NCBI Conserved Domain Search

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Conserved domains on [gi\|94971157\|ref\|YP_593205.1\|]
diguanylate cyclase [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

1e-54

208.98

100.00

2,196,0,118,317,118,39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 197 TDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYGGE 276
cd01949       1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 277 EFVIVLPETNTTGAMQVANRIRRGVEQAKFFAGSPRQVerlTISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRNQVV 356
cd01949      81 EFAILLPGTDLEEAEELAERLRKAIEEPFFIDGEEIRV---TASIGIAEYPEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

110022

pfam00990

GGDEF

GGDEF domain

false

160

4e-49

190.53

100.00

3,194,0,112,306,113,9,316,122,38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 195 AFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYG 274
pfam00990     1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 275 GEEFVIVLPETNTTGAMQVANRIRRGVEQAKF-FAGSPRQVErLTISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRN 353
pfam00990    81 GDEFAILLPDTSLEGAQELAERIRRLLAALKIpHTLSGLPLY-VTISIGIAAYPNDGEDAEDLLKRADQALYQAKNQGRN 159


                .
gi 94971157 354 Q 354
pfam00990   160 R 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

2e-47

185.14

98.77

2,194,2,120,317,122,41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 195 AFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYG 274
smart00267    3 AFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLARLG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 275 GEEFVIVLPETNTTGAMQVANRIRRGVEQAKFFAGSPRQVerlTISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRNQ 354
smart00267   83 GDEFALLLPETSLEEAIALAERILQQLREPIIIHGIPLYL---TISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                ....
gi 94971157 355 VVTH 358
smart00267  160 VAVY 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

6e-45

176.37

97.58

2,194,1,109,304,110,52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 195 AFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYG 274
TIGR00254     2 AVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRYG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 275 GEEFVIVLPETNTTGAMQVANRIRRGVEQaKFFAGSPRQVERLTISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRNQ 354
TIGR00254    82 GEEFVVILPGTPLEDALSKAERLRDAINS-KPIEVAGSETLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGRNR 160


                ..
gi 94971157 355 VV 356
TIGR00254   161 VV 162

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

1e-40

161.82

99.45

3,176,1,133,312,134,14,326,149,32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 177 VAENQLTRDYENEGLIKFAFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDV 256
COG2199       2 LLRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 257 SAVLMKDLREVDTAARYGGEEFVIVLPETNTTGAMQVANRIRRGVEQAKFFAGsprQVERLTISIGIAIY-DQDAQSKRE 335
COG2199      82 ARRLRSNLREGDLVARLGGDEFAVLLPGTSLEEAARLAERIRAALEEPFFLGG---EELRVTVSIGVALYpEDGSDDAEL 158

                       170       180
                ....*....|....*....|...
gi 94971157 336 LIEAADAALYQAKGQGRNQVVTH 358
COG2199     159 LLRRADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128379

smart00065

GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.

true

false

149

0.001

39.67

88.59

5,49,0,32,81,33,14,95,48,31,126,82,34,160,117,15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157  50 QLEATLNMLLDFAAEISFFEKSLVYFWEEDSE-QVKLRLAGGMDRET-AEPFVRGNIFNFWATRFGRPLLVTAGHNLLS- 126
smart00065    1 DLEELLQTILEELRQLLGADRVLIYLVDEDDRgELVLVAADGLTLPLlGLRYPLGEGLAGRVAETGRPLNIPDVEADPVf 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 94971157 127 --DAALESLGARSALIVPLVVSNKVIGSMQLFSAEH-ESFTREDAQLFWMLT 175
smart00065   81 alDLLGRYQGVRSFLAVPLVADGELVGVLALHNKDSpRPFTEEDEELLQALA 132

cl00853

140972

GAF

GAF domain

-1

110584

pfam01590

GAF

GAF domain

false

153

0.003

38.38

99.35

4,50,1,46,96,60,14,110,78,19,129,100,53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157  51 LEATLNMLLDFAAEISFFEKSLVYFWEEDSEQVKLRLAGGMDRETA-------------EPFVRGNIFNFWAT----RFG 113
pfam01590     2 LEELLQTILEELRELLGADRCAILLADADGLLLYLVAGDGLSDIPLaarglplgggvvgEVIAGGNPIVVPDVqddpRFR 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94971157 114 RPLLVTAGHNLLSDAA---LESLGARSALIVPLVVSNKVIGSMQLFSAEHESFTREDAQLFWMLTLVAENQL 182
pfam01590    82 DLTALAEELPAPVGCHehyLRGLGIRSCLAVPLLGGGKLIGVLVLHSTSPRAFTEEELELLQALADQVAIAL 153

cl00853

140972

GAF

GAF domain

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

1e-47

185.51

36.76

3,191,288,115,306,404,9,316,413,43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 192 IKFAFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAA 271
PRK09581    289 IEMAVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIA 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 272 RYGGEEFVIVLPETNTTGAMQVANRIRRGVEQAKF-FAGSPRQVErLTISIGIAIYDQDAQSKRELIEAADAALYQAKGQ 350
PRK09581    369 RYGGEEFVVVMPDTDIEVAIAVAERIRRKIAEEPFaISDGKERLN-VTVSIGVAELRPSGESIEALIKRADKALYEAKNT 447


                ....*....
gi 94971157 351 GRNQVVTHA 359
PRK09581    448 GRNRVVALA 456

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

2e-43

171.64

42.99

2,174,247,13,187,262,172

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 175 TLVAENQLTRDYE--NEGLIKFAFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQV 252
COG3706     248 RQLRRKRYERQLResLERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEV 327

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 253 LRDVSAVLMKDLREVDTAARYGGEEFVIVLPETNTTGAMQVANRIRRGVEQAKFFAGSPRQVERLTISIGIAIYDQDAQS 332
COG3706     328 LRQVARRLRQTVRGLDLVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELPFVHELSREPLEVTISIGVAEGKPGEDS 407

                       170       180
                ....*....|....*....|....*..
gi 94971157 333 KRELIEAADAALYQAKGQGRNQVVTHA 359
COG3706     408 IEELLKRADKALYKAKASGRNRVVVKR 434

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

9e-32

132.53

57.34

6,183,118,23,206,142,4,213,146,88,301,235,13,317,248,12,330,260,26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 184 RDYENEGLIKFAFTDFLTGLKTR-GYFEqqlELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMK 262
PRK09894    119 TDYKIYLLTIRSNMDVLTGLPGRrVLDE---SFDHQLRNREPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLAS 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 263 DLREVDTAARYGGEEFVIVLPETNTTGAMQVANRIRRGV-EQAKFFAGSPRQVerlTISIGIAIYDQDaQSKRELIEAAD 341
PRK09894    196 WTRPYETVYRYGGEEFIIILKAATDEEACRAGERIRQLIaNQAITHSEGRINI---TATFGVTRAFPE-EPLDEVIGRAD 271

                       170
                ....*....|....*
gi 94971157 342 AALYQAKGQGRNQVV 356
PRK09894    272 RAMYEGKQAGRNRVM 286

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

5e-25

110.18

14.25

2,194,687,116,312,803,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157  195 AFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYG 274
PRK09776     688 ASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLG 767

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157  275 GEEFVIVLPETNTTGAMQVANRIRRGVEQAKFFAGSprQVERLTISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRNQ 354
PRK09776     768 GDEFGLLLPDCNVESARFIATRIISAINDYRFPWEG--RVYRVGASAGITAIDDNNHQASEVMSQADIACYAAKNAGRGR 845


                 .
gi 94971157  355 V 355
PRK09776     846 V 846

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

9e-23

102.89

24.28

7,188,230,29,219,259,59,279,318,13,292,332,12,305,344,4,312,348,6,318,355,36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 189 EGLIKFAFTDFLTGLKTRGYFEQQLELEIkrAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVD 268
PRK10060    231 ERLRILANTDSITGLPNRNAIQELIDHAI--AQADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQ 308

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 269 TAARYGGEEFvIVLPETNTTGAMQ-VANRIRRGVEQAkFFAGsprQVERLT-ISIGIAIYDQDAQSKRELIEAADAALYQ 346
PRK10060    309 TLARLGGDEF-LVLASHTSQAALEaMASRILTRLRLP-FRIG---LIEVYTgCSIGIALSPEHGDDSESLIRSADTAMYT 383


                ....*...
gi 94971157 347 AKGQGRNQ 354
PRK10060    384 AKEGGRGQ 391

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

3e-22

101.51

41.51

4,197,212,108,306,320,5,312,325,2,315,327,39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 198 DFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYGGEE 277
PRK10245    213 DGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDE 292

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 94971157 278 FVIVLPETNTTGAMQVANRIRRGVEQAKfFAGSPrQVeRLTISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRNQ 354
PRK10245    293 FAVIMSGTPAESAITAMLRVHEGLNTLR-LPNAP-QV-TLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNR 366

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

2e-21

98.56

27.15

4,173,207,19,193,226,95,289,321,7,297,328,59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 174 LTLVAENQLTRDYENEGLIkFAFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGDQVL 253
COG5001     208 VTLTQRAEETRRLSDENDR-LANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLL 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 254 RDVSAVLMKDLREVDTAARYGGEEFVIVLPETNTTgAMQVANRiRRGVEQAKFFAGSPRQVERLTISIGIAIYDQDAQSK 333
COG5001     287 IEVGRRLKAFDGAPILAARLGGDEFALIIPALEDD-ALRVAGA-RALCESLQAPYDLRGVRVQVGASIGIAPFPSGADTS 364

                       170       180
                ....*....|....*....|...
gi 94971157 334 RELIEAADAALYQAKGQGRNQVV 356
COG5001     365 EQLFERADYALYHAKQNGKGAAV 387

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

4e-15

77.75

47.42

7,144,207,25,171,232,10,189,242,25,215,267,77,295,344,9,304,355,30,335,385,15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 145 VSNKVIGSMQLFSAEHESFTREDAQlfWMLTLVAENQltrdyeneGLIKFAFTDFLTGLKTRGYFEQQLElEIKRAERKR 224
PRK09966    208 VSEERIAEFHRFALDFNSLLDEMEE--WQLRLQAKNA--------QLLRTALHDPLTGLANRAAFRSGIN-TLMNNSDAR 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 225 TPIAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYGGEEFVIVLPETNTTGAMQvanRIRRGVEQA 304
PRK09966    277 KTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQ---QICSALTQI 353

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 94971157 305 --KFFAGSPRQVERLTISIGIAIYDQDAQSKReLIEAADAALYQAKGQ 350
PRK09966    354 fnLPFDLHNGHQTTMTLSIGYAMTIEHASAEK-LQELADHNMYQAKHQ 400

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

5e-13

70.64

19.27

7,188,372,6,197,378,16,213,395,9,227,404,86,316,490,8,327,498,8,335,507,19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 189 EGLIKFaftDFLTGLKTRGYFEQQL-ELEIKRAERkrtpiAMLMLDLDHFKTLNDTYGHHVGDQVLRDVSAVLMKDLREV 267
PRK11359    373 EQLIQF---DPMTGLPNRNNLHNYLdDLVDKAVSP-----VVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPD 444

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 268 DTAARYGGEEFVIVLPETNTTGAMQVANRIRRGVEQAKFFAGSPRQverLTISIGIAiydQDAQSKRE-LIEAADAALYQ 346
PRK11359    445 QYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSKPIMIDDKPFP---LTLSIGIS---YDVGKNRDyLLSTAHNAMDY 518


                ....*...
gi 94971157 347 AKGQGRNQ 354
PRK11359    519 IRKNGGNG 526

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

4e-10

60.67

24.61

7,193,226,57,250,287,11,264,298,6,270,305,36,310,341,8,318,350,8,327,358,26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 194 FAFTDFLTGLKTRGYFEQQLELEIKRAERKRTPIAMLMLDLDHFKTLNDTYGHHVGD----QVLRDVSAVLMkdlREVDT 269
PRK11059    227 NAFLDAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDellfELINLLSTFVQ---RYPGA 303

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 270 A-ARYGGEEFVIVLPETNTTGAMQVANRIRRGVEQAKFfagsPRQVERLT-ISIGIAIYdQDAQSKRELIEAADAALYQA 347
PRK11059    304 LlARYSRSDFAVLLPHRSLKEADSLASQLLKAVDSLPP----PKMLDRDDfLHIGIAAY-RSGQSTEQVMEEAEMALRSA 378


                ....*.
gi 94971157 348 KGQGRN 353
PRK11059    379 QLQGGN 384

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

2e-06

48.54

26.79

7,173,263,8,181,277,5,186,283,13,199,304,24,224,328,64,288,393,19,310,412,46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 174 LTLVAENQ------LTRDY-ENEGLIKFAFTDF--------LTGLKTRGYFEQQLELEIKRAERKrTPIAMLMLDLDHFK 238
PRK11829    264 LTLPAHHQddelgvLVRNYnRNQQLLADAYADMgrishrfpVTELPNRSLFISLLEKEIASSTRT-DHFHLLVIGIETLQ 342

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94971157 239 TLNDTYGHHVGDQVLRDVSAVLMKDLREVDTAARYGGEEFVIVLPETNTT-GAMQVANRIRRGVEQAKFFagsPRQVERL 317
PRK11829    343 EVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQLSKTEFAVLARGTRRSfPAMQLARRIMSQVTQPLFF---DEITLRP 419

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 94971157 318 TISIGIAIYDQDAQSKRELIEAADAALYQAKGQGRNQVV 356
PRK11829    420 SASIGITRYQAQQDTAESMMRNASTAMMAAHHEGRNQIM 458

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF