NCBI Conserved Domain Search

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Conserved domains on [gi\|94967990\|ref\|YP_590038.1\|]
diguanylate cyclase with PAS/PAC sensor [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

2e-30

128.86

100.00

3,303,0,106,411,106,23,434,130,27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 304 TDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHEDSVARLAGD 383
cd01949       1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94967990 384 DFVALFPYVDANRALTSLDRFKSTLEnaQLRLHDGKEITLTGACGLSDWKP-GMSAEDLLDSALKACGEAKAKGRNSVA 461
cd01949      81 EFAILLPGTDLEEAEELAERLRKAIE--EPFFIDGEEIRVTASIGIAEYPEdGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

128563

smart00267

GGDEF

diguanylate cyclase

false

163

3e-27

118.12

97.55

3,303,4,106,411,110,21,432,132,31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 304 TDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHEDSVARLAGD 383
smart00267    5 RDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLARLGGD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 384 DFVALFPYVDANRALTSLDRFKSTLEnaQLRLHDGKEITLTGACGLSDW-KPGMSAEDLLDSALKACGEAKAKGRNSVAV 462
smart00267   85 EFALLLPETSLEEAIALAERILQQLR--EPIIIHGIPLYLTISIGVAAYpNPGEDAEDLLKRADTALYQAKKAGRNQVAV 162


                .
gi 94967990 463 A 463
smart00267  163 Y 163

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

8e-27

116.76

98.90

3,284,2,125,411,127,25,436,154,27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 285 FRDVSDRKALEKQIQRDGTTDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFG 364
COG2199       3 LRLLTRLRKAEERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 365 TILRATLRHEDSVARLAGDDFVALFPYVDANRALTSLDRFKSTLEnaQLRLHDGKEITLTGACGLSDWKPGM--SAEDLL 442
COG2199      83 RRLRSNLREGDLVARLGGDEFAVLLPGTSLEEAARLAERIRAALE--EPFFLGGEELRVTVSIGVALYPEDGsdDAELLL 160

                       170       180
                ....*....|....*....|.
gi 94967990 443 DSALKACGEAKAKGRNSVAVA 463
COG2199     161 RRADLALYRAKRAGRNRVVVF 181

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

5e-24

107.33

98.75

3,303,2,106,409,109,23,432,133,27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 304 TDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHEDSVARLAGD 383
pfam00990     3 HDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLGGD 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94967990 384 DFVALFPYVDANRALTSLDRFKSTLE-NAQLRLHDGKEITLTGACGLSDW-KPGMSAEDLLDSALKACGEAKAKGRNS 459
pfam00990    83 EFAILLPDTSLEGAQELAERIRRLLAaLKIPHTLSGLPLYVTISIGIAAYpNDGEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

2e-20

95.48

98.79

2,302,2,134,436,137,28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 303 TTDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHEDSVARLAG 382
TIGR00254     3 VRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRYGG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 383 DDFVALFPYVDANRALTSLDRFKSTLENAQLRLHDGKEITLTGACGLSDWKPGM-SAEDLLDSALKACGEAKAKGRNSVA 461
TIGR00254    83 EEFVVILPGTPLEDALSKAERLRDAINSKPIEVAGSETLTVTVSIGVACYPGHGlTLEELLKRADEALYQAKKAGRNRVV 162


                ...
gi 94967990 462 VAA 464
TIGR00254   163 VAD 165

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32385

COG2203

FhlA

FOG: GAF domain [Signal transduction mechanisms]

true

false

175

1e-10

62.72

99.43

4,8,1,55,64,56,15,79,83,56,135,140,35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990   9 EAARQQELTSFQILDTPPDSSFDNLVALAAEICEAPISTVTFIDSDRQWFKAKLGvESDQTPREQSFCAHA--------- 79
COG2203       2 EEALLNELAAKIAQDLDLEEILQAALELLAELLGADRGLIYLLDEDGLLDGALVA-EAAEAGLEQLIDELFglvilpacl 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990  80 ---ILKPNEFMVVPDAAKDPRFEDNPLVTGEPNIRFYAAAPLVSKGLGLGALCIIDRQP-RTLKPFQESALRTLASQAAQ 155
COG2203      81 igiALREGRPVVVEDILQDPRFRDNPLVLLEPPIRSYLGVPLIAQGELLGLLCVHDSEPrRQWSEEELELLEELAEQVAI 160

                       170
                ....*....|....*
gi 94967990 156 LMELHRQRAMAENHR 170
COG2203     161 AIERARLYEELQEAE 175

cl00853

140972

GAF

GAF domain

-1

110584

pfam01590

GAF

GAF domain

false

153

4e-10

61.49

98.69

4,24,0,30,54,37,26,81,63,28,109,105,46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990  25 PPDSSFDNLVALAAEICEAPISTVTFIDSD-------RQWFKAKLGVESDQTPREQSFCAHAIlKPNEFMVVPDAAKDPR 97
pfam01590     1 DLEELLQTILEELRELLGADRCAILLADADglllylvAGDGLSDIPLAARGLPLGGGVVGEVI-AGGNPIVVPDVQDDPR 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94967990  98 FEDNPLVTGEPN--------------IRFYAAAPLVSKGLGLGALCIIDRQPRTLKPFQESALRTLASQAAQ 155
pfam01590    80 FRDLTALAEELPapvgchehylrglgIRSCLAVPLLGGGKLIGVLVLHSTSPRAFTEEELELLQALADQVAI 151

cl00853

140972

GAF

GAF domain

-1

128379

smart00065

GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.

false

149

5e-06

47.76

96.64

5,26,2,28,54,37,24,79,61,19,99,80,34,133,115,31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990  27 DSSFDNLVALAAEICEAPISTVTFIDSD-------RQWFKAKLGVESDQTPREQSFCAHaILKPNEFMVVPDAAKDPRFe 99
smart00065    3 EELLQTILEELRQLLGADRVLIYLVDEDdrgelvlVAADGLTLPLLGLRYPLGEGLAGR-VAETGRPLNIPDVEADPVF- 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94967990 100 DNPLVTGEPNIRFYAAAPLVSKGLGLGALCIIDR-QPRTLKPFQESALRTLASQAAQLMELHRQRA 164
smart00065   81 ALDLLGRYQGVRSFLAVPLVADGELVGVLALHNKdSPRPFTEEDEELLQALANQLAIALANAQLYE 146

cl00853

140972

GAF

GAF domain

-1

29035

cd00130

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

true

103

0.001

39.87

100.00

4,179,0,40,230,40,7,237,51,46,283,98,5

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 180 LAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLhfkpvqpdgfpIPTEDLP----SYKALATGEPQRNVIFGI 255
cd00130       1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDL-----------IHPEDREelreRLENLLSGGEPVTLEVRL 69

                        90       100       110
                ....*....|....*....|....*....|....
gi 94967990 256 TRPNKTEIWIESNASVLNDPVHGECAVI-SFRDV 288
cd00130      70 RRKDGSVIWVLVSLTPIRDEGGEVIGLLgVVRDI 103

cl02459

141436

PAS

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most...

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

7e-23

103.85

45.75

4,274,235,24,298,266,117,415,384,21,436,406,28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 275 PVHGECAVISFRDVSDRKALEKQI-------QRDGTTDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAM 347
COG3706     236 PIEEGELRARLRRQLRRKRYERQLreslerlQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEI 315

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 348 VAKHGPHAADSALKHFGTILRATLRHEDSVARLAGDDFVALFPYVDANRALTSLDRFKSTLENAQLRL-HDGKEITLTGA 426
COG3706     316 NDTYGHDVGDEVLRQVARRLRQTVRGLDLVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELPFVHeLSREPLEVTIS 395

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 94967990 427 CGLSDWKPGM-SAEDLLDSALKACGEAKAKGRNSVAVAA 464
COG3706     396 IGVAEGKPGEdSIEELLKRADKALYKAKASGRNRVVVKR 434

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

2e-17

85.74

35.67

3,303,293,117,420,411,14,434,426,30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 304 TDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHEDSVARLAGD 383
PRK09581    294 TDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARYGGE 373

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 384 DFVALFPYVDANRALTSLDRFKSTLENAQLRLHDGKE-ITLTGACGLSDWKP-GMSAEDLLDSALKACGEAKAKGRNSVA 461
PRK09581    374 EFVVVMPDTDIEVAIAVAERIRRKIAEEPFAISDGKErLNVTVSIGVAELRPsGESIEALIKRADKALYEAKNTGRNRVV 453


                ...
gi 94967990 462 VAA 464
PRK09581    454 ALA 456

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

5e-17

84.37

16.31

5,280,666,133,413,803,4,417,808,7,427,815,7,436,822,26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990  281 AVISFRDVSDRKALEKQIQRDGTTDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSAL 360
PRK09776     667 SVLVFQDVTESRAMLRQLSYSASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALL 746

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990  361 KHFGTILRATLRHEDSVARLAGDDFVALFPYVDANRALTSLDRFKSTLENAQL----RLHD-GKEITLTgacGLSDWKPg 435
PRK09776     747 RELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAINDYRFpwegRVYRvGASAGIT---AIDDNNH- 822

                        170       180
                 ....*....|....*....|....*..
gi 94967990  436 mSAEDLLDSALKACGEAKAKGRNSVAV 462
PRK09776     823 -QASEVMSQADIACYAAKNAGRGRVTV 848

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

9e-12

66.66

66.21

5,275,94,13,288,108,12,300,128,26,328,154,85,414,239,49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 276 VHGECAVISFRDV-SDRKALEKQIQR--------DGTTDPLTGLPNRAAFLNYVGKAIAAasRYKHPMSVCVASLDDLKA 346
PRK09894     95 AEGHWQDADFDAFqEGLLSFTAALTDykiylltiRSNMDVLTGLPGRRVLDESFDHQLRN--REPLNLYLALLDIDRFKL 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 347 MVAKHGPHAADSALKHFGTILRATLRHEDSVARLAGDDFVALFPYVDANRALTSLDRFKSTLENAQLrLHDGKEITLTGA 426
PRK09894    173 VNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGEEFIIILKAATDEEACRAGERIRQLIANQAI-THSEGRINITAT 251

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 94967990 427 CGLSDWKPGMSAEDLLDSALKACGEAKAKGRNSVAVA 463
PRK09894    252 FGVTRAFPEEPLDEVIGRADRAMYEGKQAGRNRVMFI 288

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

3e-10

61.58

25.79

4,291,217,101,392,320,8,400,331,31,436,362,26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 292 KALEKQIQRDGTTDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATL 371
COG5001     218 RRLSDENDRLANLDSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFD 297

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 372 RHEDSVARLAGDDFVALFPYV--DANRALTS---LDRFKSTLENAQLRLHDGKEITLTGACGLSDwkpgmSAEDLLDSAL 446
COG5001     298 GAPILAARLGGDEFALIIPALedDALRVAGAralCESLQAPYDLRGVRVQVGASIGIAPFPSGAD-----TSEQLFERAD 372

                       170
                ....*....|....*.
gi 94967990 447 KACGEAKAKGRNSVAV 462
COG5001     373 YALYHAKQNGKGAAVL 388

-1

138539

PRK11360

sensory histidine kinase AtoS; Provisional

false

true

false

607

2e-08

55.85

19.11

6,175,265,44,225,309,8,236,317,25,262,342,13,276,355,4,280,361,20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 176 VMETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLhfkpvqPDGFPIPTedlPSYKALATGEPQRNVIFGI 255
PRK11360    266 IIENAADGIIAIDRQGDITTMNPAAEVITGYQRHELVGQPYSML------FDNTQFYS---PVLDTLEHGTEHVALEISF 336

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 94967990 256 TRPNKTeIWIESNASVLNDPvHGEC--AVISFRDVSDRKALEKQIQR 300
PRK11360    337 PGRDRT-IELSVTTSRLHDT-HGEMigAVVIFSDLTARKRLQRRMAR 381

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

3e-08

55.29

45.55

3,294,202,114,410,316,28,438,345,26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 295 EKQIQRDGTTDPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHE 374
PRK10245    203 KRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGS 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 375 DSVARLAGDDFVALFPYVDANRALTSLDRFKSTLenAQLRLHDGKEITLTGACGLSDWKPGMSA-EDLLDSALKACGEAK 453
PRK10245    283 DVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGL--NTLRLPNAPQVTLRISVGVAPLNPQMSHyREWLKSADLALYKAK 360

                       170
                ....*....|.
gi 94967990 454 AKGRNSVAVAA 464
PRK10245    361 KAGRNRTEVAA 371

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

2e-07

52.42

13.73

3,303,238,25,330,263,60,392,323,6

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 304 TDPLTGLPNRAAFLNYVGKAIAAASryKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATLRHEDSVARLAGD 383
PRK10060    239 TDSITGLPNRNAIQELIDHAIAQAD--NNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQTLARLGGD 316

                        90
                ....*....|....*
gi 94967990 384 DFVALFPyvDANRAL 398
PRK10060    317 EFLVLAS--HTSQAA 329

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

2e-07

52.15

20.40

5,289,363,40,333,403,73,407,476,8,416,484,14,431,498,28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 290 DRKALEKQIQRDGTTDPLTGLPNRAAFLNYVGKAIAAASRykhpMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRA 369
PRK11359    364 EQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVS----PVVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFRE 439

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 370 TLRHEDSVARLAGDDFVALFPYVDANRALTSLDRFKStLENAQLRLhDGKEITLTGACGLSdWKPGMSAEDLLDSALKAC 449
PRK11359    440 KLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRN-VVSKPIMI-DDKPFPLTLSIGIS-YDVGKNRDYLLSTAHNAM 516

                       170
                ....*....|
gi 94967990 450 GEAKAKGRNS 459
PRK11359    517 DYIRKNGGNG 526

-1

110021

pfam00989

PAS

PAS fold

true

false

112

4e-05

44.70

100.00

5,170,0,49,230,49,9,239,62,36,275,101,7,284,108,4

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 171 RFLHTVMETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLhfkpvqpdgfpIPTEDLPSY----KALATGE 246
pfam00989     1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDL-----------IPEDDDAVAellrQALLQGE 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 94967990 247 PQRNVIFGITRPNKTEIWIESNASVLNDP---VHGECAVisFRDV 288
pfam00989    70 ESRGFEVSFRVSDGRPRHVEVRASPVRDAggeILGFLGV--LRDI 112

-1

34605

COG5000

NtrY

Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]

Signal transduction histidine kinase involved in nitrogen fixation and metabolism...

false

true

false

712

6e-05

43.79

17.28

3,154,353,65,230,418,48,280,466,10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 155 QLMELHRQRAMAENHRRFLHTVMETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLhfkpvqpdgfpIPTE 234
COG5000     354 QQEALERAKDALEQRRRFLEAVLSGLTAGVIGFDNRGCITTVNPSAEQILGKPFDQLLGQSLSAI-----------APEL 422

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 94967990 235 DLPSYKALATGEPQRNVIFGITRPNKTEIWIESNASVLNDPVHGecAVISFRDVSD 290
COG5000     423 EEVFAEAGAAARTDKRVEVKLAREGEERTLNVQATREPEDNGNG--YVVTFDDITD 476

-1

33622

COG3829

RocR

Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]

Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [...

false

true

false

560

7e-05

43.74

26.79

8,150,101,14,169,115,45,219,160,9,233,169,19,253,188,7,262,195,16,280,211,20,303,231,20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 151 SQAAQLMELHRQRAmaenhRRFLHTVMETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQtfsmlHFKPVQPDGfp 230
COG3829     102 SEALELIEENLRQL-----RQRLEAILDSIDDGLLVVDEDGIIIYYNKAYAKLLGLSPEEVLGK-----HLLDVVSAG-- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 231 iptEDLPSYKALATGEPQRNVIfGITRPNKteIWIESNASVLNDPVHGecAVISFRDVSDRKALEKQIQRdgtTDPLTGL 310
COG3829     170 ---EDSTLLEVLRTGKPIRDVV-QTYNGNK--IIVNVAPVYADGQLIG--VVGISKDVSELERLTRELEE---SEGLLRL 238

                       170
                ....*....|...
gi 94967990 311 PNRAAFLNYVGKA 323
COG3829     239 KAKYTFDDIIGES 251

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

8e-05

43.85

39.56

4,291,237,29,321,266,47,368,315,6,376,321,77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 292 KALEKQIQRDGTTDPLTGLPNRAAFLNYVgKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILR--A 369
PRK09966    238 QAKNAQLLRTALHDPLTGLANRAAFRSGI-NTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAefG 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 370 TLRHEdsVARLAGDDFVALFPYVDANRALTSLDRFKSTLENAQLRLHDGKEITLTGACGLSDWKPGMSAEDLLDSALKAC 449
PRK09966    317 GLRHK--AYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNM 394


                ....
gi 94967990 450 GEAK 453
PRK09966    395 YQAK 398

-1

117025

pfam08448

PAS_4

PAS fold

false

true

false

110

4e-04

41.63

99.09

6,177,1,50,231,51,6,239,57,14,255,71,20,276,91,4,280,97,13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 178 ETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLHFKPVQPDgfpiPTEDLPsyKALATGEPQRNVIFgiTR 257
pfam08448     2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAAR----LERALR--RALEGEEPIDFLEE--LL 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 94967990 258 PNKTEIWIESNASVLNDPvHGEC--AVISFRDVSDRKA 293
pfam08448    74 LNGEERHYELRLTPLRDP-DGEVigVLVISRDITERRR 110

-1

129332

TIGR00229

sensory_box

PAS domain S-box

false

true

false

124

5e-04

41.11

95.97

4,170,2,49,230,51,13,243,68,9,252,78,43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 171 RFLHTVMETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLhfkpvqpdgfpIPTEDLPSYKALA----TGE 246
TIGR00229     3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLEL-----------IPEEDREEVRERIerllEGE 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 94967990 247 PQRNVI-FGITRPNKTEIWIESNASVLNDPVHGECAVISFRDVSDRKALE 295
TIGR00229    72 REPYSEeRRVRRKDGSEIWVEVSVSPIRTNGGELGVVGIVRDITERKQAE 121

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

6e-04

40.98

17.77

8,163,129,13,177,142,60,241,202,12,254,214,6,261,220,9,270,230,20,294,250,4,299,254,17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 164 AMAENHRRFLHTVmETLAEGVIVRDSQRRLLAHNTMASVLLGTELKDMVGQTFSMLHFKPVQPDGFPIPTEDLPsykaLA 243
PRK11359    130 AQKEQTRQLIIAV-DHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQPDTLLNIPEFPADNRIRLQQLL----WK 204

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94967990 244 TGEPQRNVIFgITRPNKtEIWIESNAS-VLNDPVHGECAVISFRDVSDrkalEKQIqRDGTTDPLTGLPNRAAF 316
PRK11359    205 TARDQDEFLL-LTRTGE-KIWIKASISpVYDVLAHLQNLVMTFSDITE----ERQI-RQLEGNILAAMCSSPPF 271

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

6e-04

40.52

24.12

5,299,228,32,332,260,17,352,277,64,419,341,8,427,351,34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 300 RDGTTDPLTGLPNRAAFLNYVGKAIAAASRYKhPMSVCVASLDDLKAMVAkhgPHAADSALKHFGTILRATLRHEDSVAR 379
PRK13561    229 ENAMRFPVSDLPNKALLMALLEQVVARKQTTA-LMIITCETLRDTAGVLK---EAQREILLLTLVEKLKSVLSPRMVLAQ 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 380 LAGDDFVALFPYVDANRALTSLDRFKSTLENAQLRLHdgkEITLTGAC--GLSDWKPGMSAEDLLDSALKACGEAKAKGR 457
PRK13561    305 ISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQ---RIQLRPSCsiGIAMFYGDLTAEQLYSRAVSAAFTARRKGK 381


                ....
gi 94967990 458 NSVA 461
PRK13561    382 NQIQ 385

-1

138376

PRK11059

regulatory protein CsrD; Provisional

false

true

false

642

0.001

39.87

24.14

5,304,230,67,371,298,6,377,305,13,394,318,33,427,353,32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967990 305 DPLTGLPNRAAFLNYVGKAIAAASRYKHPMSVCVASLDDLKAMVAKHGPHAADSALKHFGTILRATL-RHEDSV-ARLAG 382
PRK11059    231 DAKTGLGNRLFFDNQLDTLLEDQEKVGAHGVVMLIRLPDFDLLQEELGESQVDELLFELINLLSTFVqRYPGALlARYSR 310

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94967990 383 DDFVALFPyvdaNRALTSLDRFKSTLENAQLRLHDGKEITLTGAC--GLSDWKPGMSAEDLLDSALKACGEAKAKGRNS 459
PRK11059    311 SDFAVLLP----HRSLKEADSLASQLLKAVDSLPPPKMLDRDDFLhiGIAAYRSGQSTEQVMEEAEMALRSAQLQGGNS 385

-1

33405

COG3605

PtsP

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]

Signal transduction protein containing GAF and PtsI domains [Signal transduction...

false

true

false

756

0.002

39.13

8.73

2,90,88,12,103,100,54

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 94967990  91 DAAKDPRFEDNPlVTGEPNIRFYAAAPLVSKGLGLGALCIIDRQPRTLKPFQESALRTLASQAAQLM 157
COG3605      89 DAQSHPSFKYLP-ETGEERYHSFLGVPIIRRGRLLGVLVVQQRELRQYDEDEVEFLVTLAMQLAEIV 154

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF
putative active site	0	9	9	true	29035	cd00130	PAS
heme pocket	1	6	7	true	29035	cd00130	PAS