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Conserved domains on  [gi|426247498|ref|XP_004017522|]
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PREDICTED: splicing factor 3A subunit 1 isoform 1 [Ovis aries]

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List of domain hits

Name Accession Description Interval E-value
SF3a120_C cd01800
Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing ...
710-785 2.30e-42

Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit (SF3a120) has a carboxy-terminal ubiquitin-like domain and two SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, at its amino-terminus.


:

Pssm-ID: 176395  Cd Length: 76  Bit Score: 149.14  E-value: 2.30e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 426247498 710 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK 785
Cdd:cd01800    1 PEWKLNGQMLNFTLQLSDPVSVLKVKIHEETGMPAGKQKLQYEGIFIKDSNSLAYYNLANGTIIHLQLKERGGRKK 76
PRP21_like_P super family cl18609
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
222-468 2.20e-36

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


The actual alignment was detected with superfamily member pfam12230:

Pssm-ID: 256914  Cd Length: 230  Bit Score: 137.58  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  222 PKGLFTKLKKEAE-NPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTT 300
Cdd:pfam12230   1 PESLLENLKANSVkDKYYILERAYKRAEWEKHQKKEEQKKEEEEEEERIAFASIDWQDFVVVETIEFNDIDVLELPPPLT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  301 PEELGARILIQERYEkfgeseevemevesdeedeKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPL 380
Cdd:pfam12230  81 LNELIYRSLEQKSKA-------------------LEEPDAAAAPEEEEEMEEEEEDIDEEKKEESAKKSTPPIKEMKIPA 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  381 PPTPDQVIV---DPKASKPLPPAPaPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSdDEVYAPGLD 457
Cdd:pfam12230 142 AGESRLKIRkdyVPSGNKPRAEKP-KKKMIKCPITGELIPEDEFDEHMRILLLDPRYKEQKDQYEAKNQQ-YASNLTTDD 219
                         250
                  ....*....|.
gi 426247498  458 IESSLKQLAER 468
Cdd:pfam12230 220 VYRNLKRLAKK 230
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
50-103 4.24e-25

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818  Cd Length: 54  Bit Score: 99.58  E-value: 4.24e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 426247498    50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKE 103
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
164-217 1.44e-20

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818  Cd Length: 54  Bit Score: 86.87  E-value: 1.44e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 426247498   164 LDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTK 217
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
 
Name Accession Description Interval E-value
SF3a120_C cd01800
Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing ...
710-785 2.30e-42

Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit (SF3a120) has a carboxy-terminal ubiquitin-like domain and two SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, at its amino-terminus.


Pssm-ID: 176395  Cd Length: 76  Bit Score: 149.14  E-value: 2.30e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 426247498 710 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK 785
Cdd:cd01800    1 PEWKLNGQMLNFTLQLSDPVSVLKVKIHEETGMPAGKQKLQYEGIFIKDSNSLAYYNLANGTIIHLQLKERGGRKK 76
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
222-468 2.20e-36

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


Pssm-ID: 256914  Cd Length: 230  Bit Score: 137.58  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  222 PKGLFTKLKKEAE-NPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTT 300
Cdd:pfam12230   1 PESLLENLKANSVkDKYYILERAYKRAEWEKHQKKEEQKKEEEEEEERIAFASIDWQDFVVVETIEFNDIDVLELPPPLT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  301 PEELGARILIQERYEkfgeseevemevesdeedeKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPL 380
Cdd:pfam12230  81 LNELIYRSLEQKSKA-------------------LEEPDAAAAPEEEEEMEEEEEDIDEEKKEESAKKSTPPIKEMKIPA 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  381 PPTPDQVIV---DPKASKPLPPAPaPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSdDEVYAPGLD 457
Cdd:pfam12230 142 AGESRLKIRkdyVPSGNKPRAEKP-KKKMIKCPITGELIPEDEFDEHMRILLLDPRYKEQKDQYEAKNQQ-YASNLTTDD 219
                         250
                  ....*....|.
gi 426247498  458 IESSLKQLAER 468
Cdd:pfam12230 220 VYRNLKRLAKK 230
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
50-103 4.24e-25

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 99.58  E-value: 4.24e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 426247498    50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKE 103
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
50-102 8.15e-23

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 250881  Cd Length: 55  Bit Score: 93.05  E-value: 8.15e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 426247498   50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNP-NDPYHAYYRHKVSEFK 102
Cdd:pfam01805   2 LDIIDKTAQFVARNGPEFEALLMEREQDNPQFNFLKPsNDPYHVYYRWKLAEYS 55
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
164-217 1.44e-20

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 86.87  E-value: 1.44e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 426247498   164 LDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTK 217
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
163-215 3.71e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 250881  Cd Length: 55  Bit Score: 79.95  E-value: 3.71e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 426247498  163 DLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQ-HSLFNYFTKLVEQY 215
Cdd:pfam01805   1 LLDIIDKTAQFVARNGPEFEALLMEREQDNPQFNFLKPSnDPYHVYYRWKLAEY 54
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
710-778 3.18e-15

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563  Cd Length: 72  Bit Score: 71.91  E-value: 3.18e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498   710 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 778
Cdd:smart00213   4 TVKTLDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQRLIYKGKVLEDDRTLADYGIQDGSTIHLVLR 72
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 ...
714-780 8.53e-14

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 249708  Cd Length: 69  Bit Score: 67.65  E-value: 8.53e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 426247498  714 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKER 780
Cdd:pfam00240   3 LDGKTITLEVDPSDTVLELKEKIEDKEGIPVDQQRLIYSGKVLEDDTTLSEYGIKDGSTLHLVLRLR 69
PTZ00044 PTZ00044
ubiquitin; Provisional
714-782 1.05e-04

ubiquitin; Provisional


Pssm-ID: 185411  Cd Length: 76  Bit Score: 41.35  E-value: 1.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498 714 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 782
Cdd:PTZ00044   8 LTGKKQSFNFEPDNTVQQVKMALQEKEGIDVKQIRLIYSGKQMSDDLKLSDYKVVPGSTIHMVLQLRGG 76
 
Name Accession Description Interval E-value
SF3a120_C cd01800
Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing ...
710-785 2.30e-42

Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit (SF3a120) has a carboxy-terminal ubiquitin-like domain and two SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, at its amino-terminus.


Pssm-ID: 176395  Cd Length: 76  Bit Score: 149.14  E-value: 2.30e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 426247498 710 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK 785
Cdd:cd01800    1 PEWKLNGQMLNFTLQLSDPVSVLKVKIHEETGMPAGKQKLQYEGIFIKDSNSLAYYNLANGTIIHLQLKERGGRKK 76
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
222-468 2.20e-36

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


Pssm-ID: 256914  Cd Length: 230  Bit Score: 137.58  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  222 PKGLFTKLKKEAE-NPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTT 300
Cdd:pfam12230   1 PESLLENLKANSVkDKYYILERAYKRAEWEKHQKKEEQKKEEEEEEERIAFASIDWQDFVVVETIEFNDIDVLELPPPLT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  301 PEELGARILIQERYEkfgeseevemevesdeedeKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPL 380
Cdd:pfam12230  81 LNELIYRSLEQKSKA-------------------LEEPDAAAAPEEEEEMEEEEEDIDEEKKEESAKKSTPPIKEMKIPA 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426247498  381 PPTPDQVIV---DPKASKPLPPAPaPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSdDEVYAPGLD 457
Cdd:pfam12230 142 AGESRLKIRkdyVPSGNKPRAEKP-KKKMIKCPITGELIPEDEFDEHMRILLLDPRYKEQKDQYEAKNQQ-YASNLTTDD 219
                         250
                  ....*....|.
gi 426247498  458 IESSLKQLAER 468
Cdd:pfam12230 220 VYRNLKRLAKK 230
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
50-103 4.24e-25

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 99.58  E-value: 4.24e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 426247498    50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKE 103
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
50-102 8.15e-23

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 250881  Cd Length: 55  Bit Score: 93.05  E-value: 8.15e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 426247498   50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNP-NDPYHAYYRHKVSEFK 102
Cdd:pfam01805   2 LDIIDKTAQFVARNGPEFEALLMEREQDNPQFNFLKPsNDPYHVYYRWKLAEYS 55
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
164-217 1.44e-20

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 86.87  E-value: 1.44e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 426247498   164 LDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTK 217
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
163-215 3.71e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 250881  Cd Length: 55  Bit Score: 79.95  E-value: 3.71e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 426247498  163 DLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQ-HSLFNYFTKLVEQY 215
Cdd:pfam01805   1 LLDIIDKTAQFVARNGPEFEALLMEREQDNPQFNFLKPSnDPYHVYYRWKLAEY 54
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
710-778 3.18e-15

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563  Cd Length: 72  Bit Score: 71.91  E-value: 3.18e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498   710 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 778
Cdd:smart00213   4 TVKTLDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQRLIYKGKVLEDDRTLADYGIQDGSTIHLVLR 72
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 ...
714-780 8.53e-14

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 249708  Cd Length: 69  Bit Score: 67.65  E-value: 8.53e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 426247498  714 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKER 780
Cdd:pfam00240   3 LDGKTITLEVDPSDTVLELKEKIEDKEGIPVDQQRLIYSGKVLEDDTTLSEYGIKDGSTLHLVLRLR 69
UBL cd01769
Ubiquitin-like domain of UBL; UBLs function by remodeling the surface of their target proteins, ...
710-778 1.77e-10

Ubiquitin-like domain of UBL; UBLs function by remodeling the surface of their target proteins, changing their target's half-life, enzymatic activity, protein-protein interactions, subcellular localization or other properties. At least 10 different ubiquitin-like modifications exist in mammals, and attachment of different ubls to a target leads to different biological consequences. Ubl-conjugation cascades are initiated by activating enzymes, which also coordinate the ubls with their downstream pathways.


Pssm-ID: 176364  Cd Length: 69  Bit Score: 58.05  E-value: 1.77e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498 710 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 778
Cdd:cd01769    1 TVKTLTGKTFELEVSPDDTVAELKAKIAAKEGVPPEQQRLIYAGKILKDDKTLSDYGIQDGSTLHLVLR 69
Ubiquitin cd01803
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric ...
714-782 1.48e-07

Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin protein chains)


Pssm-ID: 176398 [Multi-domain]  Cd Length: 76  Bit Score: 49.87  E-value: 1.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498 714 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 782
Cdd:cd01803    8 LTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76
Scythe_N cd01809
Ubiquitin-like domain of Scythe protein; Scythe protein (also known as Bat3) is an apoptotic ...
697-775 2.48e-07

Ubiquitin-like domain of Scythe protein; Scythe protein (also known as Bat3) is an apoptotic regulator that is highly conserved in eukaryotes and contains a ubiquitin-like domain near its N-terminus. Scythe binds reaper, a potent apoptotic inducer, and Scythe/Reaper are thought to signal apoptosis, in part through regulating the folding and activity of apoptotic signaling molecules.


Pssm-ID: 176404  Cd Length: 72  Bit Score: 49.15  E-value: 2.48e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498 697 VSIKVQVPNMQDKTewklngqvlvFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHL 775
Cdd:cd01809    1 IEIKVKTLDSQTHT----------FTVEEEITVLDLKEKIAEEVGIPVEQQRLIYSGRVLKDDETLSEYKVEDGHTIHL 69
Nedd8 cd01806
Nebb8-like ubiquitin protein; Nedd8 (also known as Rub1) has a single conserved ...
714-782 3.28e-06

Nebb8-like ubiquitin protein; Nedd8 (also known as Rub1) has a single conserved ubiquitin-like domain that is part of a protein modification pathway similar to that of ubiquitin. Nedd8 modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis.


Pssm-ID: 176401  Cd Length: 76  Bit Score: 45.93  E-value: 3.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498 714 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 782
Cdd:cd01806    8 LTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDDKTAADYKLEGGSVLHLVLALRGG 76
PTZ00044 PTZ00044
ubiquitin; Provisional
714-782 1.05e-04

ubiquitin; Provisional


Pssm-ID: 185411  Cd Length: 76  Bit Score: 41.35  E-value: 1.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498 714 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 782
Cdd:PTZ00044   8 LTGKKQSFNFEPDNTVQQVKMALQEKEGIDVKQIRLIYSGKQMSDDLKLSDYKVVPGSTIHMVLQLRGG 76
UBQ cd00196
Ubiquitin-like proteins; Ubiquitin homologs; Includes ubiquitin and ubiquitin-like proteins. ...
712-778 1.39e-04

Ubiquitin-like proteins; Ubiquitin homologs; Includes ubiquitin and ubiquitin-like proteins. Ubiquitin-mediated proteolysis is part of the regulated turnover of proteins required for controlling cell cycle progression. Other family members are protein modifiers that perform a wide range of functions. Ubiquitination usually results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. The three-step mechanism requires an activating enzyme (E1) that forms a thiol ester with the C-terminal carboxy group, a conjugating enzyme (E2) that transiently carries the activated ubiquitin molecule as a thiol ester, and a ligase (E3) that transfers the activated ubiquitin from the E2 to the substrate lysine residue. In poly-ubiquitination, ubiquitin itself is the substrate.


Pssm-ID: 176352  Cd Length: 69  Bit Score: 40.97  E-value: 1.39e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 426247498 712 WKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 778
Cdd:cd00196    3 KLNDGKTVELLVPSGTTVADLKEKLAKKLGLPPEQQRLLVNGKILPDSLTLEDYGLQDGDELVLVPR 69
RAD23_N cd01805
Ubiquitin-like domain of RAD23; RAD23 belongs to a family of adaptor molecules having affinity ...
714-766 5.20e-04

Ubiquitin-like domain of RAD23; RAD23 belongs to a family of adaptor molecules having affinity for both the proteasome and ubiquitinylated proteins and thought to shuttle these ubiquitinylated proteins to the proteasome for destruction. RAD23 interacts with ubiquitin through its C-terminal ubiquitin-associated domains (UBA) and with the proteasome through its N-terminal ubiquitin-like domain (UBL).


Pssm-ID: 176400  Cd Length: 77  Bit Score: 39.23  E-value: 5.20e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 426247498 714 LNGQVLVFTLPLTDQVSVIKVKIHEATG--MPAGKQKLQYEGIFIKDSNSLAYYN 766
Cdd:cd01805    8 LKQQTFPIEVDPDDTVAELKEKIEEEKGcdYPPEQQKLIYSGKILKDDTTLEEYK 62
AN1_N cd01802
ubiquitin-like domain of AN1; AN1 (also known as ANUBL1 and RSD-7) is ubiquitin-like protein ...
727-782 9.67e-04

ubiquitin-like domain of AN1; AN1 (also known as ANUBL1 and RSD-7) is ubiquitin-like protein with a testis-specific expression in rats that has an N-terminal ubiquitin-like domain and a C-terminal zinc-binding domain. Unlike ubiquitin polyproteins and most ubiquitin fusion proteins, the N-terminal ubiquitin-like domain of An1 does not undergo proteolytic processing. The function of AN1 is unknown.


Pssm-ID: 176397  Cd Length: 103  Bit Score: 38.32  E-value: 9.67e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 426247498 727 DQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 782
Cdd:cd01802   48 ETVISVKAKIQRLEGIPVAQQHLIWNNMELEDEYCLNDYNISEGCTLKLVLAMRGG 103
Ubiquitin_2 pfam14560
Ubiquitin-like domain; This entry contains ubiquitin-like domains.
723-774 2.39e-03

Ubiquitin-like domain; This entry contains ubiquitin-like domains.


Pssm-ID: 258698  Cd Length: 84  Bit Score: 37.10  E-value: 2.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 426247498  723 LPLTDQVSVIKVKIHEATGMPAGKQKLQY---EGIFI----KDSNSLAYYNMANGAVIH 774
Cdd:pfam14560  19 FSKSLTIEELKEKLELITGTPPSSMRLQLydkDGNLVakldDDDALLGSYGVRDGMRIH 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.11
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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