NCBI Conserved Domain Search

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Conserved domains on [gi\|94967390\|ref\|YP_589438.1\|]
unusual protein kinase [Candidatus Koribacter versatilis Ellin345]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

131037

TIGR01982

UbiB

2-polyprenylphenol 6-hydroxylase

true

false

437

3e-17

85.43

83.30

13,129,65,7,136,73,62,203,135,34,246,169,9,255,186,59,315,245,13,330,258,33,364,291,41,405,335,7,414,342,19,434,361,50,489,411,2,491,416,13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 130 KLGQVLA-RNRHLRHSVRTALSKLENGIRDVGMKDMLEVLHRELGERMELFDMKIERRLLSEASVSAVVRfswwnAEERR 208
TIGR01982    66 KFGQTLStRADLLPADIAEELSLLQDRVPPFDFKVARKVIEAALGGPLEELFAEFEEKPLAAASIAQVHR-----ARLVD 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 209 REKGVLKVLKPHIPDCFAEDMKILQELADyfgqrahkgFASGVIPDT--------FSKIRRHLQREVDFPGEQAALLEAA 280
TIGR01982   141 GKEVAVKVLRPGIEKTIAADIALLYRLAR---------IVERLSPDSrrlrptevVKEFEKTLRRELDLRREAANASELG 211

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 281 KQYSAVRRVRVPQLIPHFCTARVTAMSEEEGVKVtSAAPHLDGQGREQlsKQLVEALVAFPLLSRSPYALFHADPHAGNL 360
TIGR01982   212 ENFKNDPGVYVPEVYWDRTSERVLTMEWIDGIPL-SDIAALDEAGLDR--KALAENLARSFLNQVLRDGFFHADLHPGNI 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 361 LYNrRTGELVLLDWALAERLTREQRRRLTLLFGAVAFRNPAAACE---QIQYLSErdKHDHPGDAKTIGRVVERFFeELP 437
TIGR01982   289 FVL-KDGKIIALDFGIVGRLSEEDRRYLAEILYGFLNRDYRRVAEvhfDAGYVPS--DTDMAEFEQAIRAIGEPIF-GQP 364

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 438 VAKLPRAVDAMSLLESAAMVGVRFPSSLIMFSKVLFTLDGILDDIRGgsattEF---TIARYLLKRWVRQ 504
TIGR01982   365 LKEISVGRLLAGLFKITRDFNMELQPQLLLLQKTLLTVEGVGRQLDP-----DLnmwKVAEPFVKRWIRK 429

cl09925

142329

PKc_like

Protein Kinases, catalytic domain

-1

135177

PRK04750

ubiB

putative ubiquinone biosynthesis protein UbiB; Reviewed

false

540

0.001

40.29

41.67

16,129,67,12,141,80,36,177,117,3,181,120,12,194,132,7,203,139,8,212,147,24,249,171,18,267,191,4,271,199,11,283,210,5,288,222,26,315,248,10,325,260,10,337,270,11,350,281,11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 130 KLGQVLARNRHL-RHSVRTALSKLENGIRDVGMKDMLEVLHRELGERME-LFDmKIERRLLSEASVsAVVRFSWwnAEER 207
PRK04750     68 KFGQMLSTRRDLfPPDIADELALLQDRVPPFDGALARAIIEKALGGPVEeWFD-DFDIEPLASASI-AQVHTAR--LKDN 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 208 RREKgVLKVLKPHIPDCFAEDMKILQELAdyfgqrahkgfasGVIPDTFSKIRRHLQREV--DFPG----EQAALLEAAK 281
PRK04750    144 GREV-VVKVLRPDILPVIDADLALMRRLA-------------RWVERLLPDGRRLKPREVvaEFEKtlhdELDLMREAAN 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 282 QySAVRR-------VRVPQLIPHFCTARVTAMSEEEGVKVtSAAPHLDGQG--REQLSKQLVEalVAFPLLSRSPYalFH 352
PRK04750    210 A-SQLRRnfedsdlLYVPEVYWDYCSETVLVMERMYGIPV-SDVAALRAAGtdMKLLAERGVE--VFFTQVFRDGF--FH 283


                ....*....
gi 94967390 353 ADPHAGNLL 361
PRK04750    284 ADMHPGNIF 292

cl09925

142329

PKc_like

Protein Kinases, catalytic domain

-1

111949

pfam03109

ABC1

ABC1 family

false

117

0.002

39.50

82.05

4,190,21,8,203,29,49,253,78,6,262,84,33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 191 ASVSAVVRfswwnAEERRREKGVLKVLKPHIPDCFAEDMKILQELADYFGQRAHKGFASGVIpDTFSKIrrhLQREVDFP 270
pfam03109    22 ASIAQVHR-----AVLKDGEEVAVKVQRPGVKKRIRSDLKLLKFLAKILKKFFPGFDLDWLV-DEFRKS---LPQELDFL 92

                        90       100
                ....*....|....*....|....*
gi 94967390 271 GEQAALLEAAKQYSAVRRVRVPQLI 295
pfam03109    93 REAANAEKFRENFADLPWVYVPKVY 117

cl09925

142329

PKc_like

Protein Kinases, catalytic domain

-1

88612

cd05120

APH_ChoK_like

Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K). The family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine.

Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/...

false

155

0.003

38.50

69.03

6,257,26,25,287,51,11,298,64,18,320,82,19,341,101,22,364,123,10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 258 KIRRHLQREVDFPGEQAALLEAAKQysavrRVRVPQLIPHF--CTARVTAMSEEEGVKVTSaaphLDGQGREQLSKQLVE 335
cd05120      27 KINPSREKGADREREVAILQLLARK-----GLPVPKVLASGesDGWSYLLMEWIEGETLDE----VSEEEKEDIAEQLAE 97

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 94967390 336 ALVAfpLLSRSPYALFHADPHAGNLLYNrRTGELVLLDW 374
cd05120      98 LLAK--LHQLPLLVLCHGDLHPGNILVD-DGKILGIIDW 133

cl09925

142329

PKc_like

Protein Kinases, catalytic domain

-1

31005

COG0661

AarF

Predicted unusual protein kinase [General function prediction only]

false

true

false

517

1e-22

103.10

70.41

10,106,49,19,125,69,11,136,81,40,176,122,4,181,126,17,203,143,36,240,179,78,319,257,9,330,266,35,366,301,112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 107 ELPLKTTPEVRLLKLIARV-PGLQKLGQVLA-RNRHLRHSVRTALSKLENGIRDVGMKDMLEVLHRELGERM-ELFDmKI 183
COG0661      50 SEELREKRAERLRLALEELgPTFIKLGQILStRPDLVPPEYAEELAKLQDRVPPFPFEEAERIIEEELGRPIeELFS-EF 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 184 ERRLLSEASVSAVVRfswwnAEERRREKGVLKVLKPHIPDCFAEDMKILQELADYFgQRAHKGFASGVIPDTFSKIRRHL 263
COG0661     129 EPEPIASASIAQVHR-----AVLKSGEEVAVKVQRPGIRERIEADLKLLRRLARLI-KRLPPGGRRLDLVEVVDEFEKRL 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 264 QREVDFPGEQAALLEAAKQYSAVRRVRVPQLIPHFCTARVTAMSEEEGVKVTSAApHLDGQGREQlsKQLVEALVAFPLL 343
COG0661     203 REELDYRREAANAERFRENFKDDPDVYVPKVYWEYTTRRVLTMEWIDGIKISDIA-ALKSAGIDR--KELAELLVRAFLR 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967390 344 SRSPYALFHADPHAGNLLYNRRtGELVLLDWALAERLTREQRRRLTLLFGAVAFRNPAAACEQIQYLSERDKHDHPGDAK 423
COG0661     280 QLLRDGFFHADPHPGNILVRSD-GRIVLLDFGIVGRLDPKFRRYLAELLLAFLNRDYDRVAELHVELGYVPPDTDRDPLA 358

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 94967390 424 TIGRVVERFFEELPVAKLPRAVDAMSLLESAAMVGVRFPSSLIMFSKVLFTLDGI 478
COG0661     359 AAIRAVLEPIYGKPLEEISFGEILDKLFEVARRFPMRLPPELVLLQRTLLLVEGV 413

-1