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Conserved domains on  [gi|4503123|ref|NP_001892|]
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connective tissue growth factor precursor [Homo sapiens]

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List of domain hits

Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
253-345 8.05e-15

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam00007:

Pssm-ID: 304424  Cd Length: 105  Bit Score: 69.36  E-value: 8.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503123    253 GKKCIRTPKiskPIKFELSGCTSMKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEVMKKNM 317
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77
                          90       100
                  ....*....|....*....|....*...
gi 4503123    318 MFIKTCACHyNCPGDNDIFESLYYRKMY 345
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
IGFBP pfam00219
Insulin-like growth factor binding protein;
29-82 8.93e-12

Insulin-like growth factor binding protein;


:

Pssm-ID: 278641  Cd Length: 52  Bit Score: 59.63  E-value: 8.93e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4503123     29 CSGPCRCPDEPaPRCPAGVSLVLDGCGCCRVCAKQLGELCTERD-PCDPhkGLFC 82
Cdd:pfam00219   1 CPGPCDPERCP-PVCPAGVELVLDGCGCCKVCARQEGEPCGVYTgRCDK--GLRC 52
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
103-163 8.98e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.57  E-value: 8.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503123    103 CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPlcsmdVRLPSPDCPFPRRVKLPGKCCEE 163
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
202-243 1.93e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559  Cd Length: 53  Bit Score: 35.64  E-value: 1.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 4503123     202 QTTEWSACSKTCGMGISTRV--------TNDNASCR-LEKQSRLCMVRPCE 243
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
253-345 8.05e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 109076  Cd Length: 105  Bit Score: 69.36  E-value: 8.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503123    253 GKKCIRTPKiskPIKFELSGCTSMKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEVMKKNM 317
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77
                          90       100
                  ....*....|....*....|....*...
gi 4503123    318 MFIKTCACHyNCPGDNDIFESLYYRKMY 345
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
261-330 1.08e-12

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 62.81  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503123     261 KISKPIKFELSGCTSMkTYRAKFC-GVCTD------------GRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHY 327
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79

                   ...
gi 4503123     328 NCP 330
Cdd:smart00041  80 NCP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
29-82 8.93e-12

Insulin-like growth factor binding protein;


Pssm-ID: 278641  Cd Length: 52  Bit Score: 59.63  E-value: 8.93e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4503123     29 CSGPCRCPDEPaPRCPAGVSLVLDGCGCCRVCAKQLGELCTERD-PCDPhkGLFC 82
Cdd:pfam00219   1 CPGPCDPERCP-PVCPAGVELVLDGCGCCKVCARQEGEPCGVYTgRCDK--GLRC 52
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
31-93 8.96e-08

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 48.62  E-value: 8.96e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4503123      31 GPCRCPDEPaPRCPAGVslVLDGCGCCRVCAKQLGELCT-ERDPCdpHKGLFCDFGSPANRKIG 93
Cdd:smart00121   7 DPARCPPCP-PGCAELV--RLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
103-163 8.98e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.57  E-value: 8.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503123    103 CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPlcsmdVRLPSPDCPFPRRVKLPGKCCEE 163
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-162 2.18e-07

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.51  E-value: 2.18e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503123     103 CIFGGTVYRSGESFQSSCKYQCTCLDGA-VGCMPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 162
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
202-243 1.93e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559  Cd Length: 53  Bit Score: 35.64  E-value: 1.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 4503123     202 QTTEWSACSKTCGMGISTRV--------TNDNASCR-LEKQSRLCMVRPCE 243
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
253-345 8.05e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 109076  Cd Length: 105  Bit Score: 69.36  E-value: 8.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503123    253 GKKCIRTPKiskPIKFELSGCTSMKTYRAKFC-GVCT-------DGR-------CCTPHRTTTLPVEFKCPDGEVMKKNM 317
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77
                          90       100
                  ....*....|....*....|....*...
gi 4503123    318 MFIKTCACHyNCPGDNDIFESLYYRKMY 345
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
261-330 1.08e-12

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 62.81  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503123     261 KISKPIKFELSGCTSMkTYRAKFC-GVCTD------------GRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHY 327
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79

                   ...
gi 4503123     328 NCP 330
Cdd:smart00041  80 NCP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
29-82 8.93e-12

Insulin-like growth factor binding protein;


Pssm-ID: 278641  Cd Length: 52  Bit Score: 59.63  E-value: 8.93e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4503123     29 CSGPCRCPDEPaPRCPAGVSLVLDGCGCCRVCAKQLGELCTERD-PCDPhkGLFC 82
Cdd:pfam00219   1 CPGPCDPERCP-PVCPAGVELVLDGCGCCKVCARQEGEPCGVYTgRCDK--GLRC 52
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
31-93 8.96e-08

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 48.62  E-value: 8.96e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4503123      31 GPCRCPDEPaPRCPAGVslVLDGCGCCRVCAKQLGELCT-ERDPCdpHKGLFCDFGSPANRKIG 93
Cdd:smart00121   7 DPARCPPCP-PGCAELV--RLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
103-163 8.98e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.57  E-value: 8.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503123    103 CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPlcsmdVRLPSPDCPFPRRVKLPGKCCEE 163
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-162 2.18e-07

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 47.51  E-value: 2.18e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503123     103 CIFGGTVYRSGESFQSSCKYQCTCLDGA-VGCMPL-CSmdvrlPSPDCPFPRRVKLPGKCCE 162
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
202-243 1.93e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559  Cd Length: 53  Bit Score: 35.64  E-value: 1.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 4503123     202 QTTEWSACSKTCGMGISTRV--------TNDNASCR-LEKQSRLCMVRPCE 243
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.15
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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