NCBI Conserved Domain Search

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Conserved domains on [gi\|94970910\|ref\|YP_592958.1\|]
adenylate/guanylate cyclase [Candidatus Koribacter versatilis Ellin345]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

113977

pfam05226

CHASE2

CHASE2 domain

true

false

243

3e-39

158.25

98.77

9,39,3,18,58,21,15,76,36,61,141,97,14,179,111,50,262,161,9,272,170,11,294,181,35,329,220,23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910  40 RWLETGTYDARMTWSLDPsRADKSIVILDIDNPSfeiLKESFGRWPWTRMAWAGAIDYMADGHPKVIAFDFKFGGSEDPK 119
pfam05226     4 QRLELALYDLRLRLRPPE-PPDPRIVIVAIDEAS---LAQALGRWPWPRSVLARLLDKLAAAQPKAIGLDIYFDEPSSPP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 120 VDQAFAESIRSGRNVLLGfsfdPAQIEDVSDVKNRKlallareslsdshilgehfppadqSLNVPLDILAKASAGMGCLN 199
pfam05226    80 GDEALAAALKRSPNLVVL----PVLLEDNDGDGRGT------------------------EVAPPPPALAAAAARIGFVD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 200 AVYDDDGAVRRMPLGCNYGDLAFRTLDTRAvdyvrghdasrfirdgrygdstgeripvdanghLLVWFHGRPhGTYERVP 279
pfam05226   132 LVLDADGVVRRVLLFEGSGCQTWPSFALRL---------------------------------ALLNYRGPP-GTFPTVS 177

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 94970910 280 FWKLvcsaapdscpnLKEPIPPSYFKDKIVLVGASASGSFELHSTPVGDA----PGVFDRAAAIDNLLHGEGILIAP 352
pfam05226   178 LADV-----------LNGRVPPELLKDKIVLIGATAPGLGDLFPTPYSRSlelmPGVEIHANAVSQLLQGAALDGRP 243

cl01732

120848

CHASE2

CHASE2 domain

-1

32297

COG2114

CyaA

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction...

true

false

227

3e-27

118.74

94.27

7,424,3,23,447,27,38,487,65,66,560,131,22,587,153,22,611,175,22,633,198,19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 425 VRYVTTGRELRATRHALERHMSP-QLAQYALEHGDNLAGERRELTIFFSDIRSFTTLTESLRdhPDKLLALLNEYLTAMC 503
COG2114       4 VLNLLAKEAKVAAAGLRSDLVLRlYLARVVGRLLARGGAGDRRVTLLFADIVGSTELSESLG--DEALVELLNLYFDAVA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 504 EVIFKYEGVVDKFIGDGILAHWGAFTEGKNHALLAAQASLEMLDRLKQMNadwaaqgRDQLAIGIGLNTGEVTFGNVGAg 583
COG2114      82 EVVARHGGRVVKFIGDGFLAVFGRPSPLEDAVACALDLQLALRNPLARLR-------RESLRVRIGIHTGEVVVGNTGG- 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 584 qkteFTVIGDPVNLASRLEGLNKEHHtsIIISEFTLEHLRGLVQTRELGG-VKVKGKTIETQIYELQGLA 652
COG2114     154 ----YTVVGSAVNQAARLESLAKPGQ--VLLSEATYDLVRDLVDLFSGLGsHRLKGLARPVRVYQLCHRS 217

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

128359

smart00044

CYCc

Adenylyl- / guanylyl cyclase, catalytic domain

false

194

8e-23

103.91

95.88

8,432,1,9,442,10,18,460,30,20,482,50,48,530,99,23,556,122,29,586,151,20,608,171,16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 433 ELRATRHALeRHMSPQLAQYALEHGDNL--AGERRELTIFFSDIRSFTTLteSLRDHPDKLLALLNEYLTAMCEVIFKYE 510
smart00044    2 EKRKTDRLL-DQLLPASVAESLKRGGSPvpAESYDNVTILFTDIVGFTTL--SSEATPEQVVTLLNDLYSRFDRIIDRHG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 511 GVVDKFIGDGILAHWGAFTE-GKNHALLAAQASLEMLDRLKQMNadwAAQGRDQLAIGIGLNTGEVTFGNVGAGQKtEFT 589
smart00044   79 GYKVKTIGDAYMVVSGLPTEaLVDHAELAADEALDMVESLKTVL---SQHRGNGLRVRIGIHTGPVVAGVVGITMP-RYC 154

                       170       180       190
                ....*....|....*....|....*....|....*
gi 94970910 590 VIGDPVNLASRLEGLNKehHTSIIISEFTLEHLRG 624
smart00044  155 LFGDTVNLASRMESVGD--PGQILVSEETYSLLRR 187

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

109276

pfam00211

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

false

185

2e-22

102.33

91.89

6,464,6,21,487,27,66,557,93,25,583,118,24,609,142,16,625,162,14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 465 RELTIFFSDIRSFTTLTESLRdhPDKLLALLNEYLTAMCEVIFKYEGVVDKFIGDGILAHWGAFTEGKNHALLAAQASLE 544
pfam00211     7 DNVTILFADIVGFTALSSRHS--PEELVRLLNDLYTRFDELLDKHGVYKVKTIGDAYMAASGLPPAAAHHAALLADMALD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 545 MLDRLKQMNadwaAQGRDQLAIGIGLNTGEVTFGNVGAgQKTEFTVIGDPVNLASRLEGLNKEhhTSIIISEFTLEHLRG 624
pfam00211    85 MVETIEEVN----VGHANGLRVRIGIHTGPVVAGVIGA-RRPRYDVWGDTVNVASRMESTGVP--GKIHVSEETYRLLKG 157

                       170
                ....*....|....*....
gi 94970910 625 L----VQTRELGGVKVKGK 639
pfam00211   158 EesfqFRLEPRGEVPVKGK 176

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

33975

COG4252

Predicted transmembrane sensor domain [Signal transduction mechanisms]

false

400

1e-21

100.05

92.75

15,30,29,23,54,52,21,79,73,39,119,112,14,157,126,19,187,145,38,225,184,14,239,199,22,264,221,30,294,253,35,329,293,16,345,314,22,367,340,32,404,372,8,413,380,20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910  31 IGVENTKPMRWLETGTYDARMTWsLDPSRADKSIVILDIDNPSFEilkeSFGRWPWTRMAWAGAIDYMADGHPKVIAFDF 110
COG4252      30 LLLRLLGLLQLLELAAFDQLLRL-RPSEPPDDRILIVAIDEQDLE----SLGQWPWPRAALARLLDKLAAAQPRAIGLDI 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 111 KFGGSEDPkVDQAFAESIRSGRNvllgfsfdpaqiedvsdvknrklaLLARESLSDSHILGEHFPPadqslnvpldiLAK 190
COG4252     105 YRDLPSSP-GDRALAAVLQRAPN------------------------LIGVEKLSGDPGIAVNPPP-----------ELP 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 191 ASAGMGCLNAVYDDDGAVRRMPLGCNYGDLAFRTL-DTRAVDYVRGHDAS-RFIRDGRYGDSTGERIPVDANGhllVWFH 268
COG4252     149 RQAQIGFSDLILDSDGKVRRLLLAATPGPEPKYSLaLKLALQYLASLGISpKYPDPERLRLGKTTLPRLLGNS---GGYQ 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 269 GRPHGTYERVPFWKLVCSAAPDSCPN--LKEPIPPSYFKDKIVLVGASASGSFELHSTPVGDA-----PGVFDRAAAIDN 341
COG4252     226 GADAGGYQILLNYRSSSSDFRTVSLRdvLNGKVPAELIRGRIVLIGATAPSLNDYFATPYSSSlkelvPGVEIHANIVSQ 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94970910 342 LLHG-----EGILIAPLWQHWILIAIMALVG----WMVLTRLGVSVVGAPVMLSILGVYAVLAAAVFrvehlWLPMVSPL 412
COG4252     306 ILSAlldgrPLLPVWPDGAELLWIFAWSLLGgllaWRLRSPLRLLLAVGLALAGLLLISYLLFLAGW-----WIPLIPPL 380

                       410       420
                ....*....|....*....|.
gi 94970910 413 sAGALAYISAGGVRYVTTGRE 433
COG4252     381 -LALVGSGIWSTLFLKQLRRE 400

cl01732

120848

CHASE2

CHASE2 domain

-1