NCBI Conserved Domain Search

NewSearch

CDD Home

Conserved domains on [gi\|94967432\|ref\|YP_589480.1\|]
response regulator receiver protein [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH

of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

29071

cd00156

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

true

false

true

113

9e-10

57.17

100.00

2,4,0,59,63,62,51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   5 LCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAI---VQAAKSHSSVPVVVVSGY 81
cd00156       1 LIVDDDPLIRELLRRLLEKEGYEVVEAEDGEEALALLAEEKPDLILLDIMMPGMDGLELlrrIRKRGPDIPIIFLTAHGD 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 94967432  82 VAEAFQAAEPLADLYLEKPVNPEELVTIVNELL 114
cd00156      81 DEDAVEALKAGADDYLTKPFSPEELLARIRALL 113

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

109140

pfam00072

Response_reg

Response regulator receiver domain

false

111

4e-10

58.36

100.00

2,3,0,89,92,92,19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   4 ILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVVSGYVA 83
pfam00072     1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGEEALELLKEKRPDLILLDIRMPGMDGLELLRRIRRRPPTTPVIVLTAHG 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 94967432  84 EAFQAAEPL---ADLYLEKPVNPEELVTIVN 111
pfam00072    81 DEEDAVEALkagANDFLSKPFDPEELVAALR 111

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

128724

smart00448

REC

cheY-homologous receiver domain

false

7e-08

50.66

96.36

1,2,1,53

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRL 55
smart00448    2 RILVVDDDPLLRELLKALLEREGYEVDEATDGEEALELLKEEKPDLILLDIMM 54

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

31127

COG0784

CheY

FOG: CheY-like receiver [Signal transduction mechanisms]

false

130

2e-05

42.91

92.31

5,0,4,30,30,35,11,41,47,51,92,101,9,101,111,13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   1 MARILCIDDEPHVVTLKCAILEAAGHTVTP-SSSAHDAIEKL-KTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVV 78
COG0784       5 GLRVLVVDDEPVNRRLLKRLLEDLGYEVVEaADGEEEALELLrELPQPDLILLDINMPGMDGIELLRRLRARGPNIPVIL 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 94967432  79 SGYVAEAFQAAEPL---ADLYLEKPV-NPEELVTIVNELL 114
COG0784      85 LTAYADEADRERALaagADDYLTKPIfLEEELLAALRRLL 124

cl09944

142340

REC

Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC,...

-1

32386

COG2204

AtoC

Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]

Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding...

false

true

false

464

1e-11

63.78

26.72

2,0,3,92,92,98,29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   1 MARILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVVSG 80
COG2204       4 MARILVVDDDPDIRELLEQALELAGYEVVTAESAEEALEALSESPFDLVLLDIRMPGMDGLELLKEIKSRDPDLPVIVMT 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 94967432  81 YVAEAFQAAEPL---ADLYLEKPVNPEELVTIVNELLKTSERSA 121
COG2204      84 GHGDIDTAVEALrlgAFDFLEKPFDLDRLLAIVERALELRELQR 127

-1

31088

COG0745

OmpR

Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]

Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-...

false

true

false

229

2e-08

53.03

50.22

3,2,1,41,44,42,16,60,62,54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTnEYDAVVTDWRLGDANG----RAIVQAAKSHSSVPVVVV 78
COG0745       2 RILLVEDDPELAELLKEYLEEEGYEVDVAADGEEALEAARE-QPDLVLLDLMLPDLDGlelcRRLRAKKGSGPPIIVLTA 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 94967432  79 SGYVAEAFQAAEPLADLYLEKPVNPEELVTIVNELL 114
COG0745      81 RDDEEDRVLGLEAGADDYLTKPFSPRELLARLRALL 116

-1

33728

COG3947

Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]

Response regulator containing CheY-like receiver and SARP domains [Signal transduction...

false

true

false

361

7e-06

44.19

33.24

2,2,1,62,64,64,57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIV-QAAKSHSSVPVVVVSGY 81
COG3947       2 RIIIVDDDAAIVKLLSVILSRAGHEVRSCSHPVEALDLLEVFKPDLIFLDIVMPYMNGIEFAeQVRDIESAVPIIFISSH 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 94967432  82 VAEAFQAAEPLADLYLEKPVNPEELVTIVNELLKTSERSA 121
COG3947      82 AEYADDSFGMNLDDYLPKPVTPEKLNRAIDRRLKRVELTA 121

-1

138397

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

false

true

false

779

1e-05

43.06

7.45

1,2,526,58

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANG 60
PRK11091    527 NILLVEDIELNVIVARSLLEKLGNSVDVAMTGKDALEMFKPGEYDLVLLDIQLPDMTG 584

-1

34367

COG4753

Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]

Response regulator containing CheY-like receiver domain and AraC-type DNA-binding...

false

true

false

475

2e-05

42.99

26.32

5,0,0,15,15,16,5,20,22,5,25,28,67,92,98,27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   1 MARILCIDDEPHVVT-LKCAI-LEAAG-HTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVV 77
COG4753       1 MYKVLIVDDEPLIREgLKSLIdWEALGiEVVGTAANGKEALELIQETQPDIVITDINMPGMDGLDLIKAIKEQSPDTEFI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 94967432  78 VSGYVAEAFQAAEPL---ADLYLEKPVNPEELVTIVNELLKTSER 119
COG4753      81 ILSGYDEFEYAKKAMklgVKDYLLKPVDKAELEEALKKIIGKLEE 125

-1

139663

PRK13557

histidine kinase; Provisional

false

true

false

538

2e-05

42.40

9.48

2,2,414,39,41,454,11

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKL-KTNEYDAVVTD 52
PRK13557    415 TILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILeSHPEVDLLFTD 465

-1

130877

TIGR01818

ntrC

nitrogen regulation protein NR(I)

false

true

false

463

4e-05

41.65

23.76

2,3,0,60,63,63,47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   4 ILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAI---VQAAKSHSSVPVVVVSG 80
TIGR01818     1 VWVVDDDRSIRWVLEKALSRAGYEVRTFGNAASVLRALARGQPDLLITDVRMPGEDGLDLlpqIKKRHPQLPVIVMTAHS 80

                        90       100       110
                ....*....|....*....|....*....|
gi 94967432  81 YVAEAFQAAEPLADLYLEKPVNPEELVTIV 110
TIGR01818    81 DLDTAVAAYQRGAFEYLPKPFDLDEAVTLV 110

-1

132001

TIGR02956

TMAO_torS

TMAO reductase sytem sensor TorS

false

true

false

968

6e-05

40.92

13.02

2,1,702,89,90,797,31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   2 ARILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVVSGY 81
TIGR02956   703 QRVLLVEDNEVNQMVAQGFLTRLGHKVTLAESGQSALECFHQHAFDLALLDINLPDGDGVTLLQQLRAIYGAKNEVKFIA 782

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 94967432  82 VAEAFQAAE------PLADLYLEKPVNPEELVTIVNELLKTSERSA 121
TIGR02956   783 FSAHVFNEDvaqylaAGFDGFLAKPVVEEQLTAMIAVILAGGKSNT 828

-1

131209

TIGR02154

PhoB

phosphate regulon transcriptional regulatory protein PhoB

false

true

false

226

1e-04

40.39

52.65

2,1,2,59,60,66,55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   2 ARILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANG-----RAIVQAAKSHSSVPVV 76
TIGR02154     3 RRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGielcrRLRRRPETRAIPIIML 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 94967432  77 VVSGYVAEAFQAAEPLADLYLEKPVNPEELVTIVNELLK 115
TIGR02154    83 TARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLR 121

-1

33243

COG3437

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [...

false

true

false

360

1e-04

39.90

35.00

2,0,13,85,85,104,35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   1 MARILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVVSG 80
COG3437      14 KLTVLLVDDEPDNLEALRQLLRMIGYRVIEAENGEEALKLLQEEPPDLVLLDVRMPEMDGAEVLNKLKAMSPSTRRIPVI 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 94967432  81 YVAEA------FQAAEPLADLYLEKPVNPEELVTIVNELLKTSERS 120
COG3437      94 LLTAYadsedrQRALEAGADDYLSKPISPKELVARVSSHLQLKRNE 139

-1

34205

COG4567

Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]

Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [..

false

true

false

182

8e-04

37.25

57.69

3,3,12,16,20,28,72,92,103,14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   4 ILCIDDEPHVVTLKCAiLEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVVSGYVA 83
COG4567      13 LLVDDDTPFLRTLARA-MERRGFAVVTAESVEEALAAARTAPPAYAVVDLKLGDGSGLAVIEALRERRADMRIVVLTGYA 91

                        90       100
                ....*....|....*....|....*.
gi 94967432  84 EAFQAAEPL---ADLYLEKPVNPEEL 106
COG4567      92 SIATAVEAVklgACDYLAKPADADDI 117

-1

104359

PRK10161

transcriptional regulator PhoB; Provisional

false

true

false

229

8e-04

37.39

51.53

2,2,3,62,64,70,51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIV-----QAAKSHSSVPVVV 77
PRK10161      4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIkhlkrESMTRDIPVVMLT 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 94967432  78 VSGYVAEAFQAAEPLADLYLEKPVNPEELVTIVNELLK 115
PRK10161     84 ARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMR 121

-1

137850

PRK10365

transcriptional regulatory protein ZraR; Provisional

false

true

false

441

0.001

36.54

14.06

1,3,7,62

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94967432   4 ILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQ 65
PRK10365      8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLK 69

-1

32379

COG2197

CitB

Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]

Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain...

false

true

false

211

0.004

35.32

55.92

3,2,1,23,25,26,67,92,96,23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAG--HTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVVSG 80
COG2197       2 KVLIVDDHPLVREGLRQLLELEPdlEVVGEASNGEEALDLARELKPDVVLLDLSMPGMDGLEALKQLRARGPDIKVVVLT 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 94967432  81 YVAEAFQAAEPL---ADLYLEKPVNPEELVTIVNELLK 115
COG2197      82 AHDDPAYVIRALragADGYLLKDASPEELVEAIRAVAA 119

-1

138589

PRK11466

hybrid sensory histidine kinase TorS; Provisional

false

true

false

912

0.004

35.00

7.02

2,2,682,43,45,726,20

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94967432   3 RILCIDDEPHVVTLKCAILEAAGHTVTPSSSAHDAIEKLKTNE-YDAVVTDWRLGDANGRAIVQ 65
PRK11466    683 RLLLIEDNPLTQRITVEMLNTSGAQVVAVGNAAQALETLQNSEpFAAALVDFDLPDYDGITLAR 746

-1

33090

COG3279

LytT

Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]

Response regulator of the LytR/AlgR family [Transcription / Signal transduction...

false

true

false

244

0.009

33.79

48.77

3,0,0,23,23,25,62,85,88,31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967432   1 MARILCIDDEPHVVTLKCAILEA--AGHTVTPSSSAHDAIEKLKTNEYDAVVTDWRLGDANGRAIVQAAKSHSSVPVVVV 78
COG3279       1 MLKVLIVDDEPLAREELRRILNEipDIEIVGEAENGEEALQLLQGLRPDLVFLDIAMPDINGIELAARIRKGDPRPAIVF 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 94967432  79 SGYVAEA-FQAAEPLADLYLEKPVNPEELVTIVNELLKT 116
COG3279      81 VTAHDEYaVAAFEVEALDYLLKPISEERLAKTLERLRRY 119

-1

active site	0	8	8	true	29071	cd00156	REC
phosphorylation site	1	1	1	true	29071	cd00156	REC
intermolecular recognition site	2	5	5	true	29071	cd00156	REC
dimerization interface	3	3	3	true	29071	cd00156	REC