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Conserved domains on  [gi|402872498|ref|XP_003900147|]
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PREDICTED: voltage-dependent anion-selective channel protein 1 [Papio anubis]

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List of domain hits

Name Accession Description Interval E-value
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
4-282 3.37e-129

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


:

Pssm-ID: 132767  Cd Length: 276  Bit Score: 371.16  E-value: 3.37e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498   4 PPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLGT 83
Cdd:cd07306    1 PPTYFDIGKSAKDLLTKGYNFGAWKLDVKTKTPNGVEFTSTGSKKPDTGKVSGSLEAKYKI--KGLTLTQKWNTDNVLLT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498  84 EITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDiAGPSIRGALVLGYEGWLAGYQMNFETAKSR 163
Cdd:cd07306   79 EITIEDLLAPGLKLTLDTTFPPNTGKKSGKLKAGYKHDPININADVDLN-KGPLVGASAVLGYKGFLLGAEVVYDTAKSK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498 164 VTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLI 243
Cdd:cd07306  158 FTKYNFALGYTNGDFELSLKLNNGKTLRGSYFHKVSPRLAVGAKVTWYSGTNETTFAVGGQYALDPDALVKAKVNNDGQL 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 402872498 244 GLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQ 282
Cdd:cd07306  238 GLSYQHKLRPGVTLTLSAGFDAKNLNQGGHKFGLSLSLK 276
 
Name Accession Description Interval E-value
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
4-282 3.37e-129

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767  Cd Length: 276  Bit Score: 371.16  E-value: 3.37e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498   4 PPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLGT 83
Cdd:cd07306    1 PPTYFDIGKSAKDLLTKGYNFGAWKLDVKTKTPNGVEFTSTGSKKPDTGKVSGSLEAKYKI--KGLTLTQKWNTDNVLLT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498  84 EITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDiAGPSIRGALVLGYEGWLAGYQMNFETAKSR 163
Cdd:cd07306   79 EITIEDLLAPGLKLTLDTTFPPNTGKKSGKLKAGYKHDPININADVDLN-KGPLVGASAVLGYKGFLLGAEVVYDTAKSK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498 164 VTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLI 243
Cdd:cd07306  158 FTKYNFALGYTNGDFELSLKLNNGKTLRGSYFHKVSPRLAVGAKVTWYSGTNETTFAVGGQYALDPDALVKAKVNNDGQL 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 402872498 244 GLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQ 282
Cdd:cd07306  238 GLSYQHKLRPGVTLTLSAGFDAKNLNQGGHKFGLSLSLK 276
Porin_3 pfam01459
Eukaryotic porin;
3-276 4.62e-106

Eukaryotic porin;


Pssm-ID: 250636  Cd Length: 273  Bit Score: 312.24  E-value: 4.62e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498    3 VPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLG 82
Cdd:pfam01459   1 NPGTYEDIGKKARDLLNKDYHFDGAKLDVTTKSPLGVAFTVSGSKSLGSGLSSGDFEAKYKD--KGLTLTLKWDTDNDLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498   83 TEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKS 162
Cdd:pfam01459  79 TNATVNDQLAPGLKLKLSTQLVPGTGKKSAKLELDYKGDDFTASLKVGLPSKGPIVVGSALQGVTGLALGAEAVYDTASG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498  163 RVTQSNFAVGYKTDEFQLHTNV-NDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSS 241
Cdd:pfam01459 159 KLTKYNAALGYAARDYIASLTLnNKGDVLTASYYHKVSDKLEVGAELTWNFSSNETTFTVGYKYDLDPSTTVKAKVDSNG 238
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 402872498  242 LIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLG 276
Cdd:pfam01459 239 KVGLLLEKRLRPGVTLTLSAEVDHKKLIEGAHKFG 273
 
Name Accession Description Interval E-value
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
4-282 3.37e-129

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767  Cd Length: 276  Bit Score: 371.16  E-value: 3.37e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498   4 PPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLGT 83
Cdd:cd07306    1 PPTYFDIGKSAKDLLTKGYNFGAWKLDVKTKTPNGVEFTSTGSKKPDTGKVSGSLEAKYKI--KGLTLTQKWNTDNVLLT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498  84 EITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDiAGPSIRGALVLGYEGWLAGYQMNFETAKSR 163
Cdd:cd07306   79 EITIEDLLAPGLKLTLDTTFPPNTGKKSGKLKAGYKHDPININADVDLN-KGPLVGASAVLGYKGFLLGAEVVYDTAKSK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498 164 VTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLI 243
Cdd:cd07306  158 FTKYNFALGYTNGDFELSLKLNNGKTLRGSYFHKVSPRLAVGAKVTWYSGTNETTFAVGGQYALDPDALVKAKVNNDGQL 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 402872498 244 GLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQ 282
Cdd:cd07306  238 GLSYQHKLRPGVTLTLSAGFDAKNLNQGGHKFGLSLSLK 276
Porin3 cd07303
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
6-282 3.65e-114

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


Pssm-ID: 132765  Cd Length: 274  Bit Score: 333.09  E-value: 3.65e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498   6 TYADLGKSARDVFTKGYgFGLIKLDLKTKSENglEFTSSGSANTET----TKVTGSLETKYRWTEYGLTFTEKWNTDNTL 81
Cdd:cd07303    1 TYAELGKSARDLFTKGY-GGGIKLDVKTKSEL--EFTSSGSANTETiestTKVGGSLETKYRWSPYGLTFTEKWNTDNTL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498  82 GTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKRehINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAK 161
Cdd:cd07303   78 GLEITVEDQLSRGLKSTFDSSFSPNTGKKNAKIKTGYKR--INLGCDVDFDIAGPLIRGALVLGYEGWLAGYQMVFETVS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498 162 sRVTQSNFAVGYKTD--EFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNN 239
Cdd:cd07303  156 -RVTQSNFAVGYKTDynEFQAHTNVNDGTEFGGSIYHKVNDKLEVGVNLAATAGNSNTRFGIAAKYQVDPDACFSASVNN 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 402872498 240 SSLIGLGYTQTLKPGIKLTLSALLDGKNvnaGGHKLGLGLEFQ 282
Cdd:cd07303  235 SSLVGLGYTQTLKPGIKLTLSALLDHKA---GGHKLGLGLEFQ 274
Porin_3 pfam01459
Eukaryotic porin;
3-276 4.62e-106

Eukaryotic porin;


Pssm-ID: 250636  Cd Length: 273  Bit Score: 312.24  E-value: 4.62e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498    3 VPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWteYGLTFTEKWNTDNTLG 82
Cdd:pfam01459   1 NPGTYEDIGKKARDLLNKDYHFDGAKLDVTTKSPLGVAFTVSGSKSLGSGLSSGDFEAKYKD--KGLTLTLKWDTDNDLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498   83 TEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKS 162
Cdd:pfam01459  79 TNATVNDQLAPGLKLKLSTQLVPGTGKKSAKLELDYKGDDFTASLKVGLPSKGPIVVGSALQGVTGLALGAEAVYDTASG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498  163 RVTQSNFAVGYKTDEFQLHTNV-NDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSS 241
Cdd:pfam01459 159 KLTKYNAALGYAARDYIASLTLnNKGDVLTASYYHKVSDKLEVGAELTWNFSSNETTFTVGYKYDLDPSTTVKAKVDSNG 238
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 402872498  242 LIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLG 276
Cdd:pfam01459 239 KVGLLLEKRLRPGVTLTLSAEVDHKKLIEGAHKFG 273
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
142-279 2.18e-07

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


Pssm-ID: 132766  Cd Length: 279  Bit Score: 49.90  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402872498 142 LVLGYEG-WLAGYQMNfetaksrVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFG 220
Cdd:cd07305  149 LALGGELvYQRVPGNG-------ISVLSYAARYTAGNWIASGQLGAQGGLHLSYYRKLSDKLQLGVELELNLRTRESTAT 221
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402872498 221 IAAKYQIdPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKnvnAGGHKLGLGL 279
Cdd:cd07305  222 LGYQYDF-RQSRFRGSIDSNGKVSAVLEKRLPLPLSLLLSGELNHV---KNDYKFGFGL 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.13
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A et al. (2009), "CDD: specific functional annotation with the Conserved Domain Database.", Nucleic Acids Res.37(D)205-10.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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