NCBI Conserved Domain Search

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Conserved domains on [gi\|94969425\|ref\|YP_591473.1\|]
periplasmic sensor diguanylate phophodiesterase [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

2e-61

231.64

99.17

2,258,2,185,445,187,53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 259 IEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQFGWQDS 338
cd01948       3 LRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQAGGP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 339 SRFVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGFSY 418
cd01948      83 DLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSLSY 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 419 IQELPITTLKIDKMFIDTLRQEKQDpkRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPAEE 498
cd01948     163 LKRLPVDYLKIDRSFVRDIETDPED--RAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAEE 240

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

1e-61

232.49

99.17

6,257,2,36,293,39,4,298,43,34,334,77,7,341,86,102,445,188,53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 258 LIEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQ-PKGGnLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQfgWQ 336
smart00052    3 ELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQhPEGG-IISPDEFIPLAEETGLIVPLGRWVLEQACQQLAE--WQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 337 DSSRF--VSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFG 414
smart00052   80 AQGPPlrISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGYS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 415 GFSYIQELPITTLKIDKMFIDTLRQEKQDpkRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPM 494
smart00052  160 SLSYLKRLPVDLLKIDKSFVRDLQTDPED--EAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPL 237


                ....
gi 94969425 495 PAEE 498
smart00052  238 PLDD 241

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

1e-57

219.04

96.09

4,257,6,75,334,81,7,341,89,102,445,191,61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 258 LIEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQfgWQD 337
COG2200       7 DLRQALENGEFSLYYQPIVDLATGRIVGYEALLRWRHPDGGLISPGEFIPLAEETGLIVELGRWVLEEACRQLRT--WPR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 338 SSRF-VSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGF 416
COG2200      85 AGPLrLAVNLSPVQLRSPGLVDLLLRLLARLGLPPHRLVLEITESALIDDLDTALALLRQLRELGVRIALDDFGTGYSSL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 417 SYIQELPITTLKIDKMFIDTLRQEKQDpkRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPA 496
COG2200     165 SYLKRLPPDILKIDRSFVRDLETDARD--QAIVRAIVALAHKLGLTVVAEGVETEEQLDLLRELGCDYLQGYLFSRPLPA 242

                       250
                ....*....|
gi 94969425 497 EEFIRWMNAR 506
COG2200     243 DALDALLSSS 252

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

5e-52

200.72

98.73

5,258,3,75,333,81,20,354,101,26,381,127,61,445,188,48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 259 IEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQF---GW 335
pfam00563     4 LREALENGEFSLYFQPIVDLRTGKVLGYEALLRWQHPDGGLIPPDEFLPLAERLGLIAELDRWVLEKALAQLAEWrgnAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 336 QDSSRFVSINAVAEQITDtPFCANLLRRLAEKRIPAKNFSVEITErHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGG 415
pfam00563    84 LPPDLPLSVNLSPASLLD-PSFLEALLALKQGGLPPSRLVLEITE-SDLDEDLRLLEALARLRSLGFRLALDDFGTGYSS 161

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94969425 416 FSYIQELPITTLKIDKMFIDTLRQEKQdpkRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKP 493
pfam00563   162 LSYLSRLPPDYIKIDRSFIKDLSDPES---RALLRALIALARELGIKVVAEGVETEEQLELLKELGIDYVQGYLFSKP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

138661

PRK11596

EAL domain-containing protein; Provisional

false

255

2e-07

52.40

84.31

15,271,33,7,279,40,10,289,51,7,301,58,6,307,68,3,310,73,13,326,86,19,345,112,5,358,117,8,367,125,7,376,132,9,386,141,2,391,143,10,402,153,41,445,194,54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 272 YQPIIDSrDGSILGAEAL-VRWQPKGgnlipPGQFIP----FAE--ENHLIDPITDQLEekvLDDIKQFGWQDSSRFVSI 344
PRK11596     34 FQPIYRT-CGRLMAVELLtVVTHPSN-----PSQRLSpdryFAEitVSHRLDVVKEQLD---LLAQKADFFVRHGLLASV 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 345 N-------AVAEQitdtpfcaNLLRRLAEkRIPAKNFsvEITERHQFPdLDrgrAALQSLVEAGiEIKLDDAGTGFGGFS 417
PRK11596    105 NidgptliALRQQ--------PKILRLIE-RLPWLRF--ELVEHIRLP-KD---STFASMCEFG-PLWLDDFGTGMANFS 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 418 YIQELPITTLKIDKMFIDTLRQEKQDpkRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPAE 497
PRK11596    169 ALSEVRYDYIKVARELFVMLRQSPEG--RTLFSQLLHLMNRYCRGVIVEGVETPEEWRDVQRSPAFAAQGYFLSRPAPFD 246


                ..
gi 94969425 498 EF 499
PRK11596    247 TL 248

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

34551

COG4943

Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]

Predicted signal transduction protein containing sensor and EAL domains [Signal...

false

true

false

524

2e-57

218.67

83.21

9,77,81,28,105,112,41,148,153,10,158,164,23,184,187,12,196,203,15,211,225,170,382,395,55,439,450,67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425  78 DTLARLNFDNQYVRWYGIAQEGKVICRG---PRVGVDLSDARFHRIDDEWFLISTESPTKASNLLLAQKRGNllYLAMLE 154
COG4943      82 ARMRRIIRGYRYINELIYARDNHLLCSSlehPSNPYTIPSPDYKRKDGVRVYYYRDTPLFIGYKMTYMGRGN--YVVVID 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 155 PLLF-DFMHEVDCKACVSFEFLVSAQPNvemESAPASGPSVIH----YVVEKTRLNAQMKFT-------LNATQEYVDAF 222
COG4943     160 PLSFsDVIPTGAWGIYATVTNTVFSLSG---EASPAIIPPLIKpadlTVENNGYLYAIVPSPkrpiaiiVWASIQRLITA 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 223 AFPGRVLSMTIAAAFGLVIGLSVYGNLTKYTSTAFLIEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQPKGGNLIPP 302
COG4943     237 WHRQLFLALPLGILISLLALLLWLRIRRRYLSPRRRLQRAIERRELCVHYQPIVDLATGKCVGAEALARWPQEDGTVVSP 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 303 GQFIPFAEENHLIDPITDQLEEKVLDDIKQFGWQDSSRFVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERh 382
COG4943     317 DVFIPLAEESGMIEQITDYVIRNVFRDLGDLLRQHRDLHVSINLSASDLASPRLIDRLNRKLAQYQVRPQQIALELTER- 395

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 383 QFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGFSYIQELPITTLKIDKMFIDTLrqEKQDPKRAVLQAIIEFAKTANLH 462
COG4943     396 TFADPKKMTPIILRLREAGHEIYIDDFGTGYSNLHYLQSLPVDALKIDKSFVDTL--GTDSASHLIAPHIIEMAKSLGLK 473

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 94969425 463 AIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPAEEFIRWMNAR 506
COG4943     474 IVAEGVETEEQVDWLRKRGVHYGQGWLFSKALPAQAFLDWAEQQ 517

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

1e-43

172.93

51.54

11,237,246,56,293,303,5,299,308,33,332,351,2,343,353,23,368,376,8,376,386,7,386,393,7,393,402,48,441,451,3,447,454,59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 238 GLVIGLSVYGNLTKYTSTAFLIEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQ-PKGGNlIPPGQFIPFAEENHLID 316
PRK10551    247 GTLVGLLCYYILSLRMRPGREILTAIKREQFYVVYQPVVDTQTLRVTGLEVLLRWRhPTAGE-IPPDAFINYAEAQKLIV 325

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 317 PITDQLEEKVLDDIKQ----------FGwqdssrfvsINAVAEQITDTPFCANLLRRLAEkrIPAKNFSV--EITERHQf 384
PRK10551    326 PLTQHLFELIARDAAElqkvlpvgakLG---------INIAPAHLHSDSFKADVQRLLAS--LPADHFQIvlEITERDM- 393

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 385 pdLDRGRAA--LQSLVEAGIEIKLDDAGTGFGGFSYIQELPITTLKIDKMFIDTLRQEK-QDPkraVLQAIIEFAKTANL 461
PRK10551    394 --LQEEEALklFAWLHSQGIEIAIDDFGTGHSALIYLERFTLDYLKIDRGFINAIGTETvTSP---VLDAVLTLAKRLNM 468

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 94969425 462 HAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPAEEFIRWMNAR 506
PRK10551    469 LTVAEGVETPEQARWLREHGVNFLQGYWISRPLPLDDFVKWLKKP 513

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

1e-39

159.16

36.71

6,258,404,63,321,468,3,324,473,10,337,483,84,421,570,20,446,590,53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 259 IEQGLKRNEFLPFYQPIIDSRDGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQ-LEE--KVLDDIKQFGw 335
PRK13561    405 ILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPDGLIDRIESCGLMVTVGHWvLEEscRLLAAWQERG- 483

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 336 qdSSRFVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGG 415
PRK13561    484 --IMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRPLRNAGVRIALDDFGMGYAG 561

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 416 FSYIQE---LPITTLKIDKMFIDTLRQEKqdpkrAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSK 492
PRK13561    562 LRQLQHmksLPIDVLKIDKMFVDGLPEDS-----SMVAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGVAQGFLFAR 636


                ....*..
gi 94969425 493 PMPAEEF 499
PRK13561    637 PLPIEIF 643

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

5e-37

150.65

36.20

6,260,414,19,280,433,42,325,475,9,334,485,4,338,491,99,439,590,64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 261 QGLKRNEFLPFYQPIIDSRdGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQLeekVLDDIKQFG-WQDS- 338
PRK10060    415 KALENDQLVIHYQPKITWR-GEVRSLEALVRWQSPERGLIPPLEFISYAEESGLIVPLGRWV---ILDVVRQAAkWRDKg 490

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 339 -SRFVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGFS 417
PRK10060    491 iNLRVAVNVSARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLS 570

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 418 YIQELPITTLKIDKMFIDTLrqEKQDPKRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPAE 497
PRK10060    571 QLARFPIDAIKLDQSFVRDI--HKQPVSQSLVRAIVAVAQALNLQVIAEGVETAKEDAFLTKNGVNERQGFLFAKPMPAV 648


                ....*.
gi 94969425 498 EFIRWM 503
PRK10060    649 AFERWY 654

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

1e-36

149.41

36.20

5,257,401,7,264,412,68,334,480,6,341,486,104,447,590,51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 258 LIEQGLK----RNEFLPFYQPIIDSRDGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQf 333
COG5001     402 VVEQALRsadlEQELSVHFQPIVDIVSGKTIALEALARWHSPEIGPVPPDVFIGIAERSGQIVELTRLLLAKALREARA- 480

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 334 gWQDSSRfVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGF 413
COG5001     481 -WPMDVR-VSINLSARDLASMENVRRLLAIVSESCIAPHRLDFEITETAIVCDFDQARDALAALHELGVRTALDDFGTGY 558

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 414 GGFSYIQELPITTLKIDKMFIDTLRQEKQDPKraVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKP 493
COG5001     559 SSLSHLRALPLDKIKIDRSFVSDLEENPTSED--IVRTVLQLGRNLRMECVVEGVETEAQRDRVAALGATVMQGYHYARP 636


                ....*
gi 94969425 494 MPAEE 498
COG5001     637 MPAEE 641

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

8e-36

146.91

28.91

7,271,560,22,293,583,5,299,588,31,332,619,7,341,626,22,363,653,79,444,732,59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 272 YQPIIDSRDGSILGAEALVRWQ-PKGGNlIPPGQFIPFAEENHLIDPITDQLEEKVLDDIkqFGWQDSSrfVSINAVAEQ 350
PRK11359    561 YQPQIFAETGELYGIEALARWHdPLHGH-VPPSRFIPLAEEIGEIENIGRWVIAEACRQL--AEWRSQN--IHIPALSVN 635

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 351 ITDTPFCANLLRR-----LAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGFSYIQELPIT 425
PRK11359    636 LSALHFRSNQLPNqvsdaMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVT 715

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94969425 426 TLKIDKMFIDTLRQEKQdpKRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPAEEFIRWM 503
PRK11359    716 EIKIDKSFVDRCLTEKR--ILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEIPGWM 791

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

4e-28

121.34

32.55

5,260,479,32,292,512,11,304,523,114,418,640,23,446,663,53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 261 QGLKRNEFLPFYQPIIDSRDGSILGAEALVRW-QPKGGNLIPPGqFIPFAEENHLIDPITDQLEEKVLDDIKQFGWQDSS 339
PRK11829    480 QAIENHDFTLFLQPQWDMKRQQVIGAEALLRWcQPDGSYVLPSG-FVHFAEEEGMMVPLGNWVLEEACRILADWKARGVS 558

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 340 RFVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGFSY- 418
PRK11829    559 LPLSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDLDEALRLLRELQGLGLLIALDDFGIGYSSLRYl 638

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 419 --IQELPITTLKIDKMFIDTLRQEKqdpkrAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKPMPA 496
PRK11829    639 nhLKSLPIHMIKLDKSFVKNLPEDD-----AIARIISCVSDVLKVRVMAEGVETEEQRQWLLEHGIQCGQGFLFSPPLPR 713


                ...
gi 94969425 497 EEF 499
PRK11829    714 AEF 716

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

1e-19

93.23

21.51

7,258,868,21,279,890,12,291,903,5,297,908,19,320,927,20,340,950,103,445,1053,55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425  259 IEQGLKRNEFLPFYQPIIDSR-DGSILGAEALVR-WQPKGgNLIPPGQFIPFAEENHLIDpitdQLEEKVLDDIKQFGWQ 336
PRK09776     869 WRSMLEENQLMLQAQEIASPRiPEARNLWLISLRlWDCEG-EIIDEGAFRPAAEDPALMH----ALDRWVIHELFQQGAR 943

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425  337 DSSR---FVSINAVAEQITDTPFCANLLRRLAEKRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGF 413
PRK09776     944 AVASkglSIAIPLSVASLSSATLLPFLLEQLENSPLPPRLLHLEITETALLNHAEAASRLVQKLRLAGCRVVLDDFGRGL 1023

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425  414 GGFSYIQELPITTLKIDKMFIDTLRQEKQDpkRAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKP 493
PRK09776    1024 SSFNYLKAFMADYLKIDGELCANLQGNLMD--EMLVSIINGIAQRLGMKTIAGPVELPLTLDTLSGIGVDLAQGYVIGRP 1101


                 ....*..
gi 94969425  494 MPAEEFI 500
PRK09776    1102 QPLDLLL 1108

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

3e-14

75.30

36.45

7,257,406,20,278,426,54,334,480,32,366,513,67,433,583,2,436,585,6,446,591,49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 258 LIEQGLKRNEFLPFYQPIIDsRDGSILGAEALVRWQPKGGNLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQfgWQD 337
PRK11059    407 LLEQALVRGGPRLYQQPVVT-RDGQVHHRELMCRIRDGQGNEVRAAEFMPMVLQCGLSEQYDRQVIERVLPLLSY--WPE 483

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 338 SSRFVSINAVAEQITDTPFCANLLRRLAE-KRIPAKNFSVEITERHQFPDLDRGRAALQSLVEAGIEIKLDDAGTGFGGF 416
PRK11059    484 ESQNLSINLSVDSLLSRAFQRWLRDTLLQcERSQRKRLIFELAEADVVQHIDRLRPVLRMLRGLGCRLAVDQAGLTVVST 563

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 417 SYIQELPITTLKIDKMF---IDtLRQEKQdpkrAVLQAIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKP 493
PRK11059    564 SYIKELNVELIKLHPSLvrnIH-QRTENQ----LFVRSLVGACAGTETQVFAEGVESREEWQTLQILGVSGGQGDFFASP 638


                ..
gi 94969425 494 MP 495
PRK11059    639 QP 640

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

false

true

false

407

1e-06

49.89

45.70

8,272,7,5,278,12,17,297,29,36,343,65,2,355,67,25,382,92,26,408,123,28,451,151,42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 273 QPIIDsRDGSILGAEALVRWQPKggNLIPPGQFIPFAEENHLIDPITDQLEEKVLDDIKQFgwqdssrfvsINavaeqit 352
COG3434       8 QPILD-RNKEVFGYELLFREGEK--NKYPEDVDNSRATYRIIIEEFVIQGIDKLANGKKCF----------IN------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94969425 353 dtpFCANLLRRLAEKRIPAKNFSVEITErhQFPDLDRGRAALQSLVEAGIEIKLDD-----AGTGFGGFSYIQELPITTL 427
COG3434      68 ---FPEELLISDLPELLPPDKVVIEILE--DCPPTEKLLSAIKELKQKGYLLALDDfifsnVSEWKPLLPLSDIVKIDFK 142

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94969425 428 KIDKMFIDTlrqekqdpkravlqaIIEFAKTANLHAIAEGVETKEQVSQLSAAGVFAIQGYVYSKP 493
COG3434     143 RVTFDKARL---------------FDRDLGYINKKFLAEKVETEEEFEQAKKAGFDLFQGYFFSKP 193

-1