NCBI Conserved Domain Search

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Conserved domains on [gi\|86565633\|gb\|ABD09442.1\|]
adenylate/guanylate cyclase [Frankia sp. CcI3]

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List of domain hits		?

References:

Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.

Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the PssmId to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options

32297

COG2114

CyaA

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]

Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction...

true

false

227

8e-18

88.31

81.94

4,79,37,73,159,110,32,191,145,42,233,188,35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633   80 TPGSGARKTVTIMFVDITGSTDIGERIDSEPLQQVMWRFFTTVREVIYIHGGSVEKFIGDAVFAVFGIPVLHEddalrav 159
COG2114       38 ARGGAGDRRVTLLFADIVGSTELSESLGDEALVELLNLYFDAVAEVVARHGGRVVKFIGDGFLAVFGRPSPLE------- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  160 RAALDIRAAMEALNADLQREWGLKLRVRIGIN---TGEVTVAGGGVTGDPVNVASRLEHAAPPDEILIGDTTYRFIR-HS 235
COG2114      111 DAVACALDLQLALRNPLARLRRESLRVRIGIHtgeVVVGNTGGYTVVGSAVNQAARLESLAKPGQVLLSEATYDLVRdLV 190

                        170       180       190
                 ....*....|....*....|....*....|...
gi 86565633  236 VTVSPLGPLVVQGKRDPLRVHRLIGLVDPTAGP 268
COG2114      191 DLFSGLGSHRLKGLARPVRVYQLCHRSLRRNLE 223

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

128359

smart00044

CYCc

Adenylyl- / guanylyl cyclase, catalytic domain

false

194

1e-12

71.16

77.32

5,88,36,17,107,53,9,116,64,32,150,96,54,204,157,29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633   89 VTIMFVDITGSTDIGERidSEPLQQVMW--RFFTTVREVIYIHGGSVEKFIGDAVFAVFGIPvlHEDDALRAVRAALDIR 166
smart00044    37 VTILFTDIVGFTTLSSE--ATPEQVVTLlnDLYSRFDRIIDRHGGYKVKTIGDAYMVVSGLP--TEALVDHAELAADEAL 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 86565633  167 AAMEALNADLQREWGLKLRVRIGINTGEVTVAGGGVTG-------DPVNVASRLEHAAPPDEILIGDTTYRFIR 233
smart00044   113 DMVESLKTVLSQHRGNGLRVRIGIHTGPVVAGVVGITMpryclfgDTVNLASRMESVGDPGQILVSEETYSLLR 186

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

109276

pfam00211

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

false

185

2e-11

67.28

90.81

4,88,8,91,183,99,8,191,114,41,232,159,17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633   89 VTIMFVDITGSTDIGERIDSEPLQQVMWRFFTTVREVIYIHGGSVEKFIGDAVFAVFGIPVLHEDDALRAVRAALDIRAA 168
pfam00211      9 VTILFADIVGFTALSSRHSPEELVRLLNDLYTRFDELLDKHGVYKVKTIGDAYMAASGLPPAAAHHAALLADMALDMVET 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  169 MEALNADLQREwglkLRVRIGIN-------TGEVTVAGGGVTGDPVNVASRLEHAAPPDEILIGDTTYRFI----RHSVT 237
pfam00211     89 IEEVNVGHANG----LRVRIGIHtgpvvagVIGARRPRYDVWGDTVNVASRMESTGVPGKIHVSEETYRLLkgeeSFQFR 164

                        170
                 ....*....|..
gi 86565633  238 VSPLGPLVVQGK 249
pfam00211    165 LEPRGEVPVKGK 176

cl00925

141019

Guanylate_cyc

Adenylate and Guanylate cyclase catalytic domain

-1

33687

COG3899

Predicted ATPase [General function prediction only]

true

false

849

5e-56

215.26

58.30

14,279,0,25,305,25,25,330,51,68,398,125,9,407,138,15,422,154,28,450,183,57,507,241,53,560,297,39,601,336,24,625,366,69,701,435,23,724,459,18,742,478,17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  280 PVIGRNRERRRLQDAFEAVVEERTChLFTVLGPAGIGKSRMVGEFCAAMAN-RATVLTGRCLSYGEGIAYWPLMEMVRQA 358
COG3899        1 PLYGRETELAQLLAAFDRVSKGRGE-VVLVAGESGIGKSALVNEVHKPITQqRGYFIKGKFDQFERNIPLSPLVQAFRDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  359 TGLSADESAPDGRRRLRELLDGVTQAAEIVEALAPLVGLG------GAELGPQES----FWAVRSFFQALAARR-PLILW 427
COG3899       80 MGQLLSESDTRILSWRARLLAALGENGQVIIDVIPELELIigkrppALELSPTAAqnrfNLAFLRFIQVFTAEEhPLVIV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  428 FDDVHWAEPTLLDLLENIADWSR-DAPIMLLCLARPELLEERRDWGGGKLNATSMLLAPLTEARCQRLIRTLMGSDDLDP 506
COG3899      160 LEDLHWADSASLKLLQLLMDRIAiGAYRDNEVLLLHPLRPTLGEILKSATNITTITLAPLSRADTNQLVAATLGCTKLLP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  507 A-LVSRITTSAAGNPLFVEQMVAALVDDGLLRREGSRWIATGSLRNVTVPPTISS---LLAARLDRLDPPERRVLERAAI 582
COG3899      240 ApLLELIFEKTKGNPFFIEEFLKALYEEGLLVFNFDTGAWQCSIASLGILATTDAvveFLAARLQKLPGTTREVLKAAAC 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  583 VGERFYLDAVIDLSDPSeqPMVAAHCLSLVRKELVHPDRSDLP------GVEAFRFLHVLLRDCAYQSTAKRQRADLHQR 656
COG3899      320 IGNRFDLDTLAALAEDS--PALEAAALLDALQEGLILPLSETYrfgsnvDIATYKFLHDRVQQAAYNLIPESQRQYLHLR 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  657 FAQWLQTRLEGGPGEHDELVGYHLEQAFRYRVEIGQRDtetielgRSAATCLIEAADRVRQGDETGAA-QLLKRAITLLP 735
COG3899      398 IGQLLEQNIPEAGQEEEIFDIVNQLNAGVGLITLEEAV-------DELAELNLLAGRKAKLRSAYSAAiSYLERGLSLLL 470

                        490       500
                 ....*....|....*....|....*
gi 86565633  736 ETDPLRL-RAEIDLGWALYSFGRLS 759
COG3899      471 ADAWQNQyLLALMLHRLAAENAYLR 495

-1

32733

COG2909

MalT

ATP-dependent transcriptional regulator [Transcription]

false

true

false

894

0.002

40.29

58.61

26,269,9,27,303,36,32,335,78,7,350,85,17,376,102,19,399,121,7,421,128,13,434,142,18,452,161,32,485,193,13,499,206,25,526,231,27,558,258,27,602,285,13,618,298,21,646,319,20,668,339,13,682,352,12,695,364,25,720,392,15,736,407,12,748,421,20,770,441,23,798,464,27,825,496,5,830,502,31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  270 SRAPTHGFTAPVIGRNRERRRLQDAFEavveertCHLFTVLGPAGIGKSRMVGEFCAAMANRATVL----------TGRC 339
COG2909       10 SKLVRPVRPDNYVVRPRLLDRLRRAND-------YRLILISAPAGFGKTTLLAQWRELAADGAAVAwlsldesdndPARF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  340 LSYgegiaywpLMEMVRQATGLSADESApdgrrrlreLLDGVTQAAEIVEALAPLVglggAELGPQEsfwavrsffqala 419
COG2909       83 LSY--------LIAALQQATPTLGDEAQ---------TLLQKHQYVSLESLLSSLL----NELASYE------------- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  420 arRPLILWFDDVHWA-EPTLLDLLENIADWSRDA-PIMLLCLARPELLEERRDWGGGKLNATSMLLApLTEARCQRLIRT 497
COG2909      129 --GPLYLVLDDYHLIsDPALHEALRFLLKHAPENlTLVVTSRSRPQLGLARLRLRDELLEIGSEELR-FDTEEAAAFLND 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  498 LmGSDDLDPALVSRITTSAAGNPLFVEqmVAALVDDGLLRREGSRWIATGSLRNVTvpptiSSLLAARLDRLDPPERRVL 577
COG2909      206 R-GSLPLDAADLKALYDRTEGWAAALQ--LIALALRNNTSAEQSLRGLSGAASHLS-----DYLVEEVLDRLPPELRDFL 277

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  578 ERAAIVGErfyldavidlsdpseqpMVAAHCLSLVRKElvhPDRSDLPGVEAFRFLHVLLRDcayqstaKRQRADLHQRF 657
COG2909      278 LQTSVLSR-----------------FNDELCNALTGEE---NGQAMLEELERRGLFLQRLDD-------EGQWFRYHHLF 330

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  658 AQWLQTRLEggPGEHDELVGYHLEqAFRYRVEIGQRDtETIELGRSAATCLIEAADRVRQGDE---TGAAQLLKRAITLL 734
COG2909      331 AEFLRQRLQ--RELAARLKELHRA-AAEWFAEHGLPS-EAIDHALAAGDPEMAADLLEQLEWQlfnGSELSLLLAWLKAL 406

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86565633  735 PeTDPLRLRAEIDL--GWALYSFGRLSDAERILRQVteRARRAGEEGLRAHARLAYLRVLFstdpeGLVARTLTEAAVCL 812
COG2909      407 P-AELLASTPRLVLlqAWLLASQHRLAEAETLIARL--EHFLKAPMHSRQGDLLAEFQALR-----AQVALNRGDPEEAE 478

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 86565633  813 TNFVQAGDEVGAA-----LACRS-QANAYLAAGQFAAAERAMENAVRHAEESGVP 861
COG2909      479 DLARLALVQLPEAayrsrIVALSvLGEAAHIRGELTQALALMQQAEQMARQHDVY 533

-1