NCBI Conserved Domain Search

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Conserved domains on [gi\|94968987\|ref\|YP_591035.1\|]
diguanylate cyclase with PAS/PAC sensor [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

1e-33

138.88

98.73

3,160,1,117,278,118,5,283,124,32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 161 DPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSVDE 240
cd01949       2 DPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGDE 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94968987 241 FLILVPSSSVDSLGDIAERCRALVERANIQVGTEQLVaTISAG-ASAVDPLDTMEMFIRRLENYLQRSKYSGRNRI 315
cd01949      82 FAILLPGTDLEEAEELAERLRKAIEEPFFIDGEEIRV-TASIGiAEYPEDGEDLEELLRRADKALYQAKRSGRNRV 156

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

110022

pfam00990

GGDEF

GGDEF domain

false

160

2e-31

131.60

99.38

3,158,1,111,269,114,21,290,136,24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 159 FLDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSV 238
pfam00990     2 AHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLGG 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94968987 239 DEFLILVPSSSVDSLGDIAERCRALVERANI--QVGTEQLVATISAGASAVDPL-DTMEMFIRRLENYLQRSKYSGRNR 314
pfam00990    82 DEFAILLPDTSLEGAQELAERIRRLLAALKIphTLSGLPLYVTISIGIAAYPNDgEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

4e-30

126.98

96.32

3,158,3,111,270,114,20,290,135,25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 159 FLDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSV 238
smart00267    4 FRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLARLGG 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94968987 239 DEFLILVPSSSVDSLGDIAERCRALVERANIqVGTEQLVATISAGASAVDPL-DTMEMFIRRLENYLQRSKYSGRNRI 315
smart00267   84 DEFALLLPETSLEEAIALAERILQQLREPII-IHGIPLYLTISIGVAAYPNPgEDAEDLLKRADTALYQAKKAGRNQV 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

8e-28

119.45

95.03

3,144,6,133,278,139,8,286,149,29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 145 KARNQRAELLHSRGFLDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLA 224
COG2199       7 TRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVARRLR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 225 NAVSEADILGRWSVDEFLILVPSSSVDSLGDIAERCRALVERANIQVGTEQLVaTISAGASA--VDPLDTMEMFIRRLEN 302
COG2199      87 SNLREGDLVARLGGDEFAVLLPGTSLEEAARLAERIRAALEEPFFLGGEELRV-TVSIGVALypEDGSDDAELLLRRADL 165

                       170
                ....*....|...
gi 94968987 303 YLQRSKYSGRNRI 315
COG2199     166 ALYRAKRAGRNRV 178

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

4e-24

107.04

96.97

3,160,4,111,271,116,12,283,129,35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 161 DPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSVDE 240
TIGR00254     5 DPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRYGGEE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 241 FLILVPSSSVDSLGDIAERCRALVERANIQV-GTEQLVATISAG-ASAVDPLDTMEMFIRRLENYLQRSKYSGRNRITMK 318
TIGR00254    85 FVVILPGTPLEDALSKAERLRDAINSKPIEVaGSETLTVTVSIGvACYPGHGLTLEELLKRADEALYQAKKAGRNRVVVA 164

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128402

smart00091

PAS

PAS domain

true

false

1e-06

48.93

73.13

1,24,1,49

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 94968987  25 FFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQDNI 73
smart00091    2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50

cl02459

141436

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

-1

29035

cd00130

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

false

true

false

103

1e-04

42.57

71.84

3,32,0,41,75,41,11,90,52,22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987  33 LYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQDNIlnHVDDAGTQLCFgkcpLLTTIEHGVPHECEIYLHHKNG 112
cd00130       1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLI--HPEDREELRER----LENLLSGGEPVTLEVRLRRKDG 74

cl02459

141436

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

2e-28

121.56

35.23

3,160,294,111,271,407,18,289,426,29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 161 DPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSVDE 240
PRK09581    295 DGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARYGGEE 374

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 241 FLILVPSSSVDSLGDIAERCRALVERANIQV--GTEQLVATISAGASAVDP-LDTMEMFIRRLENYLQRSKYSGRNRITM 317
PRK09581    375 FVVVMPDTDIEVAIAVAERIRRKIAEEPFAIsdGKERLNVTVSIGVAELRPsGESIEALIKRADKALYEAKNTGRNRVVA 454


                .
gi 94968987 318 K 318
PRK09581    455 L 455

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

2e-27

117.71

39.31

3,147,259,126,273,387,16,289,404,26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 148 NQRAELLHSRGFLDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAV 227
COG3706     260 RESLERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQTV 339

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 228 SEADILGRWSVDEFLILVPSSSVDSLGDIAERCRALVERANIQVGT--EQLVATISAGASAVDP-LDTMEMFIRRLENYL 304
COG3706     340 RGLDLVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELPFVHELsrEPLEVTISIGVAEGKPgEDSIEELLKRADKAL 419

                       170
                ....*....|.
gi 94968987 305 QRSKYSGRNRI 315
COG3706     420 YKAKASGRNRV 430

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

4e-26

113.65

61.43

2,133,105,47,182,152,133

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 134 AVEMFVEANSSKARNQRAELLHSRGFLDPLTDIGNRRYLEIELFKALqeFRQHGLPFGAILADIDHLRIVNEHYGHTVGD 213
PRK09894    106 AFQEGLLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLDESFDHQL--RNREPLNLYLALLDIDRFKLVNDTYGHLIGD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 214 QVLRAVSLTLANAVSEADILGRWSVDEFLILVPSSSVDSLGDIAERCRALVERANIQVGTEQLVATISAGASAVDPLDTM 293
PRK09894    184 VVLRTLATYLASWTRPYETVYRYGGEEFIIILKAATDEEACRAGERIRQLIANQAITHSEGRINITATFGVTRAFPEEPL 263

                       170       180
                ....*....|....*....|..
gi 94968987 294 EMFIRRLENYLQRSKYSGRNRI 315
PRK09894    264 DEVIGRADRAMYEGKQAGRNRV 285

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

3e-15

77.44

20.25

7,29,563,42,71,607,7,78,618,13,92,631,7,105,638,33,140,671,19,160,690,99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987   30 LEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQD--NILNHVD----DAGTQLCFGKCPLlTTIEHGVphec 103
PRK09776     564 LDSIGEAVVCTDAAMKVTFMNPVAEKMTGWTQEEALGVPLLTvlHITFGDNgplmENPVEICLADTSR-SYLEQDV---- 638

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987  104 eiYLHHKNGHRVPVRVHVTPVRDANNQIIGAVEMFveANSSKARNQRAELLHSRGFlDPLTDIGNRRYLEIELFKALQEF 183
PRK09776     639 --VLHSRSGGSYDVQYSIAPLSTLDGENIGSVLVF--QDVTESRAMLRQLSYSASH-DALTGLANRASFEKQLREALQTV 713

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94968987  184 RQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSVDEFLILVPSSSVDSLGDIAER 259
PRK09776     714 NSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATR 789

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

5e-13

69.92

43.94

5,148,203,9,160,212,92,252,308,12,269,320,20,289,341,25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 149 QRAELLHSRgflDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVS 228
PRK10245    204 RRLQVMSTR---DGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLR 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 229 EADILGRWSVDEFLILVPSSSVDS----LGDIAERCRALVeraniQVGTEQLVATISAGASAVDP-LDTMEMFIRRLENY 303
PRK10245    281 GSDVIGRFGGDEFAVIMSGTPAESaitaMLRVHEGLNTLR-----LPNAPQVTLRISVGVAPLNPqMSHYREWLKSADLA 355

                       170
                ....*....|.
gi 94968987 304 LQRSKYSGRNR 314
PRK10245    356 LYKAKKAGRNR 366

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

2e-11

64.66

27.00

5,141,204,15,156,226,96,254,322,12,266,343,18,290,361,22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 142 NSSKARNQRAELLHS-------RGFLDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQ 214
COG5001     205 QSQVTLTQRAEETRRlsdendrLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDR 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 215 VLRAVSLTLANAVSEADILGRWSVDEFLILVPSSSVDSlgDIAERCRALVER---------ANIQVGTEQLVATISAGAs 285
COG5001     285 LLIEVGRRLKAFDGAPILAARLGGDEFALIIPALEDDA--LRVAGARALCESlqapydlrgVRVQVGASIGIAPFPSGA- 361

                       170       180
                ....*....|....*....|....*..
gi 94968987 286 avdplDTMEMFIRRLENYLQRSKYSGR 312
COG5001     362 -----DTSEQLFERADYALYHAKQNGK 383

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

3e-11

63.98

14.63

2,160,239,28,190,267,69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 161 DPLTDIGNRRYLEIELFKALQEFRQHGLpfGAILADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSVDE 240
PRK10060    240 DSITGLPNRNAIQELIDHAIAQADNNQV--GIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQTLARLGGDE 317

                        90
                ....*....|....*....
gi 94968987 241 FLILVPSSSVDSLGDIAER 259
PRK10060    318 FLVLASHTSQAALEAMASR 336

-1

138539

PRK11360

sensory histidine kinase AtoS; Provisional

true

false

607

3e-07

51.23

34.43

12,4,233,12,16,253,50,66,304,2,75,306,10,88,316,14,102,331,10,113,341,33,146,377,14,160,400,6,168,406,21,191,427,9,200,437,5

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987   5 SIPSTLTELGKI--------DAFVNSPTFFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIG-HYcqdniln 75
PRK11360    234 RLPPLPGELGQIsqainnlaQALREARTLNELIIENAADGIIAIDRQGDITTMNPAAEVITGYQRHELVGqPY------- 306

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987  76 HVDDAGTQLCfgkCPLLTTIEHGVPHE-CEIYLHHKNGhRVPVRVHVTPVRDANNQIIGAVEMFVEANSSKA---RNQRA 151
PRK11360    307 SMLFDNTQFY---SPVLDTLEHGTEHVaLEISFPGRDR-TIELSVTTSRLHDTHGEMIGAVVIFSDLTARKRlqrRMARA 382

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94968987 152 ELLHSRGFL---------DPLTDIgnRRYLEIELFKALQEFRQHGLPfgAILADIDHL-RIVNE 205
PRK11360    383 ERLAALGELmagvaheirNPLTAI--RGYVQILRQQTSDPIHQEYLS--VVLREVDSLnKVIQQ 442

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

3e-07

51.04

19.63

4,145,212,6,151,221,76,227,298,4,231,303,35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 146 ARNQRA---ELLHSRGFLDPLTDIGNRRYLEIELFKALQEFRQHGLPFGAILADIDHLRIVNEHYGHTVGDQVLRAVSLT 222
PRK11059    213 ARKERSrfdTFIRSNAFLDAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDELLFELINL 292

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 94968987 223 LANAV-SEAD-ILGRWSVDEFLILVPSSSVDSLGDIAERCRALVER 266
PRK11059    293 LSTFVqRYPGaLLARYSRSDFAVLLPHRSLKEADSLASQLLKAVDS 338

-1

129332

TIGR00229

sensory_box

PAS domain S-box

false

true

false

124

3e-06

47.66

37.90

1,21,0,47

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 94968987  22 SPTFFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHY 68
TIGR00229     1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRN 47

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

6e-06

46.76

18.40

4,160,378,30,194,408,71,266,479,20,287,499,26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987 161 DPLTDIGNRRYLEIELFKALQEFRQHGLPFgailADIDHLRIVNEHYGHTVGDQVLRAVSLTLANAVSEADILGRWSVDE 240
PRK11359    379 DPMTGLPNRNNLHNYLDDLVDKAVSPVVYL----IGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQ 454

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94968987 241 FLILVPSSSVDSLGDIAERCRALVErANIQVGTEQLVATISAGASAvDPLDTMEMFIRRLENYLQRSKYSGRN 313
PRK11359    455 FVLVSLENDVSNITQIADELRNVVS-KPIMIDDKPFPLTLSIGISY-DVGKNRDYLLSTAHNAMDYIRKNGGN 525

-1

110021

pfam00989

PAS

PAS fold

false

true

false

112

1e-05

45.47

38.39

1,23,0,43

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 94968987  24 TFFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIG 66
pfam00989     1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIG 43

-1

33622

COG3829

RocR

Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]

Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [...

false

true

false

560

1e-04

42.59

8.57

1,23,116,48

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 94968987  24 TFFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQD 71
COG3829     117 QRLEAILDSIDDGLLVVDEDGIIIYYNKAYAKLLGLSPEEVLGKHLLD 164

-1

117025

pfam08448

PAS_4

PAS fold

false

true

false

110

1e-04

42.40

94.55

4,29,0,42,74,42,11,88,53,21,110,74,30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987  30 LEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQDnilNHVDDAGTQLCfgkCPLLTTIEHGVPHECEIYLHH 109
pfam08448     1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAE---LLPPEDAARLE---RALRRALEGEEPIDFLEELLL 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 94968987 110 kNGHRVPVRVHVTPVRDANNQIIGAVEMFVE 140
pfam08448    75 -NGEERHYELRLTPLRDPDGEVIGVLVISRD 104

-1

32384

COG2202

AtoS

FOG: PAS/PAC domain [Signal transduction mechanisms]

false

true

false

232

0.001

39.19

54.31

2,16,104,65,85,169,61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987  17 DAFVNSPTFFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQDNILNHVDDAGtqlcFGKCPLLTTIE 96
COG2202     105 EALRESEERLRALLEASPDGIWVLDEDGRILYANPAAEELLGYSPEEELGRGLSDLIHPEDEERR----ELELARALAEG 180

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 94968987  97 HGVPHECEIYLHHKNGHRVPVRVHVTPVRDANNQIIGAVEMFVEANSSKA 146
COG2202     181 RGGPLEIEYRVRRKDGERVRWILSRISPVRDDGEIVGVVGIARDITERKQ 230

-1

106506

PRK13560

hypothetical protein; Provisional

false

true

false

807

0.002

38.50

16.98

5,25,333,21,46,355,21,67,389,11,80,400,18,98,419,51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94968987  26 FQRLLEELYEGVYFVDTHRRI-LYWNRAAHRISGYSAEEVIGH-------------YCQDNILNHVDdaGTQLCFGKCPL 91
PRK13560    334 LRAIIEAAPIAAIGLDADGNIcFVNNNAAERMLGWSAAEVMGKplpgmdpelneefWCGDFQEWYPD--GRPMAFDACPM 411

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 94968987  92 LTTIEHG-VPHECEIYLHHKNGHRVPVRVHVTPVRDANNQIIGAVEMFVEANSSKARNQ 149
PRK13560    412 AKTIKGGkIFDGQEVLIEREDDGPADCSAYAEPLHDADGNIIGAIALLVDITERKQVEE 470

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

0.007

36.74

4.63

1,29,17,37

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 94968987  30 LEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIG 66
PRK11359     18 LEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIG 54

-1

106506

PRK13560

hypothetical protein; Provisional

false

true

false

807

0.009

36.19

5.82

1,24,204,47

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 94968987  25 FFQRLLEELYEGVYFVDTHRRILYWNRAAHRISGYSAEEVIGHYCQD 71
PRK13560    205 FLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHD 251

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF