NCBI Conserved Domain Search

NewSearch

CDD Home

Conserved domains on [gi\|94967378\|ref\|YP_589426.1\|]
diguanylate phosphodiesterase [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH

of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

30163

cd01948

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

true

false

true

240

2e-13

71.78

91.25

13,7,16,7,14,24,11,25,50,16,41,67,10,53,77,14,67,92,11,78,112,19,97,133,27,124,161,5,129,167,7,136,177,5,141,190,15,158,205,30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378   8 QAILDTR-QQTFGYELLYR---------------AAAENFARIGDPDEAA-RRTLDDLLTLgvKELSRGKQLFLNCT-HE 69
cd01948      17 QPIVDLRtGRIVGYEALLRwrhpegglispaefiPLAEETGLIVELGRWVlEEACRQLARW--QAGGPDLRLSVNLSaRQ 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  70 LLAQGFVKL---------LPTQNLVLEILETVVPDHD--LLQSCAELKAAGYSLALDDFIPGPNTL-PLVEF-ADYIKLD 136
cd01948      95 LRDPDFLDRllellaetgLPPRRLVLEITESALIDDLeeALATLRRLRALGVRIALDDFGTGYSSLsYLKRLpVDYLKID 174

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94967378 137 ---FRAMP--------LEECGALVQQFGKKIefLAEKVETLEEFTAASDMGCSLFQGFFFAQP 188
cd01948     175 rsfVRDIEtdpedraiVRAIIALAHSLGLKV--VAEGVETEEQLELLRELGCDYVQGYLFSRP 235

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

109613

pfam00563

EAL

EAL domain

false

236

2e-19

91.71

94.49

12,3,13,12,15,26,10,25,51,16,41,68,13,54,82,19,73,102,6,79,116,17,96,134,29,125,164,4,129,169,7,136,179,16,152,200,36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378   4 YIARQAILDTRQ-QTFGYELLYR---------------AAAENFARIGDPDEAA-RRTLDDLLTLGVK-ELSRGKQLFLN 65
pfam00563    14 SLYFQPIVDLRTgKVLGYEALLRwqhpdgglippdeflPLAERLGLIAELDRWVlEKALAQLAEWRGNaLLPPDLPLSVN 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  66 CTHELLAQ-GFVKLL--------PTQNLVLEILETVVPDH-DLLQSCAELKAAGYSLALDDFIPGPNTLP-LVEF-ADYI 133
pfam00563    94 LSPASLLDpSFLEALlalkqgglPPSRLVLEITESDLDEDlRLLEALARLRSLGFRLALDDFGTGYSSLSyLSRLpPDYI 173

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94967378 134 KLD---FRAMPLEECGALVQQF-----GKKIEFLAEKVETLEEFTAASDMGCSLFQGFFFAQP 188
pfam00563   174 KIDrsfIKDLSDPESRALLRALialarELGIKVVAEGVETEEQLELLKELGIDYVQGYLFSKP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

32382

COG2200

Rtn

c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]

false

256

2e-12

68.81

85.16

12,7,21,7,14,29,11,25,55,16,41,72,17,61,89,4,65,94,14,79,117,17,96,136,28,124,165,6,130,172,8,138,188,14,152,203,36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378   8 QAILDTR-QQTFGYELLYR---------------AAAENFARIGDPDEAA-RRTLDDLLTLGVKELSRgkqLFLN-CTHE 69
COG2200      22 QPIVDLAtGRIVGYEALLRwrhpdgglispgefiPLAEETGLIVELGRWVlEEACRQLRTWPRAGPLR---LAVNlSPVQ 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  70 LLAQGFVKLL---------PTQNLVLEILETVVPDH--DLLQSCAELKAAGYSLALDDFIPGPNTL-PLVEFA-DYIKLD 136
COG2200      99 LRSPGLVDLLlrllarlglPPHRLVLEITESALIDDldTALALLRQLRELGVRIALDDFGTGYSSLsYLKRLPpDILKID 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 94967378 137 FR--------AMPLEECGALVQQF-GKKIEFLAEKVETLEEFTAASDMGCSLFQGFFFAQP 188
COG2200     179 RSfvrdletdARDQAIVRAIVALAhKLGLTVVAEGVETEEQLDLLRELGCDYLQGYLFSRP 239

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

128367

smart00052

EAL

Putative diguanylate phosphodiesterase

false

241

2e-11

65.70

51.04

6,78,113,24,102,139,18,120,158,9,129,168,8,137,180,15,152,200,36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  79 LPTQNLVLEILETVVPDHDLLQSC--AELKAAGYSLALDDFIPG-PNTLPLVEF-ADYIKLDF----RAMPLEECGALVQ 150
smart00052  114 LPPQRLELEITESVLLDDDESAVAtlQRLRELGVRIALDDFGTGySSLSYLKRLpVDLLKIDKsfvrDLQTDPEDEAIVQ 193

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 94967378 151 QF-----GKKIEFLAEKVETLEEFTAASDMGCSLFQGFFFAQP 188
smart00052  194 SIielaqKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRP 236

cl00290

140582

EAL

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called...

-1

117241

pfam08668

HDOD

HDOD domain

true

false

196

7e-11

63.41

64.80

3,195,0,92,287,98,16,303,115,12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378 196 IPPMYVNYIRLLDATCKPDFNFAEIEAIIKTDVALSYKLLRFLNSAAFCIRSTITSLRQALIILGENAIRRWVAVSAAAN 275
pfam08668     1 LPTLPDVVLRILALLEDPDVSISDIAELISRDPALTARLLRLANSAYYGFRRKISSIEQAVARLGLRTVRNLVLSLSVKR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 94967378 276 AATGKPPELLIS------ALLRARFCELLAVGAH-SNPYWAFTVGLF 315
pfam08668    81 IFRGTPSLGFDLkgfwrhSLACALAARLLARRLGlDDPEEAFTAGLL 127

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

-1

31826

COG1639

Predicted signal transduction protein [Signal transduction mechanisms]

false

289

2e-06

48.80

24.91

1,193,20,72

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94967378 194 RQIPPMYVNYIRLLDATCKPDFNFAEIEAIIKTDVALSYKLLRFLNSAAFCIRSTITSLRQALIILGENAIR 265
COG1639      21 EELPPLPDVVLKLQKACSDPNVSLSDIAELISQDPALTARLLRLANSPYFGFPREITTLNEAIVRLGIGLVI 92

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

-1

33240

COG3434

Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]

Predicted signal transduction protein containing EAL and modified HD-GYP domains [...

true

false

407

4e-79

290.25

99.75

7,0,0,30,30,31,15,45,47,76,121,125,32,153,158,146,299,305,82,381,388,18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378   1 MLRYIARQAILDTRQQTFGYELLYRAAAEN-FARIGDPDEAARRTL-DDLLTLGVKELSRGKQLFLNCTHELLAQGFVKL 78
COG3434       1 MMSFVARQPILDRNKEVFGYELLFREGEKNkYPEDVDNSRATYRIIiEEFVIQGIDKLANGKKCFINFPEELLISDLPEL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  79 LPTQNLVLEILETVVPDHDLLQSCAELKAAGYSLALDDFIPGP--NTLPLVEFADYIKLDFRAMPLEECGALVQQFG-KK 155
COG3434      81 LPPDKVVIEILEDCPPTEKLLSAIKELKQKGYLLALDDFIFSNvsEWKPLLPLSDIVKIDFKRVTFDKARLFDRDLGyIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378 156 IEFLAEKVETLEEFTAASDMGCSLFQGFFFAQPALLTMRQIPPMYVNYIRLLDATCKPDFNFAEIEAIIKTDVALSYKLL 235
COG3434     161 KKFLAEKVETEEEFEQAKKAGFDLFQGYFFSKPEIIKRGRLSPFLKTTIELLYEVIKPEVDVKRIENIIERDVGLSYKLL 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378 236 RFLNSAAFCIRSTITSLRQALIILGENAIRRWVAVSAAANAATGKPPELLISALLRARFCELLA-VGAHSNPYWAFTVGL 314
COG3434     241 KFVNSSYPRKSKKIQSIQQAVVYLGQENIRKFVSLLAMSELSDKKPEELYKLSLTRAKFCELLAkRYSPEYSEEAFLIGM 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378 315 FSMLSPLLDTPLETILASVQLPDEVRAALLGESGQLRTLFELVCGYIEGDWIAITPKCLALGLAQKQ-VTSCYLEAVRSV 393
COG3434     321 FSLLDELLDEDIESLVRELPISEEVVQALEKRYGELGQLLSLVELLENADWEEVLRLGNKLINTDEEkMRELYIEAKEWS 400


                ....*.
gi 94967378 394 DALMAL 399
COG3434     401 ENLTRL 406

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

2e-07

51.76

16.27

7,78,658,19,97,679,25,122,710,6,128,722,17,148,739,8,156,749,32,190,781,7

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  79 LPTQNLVLEILETVVPDHD--LLQSCAELKAAGYSLALDDFIPGPN------TLPLVE------FADYIKLDFRAMPLEE 144
PRK11359    659 IDGHQLTVEITESMMMEHDteIFKRIQILRDMGVGLSVDDFGTGFSglsrlvSLPVTEikidksFVDRCLTEKRILALLE 738

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 94967378 145 CgalVQQFGKKI--EFLAEKVETLEEFTAASDMGCSLFQGFFFAQPalLTMRQIP 197
PRK11359    739 A---ITSIGQSLnlTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRP--LPAEEIP 788

-1

137979

PRK10551

hypothetical protein; Provisional

false

true

false

518

6e-04

40.42

25.10

8,67,370,6,78,376,4,82,382,8,90,391,38,128,430,2,130,433,6,145,439,9,154,466,34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  68 HELLAQgfvklLPTQ--NLVLEILE-TVVPDHDLLQSCAELKAAGYSLALDDFIPGPNTLPLVE-FA-DYIKLDframpl 142
PRK10551    371 QRLLAS-----LPADhfQIVLEITErDMLQEEEALKLFAWLHSQGIEIAIDDFGTGHSALIYLErFTlDYLKID------ 439

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94967378 143 eecGALVQQFGK------------------KIEFLAEKVETLEEFTAASDMGCSLFQGFFFAQP 188
PRK10551    440 ---RGFINAIGTetvtspvldavltlakrlNMLTVAEGVETPEQARWLREHGVNFLQGYWISRP 500

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

0.001

39.69

16.67

11,23,915,15,41,930,11,52,946,4,56,959,17,76,976,25,101,1003,24,125,1028,4,129,1033,7,136,1046,6,142,1053,13,155,1068,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378   24 YRAAAENFARIGDPDeaaRRTLDDLLTLG-----VKEL---------SRGKQLFLNCTHELLAQgfvKLLPTQNLVLEIL 89
PRK09776     916 FRPAAEDPALMHALD---RWVIHELFQQGaravaSKGLsiaiplsvaSLSSATLLPFLLEQLEN---SPLPPRLLHLEIT 989

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378   90 ETVVPDHDLLQS--CAELKAAGYSLALDDFIPGPNTLP-LVEF-ADYIKLD------FRAMPL-EECGALVQQFGKK--I 156
PRK09776     990 ETALLNHAEAASrlVQKLRLAGCRVVLDDFGRGLSSFNyLKAFmADYLKIDgelcanLQGNLMdEMLVSIINGIAQRlgM 1069

                        170       180       190
                 ....*....|....*....|....*....|..
gi 94967378  157 EFLAEKVETLEEFTAASDMGCSLFQGFFFAQP 188
PRK09776    1070 KTIAGPVELPLTLDTLSGIGVDLAQGYVIGRP 1101

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

0.002

38.85

18.70

7,78,513,13,91,527,6,97,534,33,130,569,6,136,577,11,147,593,7,154,602,35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  79 LPTQNLVLEILET-VVPDHD-LLQSCAELKAAGYSLALDDFIPGPNTLPLVEFA--DYIKLD--FRAMPLEECGA----- 147
COG5001     514 IAPHRLDFEITETaIVCDFDqARDALAALHELGVRTALDDFGTGYSSLSHLRALplDKIKIDrsFVSDLEENPTSedivr 593

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 94967378 148 LVQQFGK--KIEFLAEKVETLEEFTAASDMGCSLFQGFFFAQPA 189
COG5001     594 TVLQLGRnlRMECVVEGVETEAQRDRVAALGATVMQGYHYARPM 637

-1

139666

PRK13561

putative phosphodiesterase; Provisional

false

true

false

651

0.008

36.67

18.28

7,83,519,12,95,533,25,120,567,6,130,573,6,136,582,9,145,593,9,154,603,35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967378  84 LVLEILETVVPD--HDLLQSCAELKAAGYSLALDDFIPG---------PNTLPLvefaDYIKLD---FRAMPLEEC--GA 147
PRK13561    520 LILEVTESRRIDdpHAAVAILRPLRNAGVRIALDDFGMGyaglrqlqhMKSLPI----DVLKIDkmfVDGLPEDSSmvAA 595

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 94967378 148 LVQQFGK-KIEFLAEKVETLEEFTAASDMGCSLFQGFFFAQPA 189
PRK13561    596 IIMLAQSlNLQMIAEGVETEAQRDWLAKAGVGVAQGFLFARPL 638

-1