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Conserved domains on  [gi|39930541|ref|NP_899064|]
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protein PAXX isoform 2 [Homo sapiens]

Protein Classification

HD_PAXX_N domain-containing protein( domain architecture ID 10634105)

HD_PAXX_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAXX pfam15384
PAXX, PAralog of XRCC4 and XLF, also called C9orf142; PAXX is a set of eukaryotic proteins ...
 8-204 1.44e-112

PAXX, PAralog of XRCC4 and XLF, also called C9orf142; PAXX is a set of eukaryotic proteins that belong to the XRCC4 superfamily of DNA-double-strand break-repair proteins. PAXX interacts directly with DSB-repair protein Ku and is recruited to DNA-damage sites in cells thus functioning with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents.


:

Pssm-ID: 464691  Cd Length: 194  Bit Score: 319.40  E-value: 1.44e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541     8 LCTLPPGPEPPRFVCYCEGEESGEGDRGgFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQAVAL 87
Cdd:pfam15384   1 LCTVPPGPGQPRYVCYCERKEGGAGDRV-FNLYVTDAAEVWSTEFTPDSLAQLKARFGLKSAEDYTLRFRAACEQGAVSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541    88 TLQEDRASLTLSGGPSALAFDLSKVPGPEAAPRLRALTLGLAKRVWSLERRLaAAEETAVSPRKSPRPAGPQlFLPDPDP 167
Cdd:pfam15384  80 TLQEDRASLTLGGGPEALSFDLSKVPSPEAAPELKALLFGMAERLCQLESRL-AAEESSFSPRKSYQPAGAQ-FLPDPDH 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 39930541   168 QRGGPGPGVRRRCPGESLINPGFKSKKPAGGVDFDET 204
Cdd:pfam15384 158 NRGGPGPGVKRRLPGESLINPGFKSKKPATGVDFDDE 194
 
Name Accession Description Interval E-value
PAXX pfam15384
PAXX, PAralog of XRCC4 and XLF, also called C9orf142; PAXX is a set of eukaryotic proteins ...
 8-204 1.44e-112

PAXX, PAralog of XRCC4 and XLF, also called C9orf142; PAXX is a set of eukaryotic proteins that belong to the XRCC4 superfamily of DNA-double-strand break-repair proteins. PAXX interacts directly with DSB-repair protein Ku and is recruited to DNA-damage sites in cells thus functioning with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents.


Pssm-ID: 464691  Cd Length: 194  Bit Score: 319.40  E-value: 1.44e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541     8 LCTLPPGPEPPRFVCYCEGEESGEGDRGgFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQAVAL 87
Cdd:pfam15384   1 LCTVPPGPGQPRYVCYCERKEGGAGDRV-FNLYVTDAAEVWSTEFTPDSLAQLKARFGLKSAEDYTLRFRAACEQGAVSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541    88 TLQEDRASLTLSGGPSALAFDLSKVPGPEAAPRLRALTLGLAKRVWSLERRLaAAEETAVSPRKSPRPAGPQlFLPDPDP 167
Cdd:pfam15384  80 TLQEDRASLTLGGGPEALSFDLSKVPSPEAAPELKALLFGMAERLCQLESRL-AAEESSFSPRKSYQPAGAQ-FLPDPDH 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 39930541   168 QRGGPGPGVRRRCPGESLINPGFKSKKPAGGVDFDET 204
Cdd:pfam15384 158 NRGGPGPGVKRRLPGESLINPGFKSKKPATGVDFDDE 194
HD_PAXX_N cd22286
N-terminal head domain found in paralog of XRCC4 and XLF, and similar proteins; Paralog of ...
 7-112 1.35e-37

N-terminal head domain found in paralog of XRCC4 and XLF, and similar proteins; Paralog of XRCC4 and XLF (PAXX), also called XRCC4-like small protein, is a paralog of X-ray repair cross-complementing protein 4 (XRCC4) and XRCC4-like factor (XLF). It is involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks (DSBs) in DNA. It may act as a scaffold required to stabilize the DSB-repair protein Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites in cells. It functions with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents. Similar to XRCC4 and XLF, PAXX monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two homodimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. This model corresponds to the N-terminal head domain of PAXX, which is structurally related to other XRCC4-superfamily members, XRCC4, XLF, SAS6, and CCDC61.


Pssm-ID: 409003  Cd Length: 102  Bit Score: 125.83  E-value: 1.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541   7 PLCTLPPGPEPPRFVCYCEGEEsgegdrGGFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQAVA 86
Cdd:cd22286   3 LLCTVTDGNDGSRYLCYTRLTN------DSFNICVTDGVDVWSTDFTEEELEEHRDLAGLSSTEDYLSKIRSAFESGTLS 76

                        90       100
                ....*....|....*....|....*.
gi 39930541  87 LTLQEDRASLTLSGGPSALAFDLSKV 112
Cdd:cd22286  77 LTVQDSKATLTLGKGPSALTFDLYEL 102
 
Name Accession Description Interval E-value
PAXX pfam15384
PAXX, PAralog of XRCC4 and XLF, also called C9orf142; PAXX is a set of eukaryotic proteins ...
 8-204 1.44e-112

PAXX, PAralog of XRCC4 and XLF, also called C9orf142; PAXX is a set of eukaryotic proteins that belong to the XRCC4 superfamily of DNA-double-strand break-repair proteins. PAXX interacts directly with DSB-repair protein Ku and is recruited to DNA-damage sites in cells thus functioning with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents.


Pssm-ID: 464691  Cd Length: 194  Bit Score: 319.40  E-value: 1.44e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541     8 LCTLPPGPEPPRFVCYCEGEESGEGDRGgFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQAVAL 87
Cdd:pfam15384   1 LCTVPPGPGQPRYVCYCERKEGGAGDRV-FNLYVTDAAEVWSTEFTPDSLAQLKARFGLKSAEDYTLRFRAACEQGAVSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541    88 TLQEDRASLTLSGGPSALAFDLSKVPGPEAAPRLRALTLGLAKRVWSLERRLaAAEETAVSPRKSPRPAGPQlFLPDPDP 167
Cdd:pfam15384  80 TLQEDRASLTLGGGPEALSFDLSKVPSPEAAPELKALLFGMAERLCQLESRL-AAEESSFSPRKSYQPAGAQ-FLPDPDH 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 39930541   168 QRGGPGPGVRRRCPGESLINPGFKSKKPAGGVDFDET 204
Cdd:pfam15384 158 NRGGPGPGVKRRLPGESLINPGFKSKKPATGVDFDDE 194
HD_PAXX_N cd22286
N-terminal head domain found in paralog of XRCC4 and XLF, and similar proteins; Paralog of ...
 7-112 1.35e-37

N-terminal head domain found in paralog of XRCC4 and XLF, and similar proteins; Paralog of XRCC4 and XLF (PAXX), also called XRCC4-like small protein, is a paralog of X-ray repair cross-complementing protein 4 (XRCC4) and XRCC4-like factor (XLF). It is involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks (DSBs) in DNA. It may act as a scaffold required to stabilize the DSB-repair protein Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites in cells. It functions with XRCC4 and XLF to bring about DSB repair and cell survival in response to DSB-inducing agents. Similar to XRCC4 and XLF, PAXX monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two homodimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. This model corresponds to the N-terminal head domain of PAXX, which is structurally related to other XRCC4-superfamily members, XRCC4, XLF, SAS6, and CCDC61.


Pssm-ID: 409003  Cd Length: 102  Bit Score: 125.83  E-value: 1.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541   7 PLCTLPPGPEPPRFVCYCEGEEsgegdrGGFNLYVTDAAELWSTCFTPDSLAALKARFGLSAAEDITPRFRAACEQQAVA 86
Cdd:cd22286   3 LLCTVTDGNDGSRYLCYTRLTN------DSFNICVTDGVDVWSTDFTEEELEEHRDLAGLSSTEDYLSKIRSAFESGTLS 76

                        90       100
                ....*....|....*....|....*.
gi 39930541  87 LTLQEDRASLTLSGGPSALAFDLSKV 112
Cdd:cd22286  77 LTVQDSKATLTLGKGPSALTFDLYEL 102
HD_XRCC4-like_N cd22210
N-terminal head domain found in the XRCC4 superfamily of proteins; The XRCC4 superfamily ...
 7-112 1.76e-30

N-terminal head domain found in the XRCC4 superfamily of proteins; The XRCC4 superfamily includes five families: XRCC4, XLF, PAXX, SAS6 and CCDC61. XRCC4 (X-ray repair cross-complementing protein 4), XLF (XRCC4-like factor) and PAXX (paralog of XRCC4 and XLF) play crucial roles in the non-homologous end-joining (NHEJ) DNA repair pathway. SAS6 (spindle assembly abnormal protein 6) and CCDC61 (coiled-coil domain-containing protein 61) have a centrosomal/centriolar function. Members of this superfamily have an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal low-complexity region. They form homodimers through two homodimerization domains: an N-terminal globular head domain and a parallel coiled-coil domain. In addition, some members such as XRCC4 and XLF form symmetric heterodimers that interact through their globular head domains at the opposite end of the homodimer interface, and may form XLF-XRCC4 filaments. This model corresponds to the N-terminal head domain of XRCC4 superfamily proteins.


Pssm-ID: 408999  Cd Length: 115  Bit Score: 108.01  E-value: 1.76e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39930541   7 PLCTLPPGPEPPRFVCYCEGEESgegDRGGFNLYVTDAAELWSTCFTPDSLAALKARFG-LSAAEDITPRFRAACEQ--- 82
Cdd:cd22210   1 PWRPLPLHVVLEELTFKVETEVA---NERGLRLHVSDDAFLWTGEVSESDISQLKNDQGiLVDFASFPGKLRSALEKcil 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 39930541  83 ----QAVALTLQEDRASLTLSGGPS----ALAFDLSKV 112
Cdd:cd22210  78 asdrFTFVLTIRGDEAYLKLVEILDeqlpHITFALRKV 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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