RRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVK-----------------GPELINQYVGESEKNIRLLFQRARDNSPC 756
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636    757 IIFFDELDALAPARGAKGDAGGAMDRVVAQLLVEVDgvghtrtdgsttaqVFVIGATNRPDLLDPSLLRPgRFDRLCYLG 836
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKN--------------LTVILTTNDEKDLGPALLRR-RFDRRIVLL 145


                   ..
gi 71419636    837 LP 838
Cdd:smart00382 146 LI 147
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 659-940 1.42e-94

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 301.93  E-value: 1.42e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 659 VRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKyGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDaGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPD 817
Cdd:COG1222 155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGT-SGEVQRTVNQLLAELDGF-------ESRGDVLIIAATNRPD 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 818 LLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVEsmlqr 897
Cdd:COG1222 227 LLDPALLRPGRFDRVIEVPLP-DEEAREEILKIHLRDMPLADDVDLDKLAK-LTEGFSGADLKAIVTEAGMFAIR----- 299

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 71419636 898 taaeggddtqsvgRHAEEapsffVQMRDFVRARDQLKPSVSKE 940
Cdd:COG1222 300 -------------EGRDT-----VTMEDLEKAIEKVKKKTETA 324
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 566-948 6.61e-89

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 299.90  E-value: 6.61e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   566 DRRIIAETLfQEAQRSFGVCKSLLLsfDSVASWTVGLSAADVVAYMQEC-LSVLRCMrLPEGVRPVLSESLCGSVLQ--- 641
Cdd:TIGR01243 347 DKRARKEIL-KVHTRNMPLAEDVDL--DKLAEVTHGFVGADLAALAKEAaMAALRRF-IREGKINFEAEEIPAEVLKelk 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   642 ----------KYQKAHGYSLVSTKLQPVRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTL 710
Cdd:TIGR01243 423 vtmkdfmealKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKmGIRPPKGVLLFGPPGTGKTL 502

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   711 LAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDAgGAMDRVVAQLLVE 790
Cdd:TIGR01243 503 LAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTE 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   791 VDGVghtrtdgSTTAQVFVIGATNRPDLLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpL 870
Cdd:TIGR01243 582 MDGI-------QELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP-DEEARKEIFKIHTRSMPLAEDVDLEELAE-M 652

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71419636   871 SMDYTGADFFALCSDAMMFAVESMLQRTAAEGGDDTQSvgrhaEEAPSFFVQMRDFVRARDQLKPSVSKEELQRYESL 948
Cdd:TIGR01243 653 TEGYTGADIEAVCREAAMAALRESIGSPAKEKLEVGEE-----EFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERL 725
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 671-835 5.00e-83

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 264.76  E-value: 5.00e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 671 KRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRA 750
Cdd:cd19527   2 KKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 751 RDNSPCIIFFDELDALAPARGAKGDAGGAMDRVVAQLLVEVDGVGHTRTDgsttaqVFVIGATNRPDLLDPSLLRPGRFD 830
Cdd:cd19527  82 RDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSGQD------VFVIGATNRPDLLDPALLRPGRFD 155


                ....*
gi 71419636 831 RLCYL 835
Cdd:cd19527 156 KLLYL 160
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 670-835 5.50e-80

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 256.44  E-value: 5.50e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 670 AKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQ 748
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRlGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 749 RARDNSPCIIFFDELDALAPARGAKGDaGGAMDRVVAQLLVEVDGVGHTRtdgsttaQVFVIGATNRPDLLDPSLLRPGR 828
Cdd:cd19511  81 KARQAAPCIIFFDEIDSLAPRRGQSDS-SGVTDRVVSQLLTELDGIESLK-------GVVVIAATNRPDMIDPALLRPGR 152


                ....*..
gi 71419636 829 FDRLCYL 835
Cdd:cd19511 153 LDKLIYV 159
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 540-892 1.36e-75

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 253.29  E-value: 1.36e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 540 EAPPPTVAARARNVEGVLNCANPSDTDRRIIAETLFQEAQRSFGVCKSLLLSFDSVASWTVGLSAADVVAYMQECLSVLR 619
Cdd:COG0464  35 AALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDL 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 620 CMRLPEGVRPVLSESLCGSVLQKYQKAHGYSLVSTKLQPVRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGI 698
Cdd:COG0464 115 ERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEyGLPPPRGL 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 699 LFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDagG 778
Cdd:COG0464 195 LLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGD--G 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 779 AMDRVVAQLLVEVDGVGHtrtdgsttaQVFVIGATNRPDLLDPSLLRpgRFDRLCYLGLPaTREEQLVALRALTRKFNLA 858
Cdd:COG0464 273 VGRRVVNTLLTEMEELRS---------DVVVIAATNRPDLLDPALLR--RFDEIIFFPLP-DAEERLEIFRIHLRKRPLD 340

                       330       340       350
                ....*....|....*....|....*....|....
gi 71419636 859 DDVDFDALLEPLSmDYTGADFFALCSDAMMFAVE 892
Cdd:COG0464 341 EDVDLEELAEATE-GLSGADIRNVVRRAALQALR 373
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 659-952 1.45e-73

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 247.44  E-value: 1.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  659 VRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:PRK03992 128 VTYEDIGGLEEQIREVREAVELPLKKPELFEEvGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIG 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPAR---GAKGDAggAMDRVVAQLLVEVDGVGhTRTDgsttaqVFVIGATN 814
Cdd:PRK03992 208 EGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsGTSGDR--EVQRTLMQLLAEMDGFD-PRGN------VKIIAATN 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  815 RPDLLDPSLLRPGRFDRLCYLGLPAT--REEqlvALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVE 892
Cdd:PRK03992 279 RIDILDPAILRPGRFDRIIEVPLPDEegRLE---ILKIHTRKMNLADDVDLEELAE-LTEGASGADLKAICTEAGMFAIR 354

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  893 SmlQRTAaeggddtqsvgrhaeeapsffVQMRDFVRARDQLKpsvSKEELQRYESLRSKF 952
Cdd:PRK03992 355 D--DRTE---------------------VTMEDFLKAIEKVM---GKEEKDSMEEPGVMF 388
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 671-835 1.11e-72

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 236.64  E-value: 1.11e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 671 KRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQR 749
Cdd:cd19528   2 KRELQELVQYPVEHPDKFLKfGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 750 ARDNSPCIIFFDELDALAPARGAK-GDAGGAMDRVVAQLLVEVDGVGHTRTdgsttaqVFVIGATNRPDLLDPSLLRPGR 828
Cdd:cd19528  82 ARAAAPCVLFFDELDSIAKARGGNiGDAGGAADRVINQILTEMDGMNTKKN-------VFIIGATNRPDIIDPAILRPGR 154


                ....*..
gi 71419636 829 FDRLCYL 835
Cdd:cd19528 155 LDQLIYI 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 654-942 1.39e-72

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 254.83  E-value: 1.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   654 TKLQPVRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELI 732
Cdd:TIGR01243 170 RKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHlGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIM 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   733 NQYVGESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKgdAGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGA 812
Cdd:TIGR01243 250 SKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEV--TGEVEKRVVAQLLTLMDGL-------KGRGRVIVIGA 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   813 TNRPDLLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAve 892
Cdd:TIGR01243 321 TNRPDALDPALRRPGRFDREIVIRVP-DKRARKEILKVHTRNMPLAEDVDLDKLAE-VTHGFVGADLAALAKEAAMAA-- 396

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71419636   893 smLQRTAAEGgddtqSVGRHAEEAPS-----FFVQMRDFVRARDQLKPSVSKEEL 942
Cdd:TIGR01243 397 --LRRFIREG-----KINFEAEEIPAevlkeLKVTMKDFMEALKMVEPSAIREVL 444
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 670-835 8.38e-69

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 225.84  E-value: 8.38e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 670 AKRELRETIQLPLLHPELFS-TGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQ 748
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVFKrLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 749 RARDNSPCIIFFDELDALAPARGAKGDAgGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPDLLDPSLLRPGR 828
Cdd:cd19529  81 KARQVAPCVIFFDEIDSIAPRRGTTGDS-GVTERVVNQLLTELDGL-------EEMNGVVVIAATNRPDIIDPALLRAGR 152


                ....*..
gi 71419636 829 FDRLCYL 835
Cdd:cd19529 153 FDRLIYI 159
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 659-891 1.18e-68

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 233.15  E-value: 1.18e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   659 VRWKDVGGLEEAKRELRETIQLPLLHPELFS-TGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:TIGR01242 119 VSYEDIGGLEEQIREIREAVELPLKHPELFEeVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKYIG 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   738 ESEKNIRLLFQRARDNSPCIIFFDELDALApARGAKGDAGG--AMDRVVAQLLVEVDGVgHTRTDgsttaqVFVIGATNR 815
Cdd:TIGR01242 199 EGARLVREIFELAKEKAPSIIFIDEIDAIA-AKRTDSGTSGdrEVQRTLMQLLAELDGF-DPRGN------VKVIAATNR 270

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71419636   816 PDLLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAV 891
Cdd:TIGR01242 271 PDILDPALLRPGRFDRIIEVPLP-DFEGRLEILKIHTRKMKLAEDVDLEAIAK-MTEGASGADLKAICTEAGMFAI 344
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 663-831 1.23e-65

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 217.54  E-value: 1.23e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEK 741
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRAlGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 742 NIRLLFQRARDNSPCIIFFDELDALAPARGAkgDAGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPDLLDP 821
Cdd:cd19503  81 NLREIFEEARSHAPSIIFIDEIDALAPKREE--DQREVERRVVAQLLTLMDGM-------SSRGKVVVIAATNRPDAIDP 151

                       170
                ....*....|
gi 71419636 822 SLLRPGRFDR 831
Cdd:cd19503 152 ALRRPGRFDR 161
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 667-835 2.52e-64

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 213.89  E-value: 2.52e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 667 LEEAKRELRETIQLPLLHPELF-STGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRL 745
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYkALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 746 LFQRARDNSPCIIFFDELDALAPARGAKGDAGGAmdRVVAQLLVEVDGvghtrtdGSTTAQVFVIGATNRPDLLDPSLLR 825
Cdd:cd19530  81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASE--RVVNQLLTEMDG-------LEERSNVFVIAATNRPDIIDPAMLR 151

                       170
                ....*....|
gi 71419636 826 PGRFDRLCYL 835
Cdd:cd19530 152 PGRLDKTLYV 161
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 670-834 8.01e-62

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 206.90  E-value: 8.01e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 670 AKRELRETIQLPLLHPELF-STGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQ 748
Cdd:cd19526   1 VKKALEETIEWPSKYPKIFaSSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 749 RARDNSPCIIFFDELDALAPARGAkgDAGGAMDRVVAQLLVEVDGVghtrtDGSTTaqVFVIGATNRPDLLDPSLLRPGR 828
Cdd:cd19526  81 RAQSAKPCILFFDEFDSIAPKRGH--DSTGVTDRVVNQLLTQLDGV-----EGLDG--VYVLAATSRPDLIDPALLRPGR 151


                ....*.
gi 71419636 829 FDRLCY 834
Cdd:cd19526 152 LDKLVY 157
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 661-832 5.45e-61

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 204.88  E-value: 5.45e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 661 WKDVGGLEEAKRELRETIQLPLLHPELF-STGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGES 739
Cdd:cd19502   2 YEDIGGLDEQIREIREVVELPLKHPELFeELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 740 EKNIRLLFQRARDNSPCIIFFDELDALAPARgakGDAGGAMDRVVA----QLLVEVDGVghtrtdgSTTAQVFVIGATNR 815
Cdd:cd19502  82 ARLVRELFEMAREKAPSIIFIDEIDAIGAKR---FDSGTGGDREVQrtmlELLNQLDGF-------DPRGNIKVIMATNR 151

                       170
                ....*....|....*..
gi 71419636 816 PDLLDPSLLRPGRFDRL 832
Cdd:cd19502 152 PDILDPALLRPGRFDRK 168
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 663-831 5.66e-60

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 201.90  E-value: 5.66e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELF-STGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEK 741
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPELFkAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 742 NIRLLFQRARDNSPCIIFFDELDALAPARgakGDAGGAMD-RVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPDLLD 820
Cdd:cd19519  81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKR---EKTHGEVErRIVSQLLTLMDGL-------KQRAHVIVMAATNRPNSID 150

                       170
                ....*....|.
gi 71419636 821 PSLLRPGRFDR 831
Cdd:cd19519 151 PALRRFGRFDR 161
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 659-831 2.43e-57

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 194.76  E-value: 2.43e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 659 VRWKDVGGLEEAKRELRETIQLpLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:cd19501   1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKlGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGdaGGAMD---RVVAQLLVEVDGVGhtrtdgsTTAQVFVIGATN 814
Cdd:cd19501  80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGL--GGGHDereQTLNQLLVEMDGFE-------SNTGVIVIAATN 150

                       170
                ....*....|....*..
gi 71419636 815 RPDLLDPSLLRPGRFDR 831
Cdd:cd19501 151 RPDVLDPALLRPGRFDR 167
cell_div_CdvC NF041006
cell division protein CdvC;
659-952 3.50e-57

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 201.50  E-value: 3.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  659 VRWKDVGGLEEAKRELRETIQLPLLHPELFSTGTKRraGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGE 738
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFPLGWPR--GILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  739 SEKNIRLLFQRAR-----DNSPCIIFFDELDALAparGAKGDAGGAMDRVVAQLLVEVDGVghtrTDGSTTAQVFVIGAT 813
Cdd:NF041006 178 AEKNVAKIFKKARekskeEGKPAIIFIDEIDALL---GVYSSEVGGEVRVRNQFLKEMDGL----QDKSENYHVYVIGAT 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  814 NRPDLLDPSLLRpgRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVES 893
Cdd:NF041006 251 NKPWRLDEPFLR--RFQKRIYIPLP-DREQRLELLKYYTSKIKLENDVDLDELAE-MTEGYTASDIRDIVQAAHMRVVKE 326

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 71419636  894 MLQRTAAEggddtqsvgrhaeeaPSfFVQMRDFVRARDQLKPSVSKEELQRYESLRSKF 952
Cdd:NF041006 327 MFEKGLGE---------------PR-PITMEDFKEVLKIRKPSVNQEMLKAYEAWHEKF 369
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 659-916 4.75e-57

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 204.83  E-value: 4.75e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   659 VRWKDVGGLEEAKRELRETIQLpLLHPELF-STGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:TIGR01241  52 VTFKDVAGIDEAKEELMEIVDF-LKNPSKFtKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAkgDAGGAMD---RVVAQLLVEVDGVGhtrtdgsTTAQVFVIGATN 814
Cdd:TIGR01241 131 VGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGA--GLGGGNDereQTLNQLLVEMDGFG-------TNTGVIVIAATN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   815 RPDLLDPSLLRPGRFDRLCYLGLP--ATREEqlvALRALTRKFNLADDVDFDALLEpLSMDYTGADFFALCSDAMMFAVE 892
Cdd:TIGR01241 202 RPDVLDPALLRPGRFDRQVVVDLPdiKGREE---ILKVHAKNKKLAPDVDLKAVAR-RTPGFSGADLANLLNEAALLAAR 277

                         250       260
                  ....*....|....*....|....
gi 71419636   893 SmlqrtaaeggDDTQSVGRHAEEA 916
Cdd:TIGR01241 278 K----------NKTEITMNDIEEA 291
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 670-831 3.00e-56

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 190.96  E-value: 3.00e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 670 AKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQR 749
Cdd:cd19481   1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 750 ARDNSPCIIFFDELDALAPARGAKGDaGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRPDLLDPSLLRPGRF 829
Cdd:cd19481  81 ARRLAPCILFIDEIDAIGRKRDSSGE-SGELRRVLNQLLTELDGV-------NSRSKVLVIAATNRPDLLDPALLRPGRF 152


                ..
gi 71419636 830 DR 831
Cdd:cd19481 153 DE 154
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 659-891 1.31e-55

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 198.06  E-value: 1.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  659 VRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQiGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARgakGDAGGAMDRVVAQLLVEVdgvgHTRTDG-STTAQVFVIGATNRP 816
Cdd:PTZ00454 222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKR---FDAQTGADREVQRILLEL----LNQMDGfDQTTNVKVIMATNRA 294

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71419636  817 DLLDPSLLRPGRFDRLCYLGLPATREEQLVaLRALTRKFNLADDVDFDALL---EPLSmdytGADFFALCSDAMMFAV 891
Cdd:PTZ00454 295 DTLDPALLRPGRLDRKIEFPLPDRRQKRLI-FQTITSKMNLSEEVDLEDFVsrpEKIS----AADIAAICQEAGMQAV 367
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 663-831 2.25e-54

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 186.46  E-value: 2.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELFS-TGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEK 741
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQhLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 742 NIRLLFQRARDNSPCIIFFDELDALAPAR-GAKGDaggaMD-RVVAQLLVEVDGVGHTRTDGsttAQVFVIGATNRPDLL 819
Cdd:cd19518  81 KIRELFDQAISNAPCIVFIDEIDAITPKReSAQRE----MErRIVSQLLTCMDELNNEKTAG---GPVLVIGATNRPDSL 153

                       170
                ....*....|..
gi 71419636 820 DPSLLRPGRFDR 831
Cdd:cd19518 154 DPALRRAGRFDR 165
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 661-891 6.24e-52

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 188.83  E-value: 6.24e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  661 WKDVGGLEEAKRELRETIQLPLLHPELFS-TGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGES 739
Cdd:PTZ00361 182 YADIGGLEQQIQEIKEAVELPLTHPELYDdIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDG 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  740 EKNIRLLFQRARDNSPCIIFFDELDALAPARgAKGDAGGAMD--RVVAQLLVEVDGVgHTRTDgsttaqVFVIGATNRPD 817
Cdd:PTZ00361 262 PKLVRELFRVAEENAPSIVFIDEIDAIGTKR-YDATSGGEKEiqRTMLELLNQLDGF-DSRGD------VKVIMATNRIE 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71419636  818 LLDPSLLRPGRFDRLCYLGLPATREEQLVaLRALTRKFNLADDVDfdalLEPLSM---DYTGADFFALCSDAMMFAV 891
Cdd:PTZ00361 334 SLDPALIRPGRIDRKIEFPNPDEKTKRRI-FEIHTSKMTLAEDVD----LEEFIMakdELSGADIKAICTEAGLLAL 405
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 625-860 1.24e-51

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 189.92  E-value: 1.24e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   625 EGVRP---VLSESLCGSVLQKYQKAHGYSLVSTKLQPVRWKDVGGLEEAKRELRETIQLPLLHPELFST-GTKRRAGILF 700
Cdd:TIGR03689 142 EGLRPgdtLLVDPRAGYAFEAIPRTEVEDLVLEEVPDVTYADIGGLGSQIEQIRDAVELPFLHPELYREyGLKPPKGVLL 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   701 YGPPGCGKTLLAKAVATEMNMN----------FMAVKGPELINQYVGESEKNIRLLFQRAR----DNSPCIIFFDELDAL 766
Cdd:TIGR03689 222 YGPPGCGKTLIAKAVANSLAARigaegggksyFLNIKGPELLNKYVGETERQIRLIFQRARekasEGRPVIVFFDEMDSL 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   767 APARGAkGDAGGAMDRVVAQLLVEVDGVGHTRtdgsttaQVFVIGATNRPDLLDPSLLRPGRFDRLCYLGLPATREEQLV 846
Cdd:TIGR03689 302 FRTRGS-GVSSDVETTVVPQLLAEIDGVESLD-------NVIVIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADI 373

                         250
                  ....*....|....
gi 71419636   847 ALRALTRKFNLADD 860
Cdd:TIGR03689 374 FAKYLTDDLPLPED 387
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 698-837 1.08e-50

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 174.32  E-value: 1.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   698 ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDag 777
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGD-- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   778 GAMDRVVAQLLVEVDGVghtrtdGSTTAQVFVIGATNRPDLLDPSLLrpGRFDRLCYLGL 837
Cdd:pfam00004  79 SESRRVVNQLLTELDGF------TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 664-835 6.76e-49

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 170.61  E-value: 6.76e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 664 VGGLEEAKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKNI 743
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 744 RLLFQRARDNSPCIIFFDELDALAPARGAkGDAGGAMdRVVAQLLVEVDGVGHTRTDgsttaQVFVIGATNRPDLLDPSL 823
Cdd:cd19509  81 RALFALARELQPSIIFIDEIDSLLSERGS-GEHEASR-RVKTEFLVQMDGVLNKPED-----RVLVLGATNRPWELDEAF 153

                       170
                ....*....|..
gi 71419636 824 LRpgRFDRLCYL 835
Cdd:cd19509 154 LR--RFEKRIYI 163
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
661-901 6.83e-49

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 173.53  E-value: 6.83e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 661 WKDVGGLEEAKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESE 740
Cdd:COG1223   1 LDDVVGQEEAKKKLKLIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 741 KNIRLLFQRARDNsPCIIFFDELDALAPARGAKGDaGGAMDRVVAQLLVEVDGVghtrtdgstTAQVFVIGATNRPDLLD 820
Cdd:COG1223  81 RNLRKLFDFARRA-PCVIFFDEFDAIAKDRGDQND-VGEVKRVVNALLQELDGL---------PSGSVVIAATNHPELLD 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 821 PSLLRpgRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEPLSmDYTGADFFALCSDAMMFAVESMLQRTAA 900
Cdd:COG1223 150 SALWR--RFDEVIEFPLP-DKEERKEILELNLKKFPLPFELDLKKLAKKLE-GLSGADIEKVLKTALKKAILEDREKVTK 225


                .
gi 71419636 901 E 901
Cdd:COG1223 226 E 226
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
659-866 9.34e-47

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 177.15  E-value: 9.34e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 659 VRWKDVGGLEEAKRELRETIQLpLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:COG0465 139 VTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRlGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGdaGGAMD---RVVAQLLVEVDGVghtrtDGSTTaqVFVIGATN 814
Cdd:COG0465 218 VGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGL--GGGHDereQTLNQLLVEMDGF-----EGNEG--VIVIAATN 288

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 71419636 815 RPDLLDPSLLRPGRFDRLCYLGLPATRE-EQLvaLRALTRKFNLADDVDFDAL 866
Cdd:COG0465 289 RPDVLDPALLRPGRFDRQVVVDLPDVKGrEAI--LKVHARKKPLAPDVDLEVI 339
ftsH CHL00176
cell division protein; Validated
 659-891 1.42e-46

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 177.55  E-value: 1.42e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  659 VRWKDVGGLEEAKRELRETIQLpLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAvGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAkGDAGGAMDR--VVAQLLVEVDGVgHTRTDgsttaqVFVIGATNR 815
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGA-GIGGGNDEReqTLNQLLTEMDGF-KGNKG------VIVIAATNR 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71419636  816 PDLLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFDALLEPlSMDYTGADFFALCSDAMMFAV 891
Cdd:CHL00176 331 VDILDAALLRPGRFDRQITVSLP-DREGRLDILKVHARNKKLSPDVSLELIARR-TPGFSGADLANLLNEAAILTA 404
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 659-835 4.42e-46

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 162.72  E-value: 4.42e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 659 VRWKDVGGLEEAKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGE 738
Cdd:cd19521   4 VKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 739 SEKNIRLLFQRARDNSPCIIFFDELDALAPARGaKGDAGGAMdRVVAQLLVEVDGVGHTrTDGsttaqVFVIGATNRPDL 818
Cdd:cd19521  84 SEKLVKQLFAMARENKPSIIFIDEVDSLCGTRG-EGESEASR-RIKTELLVQMNGVGND-SQG-----VLVLGATNIPWQ 155

                       170
                ....*....|....*..
gi 71419636 819 LDPSLLRpgRFDRLCYL 835
Cdd:cd19521 156 LDSAIRR--RFEKRIYI 170
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 663-831 1.60e-45

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 161.14  E-value: 1.60e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELF-STGTKRRAGILFYGPPGCGKTLLAKAVATEMN-----MNFMAVKGPELINQYV 736
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFaKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 737 GESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDAGGAmdRVVAQLLVEVDGVghtrtdgSTTAQVFVIGATNRP 816
Cdd:cd19517  81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHA--SIVSTLLALMDGL-------DNRGQVVVIGATNRP 151

                       170
                ....*....|....*
gi 71419636 817 DLLDPSLLRPGRFDR 831
Cdd:cd19517 152 DALDPALRRPGRFDR 166
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
663-890 3.59e-45

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 173.68  E-value: 3.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  663 DVGGLEEAKRELRETIQLpLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEK 741
Cdd:PRK10733 153 DVAGCDEAKEEVAELVEY-LREPSRFQKlGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGAS 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  742 NIRLLFQRARDNSPCIIFFDELDALAPARGAkGDAGGAMDR--VVAQLLVEVDGVghtrtDGSTTaqVFVIGATNRPDLL 819
Cdd:PRK10733 232 RVRDMFEQAKKAAPCIIFIDEIDAVGRQRGA-GLGGGHDEReqTLNQMLVEMDGF-----EGNEG--IIVIAATNRPDVL 303

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71419636  820 DPSLLRPGRFDRLCYLGLPATR-EEQLvaLRALTRKFNLADDVDfDALLEPLSMDYTGADFFALCSDAMMFA 890
Cdd:PRK10733 304 DPALLRPGRFDRQVVVGLPDVRgREQI--LKVHMRRVPLAPDID-AAIIARGTPGFSGADLANLVNEAALFA 372
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 663-835 8.73e-43

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 153.60  E-value: 8.73e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKN 742
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 743 IRLLFQRARDNSPCIIFFDELDALAPARGAKGDAgGAMDRVVAQLLVEVDGVGHTRTDGSTTAQVFVIGATNRPDLLDPS 822
Cdd:cd19522  81 VRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEH-EASRRVKSELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEA 159

                       170
                ....*....|...
gi 71419636 823 LLRpgRFDRLCYL 835
Cdd:cd19522 160 LRR--RLEKRIYI 170
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 664-830 1.33e-39

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 144.55  E-value: 1.33e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 664 VGGLE-EAKRELRETIQLPLLHPELFST-GTKRRAGILFYGPPGCGKTLLAKAVATEMN-MNFMAVKGPELINQYVGESE 740
Cdd:cd19504   2 IGGLDkEFSDIFRRAFASRVFPPEIVEQlGCKHVKGILLYGPPGTGKTLMARQIGKMLNaREPKIVNGPEILNKYVGESE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 741 KNIRLLF------QRAR-DNSPC-IIFFDELDALAPARGAKGDAGGAMDRVVAQLLVEVDGVghtrtdgSTTAQVFVIGA 812
Cdd:cd19504  82 ANIRKLFadaeeeQRRLgANSGLhIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGV-------EQLNNILVIGM 154

                       170
                ....*....|....*...
gi 71419636 813 TNRPDLLDPSLLRPGRFD 830
Cdd:cd19504 155 TNRKDLIDEALLRPGRLE 172
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 663-829 5.43e-39

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 142.56  E-value: 5.43e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELFSTG--TKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESE 740
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSrlLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 741 KNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDAGGAMDRvvAQLLVEVDGVghtRTDGSttAQVFVIGATNRPDLLD 820
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMK--AEFMSLWDGL---STDGN--CRVIVMGATNRPQDLD 153

                       170
                ....*....|.
gi 71419636 821 PSLLR--PGRF 829
Cdd:cd19520 154 EAILRrmPKRF 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 658-835 1.92e-36

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 135.89  E-value: 1.92e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 658 PVRWKDVGGLEEAKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVG 737
Cdd:cd19525  18 PINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 738 ESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDAggAMDRVVAQLLVEVDGVGHTRTDgsttaQVFVIGATNRPD 817
Cdd:cd19525  98 EGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHE--SSRRIKTEFLVQLDGATTSSED-----RILVVGATNRPQ 170

                       170
                ....*....|....*...
gi 71419636 818 LLDPSLLRpgRFDRLCYL 835
Cdd:cd19525 171 EIDEAARR--RLVKRLYI 186
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 663-835 1.96e-36

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 134.98  E-value: 1.96e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELFsTGTKRRA-GILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEK 741
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELF-TGLRAPArGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 742 NIRLLFQRARDNSPCIIFFDELDALAPARgaKGDAGGAMDRVVAQLLVEVDGVgHTRTDgsttAQVFVIGATNRPDLLDP 821
Cdd:cd19524  80 LVRALFAVARELQPSIIFIDEVDSLLSER--SEGEHEASRRLKTEFLIEFDGV-QSNGD----DRVLVMGATNRPQELDD 152

                       170
                ....*....|....
gi 71419636 822 SLLRpgRFDRLCYL 835
Cdd:cd19524 153 AVLR--RFTKRVYV 164
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 665-837 6.38e-27

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 107.23  E-value: 6.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 665 GGLEEAKRELRETIQLPllhpelfstgtkRRAGILFYGPPGCGKTLLAKAVATE---MNMNFMAVKGPELINQYVGESEK 741
Cdd:cd00009   1 VGQEEAIEALREALELP------------PPKNLLLYGPPGTGKTTLARAIANElfrPGAPFLYLNASDLLEGLVVAELF 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 742 N---IRLLFQRARDNSPCIIFFDELDALAPargakgDAGGAMDRVVAQLLVEVDGVGHTRtdgsttaqvfVIGATNRPDL 818
Cdd:cd00009  69 GhflVRLLFELAEKAKPGVLFIDEIDSLSR------GAQNALLRVLETLNDLRIDRENVR----------VIGATNRPLL 132

                       170
                ....*....|....*....
gi 71419636 819 LDPSLLRPGRFDRLCYLGL 837
Cdd:cd00009 133 GDLDRALYDRLDIRIVIPL 151
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 663-825 2.73e-26

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 106.12  E-value: 2.73e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKN 742
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 743 IRLLFQRARDNSPCIIFFDELDALAPARGAKGDAGGAMDrvvAQLLVEVDGVGhtrtdGSTTAQVFVIGATNRPDLLDPS 822
Cdd:cd19523  81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQ---VELLAQLDGVL-----GSGEDGVLVVCTTSKPEEIDES 152


                ...
gi 71419636 823 LLR 825
Cdd:cd19523 153 LRR 155
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 663-835 1.63e-25

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 103.60  E-value: 1.63e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 663 DVGGLEEAKRELreTIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYVGESEKN 742
Cdd:cd19507   1 DVGGLDNLKDWL--KKRKAAFSKQASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 743 IRLLFQRARDNSPCIIFFDELDALAPARGAKGDAGGAMdRVVAQLLVEVDgvghtrtdgSTTAQVFVIGATNRPDLLDPS 822
Cdd:cd19507  79 LRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDSGTSS-RVLGTFLTWLQ---------EKKKPVFVVATANNVQSLPPE 148

                       170
                ....*....|...
gi 71419636 823 LLRPGRFDRLCYL 835
Cdd:cd19507 149 LLRKGRFDEIFFV 161
ycf46 CHL00195
Ycf46; Provisional
 662-890 1.99e-19

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 92.78  E-value: 1.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  662 KDVGGLEEAKRELRetiqlplLHPELFST-----GTKRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQYV 736
Cdd:CHL00195 228 SDIGGLDNLKDWLK-------KRSTSFSKqasnyGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIV 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  737 GESEKNIRLLFQRARDNSPCIIFFDELDALAPARGAKGDaGGAMDRVVAQL---LVEvdgvghtrtdgsTTAQVFVIGAT 813
Cdd:CHL00195 301 GESESRMRQMIRIAEALSPCILWIDEIDKAFSNSESKGD-SGTTNRVLATFitwLSE------------KKSPVFVVATA 367

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71419636  814 NRPDLLDPSLLRPGRFDRLCYLGLPaTREEQLVALRALTRKFNLADDVDFD-ALLEPLSMDYTGADFFALCSDAMMFA 890
Cdd:CHL00195 368 NNIDLLPLEILRKGRFDEIFFLDLP-SLEEREKIFKIHLQKFRPKSWKKYDiKKLSKLSNKFSGAEIEQSIIEAMYIA 444
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 694-838 5.63e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 78.95  E-value: 5.63e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636    694 RRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVK-----------------GPELINQYVGESEKNIRLLFQRARDNSPC 756
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636    757 IIFFDELDALAPARGAKGDAGGAMDRVVAQLLVEVDgvghtrtdgsttaqVFVIGATNRPDLLDPSLLRPgRFDRLCYLG 836
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKN--------------LTVILTTNDEKDLGPALLRR-RFDRRIVLL 145


                   ..
gi 71419636    837 LP 838
Cdd:smart00382 146 LI 147
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 695-835 2.36e-16

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 77.01  E-value: 2.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 695 RAGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPElinqyVGESEKNIRLLFQRARDNSpcIIFFDELDA---LAPARG 771
Cdd:cd19510  23 RRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSE-----VVLTDDRLNHLLNTAPKQS--IILLEDIDAafeSREHNK 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71419636 772 AKGDAGGAMDRV-VAQLLVEVDGVghtrtdGSTTAQVFVIgATNRPDLLDPSLLRPGRFDRLCYL 835
Cdd:cd19510  96 KNPSAYGGLSRVtFSGLLNALDGV------ASSEERIVFM-TTNHIERLDPALIRPGRVDMKIYM 153
PRK04195 PRK04195
replication factor C large subunit; Provisional
 655-779 2.08e-13

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 73.80  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  655 KLQPVRWKDVGGLEEAKRELRETIqlpllhpELFSTGTKRRAgILFYGPPGCGKTLLAKAVATEMN-----MNFMAVKGP 729
Cdd:PRK04195   7 KYRPKTLSDVVGNEKAKEQLREWI-------ESWLKGKPKKA-LLLYGPPGVGKTSLAHALANDYGwevieLNASDQRTA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 71419636  730 ELINQYVGESEKNiRLLFQRARDnspcIIFFDELDALAPargaKGDAGGA 779
Cdd:PRK04195  79 DVIERVAGEAATS-GSLFGARRK----LILLDEVDGIHG----NEDRGGA 119
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 666-868 4.89e-08

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 56.78  E-value: 4.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   666 GLEEAKRE---LRETIQLPLLHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEM-------NMNFMAVKGPELINQY 735
Cdd:TIGR03922 280 GLERVKRQvaaLKSSTAMALARAERGLPVAQTSNHMLFAGPPGTGKTTIARVVAKIYcglgvlrKPLVREVSRADLIGQY 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   736 VGESEKNIRLLFQRARDNspcIIFFDELDALAPARGAKGDAGGAMdrVVAQLLVEVDgvgHTRTDgsttaqVFVIGATNR 815
Cdd:TIGR03922 360 IGESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQKDPFGLE--AIDTLLARME---NDRDR------LVVIGAGYR 425

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   816 PDlLDPSL-----LRpGRFDRLcyLGLPATREEQLVAL--RALTRKFNLADDVDFDALLE 868
Cdd:TIGR03922 426 KD-LDKFLevnegLR-SRFTRV--IEFPSYSPDELVEIarRMATERDSVLDDAAADALLE 481
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 697-832 1.11e-07

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 52.38  E-value: 1.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 697 GILFYGPPGCGKTLLAKAVATEM--------------NMNFMAVKGPELINQYVGESEKNIRLLFQRARDNSPCIIFFD- 761
Cdd:cd19505  14 GILLIGSIETGRSYLIKSLAANSyvplirislnkllyNKPDFGNDDWIDGMLILKESLHRLNLQFELAKAMSPCIIWIPn 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71419636 762 --ELDALAPARGAKGDaggamDRVVAQLLVEvdgvgHTRTD--GSTTAQVFVIGATNRPDLLDPSLLRPGRFDRL 832
Cdd:cd19505  94 ihELNVNRSTQNLEED-----PKLLLGLLLN-----YLSRDfeKSSTRNILVIASTHIPQKVDPALIAPNRLDTC 158
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 698-769 1.82e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 54.71  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  698 ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGpelinqyVGESEKNIRLLFQRARDNS----PCIIFFDEL--------DA 765
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRsagrRTILFIDEIhrfnkaqqDA 111


                 ....
gi 71419636  766 LAPA 769
Cdd:PRK13342 112 LLPH 115
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
656-769 2.95e-07

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 53.60  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  656 LQPVRWKDVGGLEEAKRELretiqlpllhpELFSTGTKRRAG----ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPEL 731
Cdd:PRK00080  19 LRPKSLDEFIGQEKVKENL-----------KIFIEAAKKRGEaldhVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 71419636  732 inqyvgeseknirllfQRARD----------NSpcIIFFDELDALAPA 769
Cdd:PRK00080  88 ----------------EKPGDlaailtnleeGD--VLFIDEIHRLSPV 117
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 698-792 4.39e-07

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 51.29  E-value: 4.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 698 ILFYGPPGCGKTLLAKAVATEMN--MNFMAVKGP-------ELINQYVGESEKNIRLLFQRAR---DNSPCIIF--FDEL 763
Cdd:cd19508  55 VLLHGPPGTGKTSLCKALAQKLSirLSSRYRYGQlieinshSLFSKWFSESGKLVTKMFQKIQeliDDKDALVFvlIDEV 134

                        90       100       110
                ....*....|....*....|....*....|.
gi 71419636 764 DALAPARGAKGDAGGAMD--RVVAQLLVEVD 792
Cdd:cd19508 135 ESLAAARSASSSGTEPSDaiRVVNAVLTQID 165
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 698-769 7.28e-07

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 52.75  E-value: 7.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 698 ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGpelinqyVGESEKNIRLLFQRARDNS----PCIIFFDEL--------DA 765
Cdd:COG2256  52 MILWGPPGTGKTTLARLIANATDAEFVALSA-------VTSGVKDIREVIEEARERRaygrRTILFVDEIhrfnkaqqDA 124


                ....
gi 71419636 766 LAPA 769
Cdd:COG2256 125 LLPH 128
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 656-731 1.02e-06

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 49.42  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   656 LQPVRWKDVGGLEEAKRELRetiqlpllhpeLFSTGTKRRAG----ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPEL 731
Cdd:pfam05496   1 LRPRTLDEYIGQEKVKENLK-----------IFIEAAKQRGEaldhVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI 69
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 671-769 1.83e-06

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 50.76  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   671 KRELRETIQLpllhpelFSTGTKRRAG----ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELinqyvgesEK----- 741
Cdd:TIGR00635   9 QEKVKEQLQL-------FIEAAKMRQEaldhLLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL--------EKpgdla 73

                          90       100
                  ....*....|....*....|....*...
gi 71419636   742 NIRLLFQRaRDnspcIIFFDELDALAPA 769
Cdd:TIGR00635  74 AILTNLEE-GD----VLFIDEIHRLSPA 96
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 698-768 1.85e-06

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 49.12  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636   698 ILFYGPPGCGKTLLAKAVATEMNM--NFMAVKG------PELINQYVGESEKNIR-----LLFQRARDNSPCIIFFDELD 764
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGdeRALIRIDmseymeEHSVSRLIGAPPGYVGyeeggQLTEAVRRKPYSIVLIDEIE 85


                  ....
gi 71419636   765 ALAP 768
Cdd:pfam07724  86 KAHP 89
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 666-780 1.45e-05

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 46.40  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 666 GLEEAKRELRETIQLPLLHPELfstgtkrRAGIL-FYGPPGCGKTLLAKAVATEMNMNF--MAVKGPELINQ-------Y 735
Cdd:cd19500  14 GLEDVKERILEYLAVRKLKGSM-------KGPILcLVGPPGVGKTSLGKSIARALGRKFvrISLGGVRDEAEirghrrtY 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 71419636 736 VGESEKNIRLLFQRARDNSPcIIFFDELDALapARGAKGDAGGAM 780
Cdd:cd19500  87 VGAMPGRIIQALKKAGTNNP-VFLLDEIDKI--GSSFRGDPASAL 128
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 656-729 1.92e-05

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 47.77  E-value: 1.92e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71419636 656 LQPVRWKDVGGLEEAKRELretiqlpllhpELFSTGTKRRAG----ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGP 729
Cdd:COG2255  22 LRPKRLDEYIGQEKVKENL-----------KIFIEAAKKRGEaldhVLLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 692-820 2.06e-05

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 45.60  E-value: 2.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 692 TKRRAG----ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPElINQYVGESEKNIRLLFQRA-RDNSPCIIFFDELDAL 766
Cdd:cd19512  15 TKKNKGlyrnILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAF 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 71419636 767 APARGAKGDAGGAMDRVVAQLLvevdgvghtRTdGSTTAQVFVIGATNRPDLLD 820
Cdd:cd19512  94 LRKRSTEKISEDLRAALNAFLY---------RT-GEQSNKFMLVLASNQPEQFD 137
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 664-764 4.96e-05

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 44.86  E-value: 4.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 664 VGGLEEAKRELRETIQLpllHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVATEM---NMNFMAVKGPE---------L 731
Cdd:cd19499  13 VVGQDEAVKAVSDAIRR---ARAGLSDPNRPIGSFLFLGPTGVGKTELAKALAELLfgdEDNLIRIDMSEymekhsvsrL 89

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 71419636 732 INQ---YVGESEKNirLLFQRARDNSPCIIFFDELD 764
Cdd:cd19499  90 IGAppgYVGYTEGG--QLTEAVRRKPYSVVLLDEIE 123
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 698-767 6.12e-05

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 45.67  E-value: 6.12e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71419636 698 ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELINQ-YVGESEKNI--RLL------FQRARDNspcIIFFDELDALA 767
Cdd:cd19497  53 ILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAgYVGEDVENIllKLLqaadydVERAQRG---IVYIDEIDKIA 128
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 921-953 5.23e-04

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 39.02  E-value: 5.23e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 71419636   921 VQMRDFVRARDQLKPSVSKEELQRYEslrsKFT 953
Cdd:pfam09336  29 VTMKDFLKALKSSRPTVSKEDLEKYE----EFT 57
rfc PRK00440
replication factor C small subunit; Reviewed
 655-766 9.34e-04

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 42.55  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  655 KLQPVRWKDVGGLEEAKRELRETIQ---LPLLhpelfstgtkrragiLFYGPPGCGKTLLAKAVATEM-----NMNFMav 726
Cdd:PRK00440  10 KYRPRTLDEIVGQEEIVERLKSYVKeknMPHL---------------LFAGPPGTGKTTAALALARELygedwRENFL-- 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 71419636  727 kgpEL-------INqYVGESEKNirllFQRARD--NSPC-IIFFDELDAL 766
Cdd:PRK00440  73 ---ELnasdergID-VIRNKIKE----FARTAPvgGAPFkIIFLDEADNL 114
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
698-767 1.02e-03

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 42.45  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71419636  698 ILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELIN-QYVGESEKNI--RLLfQRArDNSP-----CIIFFDELDALA 767
Cdd:PRK05342 111 ILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEaGYVGEDVENIllKLL-QAA-DYDVekaqrGIVYIDEIDKIA 186
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 666-774 1.03e-03

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 41.21  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636 666 GLEEAKRE----LRETIQLPLLHPELFSTGTKRraGILFYGPPGCGKTLLAKAVATEMNMNFMAVKGPELIN-QYVGESE 740
Cdd:cd19498  15 GQDEAKRAvaiaLRNRWRRMQLPEELRDEVTPK--NILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVGRDV 92

                        90       100       110
                ....*....|....*....|....*....|....
gi 71419636 741 KNIrllfqrARDNSPCIIFFDELDALAPARGAKG 774
Cdd:cd19498  93 ESI------IRDLVEGIVFIDEIDKIAKRGGSSG 120
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 698-719 1.59e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 38.74  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|..
gi 71419636   698 ILFYGPPGCGKTLLAKAVATEM 719
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARAL 22
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
654-720 1.72e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 41.72  E-value: 1.72e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71419636 654 TKLQPVRWKDVGGLEEAKRELRETIQLPLLHPelfstgtkrraGILFYGPPGCGKTLLAKAVATEMN 720
Cdd:COG2812   2 SYQVPQTFDDVVGQEHVVRTLKNALASGRLAH-----------AYLFTGPRGVGKTTLARILAKALN 57
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
697-741 2.14e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 41.49  E-value: 2.14e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 71419636 697 GILFYGPPGCGKTLLAKAVATEMNMN--FMAVKGPELinqYVGESEK 741
Cdd:COG1224  66 GILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEI---YSAELKK 109
PRK13764 PRK13764
ATPase; Provisional
 683-741 3.32e-03

ATPase; Provisional


Pssm-ID: 184311 [Multi-domain]  Cd Length: 602  Bit Score: 41.36  E-value: 3.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71419636  683 LHPELFSTGTKRRAGILFYGPPGCGKTLLAKAVAT-EMNMNFMaVK----------GPElINQYV---GESEK 741
Cdd:PRK13764 245 LSEKLKERLEERAEGILIAGAPGAGKSTFAQALAEfYADMGKI-VKtmesprdlqvPPE-ITQYSkleGSMEE 315
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 661-717 3.32e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.83  E-value: 3.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 71419636   661 WKDVGGLEEAKRELretiqlpllhpELFSTGtkrRAGILFYGPPGCGKTLLAKAVAT 717
Cdd:pfam01078   2 LADVKGQEQAKRAL-----------EIAAAG---GHNLLMIGPPGSGKTMLAKRLPG 44
PRK08116 PRK08116
hypothetical protein; Validated
 697-734 4.29e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 40.00  E-value: 4.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 71419636  697 GILFYGPPGCGKTLLAKAVATEMNMNFMAVKG---PELINQ 734
Cdd:PRK08116 116 GLLLWGSVGTGKTYLAACIANELIEKGVPVIFvnfPQLLNR 156
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
693-734 5.12e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 39.76  E-value: 5.12e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 71419636 693 KRRAGILFYGPPGCGKTLLAKAVATEMNMNFMAVK---GPELINQ 734
Cdd:COG1484  97 ERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRfttAPDLVNE 141
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 672-808 8.59e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 39.82  E-value: 8.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71419636  672 RELRETIQLpllhpelfsTGTKRRAGILFYGPPGCGKTLLAKAVATEMnmnfmaVKG--PELI----------------N 733
Cdd:PRK11034 193 KELERAIQV---------LCRRRKNNPLLVGESGVGKTAIAEGLAWRI------VQGdvPEVMadctiysldigsllagT 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71419636  734 QYVGESEKNIRLLFQRARDNSPCIIFFDELDALAparGAKGDAGGAMDrvVAQLLVEVDGVGHTRTDGSTTAQVF 808
Cdd:PRK11034 258 KYRGDFEKRFKALLKQLEQDTNSILFIDEIHTII---GAGAASGGQVD--AANLIKPLLSSGKIRVIGSTTYQEF 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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