NCBI Conserved Domain Search

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Conserved domains on [gi\|94967216\|ref\|YP_589264.1\|]
diguanylate cyclase with GAF sensor [Candidatus Koribacter versatilis Ellin345]

Graphical summary show options »	Show site features Horizontal zoom: ×	?



List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

133472

cd01949

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain has been suggested to be homologous to the adenylyl cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesiveness in bacteria.

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

true

false

true

157

3e-48

189.34

100.00

2,723,0,114,837,116,41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  724 TDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARFGGD 803
cd01949        1 TDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDLDHFKQINDTYGHAAGDEVLKEVARRLRSSLRESDLVARLGGD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 94967216  804 EFVILMPETGVDQAQILAERLRLWIATDPMLSEH--QITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAGGNKVA 878
cd01949       81 EFAILLPGTDLEEAEELAERLRKAIEEPFFIDGEeiRVTASIGIAEYPEDGEDLEELLRRADKALYQAKRSGRNRVV 157

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

28958

cd00077

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

true

false

true

145

9e-15

78.20

95.86

3,956,5,44,1007,49,26,1033,82,62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  957 HGEQVARTAEIIARELGIGGQDIQDLIFAARIHDVGKIVVPEKIlnkpamlTEDEHYLVAMHANVGAEIIDAIPDAQ--- 1033
cd00077        6 HSLRVAQLARRLAEELGLSEEDIELLRLAALLHDIGKPGTPDAI-------TEEESELEKDHAIVGAEILRELLLEEvik 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94967216 1034 ----HIRQMVRHHHEAFDGSGYPDGLKGEQIPLYARIISVAEAYVSMMVDRSYRAARSQADAVREL 1095
cd00077       79 lideLILAVDASHHERLDGLGYPDGLKGEEITLEARIVKLADRLDALRRDSREKRRRIAEEDLEEL 144

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

129356

TIGR00254

GGDEF

diguanylate cyclase (GGDEF) domain

false

165

2e-43

173.68

100.00

2,720,0,118,838,122,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  721 QSITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARF 800
TIGR00254      1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  801 GGDEFVILMPETGVDQAQILAERLRLWIATDPMLSEHQ----ITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAGGNK 876
TIGR00254     81 GGEEFVVILPGTPLEDALSKAERLRDAINSKPIEVAGSetltVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGRNR 160


                 ....*
gi 94967216  877 VATAD 881
TIGR00254    161 VVVAD 165

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

110022

pfam00990

GGDEF

GGDEF domain

false

160

2e-42

170.12

100.00

2,721,0,116,837,121,39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  722 SITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARFG 801
pfam00990      1 AAHDPLTGLPNRRYFEEELEQELQRAQRRQSPLALLLLDLDNFKRINDTYGHAVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  802 GDEFVILMPETGVDQAQILAERLRLWIATDPMLSEH-----QITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAGGNK 876
pfam00990     81 GDEFAILLPDTSLEGAQELAERIRRLLAALKIPHTLsglplYVTISIGIAAYPNDGEDAEDLLKRADQALYQAKNQGRNR 160

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128563

smart00267

GGDEF

diguanylate cyclase

false

163

2e-42

169.74

98.77

2,719,0,119,838,121,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  720 QQSITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVAR 799
smart00267     1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  800 FGGDEFVILMPETGVDQAQILAERLRLWIATDPMLSEHQ--ITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAGGNKV 877
smart00267    81 LGGDEFALLLPETSLEEAIALAERILQQLREPIIIHGIPlyLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQV 160


                 .
gi 94967216  878 A 878
smart00267   161 A 161

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

32381

COG2199

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]

c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction...

false

181

6e-38

154.89

91.71

3,715,13,123,838,138,15,853,154,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  716 QKMQQQSITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSN 795
COG2199       14 ERLERLALHDPLTGLPNRRAFEERLERALARARRHGEPLALLLLDLDHFKQINDTYGHAAGDEVLREVARRLRSNLREGD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  796 VVARFGGDEFVILMPETGVDQAQILAERLRLWIATDPMLSEHQ--ITGSFGVATYPIHGS-SVEDIMRVADAGMYVSKHA 872
COG2199       94 LVARLGGDEFAVLLPGTSLEEAARLAERIRAALEEPFFLGGEElrVTVSIGVALYPEDGSdDAELLLRRADLALYRAKRA 173


                 ....*.
gi 94967216  873 GGNKVA 878
COG2199      174 GRNRVV 179

cl00291

140583

GGDEF

Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue...

-1

128747

smart00471

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif.

false

124

2e-10

63.46

92.74

6,956,7,19,977,26,32,1017,58,9,1026,69,5,1031,76,13,1050,89,33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  957 HGEQVARTAEIIARELGIGgqDIQDLIFAARIHDVGKIVVPEKILNKPAMLTEdehylvamHANVGAEII--DAIPD--A 1032
smart00471     8 HSLRVAQLAAALAEELGLL--DIELLLLAALLHDIGKPGTPDSFLVKTSVLED--------HHFIGAEILleEEEPRilE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 94967216 1033 QHIRQMVRHHHEafdgsgYPDGLKGEQIPLYARIISVAEAYVSMMVDRSYR 1083
smart00471    78 EILATAILSHHE------RPDGLRGEPITLEARIVKVADRLDALRRDRRYR 122

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

-1

128379

smart00065

GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.

true

false

149

2e-08

57.39

100.00

3,411,0,27,438,28,25,463,55,94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  412 DPDEVLAAVHRELGRLFDTSNFYVAFL-EGLELRYEFETVGAIRQPRRSRRSK--NGLSDFVIRTGQPILIRSDMKRVSQ 488
smart00065     1 DLEELLQTILEELRQLLGADRVLIYLVdEDDRGELVLVAADGLTLPLLGLRYPlgEGLAGRVAETGRPLNIPDVEADPVF 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94967216  489 RLGIEPSSHPAKCFIGVPIRIGAVSVGVVAALNFDREFVYEQRDVEVLATAAGQVAVAIENARMFAHEQ 557
smart00065    81 ALDLLGRYQGVRSFLAVPLVADGELVGVLALHNKDSPRPFTEEDEELLQALANQLAIALANAQLYEELR 149

cl00853

140972

GAF

GAF domain

-1

110919

pfam01966

HD domain

false

108

7e-08

55.32

97.22

6,956,3,18,977,21,20,999,41,13,1017,54,19,1036,74,15,1057,89,19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  957 HGEQVARTAEIIARELGIggqDIQDLIFAARIHDVGKIVVPekILNKPAMLTEDEHylvamHANVGAEIIDAIPDAQHIR 1036
pfam01966      4 HSLRVALLARELAEELGL---DPELLLLAALLHDIGKDPFG--FLEKLEDFGIFKS-----HSVVGAEILRELEKRLGVD 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 94967216 1037 -QMVRHHHEAFDGSGYpdglkgEQIPLYARIISVAEAYVSM 1076
pfam01966     74 lELILEHHESWEGAGY------EPISLEARIVKLADRLDAL 108

cl00076

140417

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif

-1

32385

COG2203

FhlA

FOG: GAF domain [Signal transduction mechanisms]

false

175

1e-06

51.17

98.29

4,397,3,42,439,51,12,451,65,40,491,106,69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  398 ELLTQIGQVISSRLDPDEVLAAVHRELGRLFDTSNFYVAFLE------GLELRYEFETVG--AIRQPRRSRRSKNGLSDF 469
COG2203        4 ALLNELAAKIAQDLDLEEILQAALELLAELLGADRGLIYLLDedglldGALVAEAAEAGLeqLIDELFGLVILPACLIGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  470 VIRTGQPILIRSDMKRVSQRLG-IEPSSHPAKCFIGVPIRIGAVSVGVVAALNFDREFVYEQRDVEVLATAAGQVAVAIE 548
COG2203       84 ALREGRPVVVEDILQDPRFRDNpLVLLEPPIRSYLGVPLIAQGELLGLLCVHDSEPRRQWSEEELELLEELAEQVAIAIE 163

                        170
                 ....*....|..
gi 94967216  549 NARMFAHEQRRA 560
COG2203      164 RARLYEELQEAE 175

cl00853

140972

GAF

GAF domain

-1

110584

pfam01590

GAF

GAF domain

false

153

2e-05

46.85

100.00

6,411,0,27,438,29,5,444,34,18,462,54,18,480,87,41,522,128,25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  412 DPDEVLAAVHRELGRLFDTSNFYVAFL--EGLELrYEFETVGAIRQPRRSRRS--KNGLSDFVIRTGQPILIR------- 480
pfam01590      1 DLEELLQTILEELRELLGADRCAILLAdaDGLLL-YLVAGDGLSDIPLAARGLplGGGVVGEVIAGGNPIVVPdvqddpr 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94967216  481 --------SDMKRVSQRLGIEPSSHPAKCFIGVPIRIGAVSVGVVAALNfDREFVYEQRDVEVLATAAGQVAVAI 547
pfam01590     80 frdltalaEELPAPVGCHEHYLRGLGIRSCLAVPLLGGGKLIGVLVLHS-TSPRAFTEEELELLQALADQVAIAL 153

cl00853

140972

GAF

GAF domain

-1

32139

COG1956

GAF domain-containing protein [Signal transduction mechanisms]

true

false

163

0.001

41.03

33.13

3,640,90,12,652,104,4,657,108,36

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 94967216  641 TGDTSLVQDTAA--THLAgILPDSRSALCIPITYAEQLLGVLNIESRRENAFTEE 693
COG1956       91 TGETVRVDDVHAfpGHIA-CDAASNSEIVVPIFKDGKLIGVLDIDSPTPGRFDEE 144

cl00853

140972

GAF

GAF domain

-1

32388

COG2206

c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]

false

true

false

344

2e-42

169.93

54.07

3,931,125,15,946,141,88,1034,230,81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  932 KREVMMDAILALNRA-SESRELFASGHGEQVARTAEIIARELGIGGQDIQDLIFAARIHDVGKIVVPEKILNKPAMLTED 1010
COG2206      126 AREIVKKALVALARGdIKAKDDYTYGHSVRVAELAEAIAKKLGLSEEKIEELALAGLLHDIGKIGIPDSILNKPGKLTEE 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216 1011 EHYLVAMHANVGAEIIDAIPDAQH-IRQMVRHHHEAFDGSGYPDGLKGEQIPLYARIISVAEAYVSMMVDRSYRAARSQA 1089
COG2206      206 EFEIIKKHPIYGYDILKDLPEFLEsVRAVALRHHERWDGTGYPRGLKGEEIPLEARIIAVADVYDALTSDRPYKKAKSPE 285

                        170       180
                 ....*....|....*....|....*.
gi 94967216 1090 DAVRELESRSGSQFDGMLVRILIRQF 1115
COG2206      286 EALEELRKNSGGKFDPKVVDAFLKAL 311

-1

137400

PRK09581

pleD

response regulator PleD; Reviewed

false

true

false

457

1e-39

160.85

36.32

2,720,290,118,838,413,43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  721 QSITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARF 800
PRK09581     291 MAVTDGLTGLHNRRYFDMHLKQLIERANERGKPLSLMMLDIDHFKQVNDTYGHDAGDEVLREFAKRLRKNIRGTDLIARY 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  801 GGDEFVILMPETGVDQAQILAERLRLWIATDPMLSEHQ-----ITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAGGN 875
PRK09581     371 GGEEFVVVMPDTDIEVAIAVAERIRRKIAEEPFAISDGkerlnVTVSIGVAELRPSGESIEALIKRADKALYEAKNTGRN 450


                 ....*.
gi 94967216  876 KVATAD 881
PRK09581     451 RVVALA 456

-1

33243

COG3437

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and an HD-GYP domain [...

false

true

false

360

4e-37

152.37

48.06

2,941,173,88,1029,262,84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  942 ALNRASESRELFASGHGEQVARTAEIIARELGIGGQDIQDLIFAARIHDVGKIVVPEKILNKPAMLTEDEHYLVAMHANV 1021
COG3437      174 ELAALLEVRDYETGDHLERVAQYSELLAELLGLSEEEVDLIKKAAPLHDIGKVAIPDSILLKPGKLTSEEFEIMKGHPIL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216 1022 GAEIIDAI-PDAQHIRQMVRHHHEAFDGSGYPDGLKGEQIPLYARIISVAEAYVSMMVDRSYRAARSQADAVRELESRSG 1100
COG3437      254 GAEILKSSeRLMQVAAEIARHHHERWDGSGYPDGLKGDEIPLSARIVAIADVFDALVSGRPYKEAMSTEEALEIIRAQSG 333

                        170
                 ....*....|...
gi 94967216 1101 SQFDGMLVRILIR 1113
COG3437      334 RLFDPKLVEAFIQ 346

-1

33501

COG3706

PleD

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]

Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal...

false

true

false

435

4e-35

145.83

38.39

2,715,263,123,838,391,39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  716 QKMQQQSITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSN 795
COG3706      264 ERLQELALVDGLTGLFNRRYFDEHLADLWKRALREGRPLSLLMLDIDDFKEINDTYGHDVGDEVLRQVARRLRQTVRGLD 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  796 VVARFGGDEFVILMPETGVDQAQILAERLRLWIATDPMLSEHQ-----ITGSFGVATYPIHGSSVEDIMRVADAGMYVSK 870
COG3706      344 LVARYGGEEFAVVLPDTDLEAAIAIAERIRQKINELPFVHELSrepleVTISIGVAEGKPGEDSIEELLKRADKALYKAK 423


                 ....*..
gi 94967216  871 HAGGNKV 877
COG3706      424 ASGRNRV 430

-1

137576

PRK09894

hypothetical protein; Provisional

false

true

false

293

9e-31

131.37

53.92

4,724,132,19,745,151,90,835,244,10,846,254,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  725 DALTGSKTRRYFLEALQSEwkRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARFGGDE 804
PRK09894     133 DVLTGLPGRRVLDESFDHQ--LRNREPLNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRPYETVYRYGGEE 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  805 FVILMPETGVDQAQILAERLRLWIATDPMLS---EHQITGSFGVaTYPIHGSSVEDIMRVADAGMYVSKHAGGNKVATAD 881
PRK09894     211 FIIILKAATDEEACRAGERIRQLIANQAITHsegRINITATFGV-TRAFPEEPLDEVIGRADRAMYEGKQAGRNRVMFID 289


                 .
gi 94967216  882 E 882
PRK09894     290 E 290

-1

137515

PRK09776

putative sensor protein; Provisional

false

true

false

1116

3e-23

106.33

15.86

4,713,669,3,716,678,5,721,687,115,836,805,41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  714 VFQ------KMQQQ----SITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARI 783
PRK09776     670 VFQdvtesrAMLRQlsysASHDALTGLANRASFEKQLREALQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLREL 749

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  784 ARLLEQKCRQSNVVARFGGDEFVILMPETGVDQAQILAERLRLWIATDPMLSE---HQITGSFGVATYPIHGSSVEDIMR 860
PRK09776     750 ASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAINDYRFPWEgrvYRVGASAGITAIDDNNHQASEVMS 829

                        170
                 ....*....|....*..
gi 94967216  861 VADAGMYVSKHAGGNKV 877
PRK09776     830 QADIACYAAKNAGRGRV 846

-1

137662

PRK10060

RNase II stability modulator; Provisional

false

true

false

663

1e-19

94.03

22.62

4,723,238,21,746,259,70,816,333,15,833,348,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  724 TDALTGSKTRRYFLEALQSEWkrASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARFGGD 803
PRK10060     239 TDSITGLPNRNAIQELIDHAI--AQADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAILSCLEEDQTLARLGGD 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94967216  804 EFVILMPETGVDQ----AQILAERLRLWIATDpmLSEHQITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAG 873
PRK10060     317 EFLVLASHTSQAAleamASRILTRLRLPFRIG--LIEVYTGCSIGIALSPEHGDDSESLIRSADTAMYTAKEGG 388

-1

34606

COG5001

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]

Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF...

false

true

false

663

3e-19

93.17

22.93

4,724,230,91,815,326,10,828,336,9,837,346,36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  725 DALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARFGGDE 804
COG5001      231 DSLTGLPNRRRFFAELDARLAAARQSGRRLVLGVIDLDGFKPVNDAFGHATGDRLLIEVGRRLKAFDGAPILAARLGGDE 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94967216  805 FVILMPETGVD-----QAQILAERLRlwiATDPMLSEH-QITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAG 873
COG5001      311 FALIIPALEDDalrvaGARALCESLQ---APYDLRGVRvQVGASIGIAPFPSGADTSEQLFERADYALYHAKQNG 382

-1

137770

PRK10245

adrA

diguanylate cyclase AdrA; Provisional

false

true

false

371

1e-18

91.11

45.01

2,715,203,109,824,314,56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  716 QKMQQQSITDALTGSKTRRYFLEALQSEWKRASRSTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSN 795
PRK10245     204 RRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSD 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  796 VVARFGGDEFVILMPETGVDQAQILAERL--RLWIATDPMLSEHQITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAG 873
PRK10245     284 VIGRFGGDEFAVIMSGTPAESAITAMLRVheGLNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAG 363


                 ....*..
gi 94967216  874 GNKVATA 880
PRK10245     364 RNRTEVA 370

-1

138538

PRK11359

cAMP phosphodiesterase; Provisional

false

true

false

799

1e-12

71.02

24.91

10,715,369,26,744,395,9,754,404,72,827,476,11,838,490,7,846,497,4,851,501,28,882,529,14,896,549,11,908,560,8

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  716 QKMQQQSITDALTGSKTRRYFLEALQsewKRASRSTRPfSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSN 795
PRK11359     370 QHIEQLIQFDPMTGLPNRNNLHNYLD---DLVDKAVSP-VVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKLKPDQ 445

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  796 VVARFGGDEFVILMPETGVDQAQILAERLRLwIATDPMLSEHQ---ITGSFGVaTYPIhGSSVEDIMRVADAGMYVSKHA 872
PRK11359     446 YLCRIEGTQFVLVSLENDVSNITQIADELRN-VVSKPIMIDDKpfpLTLSIGI-SYDV-GKNRDYLLSTAHNAMDYIRKN 522

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 94967216  873 GGNKVATadeFIDGQNTSVQRQLI------SAYVEGFLQREhYGPEYTSE 916
PRK11359     523 GGNGWQF---FSPAMNEMVKERLVlgaalkEAISNNQLKLV-YQPQIFAE 568

-1

137615

PRK09966

hypothetical protein; Provisional

false

true

false

407

4e-08

56.18

38.57

6,716,242,29,745,272,7,754,279,55,809,336,32,841,370,13,855,383,16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  717 KMQQQSITDALTGSKTRRYFLEALQSEWK-RASRSTRpfSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSN 795
PRK09966     243 QLLRTALHDPLTGLANRAAFRSGINTLMNnSDARKTS--ALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRH 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  796 VVARFGGDEFVILM--PETGVDQAQILAERLRLWIATDPMLSEHQITG--SFGVATYPIHGSSvEDIMRVADAGMYVSKH 871
PRK09966     321 KAYRLGGDEFAMVLydVQSESEVQQICSALTQIFNLPFDLHNGHQTTMtlSIGYAMTIEHASA-EKLQELADHNMYQAKH 399

-1

138768

PRK11829

biofilm formation regulator HmsP; Provisional

false

true

false

728

1e-05

47.77

20.19

3,732,310,17,750,327,87,837,417,40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  733 RRYFLEALQSEWKRASRsTRPFSVVMIDLDKFKQVNDTMGHLEGDLVLARIARLLEQKCRQSNVVARFGGDEFVILMPET 812
PRK11829     311 RSLFISLLEKEIASSTR-TDHFHLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCIDDSDLLAQLSKTEFAVLARGT 389

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 94967216  813 GVDQAQILAERLRLWIATDPMLSEH---QITGSFGVATYPIHGSSVEDIMRVADAGMYVSKHAGGNKV 877
PRK11829     390 RRSFPAMQLARRIMSQVTQPLFFDEitlRPSASIGITRYQAQQDTAESMMRNASTAMMAAHHEGRNQI 457

-1

33404

COG3604

FhlA

Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]

Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [...

false

true

false

550

6e-04

42.22

35.82

8,395,31,51,447,82,9,456,95,25,481,121,20,501,143,15,519,158,7,526,167,54,582,221,7

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  396 EFELLTQIGQVISSRLDPDEVLAAVHRELGRLFDTSNFYVAFLEGLELRYEfETVGAIRQP----RRSRRSKNGLSDFVI 471
COG3604       32 DIRILVELTNALLSPLRLERLLAEVAKELHSLFGCDASALLRLDSKNLIPL-ATDGLSKDHlgreQRFVVEGHPLLEQIL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94967216  472 RTGQPILIRS-DMKRVSQRLGIEPSSHPAKC--FIGVPIRIGAVSVGVvaaLNFDREF--VYEQRDVEVLATAAGQVAVA 546
COG3604      111 KAGRPLVFHPaDSLFPDPYDGLLPDTEGNKKhaCIGVPLKSGDKLIGA---LTLDHTEpdQFDEDLDEELRFLAALAALA 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 94967216  547 IENARMFAHEQRRARYLSFLNNVSQTAISSQNAEemLSEIVGQ 589
COG3604      188 VANALLHRELSSLKERLEEENLALEEQLSEVVLE--VGGIIGR 228

-1

active site	0	10	10	true	133472	cd01949	GGDEF
I-site	1	3	3	true	133472	cd01949	GGDEF
Zn2+ binding site	0	4	4	true	28958	cd00077	HDc
Mg2+ binding site	1	1	1	true	28958	cd00077	HDc